Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr7 | 155598990 | . | C | A | CCDS5942.1:NM_000193.2:c.562Gag>Tag_NP_000184.1:p.188E>* | Homo sapiens sonic hedgehog (SHH), mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7e2i | 1 | Q15465 | 100.0 | 0.0 |
EM |
2021-12-08 | GLU | A:188 | G:188 | 101.0 | 0.532 | -82.1 | 179.3 | 91.0 | 0.479 | 0.053 |
B:Q96F81:0.053 |
||||||
| 6dmy | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2018-07-11 | GLU | B:168 | B:188 | 49.0 | 0.258 | -5.2 | -108.3 | 49.0 | 0.258 | 0.0 |
SER |
4.210 |
O |
N |
|||
| 6n7g | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2019-05-29 | GLU | C:165 | C:188 | 153.0 | 0.805 | S | -56.8 | 61.3 | 153.0 | 0.805 | 0.0 | ||||||
| GLU | F:165 | F:188 | 154.0 | 0.811 | S | -56.8 | 61.3 | 154.0 | 0.811 | 0.0 | |||||||||||||
| 6n7h | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2019-05-29 | GLU | C:165 | C:188 | 150.0 | 0.789 | S | -56.8 | 61.3 | 150.0 | 0.789 | 0.0 | ||||||
| 6n7k | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2019-05-29 | GLU | C:165 | C:188 | 153.0 | 0.805 | S | -56.8 | 61.3 | 153.0 | 0.805 | 0.0 | ||||||
| GLU | F:165 | F:188 | 154.0 | 0.811 | S | -56.8 | 61.3 | 154.0 | 0.811 | 0.0 | |||||||||||||
| 6rvd | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2019-10-02 | GLU | C:165 | C:188 | 142.0 | 0.747 | S | -68.2 | 145.8 | 142.0 | 0.747 | 0.0 | ||||||
| 6e1h | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2018-08-29 | GLU | B:166 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6oev | 2 | Q15465 | 100.0 | 7e-128 |
EM |
2019-04-17 | GLU | B:166 | C:188 | 184.0 | 0.968 | 49.5 | 360.0 | 184.0 | 0.968 | 0.0 | |||||||
| 3m1n | 1 | Q15465 | 100.0 | 2e-126 |
X-RAY |
2010-03-16 | GLU | A:166 | A:188 | 164.0 | 0.863 | 91.9 | 360.0 | 164.0 | 0.863 | 0.0 |
SO4 HOH |
8.097 3.200 |
O N |
O1 O |
|||
| GLU | B:166 | B:188 | 97.0 | 0.511 | T | -54.0 | -38.8 | NA | NA | NA | |||||||||||||
| 6rmg | 2 | Q15465 | 98.31 | 9e-126 |
EM |
2019-10-09 | GLU | B:276 | B:188 | 221.0 | 1.0 | 57.6 | 360.0 | 221.0 | 1.0 | 0.0 | |||||||
| 3ho5 | 2 | Q15465 | 100.0 | 2e-123 |
X-RAY |
2009-06-23 | GLU | C:160 | H:188 | 93.0 | 0.489 | S | -70.1 | -29.0 | NA | NA | NA | ||||||
| 3mxw | 1 | Q15465 | 100.0 | 2e-123 |
X-RAY |
2010-05-26 | GLU | A:160 | A:188 | 88.0 | 0.463 | G | -51.3 | -40.1 | 88.0 | 0.463 | 0.0 |
SO4 HOH |
9.438 2.763 |
OE1 OE2 |
O1 O |
||
| 6pjv | 1 | Q15465 | 100.0 | 2e-123 |
X-RAY |
2019-11-13 | GLU | A:160 | A:188 | 105.0 | 0.553 | T | -60.5 | -36.1 | 105.0 | 0.553 | 0.0 |
HOH |
2.165 |
H |
O |
||
| 3d1m | 1 | Q62226 | 97.62 | 9e-120 |
X-RAY |
2008-09-23 | GLU | A:168 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:168 | B:189 | 165.0 | NA | -67.9 | 360.0 | NA | NA | NA | ||||||||||||||
| 7rpk | 2 | Q62226 | 99.39 | 1e-119 |
EM |
2021-10-27 | GLU | B:164 | H:189 | 136.0 | 0.716 | -68.8 | 360.0 | 136.0 | 0.716 | 0.0 | |||||||
| 1vhh | 1 | Q62226 | 99.38 | 1e-117 |
X-RAY |
1996-01-29 | GLU | A:156 | A:189 | 108.0 | 0.568 | H | -60.5 | -34.6 | 108.0 | 0.568 | 0.0 |
HOH |
1.897 |
OE2 |
H1 |
||
| 3k7g | 1 | Q14623 | 88.07 | 1e-112 |
X-RAY |
2011-01-26 | GLU | A:178 | B:193 | 146.0 | 0.768 | S | -86.8 | 15.4 | 146.0 | 0.768 | 0.0 |
HOH |
2.730 |
OE2 |
O |
||
| 4c4m | 1 | Q62226 | 99.36 | 1e-112 |
X-RAY |
2013-10-02 | GLU | A:152 | A:189 | 144.0 | 0.758 | -69.8 | 153.1 | 144.0 | 0.758 | 0.0 |
HOH |
2.792 |
OE1 |
O |
|||
| 4c4n | 1 | Q62226 | 99.36 | 1e-112 |
X-RAY |
2013-10-02 | GLU | A:152 | A:189 | 94.0 | 0.495 | -67.6 | 129.1 | 94.0 | 0.495 | 0.0 |
HOH |
2.656 |
OE2 |
O |
|||
| GLU | B:152 | B:189 | 107.0 | 0.563 | T | -59.7 | -25.8 | 107.0 | 0.563 | 0.0 |
HOH |
4.861 |
OE1 |
O |
|||||||||
| 3n1r | 1 | Q62226 | 99.36 | 2e-112 |
X-RAY |
2010-06-02 | GLU | A:154 | A:189 | 176.0 | 0.926 | -118.7 | 360.0 | 176.0 | 0.926 | 0.0 |
HOH |
4.115 |
N |
O |
|||
| 3k7j | 1 | Q14623 | 87.5 | 4e-112 |
X-RAY |
2011-01-26 | GLU | A:178 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3k7i | 1 | Q14623 | 87.5 | 5e-112 |
X-RAY |
2011-01-26 | GLU | A:178 | B:193 | 119.0 | 0.626 | S | -89.8 | 15.5 | 119.0 | 0.626 | 0.0 |
HOH |
2.681 |
OE2 |
O |
||
| 3k7h | 1 | Q14623 | 87.5 | 5e-112 |
X-RAY |
2011-01-26 | GLU | A:178 | B:193 | 125.0 | 0.658 | S | -93.6 | 19.9 | 125.0 | 0.658 | 0.0 |
HOH |
2.690 |
O |
O |
||
| 2wg4 | 1 | Q62226 | 99.35 | 6e-112 |
X-RAY |
2009-06-30 | GLU | A:150 | A:189 | 130.0 | NA | -86.4 | 360.0 | 130.0 | NA | NA | |||||||
| 2wfx | 1 | Q62226 | 99.34 | 5e-110 |
X-RAY |
2009-06-30 | GLU | A:150 | A:189 | 95.0 | NA | S | -60.4 | -6.5 | 95.0 | NA | NA | ||||||
| 3n1f | 1 | Q14623 | 88.17 | 7e-107 |
X-RAY |
2010-06-02 | GLU | A:169 | A:193 | 160.0 | NA | -63.5 | 360.0 | 160.0 | NA | NA |
HOH |
2.303 |
H |
O |
|||
| GLU | B:169 | B:193 | 172.0 | NA | -65.8 | 360.0 | NA | NA | NA | ||||||||||||||
| 3n1m | 1 | Q14623 | 88.17 | 7e-107 |
X-RAY |
2010-06-02 | GLU | A:169 | B:193 | 157.0 | NA | -54.1 | 360.0 | 157.0 | NA | NA |
HOH |
2.293 |
H |
O |
|||
| 3n1o | 1 | Q14623 | 88.17 | 7e-107 |
X-RAY |
2010-06-02 | GLU | A:169 | A:193 | 172.0 | 0.905 | -108.1 | 360.0 | 172.0 | 0.905 | 0.0 |
HOH |
3.525 |
OE2 |
O |
|||
| GLU | B:169 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| GLU | C:169 | C:193 | 162.0 | 0.853 | -65.0 | 360.0 | NA | NA | NA | ||||||||||||||
| 3n1p | 1 | Q14623 | 88.17 | 7e-107 |
X-RAY |
2010-06-02 | GLU | A:169 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q15465-f1 | 1 | Q15465 | 100.0 | 0.0 | GLU | A:188 | A:188 | 54.0 | 0.284 | T | -62.2 | -32.5 | |