Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 107559499 . T A CCDS5749.1:NM_000108.3:c.1419taT>taA_NP_000099.2:p.473Y>* Homo sapiens dihydrolipoamide dehydrogenase (DLD), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3rnm 1 P09622 99.37 0.0 X-RAY
 2011-05-04 TYR A:459 A:438 190.0 0.826 H -90.5 -1.8 5.0 0.022 0.804 E:P11182:0.365
B:P09622:0.578
 HOH
 5.185
 O
 O
TYR B:459 B:438 183.0 0.796 T -94.6 4.7 3.0 0.013 0.783 E:P11182:0.335
A:P09622:0.543
 HOH
 4.086
 OH
 O
TYR C:459 C:438 185.0 0.804 T -89.6 8.7 NA NA NA
TYR D:459 D:438 184.0 0.8 H -93.5 2.5 NA NA NA
1zy8 1 P09622 100.0 0.0 X-RAY
 2005-11-15 TYR A:438 A:438 189.0 0.822 T -96.7 -3.8 13.0 0.057 0.765 K:O00330:0.4
B:P09622:0.539
 HOH
 5.192
 C
 O
TYR B:438 B:438 184.0 0.8 T -94.1 12.3 2.0 0.009 0.791 K:O00330:0.443
A:P09622:0.526
 HOH
 7.410
 OH
 O
TYR C:438 C:438 194.0 0.843 T -100.7 7.9 NA NA NA
TYR D:438 D:438 187.0 0.813 T -121.1 7.0 NA NA NA
TYR E:438 E:438 187.0 0.813 T -93.0 7.5 NA NA NA
TYR F:438 F:438 190.0 0.826 T -83.2 1.0 NA NA NA
TYR G:438 G:438 193.0 0.839 T -73.0 1.3 NA NA NA
TYR H:438 H:438 195.0 0.848 T -89.1 12.1 NA NA NA
TYR I:438 I:438 187.0 0.813 T -117.5 20.7 NA NA NA
TYR J:438 J:438 188.0 0.817 T -106.0 -7.1 NA NA NA
6i4q 1 P09622 100.0 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 194.0 0.843 T -84.9 -3.9 80.0 0.348 0.495 B:P09622:0.496
 HOH
 4.661
 HH
 O
TYR B:460 B:438 181.0 0.787 H -86.5 -5.7 57.0 0.248 0.539 A:P09622:0.539
 HOH
 2.863
 HE1
 O
6i4t 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 193.0 0.839 T -83.7 -0.6 81.0 0.352 0.487 B:P09622:0.487
 HOH
 3.708
 HH
 O
TYR B:460 B:438 191.0 0.83 H -94.9 -1.4 66.0 0.287 0.543 A:P09622:0.543
 HOH
 2.816
 HE1
 O
1zmc 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:438 A:438 197.0 0.857 H -82.7 -9.7 80.0 0.348 0.509 B:P09622:0.509
 HOH
 3.921
 OH
 O
TYR B:438 B:438 191.0 0.83 H -95.7 -2.6 65.0 0.283 0.547 A:P09622:0.548
 HOH
 3.559
 CE1
 O
TYR C:438 C:438 186.0 0.809 T -95.7 -3.3 NA NA NA
TYR D:438 D:438 200.0 0.87 H -83.2 -12.9 NA NA NA
TYR E:438 E:438 189.0 0.822 T -99.3 -1.2 NA NA NA
TYR F:438 F:438 198.0 0.861 H -84.5 -8.4 NA NA NA
TYR G:438 G:438 202.0 0.878 H -84.9 -5.0 NA NA NA
TYR H:438 H:438 190.0 0.826 H -100.5 -4.9 NA NA NA
1zmd 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:438 A:438 195.0 0.848 H -82.3 -7.5 80.0 0.348 0.5 B:P09622:0.5
 HOH
 3.864
 OH
 O
TYR B:438 B:438 188.0 0.817 H -89.7 -7.9 61.0 0.265 0.552 A:P09622:0.552
 HOH
 3.724
 CE1
 O
TYR C:438 C:438 181.0 0.787 H -88.7 -6.8 NA NA NA
TYR D:438 D:438 194.0 0.843 H -83.0 -7.0 NA NA NA
TYR E:438 E:438 187.0 0.813 H -91.9 -4.7 NA NA NA
TYR F:438 F:438 196.0 0.852 H -83.8 -4.2 NA NA NA
TYR G:438 G:438 195.0 0.848 H -83.2 -2.6 NA NA NA
TYR H:438 H:438 188.0 0.817 H -93.2 -4.2 NA NA NA
2f5z 1 P09622 99.79 0.0 X-RAY
 2006-01-17 TYR A:438 A:438 192.0 0.835 T -104.7 4.2 2.0 0.009 0.826 K:O00330:0.461
B:P09622:0.539
 HOH
 2.798
 OH
 O
TYR B:438 B:438 188.0 0.817 T -117.6 9.6 2.0 0.009 0.808 K:O00330:0.448
A:P09622:0.57
 HOH
 2.608
 O
 O
TYR C:438 C:438 188.0 0.817 T -90.8 3.9 NA NA NA
TYR D:438 D:438 192.0 0.835 T -91.0 5.1 NA NA NA
TYR E:438 E:438 191.0 0.83 T -94.5 8.9 NA NA NA
TYR F:438 F:438 186.0 0.809 T -96.7 13.3 NA NA NA
TYR G:438 G:438 189.0 0.822 T -97.6 6.9 NA NA NA
TYR H:438 H:438 191.0 0.83 T -91.2 6.4 NA NA NA
TYR I:438 I:438 192.0 0.835 T -91.0 4.2 NA NA NA
TYR J:438 J:438 193.0 0.839 T -88.4 4.0 NA NA NA
5nhg 1 P09622 100.0 0.0 X-RAY
 2018-05-16 TYR A:459 A:438 183.0 0.796 T -107.0 16.3 103.0 0.448 0.348 B:P09622:0.348
 TRS
HOH
 5.860
4.377
 O
O
 O3
O
TYR B:459 B:438 180.0 0.783 T -108.3 19.0 101.0 0.439 0.344 A:P09622:0.343
 TRS
HOH
 4.451
5.437
 HD1
C
 O1
O
TYR C:459 C:438 184.0 0.8 T -99.2 12.4 NA NA NA
TYR D:459 D:438 185.0 0.804 T -98.0 12.8 NA NA NA
TYR E:459 E:438 181.0 0.787 T -106.8 17.0 NA NA NA
TYR F:459 F:438 184.0 0.8 T -108.9 18.4 NA NA NA
TYR G:459 G:438 188.0 0.817 T -100.1 12.8 NA NA NA
TYR H:459 H:438 183.0 0.796 T -97.7 11.9 NA NA NA
6i4u 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 197.0 0.857 H -81.2 -3.8 83.0 0.361 0.496 B:P09622:0.496
 SO4
HOH
 9.339
3.720
 HE2
HH
 O1
O
TYR B:460 B:438 180.0 0.783 H -85.6 -5.8 55.0 0.239 0.544 A:P09622:0.543
 SO4
HOH
 5.130
2.875
 C
HE1
 O1
O
5j5z 1 P09622 99.79 0.0 X-RAY
 2017-11-15 TYR A:460 A:438 182.0 0.791 H -71.5 -15.8 68.0 0.296 0.495 B:P09622:0.496
 GOL
HOH
 8.693
2.629
 N
OH
 O2
O
TYR B:460 B:438 199.0 0.865 T -90.5 -0.3 80.0 0.348 0.517 A:P09622:0.517
 HOH
 3.021
 O
 O
6hg8 1 P09622 99.79 0.0 X-RAY
 2019-09-04 TYR A:460 A:438 202.0 0.878 H -82.1 -4.2 85.0 0.37 0.508 B:P09622:0.509
 HOH
 2.893
 OH
 O
TYR B:460 B:438 182.0 0.791 H -88.7 -8.2 62.0 0.27 0.521 A:P09622:0.522
 HOH
 3.121
 CE1
 O
6i4r 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 200.0 0.87 H -82.6 -3.8 86.0 0.374 0.496 B:P09622:0.496
 SO4
HOH
 9.762
3.446
 HE2
HH
 O1
O
TYR B:460 B:438 184.0 0.8 H -89.7 -5.7 59.0 0.257 0.543 A:P09622:0.543
 SO4
HOH
 5.489
2.757
 C
HE1
 O1
O
6i4p 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 201.0 0.874 T -79.8 -3.4 84.0 0.365 0.509 B:P09622:0.509
 HOH
 3.636
 HH
 O
TYR B:460 B:438 186.0 0.809 T -89.0 -3.8 59.0 0.257 0.552 A:P09622:0.552
 HOH
 2.619
 HE1
 O
6i4s 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 197.0 0.857 H -80.5 -2.2 81.0 0.352 0.505 B:P09622:0.504
 HOH
 2.531
 OH
 O
TYR B:460 B:438 183.0 0.796 T -84.7 -3.0 57.0 0.248 0.548 A:P09622:0.548
 HOH
 2.662
 HE1
 O
6i4z 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:460 A:438 197.0 0.857 H -86.2 -2.6 82.0 0.357 0.5 B:P09622:0.5
 HOH
 5.477
 HE1
 O
TYR B:460 B:438 191.0 0.83 H -89.5 -2.8 65.0 0.283 0.547 A:P09622:0.548
TYR C:460 C:438 197.0 0.857 T -86.8 -0.3 NA NA NA
TYR D:460 D:438 195.0 0.848 H -89.7 -0.8 NA NA NA
TYR E:460 E:438 198.0 0.861 H -85.4 -4.2 NA NA NA
TYR F:460 F:438 185.0 0.804 H -88.2 -2.9 NA NA NA
TYR G:460 G:438 199.0 0.865 H -85.6 -1.5 NA NA NA
TYR H:460 H:438 184.0 0.8 H -89.5 -2.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09622-f1 1 P09622 100.0 0.0 TYR A:473 A:473 201.0 0.874 T -78.2 -5.9