Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 73117191 . A C CCDS34655.1:NM_004603.3:c.662aTg>aGg_NP_004594.1:p.221M>R Homo sapiens syntaxin 1A (STX1A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3c98 2 P32851 99.63 0.0 X-RAY
 2008-03-25 MET B:233 B:221 108.0 0.584 H -70.2 -25.0 91.0 0.492 0.092 A:P61765:0.092
6mdm 3 P32851 99.22 0.0 EM
 2018-09-19 MET H:221 I:221 85.0 0.459 H -72.9 -20.8 42.0 0.227 0.232 K:P54921:0.2
G:P60881:0.038
6mdn 3 P32851 99.22 0.0 EM
 2018-09-19 MET H:221 I:221 77.0 0.416 H -85.3 -24.3 40.0 0.216 0.2 K:P54921:0.195
G:P60881:0.005
6ip1 2 P32851 99.6 0.0 EM
 2019-04-24 MET B:222 B:221 110.0 0.595 H -69.5 -45.8 32.0 0.173 0.422 E:A5D7S0:0.422
4jeh 2 P32851 99.59 5e-177 X-RAY
 2013-07-17 MET B:198 B:221 113.0 0.611 H -67.6 -28.3 89.0 0.481 0.13 A:P61765:0.13
 HOH
 8.845
 C
 O
4jeu 2 P32851 99.59 2e-176 X-RAY
 2013-07-17 MET B:220 B:221 104.0 0.562 H -83.1 -31.4 84.0 0.454 0.108 A:P61765:0.108
2m8r 1 P32851 97.17 8e-70 NMR
 2013-11-20 MET A:42 A:221 132.0 0.714 H -69.0 -62.7 132.0 0.714 0.0
3hd7 2 P32851 97.17 8e-70 X-RAY
 2009-07-14 MET B:42 B:221 115.0 0.622 H -76.7 -48.3 115.0 0.622 0.0
MET F:42 F:221 111.0 0.6 H -66.2 -50.4 NA NA NA
3ipd 2 P32851 97.17 8e-70 X-RAY
 2009-09-01 MET B:42 B:221 116.0 0.627 H -88.5 -64.9 116.0 0.627 0.0
MET F:42 F:221 117.0 0.632 H -88.3 -64.8 NA NA NA
1sfc 2 P32851 100.0 7e-53 X-RAY
 1998-10-28 MET B:42 B:221 105.0 0.568 H -67.7 -31.3 104.0 0.562 0.006 C:P60881:0.005
 SR
 6.491
 CE
 SR
MET F:42 F:221 115.0 0.622 H -66.6 -47.4 NA NA NA
MET J:42 J:221 103.0 0.557 H -59.0 -46.7 NA NA NA
1jth 2 P32851 100.0 2e-48 X-RAY
 2001-11-28 MET B:31 B:221 124.0 0.67 H -63.7 -52.0 124.0 0.67 0.0 HOH
 2.821
 O
 O
MET D:31 D:221 120.0 0.649 H -67.8 -39.0 120.0 0.649 0.0 HOH
 5.594
 CE
 O
1hvv 1 P32851 100.0 4e-47 X-RAY
 2001-01-31 MET A:32 A:221 121.0 0.654 H -75.9 -35.3 121.0 0.654 0.0 HOH
 3.905
 CG
 O
MET B:32 B:221 111.0 0.6 H -60.3 -46.5 111.0 0.6 0.0 HOH
 4.402
 N
 O
MET C:32 C:221 107.0 0.578 H -60.8 -40.2 107.0 0.578 0.0 TAR
HOH
 9.811
4.441
 N
N
 O1
O
MET D:32 D:221 127.0 0.686 H -63.5 -40.2 127.0 0.686 0.0 HOH
 6.379
 SD
 O
1urq 2 P32851 98.65 9e-45 X-RAY
 2004-08-26 MET B:37 B:221 122.0 0.659 H -67.1 -45.0 122.0 0.659 0.0 HOH
 2.787
 O
 O
2n1t 2 P32851 100.0 1e-44 NMR
 2015-06-03 MET B:34 B:221 125.0 0.676 H -62.2 -46.4 108.0 0.584 0.092 E:P21579:0.092
1n7s 2 P32851 100.0 7e-40 X-RAY
 2002-12-27 MET B:33 B:221 108.0 0.584 H -64.0 -45.1 108.0 0.584 0.0 HOH
 2.744
 O
 O
3j96 4 P32851 100.0 7e-40 EM
 2015-01-28 MET L:32 L:221 117.0 0.632 H -68.1 -20.9 54.0 0.292 0.34 G:P54921:0.341
3j97 4 P32851 100.0 7e-40 EM
 2015-01-28 MET L:32 L:221 116.0 0.627 H -73.9 -33.2 60.0 0.324 0.303 H:P54921:0.043
G:P54921:0.265
3j98 4 P32851 100.0 7e-40 EM
 2015-01-28 MET L:32 L:221 116.0 0.627 H -87.7 -23.6 60.0 0.324 0.303 H:P54921:0.005
G:P54921:0.303
3j99 4 P32851 100.0 7e-40 EM
 2015-01-28 MET L:32 L:221 118.0 0.638 H -87.7 -23.6 51.0 0.276 0.362 G:P54921:0.362
5ccg 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 MET B:32 B:221 125.0 0.676 H -59.8 -52.8 23.0 0.124 0.552 F:P21707:0.135
F:P21707:0.465
MET H:32 H:221 107.0 0.578 H -59.1 -50.5 NA NA NA
5cch 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 MET B:32 B:221 127.0 0.686 H -52.3 -57.3 14.0 0.076 0.61 F:P21707:0.135
C:P60881:0.011
F:P21707:0.589
5cci 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 MET B:32 B:221 115.0 0.622 H -56.8 -58.4 24.0 0.13 0.492 F:P21707:0.119
C:P60881:0.016
F:P21707:0.465
 MG
 9.548
 SD
 MG
5w5c 2 P32851 100.0 7e-40 X-RAY
 2017-08-23 MET B:32 B:221 99.0 0.535 H -64.0 -45.1 80.0 0.432 0.103 E:P63041:0.103
 HOH
 2.809
 O
 O
5w5d 2 P32851 100.0 7e-40 X-RAY
 2017-08-23 MET B:32 B:221 94.0 0.508 H -61.1 -52.6 79.0 0.427 0.081 E:P63041:0.081
 HOH
 3.806
 N
 O
6mti 4 P32851 100.0 7e-40 EM
 2019-04-24 MET H:32 B:221 111.0 0.6 H -56.8 -58.4 107.0 0.578 0.022 I:P60881:0.022
MET L:32 F:221 114.0 0.616 H -56.9 -58.4 110.0 0.595 0.021 M:P60881:0.022
MET P:32 J:221 114.0 0.616 H -56.7 -58.5 111.0 0.6 0.016 Q:P60881:0.016
MET T:32 N:221 115.0 0.622 H -56.8 -58.4 111.0 0.6 0.022 U:P60881:0.022
MET X:32 R:221 115.0 0.622 H -56.7 -58.4 110.0 0.595 0.027 Y:P60881:0.027
MET BA:32 V:221 114.0 0.616 H -56.8 -58.5 111.0 0.6 0.016 CA:P60881:0.016
5kj7 2 P32851 100.0 8e-40 X-RAY
 2016-10-19 MET B:31 B:221 127.0 0.686 H -63.7 -51.7 127.0 0.686 0.0
MET H:31 H:221 105.0 0.568 H -62.1 -49.6 NA NA NA
5kj8 2 P32851 100.0 8e-40 X-RAY
 2016-10-19 MET B:31 B:221 127.0 0.686 H -58.5 -52.3 127.0 0.686 0.0
MET H:31 H:221 111.0 0.6 H -59.0 -50.1 NA NA NA
6wvw 2 P32851 100.0 8e-40 X-RAY
 2021-03-17 MET B:31 B:221 122.0 0.659 H -62.8 -44.4 116.0 0.627 0.032 C:P60881:0.032
 HOH
 5.206
 O
 O
MET F:31 F:221 93.0 0.503 H -63.5 -39.8 NA NA NA
3rk2 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 MET B:33 B:221 106.0 0.573 H -56.7 -47.9 102.0 0.551 0.022 C:P60880:0.022
 HOH
 4.164
 O
 O
MET F:33 F:221 106.0 0.573 H -58.5 -45.3 NA NA NA
3rk3 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 MET B:33 B:221 114.0 0.616 H -49.2 -43.3 113.0 0.611 0.005 E:O14810:0.005
3rl0 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 MET B:33 B:221 118.0 0.638 H -63.9 -44.5 112.0 0.605 0.033 C:P60880:0.032
MET F:33 F:221 117.0 0.632 H -62.5 -45.6 NA NA NA
MET J:33 J:221 116.0 0.627 H -63.1 -45.4 NA NA NA
MET N:33 N:221 116.0 0.627 H -63.5 -45.8 NA NA NA
MET R:33 R:221 118.0 0.638 H -63.6 -45.0 NA NA NA
MET V:33 V:221 118.0 0.638 H -63.6 -44.5 NA NA NA
MET Z:33 Z:221 119.0 0.643 H -63.6 -45.3 NA NA NA
MET DA:33 d:221 115.0 0.622 H -63.0 -44.6 NA NA NA
1kil 2 P32851 100.0 2e-35 X-RAY
 2002-03-13 MET B:33 B:221 103.0 0.557 H -64.1 -39.7 103.0 0.557 0.0 HOH
 2.947
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q16623-f1 1 Q16623 100.0 0.0 MET A:221 A:221 137.0 0.741 H -64.2 -36.9
af-p61266-f1 1 P61266 83.33 3e-178 MET A:220 A:220 147.0 0.795 H -64.6 -37.0