Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55227963 . G A CCDS5514.1:NM_005228.3:c.1430tGg>tAg_NP_005219.2:p.477W>* Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 TRP A:477 A:453 9.0 0.035 T -64.7 -2.6 9.0 0.035 0.0
TRP C:477 B:453 14.0 0.055 H -60.9 -32.3 14.0 0.055 0.0
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 TRP A:477 A:453 17.0 0.067 G -69.1 -22.3 17.0 0.067 0.0
TRP B:477 B:453 7.0 0.027 G -57.5 -16.3 7.0 0.027 0.0
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 TRP A:477 A:453 13.0 0.051 H -71.1 -18.9 13.0 0.051 0.0
TRP C:477 B:453 15.0 0.059 G -64.5 -8.8 15.0 0.059 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 TRP A:477 A:453 5.0 0.02 G -61.3 -18.3 5.0 0.02 0.0
TRP C:477 B:453 14.0 0.055 T -65.5 -23.1 14.0 0.055 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 TRP A:477 A:453 14.0 0.055 G -63.3 -19.2 14.0 0.055 0.0
TRP C:477 B:453 15.0 0.059 T -63.8 -15.6 15.0 0.059 0.0
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 TRP A:477 A:453 14.0 0.055 H -63.4 -22.0 14.0 0.055 0.0
TRP C:477 B:453 19.0 0.075 G -64.9 -19.7 19.0 0.075 0.0
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 TRP A:477 A:453 16.0 0.063 G -81.9 -18.7 16.0 0.063 0.0
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 TRP A:477 A:453 16.0 0.063 H -63.4 -25.9 16.0 0.063 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 TRP A:453 A:453 16.0 0.063 H -61.6 -24.1 16.0 0.063 0.0
TRP B:453 B:453 10.0 0.039 G -75.6 -19.8 10.0 0.039 0.0 HOH
 7.118
 CD1
 O
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 TRP A:453 A:453 13.0 0.051 G -59.1 -31.7 13.0 0.051 0.0 HOH
 5.060
 N
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 TRP C:453 A:453 10.0 0.039 G -63.8 -39.4 10.0 0.039 0.0
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 TRP A:453 A:453 8.0 0.031 G -71.7 -22.5 8.0 0.031 0.0
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 TRP A:453 A:453 12.0 0.047 G -31.1 -32.9 12.0 0.047 0.0
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 TRP A:453 A:453 10.0 0.039 G -67.2 -15.8 10.0 0.039 0.0
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 TRP A:453 A:453 7.0 0.027 G -56.9 -19.1 7.0 0.027 0.0 HOH
 7.879
 O
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 TRP A:453 A:453 14.0 0.055 H -61.6 -22.1 14.0 0.055 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 TRP A:453 A:453 16.0 0.063 H -59.2 -27.7 16.0 0.063 0.0
TRP B:453 B:453 12.0 0.047 H -67.5 -28.2 12.0 0.047 0.0
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 TRP A:452 A:453 14.0 0.055 G -59.7 -32.3 13.0 0.051 0.004 B:E0ACT6+Q4G1L3:0.004
 HOH
 3.933
 CD1
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 TRP A:453 A:453 12.0 0.047 G -64.1 -22.4 12.0 0.047 0.0
TRP B:453 B:453 13.0 0.051 G -71.2 -20.8 NA NA NA
TRP C:453 C:453 21.0 0.082 G -67.1 -22.5 NA NA NA
TRP D:453 D:453 25.0 0.098 G -66.5 -24.1 25.0 0.098 0.0
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 TRP A:453 A:453 16.0 0.063 G -67.5 -19.8 16.0 0.063 0.0 HOH
 5.326
 CB
 O
TRP D:453 D:453 20.0 0.078 G -73.9 -15.0 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 TRP A:453 A:453 11.0 0.043 G -61.0 -34.6 11.0 0.043 0.0
TRP B:453 B:453 13.0 0.051 G -50.0 -41.5 13.0 0.051 0.0 HOH
 7.197
 CZ2
 O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 TRP A:453 A:453 11.0 0.043 G -67.1 -18.8 11.0 0.043 0.0
TRP B:453 B:453 12.0 0.047 T -65.4 -14.5 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 TRP A:453 A:453 6.0 0.024 G -60.4 -19.8 6.0 0.024 0.0
TRP B:453 B:453 8.0 0.031 H -61.2 -22.1 8.0 0.031 0.0
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 TRP A:453 A:453 10.0 0.039 H -72.2 -10.7 10.0 0.039 0.0
TRP B:453 B:453 8.0 0.031 H -67.9 -18.5 NA NA NA
TRP C:453 C:453 10.0 0.039 H -70.8 -18.5 NA NA NA
TRP D:453 D:453 8.0 0.031 H -77.4 -12.6 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 TRP A:144 A:453 20.0 0.078 H -59.9 -35.8 20.0 0.078 0.0 HOH
 3.216
 N
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 TRP C:147 A:453 16.0 0.063 G -70.7 -35.8 16.0 0.063 0.0 HOH
 5.405
 CB
 O
TRP F:147 B:453 18.0 0.071 G -66.5 -29.7 NA NA NA
TRP I:147 E:453 18.0 0.071 G -60.7 -36.8 NA NA NA
TRP L:147 I:453 19.0 0.075 G -69.4 -19.7 NA NA NA
TRP O:147 M:453 15.0 0.059 G -61.4 -38.7 NA NA NA
TRP R:147 P:453 21.0 0.082 G -63.1 -27.5 NA NA NA
TRP U:147 S:453 22.0 0.086 H -64.2 -28.1 NA NA NA
TRP X:147 V:453 18.0 0.071 G -57.1 -27.6 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 TRP C:147 A:453 18.0 0.071 G -55.5 -30.2 NA NA NA
TRP F:147 D:453 25.0 0.098 G -48.8 -35.9 9.0 0.035 0.063 B:None:0.063
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 TRP B:147 A:453 21.0 0.082 G -70.7 -18.8 21.0 0.082 0.0 HOH
 3.445
 N
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 TRP A:147 A:453 21.0 0.082 G -64.2 -23.0 21.0 0.082 0.0 HOH
 5.363
 HZ2
 O
TRP C:147 C:453 17.0 0.067 G -79.0 -23.9 NA NA NA
TRP E:147 E:453 22.0 0.086 G -68.8 -24.5 NA NA NA
TRP G:147 G:453 18.0 0.071 G -73.9 -20.4 NA NA NA
TRP I:147 I:453 18.0 0.071 G -69.8 -19.7 NA NA NA
TRP K:147 K:453 18.0 0.071 G -69.6 -10.5 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 TRP A:147 A:453 13.0 0.051 H -71.8 -19.3 13.0 0.051 0.0
TRP D:147 B:453 15.0 0.059 H -71.0 -19.4 NA NA NA
TRP G:147 E:453 13.0 0.051 H -70.8 -24.4 NA NA NA
TRP J:147 I:453 14.0 0.055 H -70.2 -26.3 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 TRP E:147 M:453 13.0 0.051 T -71.7 -10.8 13.0 0.051 0.0 HOH
 4.367
 CD1
 O
TRP F:147 N:453 21.0 0.082 H -74.2 -17.0 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 TRP E:147 M:453 16.0 0.063 G -71.8 -13.6 16.0 0.063 0.0
TRP F:147 N:453 17.0 0.067 G -77.6 -11.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 TRP A:477 A:477 15.0 0.059 G -50.3 -29.0