Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6426860 . G A CCDS5348.1:NM_006908.4:c.53tGc>tAc_NP_008839.2:p.18C>Y Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 CYS C:18 D:18 23.0 0.17 H -62.1 -32.9 23.0 0.17 0.0 MG
GDP
HOH
 6.281
2.936
7.071
 N
N
N
 MG
O1A
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 CYS C:18 D:18 25.0 0.185 H -65.3 -29.5 25.0 0.185 0.0 MG
GDP
HOH
 5.921
3.084
7.556
 N
N
SG
 MG
O1A
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 CYS C:18 C:18 30.0 0.222 H -44.4 -35.1 30.0 0.222 0.0
CYS F:18 F:18 29.0 0.215 H -44.4 -35.1 29.0 0.215 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 CYS B:21 B:18 17.0 0.126 H -57.0 -49.9 17.0 0.126 0.0
CYS D:21 D:18 20.0 0.148 H -56.8 -49.9 NA NA NA
CYS F:21 F:18 24.0 0.178 H -57.0 -51.3 NA NA NA
CYS H:21 H:18 22.0 0.163 H -57.4 -48.4 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 CYS C:18 D:18 25.0 0.185 H -64.2 -27.7 25.0 0.185 0.0 MG
GNP
HOH
 5.911
3.223
2.903
 N
N
O
 MG
O1A
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 CYS A:18 A:18 26.0 0.193 H -55.9 -37.5 26.0 0.193 0.0 GTP
MG
HOH
 2.913
5.857
3.990
 N
N
CB
 O1A
MG
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 CYS A:18 A:18 17.0 0.126 H -62.1 -21.4 17.0 0.126 0.0 GDP
MG
HOH
 2.986
6.190
6.166
 N
N
N
 O1A
MG
O
CYS B:18 B:18 16.0 0.119 H -54.1 -13.5 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 CYS A:18 A:18 30.0 0.222 H -56.1 -42.2 30.0 0.222 0.0 HOH
 2.768
 SG
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 CYS B:18 R:18 38.0 0.281 H -58.8 -37.6 38.0 0.281 0.0 MG
GDP
AF3
HOH
 6.309
2.824
8.369
3.549
 N
N
N
SG
 MG
O1A
F1
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 CYS A:22 A:18 14.0 0.104 H -74.5 -42.9 14.0 0.104 0.0 MG
GDP
 6.213
2.955
 N
N
 MG
O1A
CYS B:22 B:18 16.0 0.119 H -70.0 -30.3 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 CYS A:22 A:18 13.0 0.096 H -61.0 -38.6 13.0 0.096 0.0 ZN
GDP
HOH
 5.820
2.788
4.293
 N
N
CB
 ZN
O1A
O
CYS B:22 B:18 12.0 0.089 H -61.3 -37.6 12.0 0.089 0.0 ZN
GDP
HOH
 5.809
2.768
4.166
 N
N
CB
 ZN
O1A
O
CYS C:22 C:18 13.0 0.096 H -63.5 -36.6 13.0 0.096 0.0 ZN
GDP
HOH
 5.828
2.813
4.302
 N
N
CB
 ZN
O1A
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 CYS A:20 A:18 26.0 0.193 H -60.2 -42.1 26.0 0.193 0.0 MG
GNP
HOH
 5.820
2.802
3.576
 N
N
SG
 MG
O1A
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 CYS A:18 A:18 17.0 0.126 H -58.8 -36.7 17.0 0.126 0.0 MG
GDP
HOH
 5.958
2.835
4.249
 N
N
CB
 MG
O1A
O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 CYS C:37 C:18 31.0 0.23 H -61.4 -33.0 NA NA NA
CYS D:37 D:18 34.0 0.252 H -60.7 -32.9 34.0 0.252 0.0 HOH
 2.995
 SG
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 CYS A:18 A:18 31.0 0.23 H -61.1 -43.7 31.0 0.23 0.0 MG
GNP
 5.977
2.852
 N
N
 MG
O1A
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 CYS A:18 A:18 24.0 0.178 H -57.0 -50.1 24.0 0.178 0.0 MG
GNP
 6.880
2.902
 N
N
 MG
O1A
CYS B:18 B:18 25.0 0.185 H -56.2 -51.2 NA NA NA
CYS C:18 C:18 25.0 0.185 H -56.9 -50.2 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 CYS C:18 B:18 45.0 0.333 H -63.4 -42.4 45.0 0.333 0.0 HOH
 2.762
 SG
 O
CYS D:18 D:18 55.0 0.407 H -61.9 -43.7 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 CYS A:18 A:18 31.0 0.23 H -61.2 -31.8 31.0 0.23 0.0 MG
GSP
HOH
 5.636
2.796
4.357
 N
N
CB
 MG
O1A
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 13.0 0.096 H -62.1 -37.2 13.0 0.096 0.0 JGA
HOH
 4.388
4.615
 CB
N
 C12
O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 13.0 0.096 H -56.6 -47.2 13.0 0.096 0.0 N5S
HOH
 4.302
4.611
 CB
N
 C12
O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 12.0 0.089 H -58.7 -45.1 12.0 0.089 0.0 N5V
HOH
 3.898
4.709
 CB
N
 S
O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 13.0 0.096 H -59.2 -41.2 13.0 0.096 0.0 N64
HOH
 4.236
4.428
 CB
N
 C
O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 12.0 0.089 H -58.6 -43.8 12.0 0.089 0.0 N67
HOH
 4.360
4.596
 SG
N
 C8
O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 16.0 0.119 H -62.7 -42.3 16.0 0.119 0.0 N6D
HOH
 3.631
4.584
 CB
N
 C11
O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 13.0 0.096 H -58.5 -44.2 13.0 0.096 0.0 N6J
HOH
 4.033
4.532
 CB
N
 C
O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 11.0 0.081 H -54.0 -42.1 11.0 0.081 0.0 N6V
HOH
 4.309
4.635
 CB
N
 C15
O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 11.0 0.081 H -62.8 -42.2 11.0 0.081 0.0 N71
HOH
 4.441
4.753
 CB
N
 C
O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 14.0 0.104 H -61.8 -41.9 14.0 0.104 0.0 N74
HOH
 4.006
4.605
 CB
N
 C
O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:19 A:18 13.0 0.096 H -59.5 -43.4 13.0 0.096 0.0 N5D
HOH
 4.265
4.715
 SG
N
 O2
O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 CYS A:19 A:18 14.0 0.104 H -60.5 -40.5 14.0 0.104 0.0 HOH
 4.681
 CB
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 CYS B:18 B:18 13.0 0.096 H -61.0 -53.8 13.0 0.096 0.0 SO4
HOH
 4.872
6.521
 N
SG
 O1
O
CYS D:18 D:18 13.0 0.096 H -60.0 -54.0 NA NA NA
CYS F:18 F:18 14.0 0.104 H -59.5 -53.9 NA NA NA
CYS H:18 H:18 14.0 0.104 H -60.1 -54.1 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 CYS A:18 A:18 26.0 0.193 H -57.8 -45.2 26.0 0.193 0.0 HOH
 2.983
 SG
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 CYS C:18 C:18 49.0 0.363 H -59.3 -44.7 NA NA NA
CYS D:18 D:18 17.0 0.126 H -77.3 -51.0 17.0 0.126 0.0
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 CYS A:18 A:18 15.0 0.111 H -61.9 -43.5 15.0 0.111 0.0 GDP
HOH
 2.596
4.167
 N
CB
 O1A
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 CYS B:25 B:18 30.0 0.222 H -52.3 -48.6 30.0 0.222 0.0
CYS D:25 D:18 31.0 0.23 H -55.5 -45.2 31.0 0.23 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 CYS B:25 B:18 40.0 0.296 H -61.7 -40.8 35.0 0.259 0.037 A:Q9H7D0:0.037
CYS E:25 E:18 42.0 0.311 H -61.8 -40.8 36.0 0.267 0.044 D:Q9H7D0:0.044
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 CYS A:20 A:18 37.0 0.274 H -65.7 -39.7 37.0 0.274 0.0 MG
GDP
HOH
 5.765
2.788
3.743
 N
N
SG
 MG
O1A
O
CYS B:20 B:18 35.0 0.259 H -61.7 -43.8 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 CYS A:20 A:18 37.0 0.274 H -62.6 -35.2 37.0 0.274 0.0 MG
GNP
HOH
 5.766
2.841
4.419
 N
N
CB
 MG
O1A
O
CYS B:20 B:18 37.0 0.274 H -60.9 -38.6 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 CYS A:45 A:18 27.0 0.2 H -55.9 -39.9 27.0 0.2 0.0 GNP
MG
HOH
 2.879
5.773
5.695
 N
N
N
 O1A
MG
O
CYS B:45 B:18 35.0 0.259 H -55.4 -32.4 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 CYS A:18 A:18 30.0 0.222 H -59.4 -50.9 30.0 0.222 0.0 GSP
MG
HOH
 1.746
5.581
3.618
 HG
H
SG
 H2'
MG
O
CYS C:18 B:18 30.0 0.222 H -58.3 -50.0 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 CYS A:17 A:18 14.0 0.104 H -67.0 -36.3 14.0 0.104 0.0 GDP
MG
HOH
 2.867
5.945
5.745
 SG
N
N
 H2'
MG
O
CYS B:17 B:18 20.0 0.148 H -57.0 -40.2 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 CYS B:20 B:18 31.0 0.23 H -61.3 -43.2 31.0 0.23 0.0 HOH
 3.018
 SG
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 CYS C:21 C:18 26.0 0.193 H -66.5 -25.1 26.0 0.193 0.0 MG
GNP
 6.560
2.922
 N
N
 MG
O1A
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 CYS A:45 A:18 40.0 0.296 H -45.5 -40.6 40.0 0.296 0.0 GSP
MG
 2.775
5.969
 N
N
 O2A
MG
CYS B:45 B:18 39.0 0.289 H -45.4 -40.4 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 CYS A:28 A:18 33.0 0.244 H -53.1 -40.9 33.0 0.244 0.0 GNP
MG
HOH
 2.875
5.773
2.689
 N
N
O
 O1A
MG
O
CYS B:28 B:18 40.0 0.296 H -63.3 -41.8 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 CYS A:28 A:18 30.0 0.222 H -45.8 -31.5 30.0 0.222 0.0 GNP
MG
HOH
 2.833
5.978
4.305
 N
N
SG
 O1A
MG
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 CYS A:18 A:18 78.0 0.578 H -63.2 -36.8 78.0 0.578 0.0 GDP
MG
 1.898
5.358
 H
H
 O1A
MG
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 CYS C:18 C:18 39.0 0.289 H -60.7 -39.5 39.0 0.289 0.0 GDP
AF3
MG
HOH
 2.946
7.533
5.780
3.361
 N
N
N
SG
 O1A
F3
MG
O
CYS D:18 D:18 37.0 0.274 H -58.1 -42.9 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 CYS A:45 A:18 30.0 0.222 H -59.6 -39.3 30.0 0.222 0.0 GNP
MG
HOH
 2.730
5.810
4.156
 N
N
CB
 O1A
MG
O
CYS B:45 B:18 29.0 0.215 H -57.1 -39.6 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 CYS A:21 BBB:18 28.0 0.207 H -65.4 -41.2 28.0 0.207 0.0 MG
GNP
HOH
 6.066
2.954
5.993
 N
N
N
 MG
O2A
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 CYS A:170 A:561 34.0 0.252 H -59.8 -41.1 34.0 0.252 0.0 GTP
MG
HOH
 2.823
5.812
3.488
 N
N
SG
 O2A
MG
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 CYS A:170 A:561 31.0 0.23 H -63.1 -37.1 31.0 0.23 0.0 GTP
MG
HOH
 2.770
5.740
4.028
 N
N
CB
 O2A
MG
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 CYS A:170 A:561 24.0 0.178 H -61.6 -38.9 24.0 0.178 0.0 GTP
MG
HOH
 2.754
5.798
4.131
 N
N
CB
 O2A
MG
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 CYS B:18 A:18 47.0 0.348 H -58.0 -32.0 47.0 0.348 0.0
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 CYS A:19 A:18 12.0 0.089 H -59.9 -40.0 12.0 0.089 0.0 MG
CL
GDP
HOH
 5.838
9.444
2.771
4.075
 N
N
N
SG
 MG
CL
O1A
O
CYS B:19 B:18 14.0 0.104 H -60.2 -39.4 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 CYS A:19 A:18 28.0 0.207 H -57.0 -39.9 28.0 0.207 0.0 MG
GCP
HOH
 5.773
2.758
3.571
 N
N
SG
 MG
O1A
O
CYS B:19 F:18 28.0 0.207 H -56.2 -43.9 NA NA NA
CYS C:19 B:18 30.0 0.222 H -57.7 -41.9 NA NA NA
CYS D:19 C:18 29.0 0.215 H -62.0 -40.8 NA NA NA
CYS E:19 G:18 29.0 0.215 H -61.1 -44.9 NA NA NA
CYS F:19 D:18 26.0 0.193 H -55.7 -41.3 NA NA NA
CYS G:19 E:18 28.0 0.207 H -61.6 -38.3 NA NA NA
CYS H:19 H:18 29.0 0.215 H -55.7 -44.8 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 CYS A:19 A:18 26.0 0.193 H -60.6 -38.8 26.0 0.193 0.0 MG
GCP
HOH
 5.888
2.820
3.508
 N
N
SG
 MG
O1A
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 CYS A:19 A:18 13.0 0.096 H -65.4 -37.9 13.0 0.096 0.0 MG
GNP
HOH
 5.827
2.843
4.245
 N
N
CB
 MG
O1A
O
CYS B:19 B:18 13.0 0.096 H -63.0 -36.9 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 CYS A:18 A:18 31.0 0.23 H -62.8 -40.6 31.0 0.23 0.0 GDP
MG
HOH
 2.768
5.783
3.632
 N
N
SG
 O1A
MG
O
CYS B:18 B:18 34.0 0.252 H -59.0 -38.7 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 CYS A:24 A:18 12.0 0.089 H -56.3 -41.3 12.0 0.089 0.0 MG
GDP
HOH
 5.735
2.715
4.188
 N
N
CB
 MG
O1A
O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 CYS A:24 A:18 29.0 0.215 H -53.7 -42.8 29.0 0.215 0.0 GSP
MG
HOH
 2.975
6.089
9.124
 N
N
O
 O1A
MG
O
CYS B:24 B:18 22.0 0.163 H -55.2 -40.8 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 CYS A:25 A:18 15.0 0.111 H -58.2 -40.9 15.0 0.111 0.0 GTP
HOH
 2.771
6.209
 N
SG
 O1A
O
CYS B:25 B:18 13.0 0.096 H -53.8 -41.4 NA NA NA
CYS C:25 C:18 15.0 0.111 H -56.4 -42.6 NA NA NA
CYS D:25 D:18 12.0 0.089 H -55.4 -42.4 NA NA NA
5hzh 1 P63000,O49003 100.0 3e-26 X-RAY
 2016-12-21 CYS A:21 A:18 29.0 0.215 H -64.1 -39.4 29.0 0.215 0.0 GTP
MG
HOH
 2.794
6.117
4.334
 N
N
CB
 O1A
MG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 CYS A:18 A:18 22.0 0.163 H -60.1 -40.2
af-p15153-f1 1 P15153 92.19 1e-133 CYS A:18 A:18 25.0 0.185 H -59.1 -40.8
af-p60763-f1 1 P60763 95.51 1e-128 CYS A:18 A:18 22.0 0.163 H -59.2 -40.8