Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr7 | 55223621 | . | G | A | CCDS5514.1:NM_005228.3:c.988Gaa>Aaa_NP_005219.2:p.330E>K | Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7syd | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | GLU | A:330 | A:306 | 123.0 | 0.647 | -109.9 | 99.0 | 123.0 | 0.647 | 0.0 | |||||||
| GLU | C:330 | B:306 | 167.0 | 0.879 | S | -109.7 | 117.4 | 167.0 | 0.879 | 0.0 | |||||||||||||
| 7sye | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | GLU | A:330 | A:306 | 85.0 | 0.447 | S | -89.4 | 65.1 | 85.0 | 0.447 | 0.0 | ||||||
| GLU | B:330 | B:306 | 121.0 | 0.637 | S | -107.3 | 37.3 | 121.0 | 0.637 | 0.0 | |||||||||||||
| 7sz5 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | GLU | A:330 | A:306 | 131.0 | 0.689 | -93.1 | 54.9 | 131.0 | 0.689 | 0.0 | |||||||
| GLU | C:330 | B:306 | 149.0 | 0.784 | S | -93.4 | 48.9 | 149.0 | 0.784 | 0.0 | |||||||||||||
| 7sz7 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-15 | GLU | A:330 | A:306 | 147.0 | 0.774 | -98.7 | 139.9 | 147.0 | 0.774 | 0.0 | |||||||
| GLU | C:330 | B:306 | 141.0 | 0.742 | S | -72.8 | 112.3 | 141.0 | 0.742 | 0.0 | |||||||||||||
| 7sz0 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | GLU | A:330 | A:306 | 161.0 | 0.847 | S | -68.0 | -12.4 | 161.0 | 0.847 | 0.0 | ||||||
| GLU | C:330 | B:306 | 141.0 | 0.742 | S | -97.5 | 87.2 | 141.0 | 0.742 | 0.0 | |||||||||||||
| 7sz1 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | GLU | A:330 | A:306 | 138.0 | 0.726 | -84.9 | 131.1 | 138.0 | 0.726 | 0.0 | |||||||
| GLU | C:330 | B:306 | 108.0 | 0.568 | -145.6 | 130.9 | 108.0 | 0.568 | 0.0 | ||||||||||||||
| 5xwd | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2018-02-28 | GLU | A:330 | A:306 | 160.0 | 0.842 | S | -68.0 | 93.6 | 160.0 | 0.842 | 0.0 | ||||||
| 3qwq | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2012-02-01 | GLU | A:330 | A:306 | 116.0 | NA | S | -26.1 | -85.1 | 116.0 | NA | NA |
NAG |
9.588 |
O |
O6 |
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| 1ivo | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2002-10-16 | GLU | A:306 | A:306 | 176.0 | 0.926 | S | -102.8 | 93.7 | 176.0 | 0.926 | 0.0 |
HOH |
5.485 |
OE2 |
O |
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| GLU | B:306 | B:306 | 177.0 | 0.932 | S | -21.0 | 125.5 | 169.0 | 0.889 | 0.043 |
A:P00533:0.042 |
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| 4uv7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-10-14 | GLU | A:306 | A:306 | 199.0 | 1.0 | S | -92.6 | 108.8 | 199.0 | 1.0 | 0.0 |
HOH |
2.641 |
N |
O |
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| 3b2v | 3 | P00533 | 100.0 | 0.0 |
X-RAY |
2008-02-19 | GLU | C:306 | A:306 | 175.0 | 0.921 | 32.9 | 83.7 | 175.0 | 0.921 | 0.0 | |||||||
| 4kro | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2013-08-28 | GLU | A:306 | A:306 | 96.0 | NA | S | -78.0 | 93.5 | 81.0 | NA | NA |
B:None:NA |
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| 1nql | 1 | 4885199 | 99.84 | 0.0 |
X-RAY |
2003-03-11 | GLU | A:306 | A:306 | 184.0 | 0.968 | S | -103.3 | -11.2 | 184.0 | 0.968 | 0.0 |
NAG |
9.903 |
C |
O7 |
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| 4krp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2013-08-28 | GLU | A:306 | A:306 | 97.0 | NA | S | -64.2 | 89.4 | 69.0 | NA | NA |
B:None:NA |
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| 1yy9 | 1 | P00533 | 99.51 | 0.0 |
X-RAY |
2005-04-26 | GLU | A:306 | A:306 | 191.0 | 1.0 | S | -94.5 | 98.1 | 191.0 | 1.0 | 0.0 | ||||||
| 6aru | 1 | P00533 | 99.68 | 0.0 |
X-RAY |
2018-08-29 | GLU | A:306 | A:306 | 198.0 | 1.0 | S | -64.5 | -59.3 | 198.0 | 1.0 | 0.0 | ||||||
| 3njp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2010-10-13 | GLU | A:306 | A:306 | 193.0 | 1.0 | S | -88.1 | 41.2 | 159.0 | 0.837 | 0.163 |
B:P00533:0.179 |
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| GLU | B:306 | B:306 | 171.0 | 0.9 | S | -72.0 | 86.4 | 128.0 | 0.674 | 0.226 |
A:P00533:0.226 |
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| 4uip | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-11-25 | GLU | A:305 | A:306 | 210.0 | 1.0 | S | 90.5 | -23.3 | 210.0 | 1.0 | 0.0 | ||||||
| 5wb7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | GLU | A:306 | A:306 | 119.0 | NA | S | -60.7 | -43.5 | 119.0 | NA | NA | ||||||
| GLU | B:306 | B:306 | 109.0 | NA | S | -57.3 | -35.4 | NA | NA | NA | |||||||||||||
| GLU | C:306 | C:306 | 145.0 | 0.763 | 162.8 | -170.7 | NA | NA | NA | ||||||||||||||
| GLU | D:306 | D:306 | 154.0 | 0.811 | -134.9 | 160.4 | 154.0 | 0.811 | 0.0 |
HOH |
4.622 |
N |
O |
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| 5wb8 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | GLU | A:306 | A:306 | 145.0 | 0.763 | -148.7 | 143.5 | 145.0 | 0.763 | 0.0 |
HOH |
8.209 |
O |
O |
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| GLU | D:306 | D:306 | 114.0 | NA | S | -77.6 | 98.7 | NA | NA | NA | |||||||||||||
| 1mox | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2003-09-10 | GLU | A:306 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:306 | B:306 | 110.0 | NA | S | -59.0 | -36.1 | 110.0 | NA | NA |
HOH |
8.748 |
CB |
O |
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| 7len | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | GLU | A:306 | A:306 | 117.0 | NA | S | -72.7 | 0.4 | 117.0 | NA | NA | ||||||
| GLU | B:306 | B:306 | 107.0 | NA | S | -64.3 | -42.8 | NA | NA | NA | |||||||||||||
| 7lfr | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | GLU | A:306 | A:306 | 106.0 | NA | -127.6 | 109.1 | 106.0 | NA | NA | |||||||
| GLU | B:306 | B:306 | 134.0 | 0.705 | -67.5 | -35.0 | 134.0 | 0.705 | 0.0 | ||||||||||||||
| 7lfs | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | GLU | A:306 | A:306 | 97.0 | NA | S | -91.7 | 101.1 | 97.0 | NA | NA | ||||||
| GLU | B:306 | B:306 | 86.0 | NA | -75.8 | -45.4 | NA | NA | NA | ||||||||||||||
| GLU | C:306 | C:306 | 114.0 | NA | S | -62.7 | -42.0 | NA | NA | NA | |||||||||||||
| GLU | D:306 | D:306 | 50.0 | NA | -147.1 | 162.9 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00533-f1 | 1 | P00533 | 100.0 | 0.0 | GLU | A:330 | A:330 | 168.0 | 0.884 | S | -78.4 | 76.4 | |