Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 55228007 . A C CCDS5514.1:NM_005228.3:c.1474Agc>Cgc_NP_005219.2:p.492S>R Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7syd 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:492 A:468 81.0 0.704 S 63.6 63.6 63.0 0.548 0.156 B:P01133:0.157
SER C:492 B:468 86.0 0.748 S 59.4 44.0 62.0 0.539 0.209 D:P01133:0.209
7sye 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:492 A:468 90.0 0.783 S 63.9 36.3 64.0 0.557 0.226 C:P01133:0.226
SER B:492 B:468 88.0 0.765 S 56.0 42.3 64.0 0.557 0.208 D:P01133:0.209
7sz5 1 P00533 99.92 0.0 EM
 2021-12-22 SER A:492 A:468 73.0 0.635 S 57.5 47.4 73.0 0.635 0.0
SER C:492 B:468 71.0 0.617 S 51.1 59.2 71.0 0.617 0.0
7sz7 1 P00533 99.92 0.0 EM
 2021-12-15 SER A:492 A:468 85.0 0.739 S 56.8 18.8 85.0 0.739 0.0
SER C:492 B:468 84.0 0.73 S 62.6 45.4 84.0 0.73 0.0
7sz0 1 P00533 99.83 0.0 EM
 2021-12-22 SER A:492 A:468 87.0 0.757 S 51.0 27.6 61.0 0.53 0.227 B:P01133:0.226
SER C:492 B:468 103.0 0.896 S 61.0 30.4 77.0 0.67 0.226 D:P01133:0.226
7sz1 1 P00533 99.83 0.0 EM
 2021-12-22 SER A:492 A:468 82.0 0.713 S 63.2 1.0 64.0 0.557 0.156 B:P01133:0.157
SER C:492 B:468 90.0 0.783 S 54.8 54.9 71.0 0.617 0.166 D:P01133:0.165
5xwd 1 P00533 99.84 0.0 X-RAY
 2018-02-28 SER A:492 A:468 78.0 0.678 S 53.6 46.6 21.0 0.183 0.495 C:None:0.496
3qwq 1 P00533 100.0 0.0 X-RAY
 2012-02-01 SER A:492 A:468 95.0 0.826 S 52.9 36.5 95.0 0.826 0.0
1ivo 1 P00533 100.0 0.0 X-RAY
 2002-10-16 SER A:468 A:468 94.0 0.817 S 35.1 68.7 66.0 0.574 0.243 C:P01133:0.243
 NAG
 9.702
 O
 C8
SER B:468 B:468 98.0 0.852 S 49.4 71.0 70.0 0.609 0.243 D:P01133:0.243
 HOH
 9.335
 CA
 O
4uv7 1 P00533 100.0 0.0 X-RAY
 2015-10-14 SER A:468 A:468 87.0 0.757 S 58.8 33.9 87.0 0.757 0.0 HOH
 5.813
 CB
 O
3b2v 3 P00533 100.0 0.0 X-RAY
 2008-02-19 SER C:468 A:468 99.0 0.861 S 76.0 36.8 11.0 0.096 0.765 A:None:0.635
B:None:0.2
4kro 1 P00533 100.0 0.0 X-RAY
 2013-08-28 SER A:468 A:468 101.0 0.878 S 58.2 55.0 2.0 0.017 0.861 D:None:0.243
C:None:0.713
 HOH
 7.365
 O
 O
1nql 1 4885199 99.84 0.0 X-RAY
 2003-03-11 SER A:468 A:468 91.0 0.791 S 68.5 25.5 91.0 0.791 0.0
4krp 1 P00533 99.84 0.0 X-RAY
 2013-08-28 SER A:468 A:468 101.0 0.878 S 50.2 55.4 1.0 0.009 0.869 D:None:0.209
C:None:0.748
1yy9 1 P00533 99.51 0.0 X-RAY
 2005-04-26 SER A:468 A:468 95.0 0.826 S 59.4 51.0 1.0 0.009 0.817 B:None:0.722
C:None:0.209
 HOH
 2.778
 OG
 O
6aru 1 P00533 99.68 0.0 X-RAY
 2018-08-29 SER A:468 A:468 103.0 0.896 S 53.4 44.8 103.0 0.896 0.0
3njp 1 P00533 99.84 0.0 X-RAY
 2010-10-13 SER A:468 A:468 93.0 0.809 S 42.0 58.4 64.0 0.557 0.252 C:Q6QBS2:0.252
SER B:468 B:468 80.0 0.696 S 54.4 40.7 54.0 0.47 0.226 D:Q6QBS2:0.226
4uip 1 P00533 100.0 0.0 X-RAY
 2015-11-25 SER A:467 A:468 97.0 0.843 S 48.9 41.6 6.0 0.052 0.791 B:E0ACT6+Q4G1L3:0.791
 HOH
 4.936
 N
 O
5wb7 1 P00533 100.0 0.0 X-RAY
 2017-10-18 SER A:468 A:468 89.0 0.774 S 56.9 39.6 89.0 0.774 0.0
SER B:468 B:468 98.0 0.852 S 65.0 30.8 NA NA NA
SER C:468 C:468 97.0 0.843 S 54.4 32.8 NA NA NA
SER D:468 D:468 96.0 0.835 S 54.5 27.8 96.0 0.835 0.0
5wb8 1 P00533 100.0 0.0 X-RAY
 2017-10-18 SER A:468 A:468 58.0 0.504 S 61.7 30.9 58.0 0.504 0.0 HOH
 4.271
 N
 O
SER D:468 D:468 72.0 0.626 S 56.7 15.7 NA NA NA
1mox 1 P00533 100.0 0.0 X-RAY
 2003-09-10 SER A:468 A:468 94.0 0.817 S 55.9 37.5 94.0 0.817 0.0 HOH
 7.932
 O
 O
SER B:468 B:468 76.0 0.661 S 48.6 39.0 74.0 0.643 0.018 D:P01135:0.017
 HOH
 7.365
 O
 O
7len 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:468 A:468 77.0 0.67 S 59.9 32.3 77.0 0.67 0.0
SER B:468 B:468 104.0 0.904 S 52.4 30.2 NA NA NA
7lfr 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:468 A:468 88.0 0.765 S 58.0 30.8 88.0 0.765 0.0
SER B:468 B:468 93.0 0.809 S 51.8 45.3 93.0 0.809 0.0
7lfs 1 P00533 99.8 0.0 X-RAY
 2021-11-17 SER A:468 A:468 89.0 0.774 S 56.8 21.4 89.0 0.774 0.0
SER B:468 B:468 93.0 0.809 S 55.0 31.3 NA NA NA
SER C:468 C:468 88.0 0.765 S 58.8 40.5 NA NA NA
SER D:468 D:468 87.0 0.757 E 57.1 26.8 NA NA NA
3p0y 1 P00533 99.52 3e-141 X-RAY
 2011-10-26 SER A:159 A:468 78.0 0.678 S 59.4 37.8 78.0 0.678 0.0 HOH
 3.051
 N
 O
3b2u 3 P00533 99.51 2e-140 X-RAY
 2008-02-19 SER C:162 A:468 103.0 0.896 S 53.5 32.8 11.0 0.096 0.8 B:None:0.183
A:None:0.678
 HOH
 2.849
 O
 O
SER F:162 B:468 97.0 0.843 S 57.6 30.8 NA NA NA
SER I:162 E:468 99.0 0.861 S 58.8 33.2 NA NA NA
SER L:162 I:468 96.0 0.835 S 56.3 33.7 NA NA NA
SER O:162 M:468 100.0 0.87 S 58.9 27.7 NA NA NA
SER R:162 P:468 103.0 0.896 S 56.9 26.2 NA NA NA
SER U:162 S:468 98.0 0.852 S 50.2 28.1 NA NA NA
SER X:162 V:468 102.0 0.887 S 54.5 35.0 NA NA NA
3c09 3 P00533 99.51 2e-140 X-RAY
 2008-04-15 SER C:162 A:468 92.0 0.8 S 68.1 22.3 NA NA NA
SER F:162 D:468 96.0 0.835 S 74.0 44.2 96.0 0.835 0.0
4krl 2 P00533 99.51 2e-140 X-RAY
 2013-08-28 SER B:162 A:468 90.0 0.783 S 61.1 30.2 72.0 0.626 0.157 A:None:0.157
 HOH
 5.832
 O
 O
4krm 1 P00533 99.51 2e-140 X-RAY
 2013-08-28 SER A:162 A:468 91.0 0.791 S 51.6 28.7 80.0 0.696 0.095 B:None:0.096
 HOH
 7.261
 HG
 O
SER C:162 C:468 94.0 0.817 S 51.6 30.4 NA NA NA
SER E:162 E:468 93.0 0.809 S 53.6 30.4 NA NA NA
SER G:162 G:468 92.0 0.8 S 53.9 31.2 NA NA NA
SER I:162 I:468 101.0 0.878 S 67.9 24.9 NA NA NA
SER K:162 K:468 90.0 0.783 S 53.7 22.0 NA NA NA
6b3s 1 P00533 99.02 1e-139 X-RAY
 2017-12-06 ARG A:162 A:468 212.0 0.942 S 55.7 18.7 0.0 0.0 0.942 B:None:0.636
C:None:0.449
 HOH
 2.936
 NH1
 O
ARG D:162 B:468 212.0 0.942 S 51.8 28.8 NA NA NA
ARG G:162 E:468 213.0 0.947 S 62.6 22.3 NA NA NA
ARG J:162 I:468 206.0 0.916 S 58.2 28.3 NA NA NA
5sx4 3 P00533 98.44 5e-129 X-RAY
 2016-10-05 SER E:162 M:468 98.0 0.852 S 54.5 35.7 1.0 0.009 0.843 B:None:0.261
A:None:0.696
 HOH
 2.524
 OG
 O
SER F:162 N:468 96.0 0.835 S 55.4 33.2 NA NA NA
5sx5 3 P00533 97.92 3e-128 X-RAY
 2016-10-05 ARG E:162 M:468 187.0 0.831 S 54.4 39.6 0.0 0.0 0.831 B:None:0.533
A:None:0.418
 HOH
 4.639
 NE
 O
ARG F:162 N:468 189.0 0.84 S 53.0 35.2 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00533-f1 1 P00533 100.0 0.0 SER A:492 A:492 93.0 0.809 S 54.1 26.7