Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55229255 . G A CCDS5514.1:NM_005228.3:c.1562aGg>aAg_NP_005219.2:p.521R>K Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 ARG A:521 A:497 99.0 0.44 G -84.7 1.1 99.0 0.44 0.0
ARG C:521 B:497 101.0 0.449 T -79.1 6.6 101.0 0.449 0.0
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 ARG A:521 A:497 102.0 0.453 S -82.5 -43.3 102.0 0.453 0.0
ARG B:521 B:497 110.0 0.489 T -50.3 -55.9 110.0 0.489 0.0
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 ARG A:521 A:497 68.0 0.302 T -94.1 -13.1 68.0 0.302 0.0
ARG C:521 B:497 149.0 0.662 T -63.2 -28.9 149.0 0.662 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 ARG A:521 A:497 95.0 0.422 G -76.1 9.1 95.0 0.422 0.0
ARG C:521 B:497 106.0 0.471 G -66.5 -7.6 106.0 0.471 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 ARG A:521 A:497 93.0 0.413 G -78.9 11.9 93.0 0.413 0.0
ARG C:521 B:497 99.0 0.44 G -77.3 -7.7 99.0 0.44 0.0
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 ARG A:521 A:497 130.0 0.578 T -57.5 -37.2 130.0 0.578 0.0
ARG C:521 B:497 158.0 0.702 T -57.4 -32.1 158.0 0.702 0.0
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 ARG A:521 A:497 133.0 0.591 G -70.2 -9.9 133.0 0.591 0.0 ZN
 9.513
 CB
 ZN
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 ARG A:521 A:497 107.0 0.476 T -86.8 -20.4 107.0 0.476 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 ARG A:497 A:497 110.0 0.489 T -101.3 -6.6 110.0 0.489 0.0 HOH
 8.139
 N
 O
ARG B:497 B:497 117.0 0.52 G -63.0 -41.8 117.0 0.52 0.0
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 ARG A:497 A:497 86.0 0.382 T -87.3 -3.7 86.0 0.382 0.0 HOH
 2.874
 O
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 ARG C:497 A:497 102.0 0.453 G -38.8 -27.8 102.0 0.453 0.0
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 ARG A:497 A:497 120.0 0.533 G -75.3 -7.3 120.0 0.533 0.0
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 ARG A:497 A:497 36.0 NA G -59.4 -9.2 36.0 NA NA
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 ARG A:497 A:497 98.0 0.436 G -82.2 9.1 98.0 0.436 0.0
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 ARG A:497 A:497 84.0 0.373 G -80.1 2.8 84.0 0.373 0.0 HOH
 6.308
 N
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 ARG A:497 A:497 112.0 0.498 T -88.9 -19.3 112.0 0.498 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 ARG A:497 A:497 94.0 0.418 T -89.9 -7.6 94.0 0.418 0.0 HOH
 7.847
 NH2
 O
ARG B:497 B:497 79.0 0.351 G -77.5 -17.3 79.0 0.351 0.0
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 ARG A:496 A:497 103.0 0.458 T -102.2 5.5 103.0 0.458 0.0 HOH
 6.348
 NH2
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 ARG A:497 A:497 166.0 0.738 T -59.8 -27.4 166.0 0.738 0.0 HOH
 9.333
 NH1
 O
ARG B:497 B:497 155.0 0.689 T -75.9 -27.7 NA NA NA
ARG C:497 C:497 168.0 0.747 S -82.5 -35.0 NA NA NA
ARG D:497 D:497 70.0 NA G -53.1 -29.8 70.0 NA NA HOH
 9.149
 O
 O
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 ARG A:497 A:497 128.0 0.569 G -69.8 -8.7 128.0 0.569 0.0 HOH
 2.831
 N
 O
ARG D:497 D:497 66.0 NA G -62.6 -14.8 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 ARG A:497 A:497 141.0 0.627 G -80.1 6.8 141.0 0.627 0.0 CD
CD
CD
CL
HOH
 6.225
8.027
5.279
7.340
5.761
 C
O
NH2
NH2
N
 CD
CD
CD
CL
O
ARG B:497 B:497 143.0 0.636 G -75.7 -6.0 143.0 0.636 0.0 CD
CD
HOH
 5.743
5.147
5.780
 NH2
NH2
NH1
 CD
CD
O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ARG A:497 A:497 155.0 0.689 G -75.2 -32.0 155.0 0.689 0.0
ARG B:497 B:497 70.0 NA G -60.8 -20.5 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ARG A:497 A:497 136.0 0.604 G -61.3 -37.1 136.0 0.604 0.0
ARG B:497 B:497 71.0 NA G -66.5 -7.6 71.0 NA NA
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 ARG A:497 A:497 150.0 0.667 G -59.5 -30.5 150.0 0.667 0.0
ARG B:497 B:497 79.0 NA T -67.5 -23.5 NA NA NA
ARG C:497 C:497 162.0 0.72 T -64.2 -38.9 NA NA NA
ARG D:497 D:497 73.0 NA T -64.5 -39.6 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 ARG A:188 A:497 149.0 0.662 G -68.4 -17.3 149.0 0.662 0.0 HOH
 3.071
 NH2
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 ARG C:191 A:497 61.0 NA G -66.1 2.1 61.0 NA NA HOH
 3.165
 O
 O
ARG F:191 B:497 86.0 NA G -66.4 -20.4 NA NA NA
ARG I:191 E:497 70.0 NA G -63.0 -22.9 NA NA NA
ARG L:191 I:497 68.0 NA G -66.4 -12.3 NA NA NA
ARG O:191 M:497 64.0 NA S -85.6 -41.4 NA NA NA
ARG R:191 P:497 74.0 NA G -63.5 -9.5 NA NA NA
ARG U:191 S:497 159.0 0.707 G -62.6 -28.0 NA NA NA
ARG X:191 V:497 68.0 NA G -58.8 -11.4 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 ARG C:191 A:497 157.0 0.698 G -97.0 28.1 NA NA NA
ARG F:191 D:497 93.0 NA T -75.9 39.6 93.0 NA NA
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 ARG B:191 A:497 32.0 NA G -78.6 -12.1 32.0 NA NA HOH
 7.258
 C
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 ARG A:191 A:497 72.0 NA G -66.6 -25.2 72.0 NA NA
ARG C:191 C:497 66.0 NA G -61.7 -18.3 NA NA NA
ARG E:191 E:497 60.0 NA G -61.3 -14.3 NA NA NA
ARG G:191 G:497 127.0 0.564 G -74.2 -17.0 NA NA NA
ARG I:191 I:497 62.0 NA G -59.8 -28.4 NA NA NA
ARG K:191 K:497 60.0 NA G -71.3 -14.4 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 ARG A:191 A:497 79.0 NA G -57.1 -23.0 79.0 NA NA
ARG D:191 B:497 78.0 NA G -56.8 -17.9 NA NA NA
ARG G:191 E:497 58.0 NA G -59.8 -26.1 NA NA NA
ARG J:191 I:497 80.0 NA G -61.5 -8.7 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 ARG E:191 M:497 147.0 0.653 T -83.3 -30.1 147.0 0.653 0.0
ARG F:191 N:497 162.0 0.72 G -69.9 -21.3 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 ARG E:191 M:497 139.0 0.618 G -78.1 -16.4 139.0 0.618 0.0
ARG F:191 N:497 162.0 0.72 G -69.6 -15.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 ARG A:521 A:521 70.0 0.311 T -79.8 -13.1