Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155604554 . T A CCDS5942.1:NM_000193.2:c.263gAt>gTt_NP_000184.1:p.88D>V Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ASP A:88 G:88 39.0 0.26 54.6 45.5 39.0 0.26 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ASP B:68 B:88 33.0 0.22 57.9 63.6 33.0 0.22 0.0 CA
CA
 8.222
5.198
 CA
N
 CA
CA
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:65 C:88 33.0 0.22 57.9 63.7 30.0 0.2 0.02 A:Q13635:0.02
 CA
CA
 8.222
5.199
 CA
N
 CA
CA
ASP F:65 F:88 34.0 0.227 58.0 63.6 30.0 0.2 0.027 D:Q13635:0.027
 CA
CA
 8.222
5.198
 CA
N
 CA
CA
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:65 C:88 33.0 0.22 57.9 63.7 29.0 0.193 0.027 A:Q13635:0.027
 CA
CA
 8.222
5.198
 CA
N
 CA
CA
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:65 C:88 33.0 0.22 57.9 63.7 30.0 0.2 0.02 A:Q13635:0.02
 CA
CA
 8.222
5.199
 CA
N
 CA
CA
ASP F:65 F:88 34.0 0.227 58.0 63.6 30.0 0.2 0.027 D:Q13635:0.027
 CA
CA
 8.222
5.198
 CA
N
 CA
CA
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ASP C:65 C:88 32.0 0.213 48.8 45.9 32.0 0.213 0.0 CA
CA
 8.035
4.564
 CA
N
 CA
CA
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ASP B:66 C:88 38.0 0.253 62.7 55.9 34.0 0.227 0.026 C:Q13635:0.027
 CA
CA
 4.440
5.758
 N
CA
 CA
CA
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ASP B:66 C:88 6.0 0.04 56.2 63.6 6.0 0.04 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ASP A:66 A:88 43.0 0.287 51.3 50.5 43.0 0.287 0.0 SO4
HOH
 6.589
2.796
 N
OD2
 O1
O
ASP B:66 B:88 29.0 0.193 47.9 54.3 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ASP B:176 B:88 44.0 0.293 55.8 46.7 38.0 0.253 0.04 A:Q13635+U6GSR1:0.04
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ASP C:60 H:88 40.0 0.267 42.0 60.6 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ASP A:60 A:88 43.0 0.287 48.1 47.9 43.0 0.287 0.0 CA
CA
HOH
 4.553
8.000
2.741
 N
CA
OD1
 CA
CA
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ASP A:60 A:88 29.0 0.193 46.1 55.1 29.0 0.193 0.0 DMS
MG
CL
HOH
 6.677
5.976
6.038
1.960
 OD2
HA
N
H
 H12
MG
CL
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ASP A:68 A:89 46.0 0.307 49.4 45.8 45.0 0.3 0.007 D:Q4KMG0:0.007
 CA
CA
HOH
 4.403
7.804
2.635
 N
CA
OD2
 CA
CA
O
ASP B:68 B:89 44.0 0.293 51.2 41.0 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ASP B:64 H:89 25.0 0.167 -79.4 87.4 10.0 0.067 0.1 A:Q3TDN0:0.1
 CA
CA
SO4
 3.537
6.219
8.170
 CA
OD2
N
 CA
CA
O2
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ASP A:56 A:89 40.0 0.267 45.5 51.3 40.0 0.267 0.0 SO4
HOH
 9.049
1.957
 H
OD1
 O4
H2
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ASP A:78 B:93 39.0 0.26 49.0 52.9 39.0 0.26 0.0 SO4
HOH
 6.664
2.715
 CB
OD2
 O1
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASP A:52 A:89 37.0 0.247 47.9 44.4 37.0 0.247 0.0 ASG
BDP
CA
CA
ACT
HOH
 8.379
9.459
8.049
4.638
9.141
2.490
 N
C
CA
N
N
OD1
 OSC
O6B
CA
CA
OXT
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASP A:52 A:89 39.0 0.26 47.6 49.7 22.0 0.147 0.113 B:Q62226:0.113
 IDS
SGN
CA
CA
HOH
 8.221
5.706
7.961
4.427
7.212
 N
N
CA
N
OD2
 O3
O1S
CA
CA
O
ASP B:52 B:89 38.0 0.253 47.2 51.6 28.0 0.187 0.066 A:Q62226:0.067
 SGN
SGN
CA
CA
CL
HOH
 6.488
9.078
4.600
8.099
7.220
2.883
 N
N
N
CA
OD1
OD1
 O2S
O6S
CA
CA
CL
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ASP A:54 A:89 35.0 0.233 58.5 52.6 35.0 0.233 0.0 CA
HOH
 3.442
2.935
 N
OD2
 CA
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ASP A:78 NA:NA DO NA DO DO DO NA NA NA
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASP A:78 B:93 41.0 0.273 51.2 50.6 41.0 0.273 0.0 HOH
 2.629
 OD2
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASP A:78 B:93 51.0 0.34 49.8 49.1 51.0 0.34 0.0 SO4
HOH
 9.219
2.591
 N
OD1
 O3
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ASP A:50 A:89 154.0 1.0 57.4 360.0 154.0 1.0 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ASP A:50 A:89 37.0 0.247 46.5 48.1 37.0 0.247 0.0 CA
CA
 4.509
7.862
 N
C
 CA
CA
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:69 A:93 43.0 0.287 44.4 48.3 42.0 0.28 0.007 D:Q4KMG0:0.007
 CA
CA
CA
HOH
 3.962
6.967
4.346
2.554
 H
HA
OD2
HA
 CA
CA
CA
O
ASP B:69 B:93 42.0 0.28 51.3 46.6 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:69 B:93 43.0 0.287 53.1 47.7 43.0 0.287 0.0 CA
CA
HOH
 3.813
7.014
2.552
 H
HA
HA
 CA
CA
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:69 A:93 51.0 0.34 55.0 48.9 51.0 0.34 0.0 HOH
 2.732
 OD1
 O
ASP B:69 B:93 50.0 0.333 44.7 54.4 NA NA NA
ASP C:69 C:93 33.0 0.22 37.9 65.2 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:69 B:93 40.0 0.267 42.5 50.4 40.0 0.267 0.0 CA
CA
HOH
 4.567
8.060
6.927
 N
CA
CA
 CA
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ASP A:88 A:88 35.0 0.233 43.4 59.7