Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55224313 . T A CCDS5514.1:NM_005228.3:c.1094aTc>aAc_NP_005219.2:p.365I>N Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 ILE A:365 A:341 0.0 0.0 E -108.4 104.3 0.0 0.0 0.0
ILE C:365 B:341 0.0 0.0 B -68.7 121.4 0.0 0.0 0.0
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 ILE A:365 A:341 0.0 0.0 E -94.0 120.4 0.0 0.0 0.0
ILE B:365 B:341 4.0 0.023 E -118.3 109.1 4.0 0.023 0.0
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 ILE A:365 A:341 0.0 0.0 E -92.2 104.7 0.0 0.0 0.0
ILE C:365 B:341 3.0 0.017 E -58.6 122.1 3.0 0.017 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 ILE A:365 A:341 0.0 0.0 E -85.2 106.6 0.0 0.0 0.0
ILE C:365 B:341 0.0 0.0 E -127.6 94.0 0.0 0.0 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 ILE A:365 A:341 0.0 0.0 E -80.6 93.1 0.0 0.0 0.0
ILE C:365 B:341 0.0 0.0 E -87.0 96.9 0.0 0.0 0.0
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 ILE A:365 A:341 0.0 0.0 E -131.9 105.7 0.0 0.0 0.0
ILE C:365 B:341 0.0 0.0 E -82.6 99.3 0.0 0.0 0.0
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 ILE A:365 A:341 0.0 0.0 E -91.7 121.0 0.0 0.0 0.0
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 ILE A:365 A:341 0.0 0.0 E -106.9 116.1 0.0 0.0 0.0 HOH
 8.991
 CG1
 O
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 ILE A:341 A:341 0.0 0.0 E -93.5 121.1 0.0 0.0 0.0 HOH
 8.681
 O
 O
ILE B:341 B:341 0.0 0.0 E -87.1 108.4 0.0 0.0 0.0 HOH
 8.373
 CG1
 O
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 ILE A:341 A:341 0.0 0.0 E -104.0 123.0 0.0 0.0 0.0 HOH
 6.580
 O
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 ILE C:341 A:341 0.0 0.0 E -137.7 90.5 0.0 0.0 0.0
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 ILE A:341 A:341 0.0 0.0 E -135.7 117.3 0.0 0.0 0.0 HOH
 7.899
 H
 O
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 ILE A:341 A:341 0.0 0.0 E -108.2 117.0 0.0 0.0 0.0
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 ILE A:341 A:341 1.0 0.006 E -97.3 117.4 1.0 0.006 0.0
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 ILE A:341 A:341 0.0 0.0 E -110.9 123.3 0.0 0.0 0.0 HOH
 5.908
 CG2
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 ILE A:341 A:341 0.0 0.0 E -105.8 114.6 0.0 0.0 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 ILE A:341 A:341 0.0 0.0 E -75.5 118.5 0.0 0.0 0.0
ILE B:341 B:341 0.0 0.0 E -94.4 100.8 0.0 0.0 0.0
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 ILE A:340 A:341 0.0 0.0 E -110.1 117.2 0.0 0.0 0.0 HOH
 8.361
 CD1
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 ILE A:341 A:341 0.0 0.0 E -97.5 124.9 0.0 0.0 0.0
ILE B:341 B:341 0.0 0.0 E -101.3 116.1 NA NA NA
ILE C:341 C:341 0.0 0.0 E -98.3 115.6 NA NA NA
ILE D:341 D:341 0.0 0.0 E -110.9 120.1 0.0 0.0 0.0
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 ILE A:341 A:341 1.0 0.006 E -101.3 120.0 1.0 0.006 0.0 HOH
 7.472
 N
 O
ILE D:341 D:341 1.0 0.006 E -99.6 131.0 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 ILE A:341 A:341 0.0 0.0 E -105.1 123.2 0.0 0.0 0.0 HOH
 5.930
 CG2
 O
ILE B:341 B:341 0.0 0.0 E -109.8 114.3 0.0 0.0 0.0 HOH
 6.068
 CG2
 O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ILE A:341 A:341 0.0 0.0 E -98.2 112.9 0.0 0.0 0.0
ILE B:341 B:341 0.0 0.0 E -108.9 122.4 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ILE A:341 A:341 0.0 0.0 E -106.7 113.5 0.0 0.0 0.0
ILE B:341 B:341 0.0 0.0 E -113.3 111.2 0.0 0.0 0.0
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ILE A:341 A:341 3.0 0.017 E -111.8 98.9 3.0 0.017 0.0
ILE B:341 B:341 0.0 0.0 E -112.3 107.5 NA NA NA
ILE C:341 C:341 1.0 0.006 E -112.1 103.9 NA NA NA
ILE D:341 D:341 0.0 0.0 E -113.9 106.5 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 ILE A:32 A:341 0.0 0.0 E -96.6 117.6 0.0 0.0 0.0 HOH
 5.916
 CG2
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 ILE C:35 A:341 0.0 0.0 E -101.1 125.2 0.0 0.0 0.0 HOH
 6.933
 O
 O
ILE F:35 B:341 0.0 0.0 E -97.5 128.6 NA NA NA
ILE I:35 E:341 1.0 0.006 E -93.1 116.5 NA NA NA
ILE L:35 I:341 0.0 0.0 E -104.0 120.6 NA NA NA
ILE O:35 M:341 2.0 0.011 E -114.8 127.4 NA NA NA
ILE R:35 P:341 0.0 0.0 E -87.8 115.8 NA NA NA
ILE U:35 S:341 0.0 0.0 E -96.2 123.1 NA NA NA
ILE X:35 V:341 0.0 0.0 E -103.1 131.2 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 ILE C:35 A:341 0.0 0.0 E -114.6 107.4 NA NA NA
ILE F:35 D:341 1.0 0.006 E -120.0 97.4 1.0 0.006 0.0
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 ILE B:35 A:341 0.0 0.0 E -105.3 109.7 0.0 0.0 0.0 HOH
 6.363
 CG2
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 ILE A:35 A:341 0.0 0.0 E -97.0 115.1 0.0 0.0 0.0 HOH
 5.456
 HG22
 O
ILE C:35 C:341 0.0 0.0 E -101.9 119.3 NA NA NA
ILE E:35 E:341 0.0 0.0 E -101.0 116.0 NA NA NA
ILE G:35 G:341 0.0 0.0 E -90.9 118.1 NA NA NA
ILE I:35 I:341 0.0 0.0 E -105.4 114.2 NA NA NA
ILE K:35 K:341 0.0 0.0 E -102.0 119.3 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 ILE A:35 A:341 0.0 0.0 E -109.7 114.8 0.0 0.0 0.0
ILE D:35 B:341 0.0 0.0 E -116.5 121.2 NA NA NA
ILE G:35 E:341 0.0 0.0 E -110.0 122.3 NA NA NA
ILE J:35 I:341 0.0 0.0 E -103.1 117.7 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 ILE E:35 M:341 1.0 0.006 E -108.1 123.0 1.0 0.006 0.0 HOH
 5.857
 O
 O
ILE F:35 N:341 0.0 0.0 E -109.4 120.1 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 ILE E:35 M:341 0.0 0.0 E -107.8 124.1 0.0 0.0 0.0
ILE F:35 N:341 0.0 0.0 E -104.7 121.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 ILE A:365 A:365 0.0 0.0 E -99.5 113.0