Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599074 . T A CCDS5942.1:NM_000193.2:c.478Atg>Ttg_NP_000184.1:p.160M>L Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 MET A:160 G:160 23.0 0.124 H -74.3 -35.3 23.0 0.124 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 MET B:140 B:160 52.0 0.281 H -64.7 -31.1 52.0 0.281 0.0
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 MET C:137 C:160 54.0 0.292 H -69.1 -35.2 24.0 0.13 0.162 B:Q13635:0.162
MET F:137 F:160 56.0 0.303 H -69.1 -35.2 24.0 0.13 0.173 E:Q13635:0.173
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 MET C:137 C:160 53.0 0.286 H -69.1 -35.2 22.0 0.119 0.167 B:Q13635:0.168
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 MET C:137 C:160 54.0 0.292 H -69.1 -35.2 24.0 0.13 0.162 B:Q13635:0.162
MET F:137 F:160 56.0 0.303 H -69.1 -35.2 24.0 0.13 0.173 E:Q13635:0.173
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 MET C:137 C:160 40.0 0.216 H -59.1 -43.3 12.0 0.065 0.151 A:Q13635:0.151
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 MET B:138 C:160 35.0 0.189 H -66.7 -41.4 8.0 0.043 0.146 A:Q13635:0.146
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 MET B:138 C:160 54.0 0.292 H -61.6 -57.3 28.0 0.151 0.141 A:Q13635:0.141
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 MET A:138 A:160 31.0 0.168 H -74.3 -40.3 31.0 0.168 0.0 HOH
 2.924
 N
 O
MET B:138 B:160 39.0 0.211 H -76.9 -39.5 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 MET B:248 B:160 37.0 0.2 H -58.4 -39.4 37.0 0.2 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 MET C:132 H:160 41.0 0.222 H -70.4 -31.3 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 MET A:132 A:160 34.0 0.184 H -70.3 -40.1 34.0 0.184 0.0 HOH
 2.918
 N
 O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 MET A:132 A:160 40.0 0.216 H -69.7 -38.5 40.0 0.216 0.0 GOL
HOH
 2.366
2.156
 HE3
H
 HO3
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 MET A:140 A:161 55.0 0.297 H -74.9 -36.4 55.0 0.297 0.0 HOH
 2.788
 N
 O
MET B:140 B:161 37.0 0.2 H -71.0 -39.7 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 MET B:136 H:161 26.0 0.141 H -75.8 -33.6 26.0 0.141 0.0
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 MET A:128 A:161 37.0 0.2 H -72.0 -35.6 37.0 0.2 0.0 HOH
 1.986
 H
 O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 LEU A:150 B:165 38.0 0.224 H -70.4 -39.5 38.0 0.224 0.0 HOH
 2.941
 N
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 MET A:124 A:161 28.0 0.151 H -73.0 -35.2 28.0 0.151 0.0 HOH
 2.961
 N
 O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 MET A:124 A:161 37.0 0.2 H -73.8 -36.6 37.0 0.2 0.0 HOH
 3.008
 N
 O
MET B:124 B:161 36.0 0.195 H -74.2 -36.4 36.0 0.195 0.0 HOH
 7.299
 O
 O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 MET A:126 A:161 24.0 0.13 H -79.9 -34.9 24.0 0.13 0.0 HOH
 3.257
 N
 O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 LEU A:150 B:165 35.0 0.206 H -71.3 -37.7 35.0 0.206 0.0 HOH
 2.850
 N
 O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 LEU A:150 B:165 39.0 0.229 H -68.4 -41.3 39.0 0.229 0.0 HOH
 2.953
 N
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 LEU A:150 B:165 38.0 0.224 H -70.5 -37.9 38.0 0.224 0.0 HOH
 2.947
 N
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 MET A:122 A:161 32.0 0.173 H -70.7 -34.1 32.0 0.173 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 MET A:122 A:161 19.0 0.103 H -64.3 -35.9 19.0 0.103 0.0
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 LEU A:141 A:165 30.0 0.176 H -76.3 -37.4 30.0 0.176 0.0 HOH
 2.198
 H
 O
LEU B:141 B:165 31.0 0.182 H -69.6 -36.0 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 LEU A:141 B:165 45.0 0.265 H -68.8 -40.6 45.0 0.265 0.0 HOH
 2.236
 H
 O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 LEU A:141 A:165 33.0 0.194 H -68.4 -40.4 33.0 0.194 0.0 HOH
 2.768
 N
 O
LEU B:141 B:165 29.0 0.171 H -64.9 -34.8 NA NA NA
LEU C:141 C:165 34.0 0.2 H -69.4 -41.8 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 LEU A:141 B:165 40.0 0.235 H -56.4 -46.7 40.0 0.235 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 MET A:160 A:160 37.0 0.2 H -75.2 -37.0