Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55227858 . G A CCDS5514.1:NM_005228.3:c.1325aGc>aAc_NP_005219.2:p.442S>N Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:442 A:418 80.0 0.696 S 55.7 60.8 74.0 0.643 0.053 B:P01133:0.052
SER C:442 B:418 91.0 0.791 S 62.7 54.2 66.0 0.574 0.217 D:P01133:0.217
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:442 A:418 79.0 0.687 S 62.8 57.2 69.0 0.6 0.087 C:P01133:0.087
SER B:442 B:418 75.0 0.652 S 52.9 65.8 58.0 0.504 0.148 D:P01133:0.148
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:442 A:418 68.0 0.591 S 58.2 62.2 55.0 0.478 0.113 B:P01135:0.113
SER C:442 B:418 74.0 0.643 S 67.4 41.6 58.0 0.504 0.139 D:P01135:0.139
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 SER A:442 A:418 76.0 0.661 S 55.1 58.8 62.0 0.539 0.122 B:P01135:0.122
SER C:442 B:418 76.0 0.661 S 58.0 64.3 55.0 0.478 0.183 D:P01135:0.183
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 SER A:442 A:418 84.0 0.73 S 60.5 60.7 66.0 0.574 0.156 B:P01133:0.157
SER C:442 B:418 71.0 0.617 S 61.8 57.2 53.0 0.461 0.156 D:P01133:0.157
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 SER A:442 A:418 84.0 0.73 E 60.7 61.6 69.0 0.6 0.13 B:P01133:0.13
SER C:442 B:418 82.0 0.713 S 53.6 65.4 73.0 0.635 0.078 D:P01133:0.078
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 SER A:442 A:418 82.0 0.713 S 56.1 62.2 14.0 0.122 0.591 B:None:0.052
C:None:0.583
 NAG
 5.433
 O
 C8
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 SER A:442 A:418 69.0 0.6 S 46.9 69.9 69.0 0.6 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 SER A:418 A:418 75.0 0.652 S 78.5 18.7 49.0 0.426 0.226 C:P01133:0.226
 NAG
NAG
HOH
 4.660
3.379
3.056
 O
O
OG
 O5
O7
O
SER B:418 B:418 83.0 0.722 S 66.8 41.3 53.0 0.461 0.261 D:P01133:0.261
 HOH
 3.265
 OG
 O
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 SER A:418 A:418 80.0 0.696 S 62.0 40.7 80.0 0.696 0.0 NAG
HOH
 9.778
4.013
 O
OG
 C1
O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 SER C:418 A:418 72.0 0.626 S 44.2 73.5 5.0 0.043 0.583 B:None:0.583
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 SER A:418 A:418 94.0 0.817 S 58.5 46.4 20.0 0.174 0.643 D:None:0.643
 NAG
HOH
 9.610
3.769
 O
HA
 C1
O
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 SER A:418 A:418 89.0 0.774 S 62.1 47.0 89.0 0.774 0.0 NAG
 9.428
 O
 C1
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 SER A:418 A:418 83.0 0.722 S 57.7 56.5 20.0 0.174 0.548 D:None:0.548
 NAG
HOH
 9.363
8.562
 O
HB2
 H1
O
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 SER A:418 A:418 86.0 0.748 S 63.7 50.5 19.0 0.165 0.583 C:None:0.583
 NAG
HOH
 9.573
2.751
 O
OG
 C1
O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 SER A:418 A:418 66.0 0.574 S 44.3 74.2 66.0 0.574 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 SER A:418 A:418 87.0 0.757 S 60.2 28.3 52.0 0.452 0.305 C:Q6QBS2:0.304
 NAG
HOH
 9.397
5.657
 O
O
 C1
O
SER B:418 B:418 86.0 0.748 S 57.2 48.0 51.0 0.443 0.305 D:Q6QBS2:0.304
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 SER A:417 A:418 80.0 0.696 S 63.3 50.6 70.0 0.609 0.087 B:E0ACT6+Q4G1L3:0.087
 NAG
HOH
 4.642
8.989
 O
N
 O6
O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 SER A:418 A:418 85.0 0.739 S 76.6 41.7 55.0 0.478 0.261 E:O14944:0.261
 NAG
HOH
 6.228
9.135
 O
OG
 O7
O
SER B:418 B:418 72.0 0.626 S 57.5 58.2 NA NA NA
SER C:418 C:418 75.0 0.652 S 60.1 55.8 NA NA NA
SER D:418 D:418 79.0 0.687 S 58.4 52.9 60.0 0.522 0.165 H:O14944:0.165
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 SER A:418 A:418 83.0 0.722 S 57.6 37.9 69.0 0.6 0.122 C:Q6UW88:0.122
 NAG
HOH
 9.392
5.652
 O
CB
 C1
O
SER D:418 D:418 82.0 0.713 S 55.8 44.0 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 SER A:418 A:418 75.0 0.652 S 49.4 41.2 58.0 0.504 0.148 C:P01135:0.148
 CD
HOH
 8.921
3.003
 OG
OG
 CD
O
SER B:418 B:418 72.0 0.626 S 44.0 52.8 54.0 0.47 0.156 D:P01135:0.157
 HOH
 6.027
 C
 O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:418 A:418 73.0 0.635 S 57.6 60.4 59.0 0.513 0.122 C:O14944:0.122
SER B:418 B:418 86.0 0.748 S 64.5 50.0 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:418 A:418 75.0 0.652 S 63.6 53.9 52.0 0.452 0.2 C:O14944:0.2
SER B:418 B:418 79.0 0.687 S 62.6 63.8 62.0 0.539 0.148 D:O14944:0.148
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:418 A:418 91.0 0.791 S 62.2 57.5 76.0 0.661 0.13 E:O14944:0.13
SER B:418 B:418 69.0 0.6 S 55.5 57.4 NA NA NA
SER C:418 C:418 71.0 0.617 S 56.3 73.6 NA NA NA
SER D:418 D:418 73.0 0.635 S 59.7 49.4 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 SER A:109 A:418 76.0 0.661 S 55.3 42.5 76.0 0.661 0.0 NAG
HOH
 9.805
2.850
 O
OG
 C1
O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 SER C:112 A:418 81.0 0.704 S 56.3 48.5 6.0 0.052 0.652 B:None:0.652
 NAG
HOH
 9.555
3.214
 O
OG
 C1
O
SER F:112 B:418 82.0 0.713 S 57.3 52.1 NA NA NA
SER I:112 E:418 83.0 0.722 S 56.9 43.0 NA NA NA
SER L:112 I:418 82.0 0.713 S 54.3 49.5 NA NA NA
SER O:112 M:418 90.0 0.783 S 57.6 47.0 NA NA NA
SER R:112 P:418 73.0 0.635 S 50.8 66.6 NA NA NA
SER U:112 S:418 82.0 0.713 S 56.0 51.6 NA NA NA
SER X:112 V:418 81.0 0.704 S 46.6 66.6 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 SER C:112 A:418 76.0 0.661 S 68.0 50.1 NA NA NA
SER F:112 D:418 78.0 0.678 S 35.3 57.3 78.0 0.678 0.0
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 SER B:112 A:418 80.0 0.696 S 55.8 45.5 26.0 0.226 0.47 A:None:0.47
 NAG
HOH
 5.598
2.741
 O
OG
 N2
O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 SER A:112 A:418 77.0 0.67 S 58.4 45.6 29.0 0.252 0.418 B:None:0.417
 NAG
HOH
 4.884
3.735
 O
HG
 H1
O
SER C:112 C:418 77.0 0.67 S 57.7 48.9 NA NA NA
SER E:112 E:418 75.0 0.652 S 59.4 45.6 NA NA NA
SER G:112 G:418 73.0 0.635 S 58.2 51.5 NA NA NA
SER I:112 I:418 76.0 0.661 S 57.6 48.2 NA NA NA
SER K:112 K:418 74.0 0.643 S 53.2 52.2 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 SER A:112 A:418 77.0 0.67 S 59.8 68.4 5.0 0.043 0.627 B:None:0.626
 NAG
HOH
 9.830
2.930
 O
O
 C1
O
SER D:112 B:418 81.0 0.704 S 55.1 54.4 NA NA NA
SER G:112 E:418 83.0 0.722 S 56.2 54.8 NA NA NA
SER J:112 I:418 83.0 0.722 S 63.6 47.2 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 SER E:112 M:418 73.0 0.635 S 55.1 72.3 4.0 0.035 0.6 B:None:0.6
 HOH
 8.900
 OG
 O
SER F:112 N:418 73.0 0.635 S 59.0 71.1 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 SER E:112 M:418 75.0 0.652 S 59.8 69.7 3.0 0.026 0.626 B:None:0.626
 HOH
 6.055
 C
 O
SER F:112 N:418 76.0 0.661 S 60.1 65.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 SER A:442 A:442 87.0 0.757 S 59.7 32.8