Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55227976 . T A CCDS5514.1:NM_005228.3:c.1443ttT>ttA_NP_005219.2:p.481F>L Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 PHE A:481 A:457 26.0 0.124 B -69.3 156.5 26.0 0.124 0.0
PHE C:481 B:457 26.0 0.124 B -70.7 113.5 26.0 0.124 0.0
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 PHE A:481 A:457 32.0 0.152 B -98.7 118.8 32.0 0.152 0.0
PHE B:481 B:457 23.0 0.11 B -98.0 103.8 23.0 0.11 0.0
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 PHE A:481 A:457 18.0 0.086 -65.3 168.0 18.0 0.086 0.0
PHE C:481 B:457 19.0 0.09 B -128.6 130.8 19.0 0.09 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 PHE A:481 A:457 22.0 0.105 B -74.1 159.4 22.0 0.105 0.0
PHE C:481 B:457 12.0 0.057 H -75.9 -54.9 12.0 0.057 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 PHE A:481 A:457 21.0 0.1 B -65.4 135.2 21.0 0.1 0.0
PHE C:481 B:457 21.0 0.1 B -57.2 132.0 21.0 0.1 0.0
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 PHE A:481 A:457 28.0 0.133 B -88.6 119.8 28.0 0.133 0.0
PHE C:481 B:457 17.0 0.081 -66.8 120.1 17.0 0.081 0.0
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 PHE A:481 A:457 41.0 0.195 B -73.2 161.4 41.0 0.195 0.0
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 PHE A:481 A:457 22.0 0.105 B -59.7 133.5 22.0 0.105 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 PHE A:457 A:457 13.0 0.062 -143.2 153.5 13.0 0.062 0.0
PHE B:457 B:457 23.0 0.11 -137.9 157.2 23.0 0.11 0.0 HOH
 6.008
 CZ
 O
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 PHE A:457 A:457 36.0 0.171 B -85.3 143.4 36.0 0.171 0.0 HOH
 6.559
 N
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 PHE C:457 A:457 21.0 0.1 B -95.6 110.4 21.0 0.1 0.0
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 PHE A:457 A:457 33.0 0.157 B -63.0 147.9 17.0 0.081 0.076 B:None:0.076
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 PHE A:457 A:457 43.0 0.205 B -81.1 147.8 43.0 0.205 0.0
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 PHE A:457 A:457 37.0 0.176 B -74.5 145.2 15.0 0.071 0.105 B:None:0.105
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 PHE A:457 A:457 30.0 0.143 B -83.7 152.3 30.0 0.143 0.0 HOH
 4.626
 O
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 PHE A:457 A:457 25.0 0.119 B -58.8 136.7 25.0 0.119 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 PHE A:457 A:457 26.0 0.124 -65.7 165.4 26.0 0.124 0.0
PHE B:457 B:457 31.0 0.148 B -73.2 163.5 31.0 0.148 0.0
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 PHE A:456 A:457 37.0 0.176 B -79.2 138.9 36.0 0.171 0.005 B:E0ACT6+Q4G1L3:0.005
 HOH
 8.635
 CE2
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 PHE A:457 A:457 40.0 0.19 B -81.0 146.9 40.0 0.19 0.0
PHE B:457 B:457 30.0 0.143 B -81.1 154.9 NA NA NA
PHE C:457 C:457 30.0 0.143 B -69.9 165.5 NA NA NA
PHE D:457 D:457 31.0 0.148 B -71.0 163.7 31.0 0.148 0.0
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 PHE A:457 A:457 36.0 0.171 B -68.5 143.2 36.0 0.171 0.0 HOH
 4.268
 CE2
 O
PHE D:457 D:457 42.0 0.2 B -77.2 137.9 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 PHE A:457 A:457 35.0 0.167 B -71.7 152.2 35.0 0.167 0.0
PHE B:457 B:457 31.0 0.148 B -88.5 108.6 31.0 0.148 0.0 HOH
 9.616
 C
 O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PHE A:457 A:457 30.0 0.143 B -80.0 143.6 30.0 0.143 0.0
PHE B:457 B:457 38.0 0.181 B -85.6 143.2 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PHE A:457 A:457 27.0 0.129 B -97.3 141.7 27.0 0.129 0.0
PHE B:457 B:457 30.0 0.143 B -70.8 153.4 30.0 0.143 0.0
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 PHE A:457 A:457 28.0 0.133 B -68.8 137.9 28.0 0.133 0.0
PHE B:457 B:457 28.0 0.133 B -64.1 144.0 NA NA NA
PHE C:457 C:457 24.0 0.114 B -69.9 146.3 NA NA NA
PHE D:457 D:457 24.0 0.114 B -68.2 134.8 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 PHE A:148 A:457 35.0 0.167 B -72.3 146.2 35.0 0.167 0.0 HOH
 2.635
 O
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 PHE C:151 A:457 43.0 0.205 B -73.2 153.1 43.0 0.205 0.0 HOH
 4.432
 CE2
 O
PHE F:151 B:457 45.0 0.214 B -84.6 154.9 NA NA NA
PHE I:151 E:457 45.0 0.214 B -81.6 149.0 NA NA NA
PHE L:151 I:457 45.0 0.214 B -61.4 156.3 NA NA NA
PHE O:151 M:457 49.0 0.233 B -57.5 158.0 NA NA NA
PHE R:151 P:457 45.0 0.214 B -75.6 138.7 NA NA NA
PHE U:151 S:457 44.0 0.21 B -87.6 148.4 NA NA NA
PHE X:151 V:457 41.0 0.195 B -78.3 145.9 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 PHE C:151 A:457 26.0 0.124 -79.1 150.6 NA NA NA
PHE F:151 D:457 37.0 0.176 B -113.9 153.0 2.0 0.01 0.166 B:None:0.167
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 PHE B:151 A:457 30.0 0.143 B -71.8 162.6 30.0 0.143 0.0 HOH
 3.217
 O
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 PHE A:151 A:457 32.0 0.152 B -80.0 167.9 32.0 0.152 0.0
PHE C:151 C:457 28.0 0.133 B -66.9 142.7 NA NA NA
PHE E:151 E:457 32.0 0.152 B -67.4 161.7 NA NA NA
PHE G:151 G:457 34.0 0.162 B -72.3 164.5 NA NA NA
PHE I:151 I:457 32.0 0.152 B -68.8 163.9 NA NA NA
PHE K:151 K:457 38.0 0.181 -68.9 169.6 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 PHE A:151 A:457 26.0 0.124 B -62.5 144.1 26.0 0.124 0.0
PHE D:151 B:457 36.0 0.171 B -68.1 145.2 NA NA NA
PHE G:151 E:457 30.0 0.143 B -62.5 147.2 NA NA NA
PHE J:151 I:457 38.0 0.181 B -65.3 141.9 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 PHE E:151 M:457 39.0 0.186 -74.1 163.5 39.0 0.186 0.0 HOH
 5.989
 O
 O
PHE F:151 N:457 35.0 0.167 B -72.1 160.5 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 PHE E:151 M:457 38.0 0.181 B -64.9 147.2 38.0 0.181 0.0
PHE F:151 N:457 38.0 0.181 B -72.5 166.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 PHE A:481 A:481 38.0 0.181 B -76.1 117.8