Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55229246 . C A CCDS5514.1:NM_005228.3:c.1553cCg>cAg_NP_005219.2:p.518P>Q Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 PRO A:518 A:494 59.0 0.407 S -83.6 -17.2 59.0 0.407 0.0
PRO C:518 B:494 57.0 0.393 S -90.1 -15.5 57.0 0.393 0.0
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 PRO A:518 A:494 53.0 0.366 S -86.1 -24.8 53.0 0.366 0.0
PRO B:518 B:494 52.0 0.359 S -69.4 -41.3 52.0 0.359 0.0
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 PRO A:518 A:494 60.0 0.414 S -82.3 -22.3 60.0 0.414 0.0
PRO C:518 B:494 34.0 0.234 S -77.6 -30.4 34.0 0.234 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 PRO A:518 A:494 56.0 0.386 S -75.2 -32.8 56.0 0.386 0.0
PRO C:518 B:494 51.0 0.352 S -93.0 -8.3 51.0 0.352 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 PRO A:518 A:494 57.0 0.393 S -83.6 -26.9 57.0 0.393 0.0
PRO C:518 B:494 38.0 0.262 S -83.3 -21.2 38.0 0.262 0.0
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 PRO A:518 A:494 57.0 0.393 S -70.0 -49.5 57.0 0.393 0.0
PRO C:518 B:494 61.0 0.421 S -89.3 4.8 61.0 0.421 0.0
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 PRO A:518 A:494 45.0 0.31 S -78.8 -36.8 45.0 0.31 0.0 ZN
 9.022
 CD
 ZN
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 PRO A:518 A:494 47.0 0.324 S -75.1 -28.3 47.0 0.324 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 PRO A:494 A:494 54.0 0.372 S -73.8 -60.2 54.0 0.372 0.0 HOH
 8.809
 O
 O
PRO B:494 B:494 59.0 0.407 S -86.1 -44.2 59.0 0.407 0.0
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 PRO A:494 A:494 44.0 0.303 S -85.9 -8.6 44.0 0.303 0.0 HOH
 2.750
 O
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 PRO C:494 A:494 55.0 0.379 S -125.7 -37.5 55.0 0.379 0.0
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 PRO A:494 A:494 65.0 0.448 S -82.4 -27.7 65.0 0.448 0.0 NAG
 9.277
 HG3
 HO6
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 PRO A:494 A:494 56.0 0.386 S -80.4 -34.3 56.0 0.386 0.0 NAG
 8.547
 CG
 C8
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 PRO A:494 A:494 59.0 0.407 S -77.4 -21.4 59.0 0.407 0.0 NAG
 9.310
 HG3
 HO6
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 PRO A:494 A:494 56.0 0.386 S -75.0 -47.0 56.0 0.386 0.0 HOH
 2.905
 O
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 PRO A:494 A:494 53.0 0.366 S -73.6 -28.6 53.0 0.366 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 PRO A:494 A:494 56.0 0.386 S -77.9 -36.4 56.0 0.386 0.0
PRO B:494 B:494 53.0 0.366 S -81.2 -48.2 53.0 0.366 0.0
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 PRO A:493 A:494 53.0 0.366 S -77.9 -16.3 53.0 0.366 0.0 HOH
 3.853
 CB
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 PRO A:494 A:494 45.0 0.31 S -75.4 -18.5 45.0 0.31 0.0 HOH
 4.248
 CD
 O
PRO B:494 B:494 46.0 0.317 S -71.4 -28.7 NA NA NA
PRO C:494 C:494 45.0 0.31 S -71.8 -20.7 NA NA NA
PRO D:494 D:494 66.0 0.455 S -62.5 -34.0 66.0 0.455 0.0
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 PRO A:494 A:494 68.0 0.469 S -86.4 -5.4 68.0 0.469 0.0 HOH
 3.471
 CD
 O
PRO D:494 D:494 53.0 0.366 S -86.9 -35.0 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 PRO A:494 A:494 57.0 0.393 S -74.7 -25.3 57.0 0.393 0.0 CD
CD
CD
CL
HOH
 4.626
8.114
7.654
3.891
3.173
 CD
CD
CG
CD
O
 CD
CD
CD
CL
O
PRO B:494 B:494 58.0 0.4 S -90.6 -29.9 58.0 0.4 0.0 CD
CD
HOH
 9.386
7.439
5.199
 CD
CG
CD
 CD
CD
O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PRO A:494 A:494 57.0 0.393 S -74.1 -22.7 57.0 0.393 0.0
PRO B:494 B:494 57.0 0.393 S -86.9 -18.1 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PRO A:494 A:494 53.0 0.366 S -72.5 -32.3 53.0 0.366 0.0
PRO B:494 B:494 52.0 0.359 S -78.3 -34.2 52.0 0.359 0.0
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PRO A:494 A:494 56.0 0.386 S -72.1 -32.2 56.0 0.386 0.0
PRO B:494 B:494 48.0 0.331 S -75.1 -26.1 NA NA NA
PRO C:494 C:494 61.0 0.421 S -70.4 -32.6 NA NA NA
PRO D:494 D:494 58.0 0.4 S -68.9 -29.8 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 PRO A:185 A:494 46.0 0.317 S -79.2 -15.2 46.0 0.317 0.0 HOH
 3.011
 O
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 PRO C:188 A:494 53.0 0.366 S -78.3 -19.7 53.0 0.366 0.0 HOH
 7.931
 N
 O
PRO F:188 B:494 69.0 0.476 S -80.6 -29.9 NA NA NA
PRO I:188 E:494 48.0 0.331 S -76.3 -24.6 NA NA NA
PRO L:188 I:494 52.0 0.359 S -88.7 -15.3 NA NA NA
PRO O:188 M:494 66.0 0.455 S -73.2 -40.0 NA NA NA
PRO R:188 P:494 46.0 0.317 S -67.8 -29.0 NA NA NA
PRO U:188 S:494 49.0 0.338 S -88.4 -6.0 NA NA NA
PRO X:188 V:494 51.0 0.352 S -64.6 -37.2 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 PRO C:188 A:494 64.0 0.441 S -73.3 -27.1 NA NA NA
PRO F:188 D:494 68.0 0.469 S -77.2 -67.6 68.0 0.469 0.0
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 PRO B:188 A:494 55.0 0.379 S -75.6 -21.9 55.0 0.379 0.0 HOH
 3.583
 CD
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 PRO A:188 A:494 58.0 0.4 S -88.3 2.3 58.0 0.4 0.0 HOH
 7.245
 HD3
 O
PRO C:188 C:494 59.0 0.407 S -76.7 -17.2 NA NA NA
PRO E:188 E:494 63.0 0.434 S -83.1 -5.4 NA NA NA
PRO G:188 G:494 51.0 0.352 S -80.2 -18.5 NA NA NA
PRO I:188 I:494 63.0 0.434 S -81.7 -39.1 NA NA NA
PRO K:188 K:494 60.0 0.414 S -77.3 -24.4 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 PRO A:188 A:494 60.0 0.414 S -78.0 -28.7 60.0 0.414 0.0
PRO D:188 B:494 51.0 0.352 S -77.6 -46.6 NA NA NA
PRO G:188 E:494 55.0 0.379 S -81.0 -43.1 NA NA NA
PRO J:188 I:494 54.0 0.372 S -76.6 -23.7 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 PRO E:188 M:494 60.0 0.414 S -81.2 -22.2 60.0 0.414 0.0 HOH
 3.957
 CD
 O
PRO F:188 N:494 61.0 0.421 S -77.4 -18.6 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 PRO E:188 M:494 54.0 0.372 S -81.9 -26.2 54.0 0.372 0.0 HOH
 4.328
 CD
 O
PRO F:188 N:494 54.0 0.372 S -73.9 -24.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 PRO A:518 A:518 54.0 0.372 S -79.9 -18.5