Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr7 | 55227933 | . | A | C | CCDS5514.1:NM_005228.3:c.1400aAa>aCa_NP_005219.2:p.467K>T | Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7syd | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:467 | A:443 | 154.0 | 0.77 | T | -64.6 | -34.1 | 154.0 | 0.77 | 0.0 | ||||||
| LYS | C:467 | B:443 | 146.0 | 0.73 | S | -65.4 | -16.1 | 146.0 | 0.73 | 0.0 | |||||||||||||
| 7sye | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:467 | A:443 | 156.0 | 0.78 | S | -62.5 | -57.8 | 156.0 | 0.78 | 0.0 | ||||||
| LYS | B:467 | B:443 | 137.0 | 0.685 | S | -66.7 | -44.6 | 137.0 | 0.685 | 0.0 | |||||||||||||
| 7sz5 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:467 | A:443 | 130.0 | 0.65 | S | -78.5 | -58.4 | 130.0 | 0.65 | 0.0 | ||||||
| LYS | C:467 | B:443 | 148.0 | 0.74 | S | -61.6 | -45.8 | 148.0 | 0.74 | 0.0 | |||||||||||||
| 7sz7 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-15 | LYS | A:467 | A:443 | 147.0 | 0.735 | T | -62.3 | -26.8 | 147.0 | 0.735 | 0.0 | ||||||
| LYS | C:467 | B:443 | 139.0 | 0.695 | S | -64.8 | -36.7 | 139.0 | 0.695 | 0.0 | |||||||||||||
| 7sz0 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | LYS | A:467 | A:443 | 154.0 | 0.77 | T | -62.9 | -35.6 | 150.0 | 0.75 | 0.02 |
B:P01133:0.02 |
|||||
| LYS | C:467 | B:443 | 146.0 | 0.73 | S | -64.2 | -59.9 | 146.0 | 0.73 | 0.0 | |||||||||||||
| 7sz1 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | LYS | A:467 | A:443 | 137.0 | 0.685 | S | -61.5 | -64.0 | 137.0 | 0.685 | 0.0 | ||||||
| LYS | C:467 | B:443 | 144.0 | 0.72 | S | -73.3 | -25.0 | 144.0 | 0.72 | 0.0 | |||||||||||||
| 5xwd | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2018-02-28 | LYS | A:467 | A:443 | 128.0 | 0.64 | T | -67.3 | -0.1 | 25.0 | 0.125 | 0.515 |
C:None:0.515 |
NAG |
7.664 |
CB |
C1 |
|
| 3qwq | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2012-02-01 | LYS | A:467 | A:443 | 63.0 | NA | T | -46.7 | -38.4 | 63.0 | NA | NA |
NAG |
7.517 |
C |
O5 |
||
| 1ivo | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2002-10-16 | LYS | A:443 | A:443 | 132.0 | 0.66 | T | -15.7 | -72.8 | 132.0 | 0.66 | 0.0 |
NAG NAG |
2.931 5.962 |
NZ NZ |
O7 N2 |
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| LYS | B:443 | B:443 | 129.0 | 0.645 | T | -26.3 | -64.5 | 129.0 | 0.645 | 0.0 |
HOH |
9.718 |
O |
O |
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| 4uv7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-10-14 | LYS | A:443 | A:443 | 145.0 | 0.725 | T | -69.4 | -25.4 | 145.0 | 0.725 | 0.0 |
NAG NAG HOH |
6.159 8.880 2.935 |
CE O N |
C1 C8 O |
||
| 3b2v | 3 | P00533 | 100.0 | 0.0 |
X-RAY |
2008-02-19 | LYS | C:443 | A:443 | 128.0 | 0.64 | 100.9 | -16.2 | 59.0 | 0.295 | 0.345 |
A:None:0.085 B:None:0.31 |
NAG NAG |
6.945 8.335 |
NZ NZ |
C1 O7 |
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| 4kro | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2013-08-28 | LYS | A:443 | A:443 | 149.0 | 0.745 | T | -59.8 | -22.4 | 54.0 | 0.27 | 0.475 |
D:None:0.325 C:None:0.285 |
NAG NAG HOH |
5.853 7.458 2.384 |
HD2 HD3 HG2 |
H5 H81 O |
|
| 1nql | 1 | 4885199 | 99.84 | 0.0 |
X-RAY |
2003-03-11 | LYS | A:443 | A:443 | 61.0 | NA | T | -63.0 | 8.1 | 61.0 | NA | NA |
NAG NAG |
6.763 8.692 |
O O |
C6 O7 |
||
| 4krp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2013-08-28 | LYS | A:443 | A:443 | 141.0 | 0.705 | T | -63.8 | -20.4 | 63.0 | 0.315 | 0.39 |
D:None:0.215 C:None:0.285 |
NAG NAG |
5.690 9.107 |
HD2 HD3 |
H1 O7 |
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| 1yy9 | 1 | P00533 | 99.51 | 0.0 |
X-RAY |
2005-04-26 | LYS | A:443 | A:443 | 151.0 | 0.755 | T | -71.2 | -14.2 | 59.0 | 0.295 | 0.46 |
B:None:0.33 C:None:0.255 |
NAG NAG HOH |
7.182 7.639 6.823 |
CE CD N |
C1 O7 O |
|
| 6aru | 1 | P00533 | 99.68 | 0.0 |
X-RAY |
2018-08-29 | LYS | A:443 | A:443 | 129.0 | 0.645 | T | -46.4 | -30.3 | 129.0 | 0.645 | 0.0 |
NAG NAG |
7.075 9.196 |
NZ O |
C1 O7 |
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| 3njp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2010-10-13 | LYS | A:443 | A:443 | 138.0 | 0.69 | T | -28.1 | -72.3 | 138.0 | 0.69 | 0.0 |
NAG HOH |
5.648 4.319 |
NZ NZ |
C1 O |
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| LYS | B:443 | B:443 | 117.0 | 0.585 | T | -58.6 | -56.5 | 117.0 | 0.585 | 0.0 | |||||||||||||
| 4uip | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-11-25 | LYS | A:442 | A:443 | 162.0 | 0.81 | T | -58.4 | -28.7 | 147.0 | 0.735 | 0.075 |
B:E0ACT6+Q4G1L3:0.075 |
NAG HOH |
6.547 9.424 |
CD O |
O3 O |
|
| 5wb7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | LYS | A:443 | A:443 | 144.0 | 0.72 | T | -55.7 | -24.1 | 144.0 | 0.72 | 0.0 |
NAG |
4.899 |
CD |
C8 |
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| LYS | B:443 | B:443 | 151.0 | 0.755 | T | -68.0 | -40.7 | NA | NA | NA | |||||||||||||
| LYS | C:443 | C:443 | 66.0 | NA | T | -70.2 | -6.4 | NA | NA | NA | |||||||||||||
| LYS | D:443 | D:443 | 60.0 | NA | T | -63.0 | -25.0 | 60.0 | NA | NA | |||||||||||||
| 5wb8 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | LYS | A:443 | A:443 | 122.0 | 0.61 | T | -65.7 | -11.8 | 122.0 | 0.61 | 0.0 |
NAG NAG HOH |
7.786 8.359 8.062 |
C O CA |
C6 O7 O |
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| LYS | D:443 | D:443 | 131.0 | 0.655 | T | -68.4 | 8.1 | NA | NA | NA | |||||||||||||
| 1mox | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2003-09-10 | LYS | A:443 | A:443 | 124.0 | 0.62 | T | -40.8 | -30.0 | 124.0 | 0.62 | 0.0 |
HOH |
3.736 |
N |
O |
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| LYS | B:443 | B:443 | 115.0 | 0.575 | T | -52.5 | -24.1 | 115.0 | 0.575 | 0.0 |
HOH |
3.322 |
N |
O |
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| 7len | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:443 | A:443 | 141.0 | 0.705 | T | -70.5 | -13.8 | 141.0 | 0.705 | 0.0 |
NAG |
6.205 |
CE |
C1 |
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| LYS | B:443 | B:443 | 68.0 | NA | T | -69.7 | -10.2 | NA | NA | NA | |||||||||||||
| 7lfr | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:443 | A:443 | 106.0 | 0.53 | T | -67.1 | -20.7 | 106.0 | 0.53 | 0.0 | ||||||
| LYS | B:443 | B:443 | 61.0 | NA | T | -69.7 | -26.9 | 61.0 | NA | NA | |||||||||||||
| 7lfs | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:443 | A:443 | 137.0 | 0.685 | T | -65.8 | -32.1 | 137.0 | 0.685 | 0.0 | ||||||
| LYS | B:443 | B:443 | 128.0 | 0.64 | T | -67.1 | -46.4 | NA | NA | NA | |||||||||||||
| LYS | C:443 | C:443 | 71.0 | NA | T | -66.4 | -14.6 | NA | NA | NA | |||||||||||||
| LYS | D:443 | D:443 | 78.0 | NA | T | -67.8 | -8.5 | NA | NA | NA | |||||||||||||
| 3p0y | 1 | P00533 | 99.52 | 3e-141 |
X-RAY |
2011-10-26 | LYS | A:134 | A:443 | 137.0 | 0.685 | T | -63.2 | -20.7 | 137.0 | 0.685 | 0.0 |
NAG NAG HOH |
7.652 8.913 2.636 |
C O O |
C6 O7 O |
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| 3b2u | 3 | P00533 | 99.51 | 2e-140 |
X-RAY |
2008-02-19 | LYS | C:137 | A:443 | 150.0 | 0.75 | T | -70.6 | -10.5 | 70.0 | 0.35 | 0.4 |
B:None:0.365 A:None:0.08 |
NAG NAG SO4 HOH |
6.675 8.279 8.303 2.929 |
CE CE O NZ |
C1 O7 O1 O |
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| LYS | F:137 | B:443 | 148.0 | 0.74 | T | -66.2 | -15.0 | NA | NA | NA | |||||||||||||
| LYS | I:137 | E:443 | 150.0 | 0.75 | T | -63.3 | -7.8 | NA | NA | NA | |||||||||||||
| LYS | L:137 | I:443 | 150.0 | 0.75 | T | -57.7 | -19.3 | NA | NA | NA | |||||||||||||
| LYS | O:137 | M:443 | 148.0 | 0.74 | T | -57.2 | -14.6 | NA | NA | NA | |||||||||||||
| LYS | R:137 | P:443 | 147.0 | 0.735 | T | -59.3 | -12.1 | NA | NA | NA | |||||||||||||
| LYS | U:137 | S:443 | 147.0 | 0.735 | T | -67.8 | -21.2 | NA | NA | NA | |||||||||||||
| LYS | X:137 | V:443 | 154.0 | 0.77 | T | -56.5 | -15.9 | NA | NA | NA | |||||||||||||
| 3c09 | 3 | P00533 | 99.51 | 2e-140 |
X-RAY |
2008-04-15 | LYS | C:137 | A:443 | 72.0 | NA | T | -23.4 | -45.6 | NA | NA | NA | ||||||
| LYS | F:137 | D:443 | 68.0 | NA | T | -35.1 | -32.0 | 68.0 | NA | NA | |||||||||||||
| 4krl | 2 | P00533 | 99.51 | 2e-140 |
X-RAY |
2013-08-28 | LYS | B:137 | A:443 | 57.0 | NA | T | -50.2 | -35.5 | 49.0 | NA | NA |
A:None:NA |
NAG HOH |
5.347 2.516 |
CB O |
O6 O |
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| 4krm | 1 | P00533 | 99.51 | 2e-140 |
X-RAY |
2013-08-28 | LYS | A:137 | A:443 | 61.0 | NA | T | -61.9 | -15.7 | 54.0 | NA | NA |
B:None:NA |
NAG HOH |
5.465 3.214 |
CB N |
O6 O |
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| LYS | C:137 | C:443 | 59.0 | NA | T | -56.6 | -22.6 | NA | NA | NA | |||||||||||||
| LYS | E:137 | E:443 | 132.0 | 0.66 | T | -60.8 | -22.0 | NA | NA | NA | |||||||||||||
| LYS | G:137 | G:443 | 60.0 | NA | T | -60.7 | -15.4 | NA | NA | NA | |||||||||||||
| LYS | I:137 | I:443 | 57.0 | NA | T | -63.5 | -17.3 | NA | NA | NA | |||||||||||||
| LYS | K:137 | K:443 | 57.0 | NA | T | -61.5 | -15.1 | NA | NA | NA | |||||||||||||
| 6b3s | 1 | P00533 | 99.02 | 1e-139 |
X-RAY |
2017-12-06 | LYS | A:137 | A:443 | 158.0 | 0.79 | T | -73.7 | -8.2 | 85.0 | 0.425 | 0.365 |
B:None:0.34 C:None:0.06 |
NAG NAG |
6.446 8.984 |
CE O |
C1 C8 |
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| LYS | D:137 | B:443 | 151.0 | 0.755 | T | -76.9 | -16.0 | NA | NA | NA | |||||||||||||
| LYS | G:137 | E:443 | 152.0 | 0.76 | T | -68.5 | -17.5 | NA | NA | NA | |||||||||||||
| LYS | J:137 | I:443 | 155.0 | 0.775 | T | -66.9 | -12.0 | NA | NA | NA | |||||||||||||
| 5sx4 | 3 | P00533 | 98.44 | 5e-129 |
X-RAY |
2016-10-05 | LYS | E:137 | M:443 | 141.0 | 0.705 | S | -78.6 | -18.0 | 61.0 | 0.305 | 0.4 |
B:None:0.38 A:None:0.08 |
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| LYS | F:137 | N:443 | 140.0 | 0.7 | S | -76.8 | -22.8 | NA | NA | NA | |||||||||||||
| 5sx5 | 3 | P00533 | 97.92 | 3e-128 |
X-RAY |
2016-10-05 | LYS | E:137 | M:443 | 137.0 | 0.685 | S | -72.2 | -23.9 | 58.0 | 0.29 | 0.395 |
B:None:0.355 A:None:0.095 |
HOH |
3.213 |
N |
O |
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| LYS | F:137 | N:443 | 139.0 | 0.695 | T | -71.9 | -19.8 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00533-f1 | 1 | P00533 | 100.0 | 0.0 | LYS | A:467 | A:467 | 121.0 | 0.605 | T | -51.6 | -27.2 | |