Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 25163660 . G A CCDS5393.1:NM_018947.5:c.79Cac>Tac_NP_061820.1:p.27H>Y Homo sapiens cytochrome c, somatic (CYCS), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2n9i 1 P99999 100.0 2e-73 NMR
 2016-02-17 HIS A:26 A:26 73.0 0.374 -91.7 42.0 73.0 0.374 0.0 HEC
 6.375
 O
 HMD1
2n9j 1 P99999 100.0 2e-73 NMR
 2016-02-17 HIS A:26 A:26 86.0 0.441 -67.8 125.7 86.0 0.441 0.0 HEC
 7.205
 HB3
 HMD1
3zcf 1 P99999 100.0 2e-73 X-RAY
 2013-10-23 HIS A:26 A:26 68.0 0.349 -69.3 140.5 68.0 0.349 0.0 HEC
HOH
 8.297
2.837
 CE1
N
 O1A
O
HIS B:26 B:26 62.0 0.318 -75.9 142.9 NA NA NA
HIS C:26 C:26 64.0 0.328 -66.0 143.8 NA NA NA
HIS D:26 D:26 68.0 0.349 -64.2 144.4 NA NA NA
2n3y 1 P99999 99.04 7e-73 NMR
 2016-12-14 HIS A:26 A:26 114.0 0.585 -125.4 143.8 114.0 0.585 0.0 MH0
 6.596
 HE1
 O2D
3zoo 1 P99999 99.04 7e-73 X-RAY
 2013-10-23 HIS A:26 A:26 69.0 0.354 -69.1 146.1 69.0 0.354 0.0 HEC
HOH
 8.331
2.865
 CE1
N
 O1A
O
HIS B:26 B:26 62.0 0.318 -75.9 143.3 NA NA NA
HIS C:26 C:26 59.0 0.303 -68.4 139.3 NA NA NA
HIS D:26 D:26 67.0 0.344 -72.7 146.4 NA NA NA
5ty3 1 P99999 99.04 9e-73 X-RAY
 2017-09-06 HIS A:26 A:26 70.0 0.359 -73.6 146.3 70.0 0.359 0.0 HEC
HOH
 7.610
2.055
 HB3
H
 HMD1
O
HIS B:26 B:26 68.0 0.349 -72.0 145.2 NA NA NA
6xnk 1 P99999 99.04 9e-73 X-RAY
 2021-07-07 HIS A:26 A:26 56.0 0.287 -73.4 133.6 56.0 0.287 0.0 HEC
HOH
 7.116
2.827
 HE1
HD2
 O1A
O
HIS B:26 C:26 60.0 0.308 -76.0 135.3 60.0 0.308 0.0 HEC
HOH
 6.893
2.103
 HE1
H
 O1A
O
HIS C:26 E:26 67.0 0.344 -72.2 137.2 NA NA NA
HIS D:26 G:26 67.0 0.344 -72.4 134.8 NA NA NA
3nwv 1 P99999 99.04 1e-72 X-RAY
 2011-03-09 HIS A:26 A:26 66.0 0.338 -73.9 139.5 66.0 0.338 0.0 HEC
HOH
 8.119
2.618
 CE1
O
 O1A
O
HIS B:26 B:26 67.0 0.344 -75.6 144.0 NA NA NA
HIS C:26 C:26 63.0 0.323 -75.9 146.4 NA NA NA
HIS D:26 D:26 68.0 0.349 -73.6 147.0 NA NA NA
5exq 1 P99999 99.04 1e-72 X-RAY
 2016-11-30 HIS A:26 A:26 63.0 0.323 -76.4 143.8 63.0 0.323 0.0 HEC
HOH
 8.804
2.565
 CE1
O
 O1A
O
HIS B:26 B:26 73.0 0.374 -76.2 142.3 NA NA NA
5o10 1 P99999 99.04 1e-72 X-RAY
 2018-03-28 HIS A:26 A:26 68.0 0.349 -75.1 142.0 68.0 0.349 0.0 HEC
HOH
 8.617
2.908
 CE1
N
 O1A
O
HIS B:26 B:26 67.0 0.344 -70.5 137.8 67.0 0.344 0.0 HEC
HOH
 8.652
2.960
 CE1
N
 O1A
O
6duj 1 P99999 99.04 1e-72 X-RAY
 2019-06-26 HIS A:26 A:26 70.0 0.359 -71.8 133.3 70.0 0.359 0.0 HEC
HOH
 7.607
2.734
 HB3
H
 HMD1
O
HIS B:26 C:26 62.0 0.318 -65.6 146.5 NA NA NA
6ecj 1 P99999 99.04 2e-72 X-RAY
 2019-08-14 HIS A:26 A:26 72.0 0.369 -72.5 135.0 72.0 0.369 0.0 HEC
HOH
 8.506
3.676
 CE1
CB
 O1A
O
HIS B:26 B:26 69.0 0.354 -72.7 135.2 NA NA NA
HIS C:26 C:26 68.0 0.349 -72.1 133.7 NA NA NA
HIS D:26 D:26 70.0 0.359 -72.4 135.1 NA NA NA
HIS E:26 E:26 70.0 0.359 -72.3 134.6 NA NA NA
HIS F:26 F:26 68.0 0.349 -73.1 134.4 NA NA NA
HIS G:26 G:26 69.0 0.354 -72.4 134.5 NA NA NA
HIS H:26 H:26 75.0 0.385 -71.5 134.2 NA NA NA
5dfs 1 P00003 95.24 3e-71 X-RAY
 2016-03-02 HIS A:27 A:26 66.0 0.338 -75.9 143.8 66.0 0.338 0.0 HEC
HOH
 7.762
2.115
 HB3
H
 HMD1
O
HIS B:27 B:26 67.0 0.344 -73.2 142.6 NA NA NA
5c0z 1 P62898 91.43 7e-68 X-RAY
 2016-09-21 HIS A:27 A:26 66.0 0.338 -69.1 146.3 66.0 0.338 0.0 HEC
HOH
 8.455
2.728
 CE1
O
 O1A
O
HIS B:27 B:26 68.0 0.349 -69.5 145.9 NA NA NA
HIS C:27 C:26 64.0 0.328 -73.6 146.1 NA NA NA
HIS D:27 D:26 68.0 0.349 -76.8 149.0 NA NA NA
5c9m 1 P62898 90.48 3e-67 X-RAY
 2016-09-21 HIS A:27 A:26 67.0 0.344 -74.5 146.4 67.0 0.344 0.0 HEC
HOH
 8.429
2.840
 CE1
O
 O1A
O
HIS B:27 B:26 67.0 0.344 -73.6 145.1 NA NA NA
HIS C:27 C:26 66.0 0.338 -76.9 145.0 NA NA NA
HIS D:27 D:26 64.0 0.328 -75.8 147.6 NA NA NA
7ljx 1 P62898 90.38 1e-66 X-RAY
 2021-05-12 HIS A:26 A:26 69.0 0.354 -66.8 140.6 69.0 0.354 0.0 HEC
HOH
 7.648
2.734
 CE1
O
 O1A
O
HIS B:26 B:26 70.0 0.359 -68.3 141.5 NA NA NA
2b4z 1 P62894 90.38 2e-66 X-RAY
 2005-10-11 HIS A:26 A:26 63.0 0.323 -81.2 151.3 63.0 0.323 0.0 HEM
HOH
 8.075
2.714
 CE1
O
 O2A
O
2ybb 33 P62894 90.38 2e-66 EM
 2011-10-19 HIS GA:26 Y:26 61.0 0.313 -81.2 151.3 61.0 0.313 0.0 HEM
HOH
 8.074
2.712
 CE1
O
 O1A
O
3j2t 2 P62894 90.38 2e-66 EM
 2013-04-10 HIS H:26 H:26 62.0 0.318 -81.3 151.4 48.0 0.246 0.072 A:O14727:0.072
 HEM
 8.076
 CE1
 O2A
HIS I:26 I:26 63.0 0.323 -81.3 151.3 48.0 0.246 0.077 B:O14727:0.077
 HEM
 8.076
 CE1
 O2A
HIS J:26 J:26 63.0 0.323 -81.3 151.4 48.0 0.246 0.077 C:O14727:0.077
 HEM
 8.076
 CE1
 O2A
HIS K:26 K:26 63.0 0.323 -81.3 151.4 47.0 0.241 0.082 D:O14727:0.082
 HEM
 8.076
 CE1
 O2A
HIS L:26 L:26 63.0 0.323 -81.3 151.4 46.0 0.236 0.087 E:O14727:0.087
 HEM
 8.076
 CE1
 O2A
HIS M:26 M:26 63.0 0.323 -81.3 151.4 47.0 0.241 0.082 F:O14727:0.082
 HEM
 8.076
 CE1
 O2A
HIS N:26 N:26 63.0 0.323 -81.3 151.4 47.0 0.241 0.082 G:O14727:0.082
 HEM
 8.076
 CE1
 O2A
5juy 2 P62894 90.38 2e-66 EM
 2016-10-19 HIS H:26 H:26 53.0 0.272 -79.0 152.4 53.0 0.272 0.0 HEC
 8.142
 CE1
 O2A
HIS I:26 I:26 53.0 0.272 -78.9 152.4 53.0 0.272 0.0 HEC
 8.143
 CE1
 O2A
HIS J:26 J:26 54.0 0.277 -78.9 152.4 54.0 0.277 0.0 HEC
 8.143
 CE1
 O2A
HIS K:26 K:26 54.0 0.277 -78.9 152.4 54.0 0.277 0.0 HEC
 8.143
 CE1
 O2A
HIS L:26 L:26 53.0 0.272 -79.0 152.4 53.0 0.272 0.0 HEC
 8.143
 CE1
 O2A
HIS M:26 M:26 54.0 0.277 -78.9 152.4 54.0 0.277 0.0 HEC
 8.142
 CE1
 O2A
HIS N:26 N:26 54.0 0.277 -78.9 152.4 54.0 0.277 0.0 HEC
 8.144
 CE1
 O2A
6ff5 1 P62894 90.38 2e-66 X-RAY
 2018-03-21 HIS A:26 A:26 58.0 0.297 -71.6 137.1 58.0 0.297 0.0 HEC
NO3
NO3
HOH
 8.376
8.789
8.372
3.087
 CE1
N
CE1
N
 O2A
O2
O2
O
6n1o 1 P62898 90.38 4e-66 X-RAY
 2019-10-23 HIS A:26 A:26 65.0 0.333 -71.1 141.2 65.0 0.333 0.0 HEC
EDO
FC6
HOH
 8.437
5.283
7.384
2.860
 CE1
CE1
O
N
 O1A
O1
N24
O
HIS B:26 B:26 68.0 0.349 -70.2 141.6 NA NA NA
HIS C:26 C:26 65.0 0.333 -71.2 144.1 NA NA NA
HIS D:26 D:26 67.0 0.344 -71.3 141.3 NA NA NA
3jbt 2 P00004 88.57 4e-66 EM
 2015-11-18 HIS B:27 B:26 71.0 0.364 -72.2 131.9 71.0 0.364 0.0 HEM
 8.328
 CE1
 O1A
HIS D:27 D:26 71.0 0.364 -72.1 131.9 71.0 0.364 0.0 HEM
 8.329
 CE1
 O1A
HIS F:27 F:26 71.0 0.364 -72.2 131.9 71.0 0.364 0.0 HEM
 8.328
 CE1
 O1A
HIS H:27 H:26 70.0 0.359 -72.2 131.9 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
HIS J:27 J:26 70.0 0.359 -72.2 131.9 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
HIS L:27 L:26 70.0 0.359 -72.2 131.9 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
HIS N:27 N:26 70.0 0.359 -72.3 131.9 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
5wve 2 P00004 88.57 4e-66 EM
 2017-02-08 HIS B:27 B:26 69.0 0.354 -72.1 132.0 69.0 0.354 0.0 HEM
 8.330
 CE1
 O1A
HIS D:27 D:26 70.0 0.359 -72.1 131.9 70.0 0.359 0.0 HEM
 8.329
 CE1
 O1A
HIS F:27 F:26 70.0 0.359 -72.1 132.0 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
HIS H:27 H:26 70.0 0.359 -72.2 131.9 70.0 0.359 0.0 HEM
 8.328
 CE1
 O1A
HIS J:27 J:26 71.0 0.364 -72.1 131.9 71.0 0.364 0.0 HEM
 8.327
 CE1
 O1A
HIS L:27 L:26 71.0 0.364 -72.1 131.9 71.0 0.364 0.0 HEM
 8.328
 CE1
 O1A
HIS N:27 N:26 68.0 0.349 -72.3 131.9 68.0 0.349 0.0 HEM
 8.327
 CE1
 O1A
5df5 1 P62898 90.38 5e-66 X-RAY
 2016-09-14 HIS A:26 A:26 66.0 0.338 -72.4 148.0 66.0 0.338 0.0 HEC
HOH
 8.433
2.849
 CE1
N
 O1A
O
HIS B:26 B:26 65.0 0.333 -72.3 143.9 NA NA NA
HIS C:26 C:26 65.0 0.333 -73.6 148.1 NA NA NA
HIS D:26 D:26 64.0 0.328 -74.1 143.2 NA NA NA
1ocd 1 P00004 88.46 3e-65 NMR
 1997-06-16 HIS A:26 A:26 80.0 0.41 -87.4 58.9 80.0 0.41 0.0 HEC
HOH
 6.493
3.341
 HB3
HE1
 HMD2
H1
1u75 2 P00004 88.46 3e-65 X-RAY
 2004-09-28 HIS B:26 B:26 51.0 0.262 -78.3 125.4 51.0 0.262 0.0 HEC
HOH
 9.436
3.566
 NE2
O
 O1A
O
2frc 1 P00004 88.46 3e-65 NMR
 1997-07-29 HIS A:26 A:26 23.0 0.118 -55.4 173.7 23.0 0.118 0.0 HEC
HOH
 8.149
4.723
 HB3
HD1
 HMD3
H1
2n3b 1 P00004 88.46 3e-65 NMR
 2015-10-28 HIS A:26 A:26 94.0 0.482 -54.8 116.7 94.0 0.482 0.0 HEC
HOH
 7.701
2.664
 HB2
HA
 HMD1
H2
2pcb 2 P00004 88.46 3e-65 X-RAY
 1993-07-15 HIS B:26 B:26 48.0 0.246 -88.8 125.6 48.0 0.246 0.0 HEM
HOH
 9.290
2.620
 NE2
CB
 CBA
O
3nbs 1 P00004 88.46 3e-65 X-RAY
 2010-07-14 HIS A:26 A:26 62.0 0.318 -84.7 142.7 62.0 0.318 0.0 HEC
HOH
 7.871
3.227
 CE1
CE1
 O1A
O
HIS B:26 B:26 70.0 0.359 -87.9 139.3 70.0 0.359 0.0 HEC
HOH
 8.211
3.888
 CE1
CA
 O1A
O
HIS C:26 C:26 67.0 0.344 -82.3 150.7 NA NA NA
HIS D:26 D:26 71.0 0.364 -85.5 145.5 NA NA NA
3nbt 1 P00004 88.46 3e-65 X-RAY
 2010-07-14 HIS A:26 A:26 52.0 0.267 -85.5 147.8 30.0 0.154 0.113 F:P00004:0.113
 HEC
PEG
HOH
 8.463
9.585
2.851
 CE1
CB
N
 O1A
O4
O
HIS B:26 B:26 60.0 0.308 -84.4 146.0 NA NA NA
HIS C:26 C:26 60.0 0.308 -80.6 146.0 NA NA NA
HIS D:26 D:26 57.0 0.292 -85.6 147.0 NA NA NA
HIS E:26 E:26 62.0 0.318 -89.6 140.4 34.0 0.174 0.144 A:P00004:0.144
 HEC
PEG
HOH
 8.409
8.697
2.964
 CE1
C
N
 O1A
O1
O
HIS F:26 F:26 64.0 0.328 -82.4 149.9 39.0 0.2 0.128 E:P00004:0.128
 HEC
PGE
HOH
 8.338
9.560
2.822
 CE1
CB
N
 O1A
C2
O
3wc8 1 P00004 88.46 3e-65 X-RAY
 2013-12-11 HIS A:26 A:26 63.0 0.323 -72.0 143.0 63.0 0.323 0.0 HEC
PEG
PEG
HOH
 8.073
9.772
3.816
2.769
 CE1
CB
NE2
O
 O1A
C3
C1
O
3wui 1 P00004 88.46 3e-65 X-RAY
 2014-07-16 HIS A:26 A:26 66.0 0.338 -71.5 140.8 66.0 0.338 0.0 HEC
HOH
 8.168
3.025
 CE1
N
 O1A
O
4rsz 1 P00004 88.46 3e-65 X-RAY
 2015-01-14 HIS A:26 A:26 69.0 0.354 -72.1 132.0 69.0 0.354 0.0 HEC
NO3
HOH
 8.016
9.174
3.640
 CE1
N
CA
 O1A
O2
O
HIS B:26 B:26 67.0 0.344 -73.0 132.9 NA NA NA
HIS C:26 C:26 68.0 0.349 -70.7 130.3 NA NA NA
HIS D:26 D:26 90.0 0.462 -74.1 134.4 NA NA NA
HIS E:26 E:26 101.0 0.518 -76.4 135.6 NA NA NA
HIS F:26 F:26 83.0 0.426 -69.7 129.6 NA NA NA
6suv 1 P00004 88.46 3e-65 X-RAY
 2020-07-22 HIS A:26 AaA:26 64.0 0.328 -74.4 139.1 64.0 0.328 0.0 HEC
HOH
 8.548
3.564
 CE1
C
 O1A
O
HIS B:26 BaB:26 64.0 0.328 -75.0 139.7 NA NA NA
HIS C:26 CaC:26 69.0 0.354 -77.0 139.4 NA NA NA
HIS D:26 DaD:26 62.0 0.318 -74.8 139.3 NA NA NA
HIS E:26 EaE:26 63.0 0.323 -75.6 138.9 NA NA NA
HIS F:26 FaF:26 62.0 0.318 -74.9 139.1 NA NA NA
HIS G:26 GaG:26 63.0 0.323 -76.1 138.7 NA NA NA
HIS H:26 HaH:26 66.0 0.338 -76.0 139.3 NA NA NA
1crc 1 P00004 88.46 3e-65 X-RAY
 1996-03-08 HIS A:27 A:26 69.0 0.354 -81.6 140.2 69.0 0.354 0.0 HEC
HOH
 8.734
3.112
 CE1
N
 O1A
O
HIS B:27 B:26 64.0 0.328 -38.5 135.3 NA NA NA
1hrc 1 P00004 88.46 3e-65 X-RAY
 1994-11-01 HIS A:27 A:26 60.0 0.308 -89.1 125.3 60.0 0.308 0.0 HEC
HOH
 8.590
2.624
 CE1
O
 O1A
O
1wej 3 P00004 88.46 3e-65 X-RAY
 1998-12-09 HIS C:27 F:26 64.0 0.328 -81.9 134.7 64.0 0.328 0.0 HEM
HOH
 8.332
3.165
 NE2
NE2
 O1A
O
3o1y 1 P00004 88.46 3e-65 X-RAY
 2012-01-25 HIS A:27 A:26 63.0 0.323 -72.4 149.8 63.0 0.323 0.0 HEC
NO3
HOH
 8.445
9.147
2.869
 CE1
N
N
 O1A
O1
O
HIS B:27 B:26 62.0 0.318 -74.8 135.3 NA NA NA
HIS C:27 C:26 60.0 0.308 -78.0 141.7 NA NA NA
3o20 1 P00004 88.46 3e-65 X-RAY
 2012-01-25 HIS A:27 A:26 55.0 0.282 -74.1 137.8 55.0 0.282 0.0 HEC
NO3
NO3
HOH
 8.018
8.742
3.786
3.597
 CE1
N
CB
CB
 O1A
O2
O3
O
HIS B:27 B:26 58.0 0.297 -68.9 133.2 NA NA NA
HIS C:27 C:26 60.0 0.308 -64.5 124.9 NA NA NA
5iy5 14 P00004 88.46 3e-65 X-RAY
 2017-01-11 HIS AA:27 1:26 43.0 0.221 -63.1 132.9 43.0 0.221 0.0 HEC
HOH
 8.665
3.662
 CE1
CA
 O1A
O
HIS BA:27 2:26 60.0 0.308 -52.4 143.9 NA NA NA
6k9i 1 P00004 88.46 3e-65 X-RAY
 2020-06-17 HIS A:27 A:26 66.0 0.338 -78.0 132.4 66.0 0.338 0.0 HEC
HOH
 8.444
3.097
 NE2
N
 O1A
O
6k9j 1 P00004 88.46 3e-65 X-RAY
 2020-06-17 HIS A:27 A:26 69.0 0.354 -75.9 144.0 69.0 0.354 0.0 HEC
HOH
 8.418
2.739
 CE1
O
 O1A
O
5zkv 1 P00004 87.5 6e-64 NMR
 2019-05-22 HIS A:26 A:26 122.0 0.626 -63.0 141.1 122.0 0.626 0.0 HEC
 7.926
 O
 HMD2
4nfg 2 P00004 85.58 5e-63 X-RAY
 2014-09-24 ASN B:26 B:26 57.0 0.356 -83.9 123.5 57.0 0.356 0.0 HEC
HOH
 8.155
3.768
 OD1
ND2
 O1A
O
2aiu 1 P00015 83.65 2e-62 X-RAY
 2006-07-18 HIS A:27 A:27 71.0 0.364 -79.0 145.2 71.0 0.364 0.0 PO4
HEM
HOH
 9.630
8.474
2.821
 C
CE1
N
 O2
O1A
O
1cyc 1 P00025 80.58 3e-58 X-RAY
 1976-10-06 HIS A:26 A:26 66.0 0.338 -74.4 -141.1 66.0 0.338 0.0 HEC
 8.597
 CE1
 O1A
HIS B:26 B:26 66.0 0.338 -74.4 -141.1 NA NA NA
1i54 1 P81459 80.58 3e-58 X-RAY
 2001-05-09 HIS A:26 A:26 64.0 0.328 -80.5 131.4 64.0 0.328 0.0 HEC
ZNH
HOH
 8.264
8.275
2.857
 CE1
CE1
O
 O1A
O1A
O
HIS B:26 B:26 54.0 0.277 -80.9 143.0 NA NA NA
1i55 1 P81459 80.58 3e-58 X-RAY
 2001-05-09 HIS A:26 A:26 63.0 0.323 -83.5 131.6 63.0 0.323 0.0 HEC
ZNH
HOH
 8.327
8.311
2.937
 CE1
CE1
O
 O1A
O1A
O
HIS B:26 B:26 56.0 0.287 -81.8 136.8 NA NA NA
1lfm 1 P81459 80.58 3e-58 X-RAY
 2002-07-19 HIS A:26 A:26 66.0 0.338 -82.4 134.1 66.0 0.338 0.0 COH
HOH
 8.319
3.179
 CE1
CE1
 O1A
O
HIS B:26 B:26 57.0 0.292 -79.5 145.6 NA NA NA
3cyt 1 P81459 80.58 3e-58 X-RAY
 1980-09-16 HIS A:27 O:26 64.0 0.328 -80.9 131.2 64.0 0.328 0.0 HEC
HOH
 8.442
2.406
 CE1
O
 O1A
O
HIS B:27 I:26 63.0 0.323 -73.8 138.5 NA NA NA
5cyt 1 P81459 80.58 3e-58 X-RAY
 1989-07-12 HIS A:27 R:26 63.0 0.323 -88.8 96.7 63.0 0.323 0.0 HEC
HOH
 8.239
3.038
 CE1
N
 O1A
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p99999-f1 1 P99999 100.0 1e-74 HIS A:27 A:27 67.0 0.344 -66.8 146.9