Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6426893 . C A CCDS5348.1:NM_006908.4:c.86cCt>cAt_NP_008839.2:p.29P>H Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 PRO C:29 D:29 2.0 0.014 -62.9 33.2 2.0 0.014 0.0 MG
GDP
HOH
 9.522
6.111
5.313
 CG
CG
CA
 MG
O1A
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 PRO C:29 D:29 8.0 0.055 T -74.4 -6.7 8.0 0.055 0.0 MG
GDP
HOH
 8.167
5.500
8.839
 CG
CG
CG
 MG
O1A
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 PRO C:29 C:29 65.0 0.448 S -41.1 -59.3 43.0 0.297 0.151 A:Q92608:0.152
PRO F:29 F:29 64.0 0.441 S -41.2 -59.3 38.0 0.262 0.179 D:Q92608:0.179
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 PRO B:32 B:29 49.0 0.338 -52.5 -26.7 49.0 0.338 0.0
PRO D:32 D:29 42.0 0.29 -52.5 -27.1 NA NA NA
PRO F:32 F:29 39.0 0.269 -49.6 -25.0 NA NA NA
PRO H:32 H:29 43.0 0.297 -52.3 -26.1 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 PRO C:29 D:29 3.0 0.021 S -57.7 -3.5 3.0 0.021 0.0 MG
GNP
HOH
 8.164
5.506
2.688
 CB
CG
CD
 MG
O1A
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 PRO A:29 A:29 37.0 0.255 -80.3 111.2 24.0 0.166 0.089 B:P19878:0.09
 GTP
MG
HOH
 3.625
8.821
3.599
 O
CG
CA
 O2'
MG
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 PRO A:29 A:29 24.0 0.166 -77.9 140.5 24.0 0.166 0.0 GDP
HOH
 4.576
9.915
 O
CG
 O2'
O
PRO B:29 B:29 31.0 0.214 -73.0 169.6 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 PRO A:29 A:29 44.0 0.303 -40.8 -24.0 44.0 0.303 0.0 HOH
 2.746
 O
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 PRO B:29 R:29 34.0 0.234 -51.7 133.9 34.0 0.234 0.0 MG
GDP
HOH
 9.318
6.379
2.941
 CG
CG
O
 MG
O1A
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 PRO A:33 A:29 24.0 0.166 -69.5 145.4 24.0 0.166 0.0 MG
GDP
 9.931
5.548
 CG
O
 MG
O2'
PRO B:33 B:29 34.0 0.234 -70.1 -24.2 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 PRO A:33 A:29 23.0 0.159 -57.0 160.6 23.0 0.159 0.0 ZN
GDP
HOH
 9.172
5.690
2.764
 CG
O
O
 ZN
O2'
O
PRO B:33 B:29 20.0 0.138 -56.6 160.9 20.0 0.138 0.0 ZN
GDP
HOH
 9.390
5.785
3.485
 CG
O
O
 ZN
O2'
O
PRO C:33 C:29 23.0 0.159 -61.1 157.8 23.0 0.159 0.0 ZN
GDP
HOH
 9.229
5.709
3.152
 CG
O
O
 ZN
O2'
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 PRO A:31 A:29 34.0 0.234 -57.8 149.3 34.0 0.234 0.0 MG
GNP
HOH
 8.794
5.417
3.402
 CG
O
O
 MG
O2'
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 PRO A:29 A:29 33.0 0.228 -52.0 -73.5 33.0 0.228 0.0 MG
GDP
HOH
 9.779
6.480
4.455
 CG
CB
C
 MG
O2'
O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 PRO C:48 C:29 40.0 0.276 S -50.0 -48.4 NA NA NA
PRO D:48 D:29 36.0 0.248 S -61.0 -46.0 22.0 0.152 0.096 B:Q92608:0.097
 HOH
 6.194
 N
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 PRO A:29 A:29 51.0 0.352 -72.4 -42.5 51.0 0.352 0.0 MG
GNP
 8.708
5.848
 CG
C
 MG
O2'
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 PRO A:29 A:29 55.0 0.379 -58.7 -59.1 55.0 0.379 0.0 MG
GNP
 9.302
5.891
 CG
CG
 MG
O1A
PRO B:29 B:29 56.0 0.386 -58.3 -58.8 NA NA NA
PRO C:29 C:29 54.0 0.372 -59.2 -58.9 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 PRO C:29 B:29 98.0 0.676 T -47.4 135.1 98.0 0.676 0.0 HOH
 9.097
 CB
 O
PRO D:29 D:29 95.0 0.655 T -51.2 138.3 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 PRO A:29 A:29 34.0 0.234 -43.3 139.8 34.0 0.234 0.0 MG
GSP
HOH
 7.914
4.923
5.726
 CG
O
N
 MG
O2'
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 34.0 0.234 -74.7 -11.4 34.0 0.234 0.0 JGA
HOH
 7.805
3.486
 CD
CA
 C08
O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 31.0 0.214 -76.9 -21.9 31.0 0.214 0.0 N5S
HOH
 7.200
3.447
 C
CA
 C2
O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 37.0 0.255 -72.4 -28.7 37.0 0.255 0.0 N5V
HOH
 7.219
3.235
 CD
CA
 O
O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 38.0 0.262 -70.4 -20.5 38.0 0.262 0.0 N64
HOH
 7.457
3.608
 CD
CA
 C2
O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 33.0 0.228 -77.0 -20.7 33.0 0.228 0.0 N67
HOH
 7.345
3.408
 CD
CA
 O2
O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 34.0 0.234 -77.4 -24.8 34.0 0.234 0.0 N6D
HOH
 7.415
3.394
 CD
CA
 C9
O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 35.0 0.241 -71.1 -29.7 35.0 0.241 0.0 N6J
HOH
 7.480
3.313
 CD
CA
 O
O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 35.0 0.241 -77.4 -17.2 35.0 0.241 0.0 N6V
HOH
 7.483
3.355
 CD
CA
 O
O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 36.0 0.248 -66.8 -26.2 36.0 0.248 0.0 N71
HOH
 6.792
3.381
 C
CA
 C10
O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 34.0 0.234 -75.7 -22.0 34.0 0.234 0.0 N74
HOH
 6.691
3.451
 C
CA
 C11
O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 PRO A:30 A:29 36.0 0.248 -72.0 -22.1 36.0 0.248 0.0 N5D
HOH
 7.609
3.294
 CD
CA
 N5
O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 PRO A:30 A:29 36.0 0.248 -69.9 -17.7 36.0 0.248 0.0 HOH
 3.642
 CA
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 PRO B:29 B:29 39.0 0.269 -54.6 -42.8 39.0 0.269 0.0 HOH
 8.350
 O
 O
PRO D:29 D:29 38.0 0.262 -55.2 -41.7 NA NA NA
PRO F:29 F:29 38.0 0.262 -54.4 -42.9 NA NA NA
PRO H:29 H:29 39.0 0.269 -54.9 -42.9 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 PRO A:29 A:29 73.0 0.503 -66.7 94.0 73.0 0.503 0.0 HOH
 4.156
 C
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 PRO C:29 C:29 119.0 0.821 -101.0 -1.7 NA NA NA
PRO D:29 D:29 57.0 0.393 -97.0 -27.5 57.0 0.393 0.0 HOH
 9.496
 N
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 PRO A:29 A:29 26.0 0.179 -81.1 19.6 26.0 0.179 0.0 GDP
EDO
HOH
 7.005
9.892
3.641
 CG
CB
CA
 O2'
C1
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 PRO B:36 B:29 51.0 0.352 T -58.8 127.3 46.0 0.317 0.035 A:Q92608:0.034
PRO D:36 D:29 52.0 0.359 T -54.1 129.3 45.0 0.31 0.049 C:Q92608:0.048
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 PRO B:36 B:29 40.0 0.276 T -57.0 136.8 33.0 0.228 0.048 A:Q9H7D0:0.048
PRO E:36 E:29 38.0 0.262 T -57.1 136.8 33.0 0.228 0.034 D:Q9H7D0:0.034
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 PRO A:31 A:29 25.0 0.172 -73.8 127.2 25.0 0.172 0.0 MG
GDP
HOH
 9.431
5.349
2.729
 CG
O
O
 MG
O2'
O
PRO B:31 B:29 25.0 0.172 -79.7 127.2 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 PRO A:31 A:29 25.0 0.172 -73.9 109.6 25.0 0.172 0.0 MG
GNP
HOH
 9.481
5.367
5.851
 CG
O
N
 MG
O2'
O
PRO B:31 B:29 26.0 0.179 -78.7 125.9 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 PRO A:56 A:29 26.0 0.179 -56.5 138.0 26.0 0.179 0.0 GNP
MG
HOH
 5.109
8.562
5.122
 O
CG
O
 O2'
MG
O
PRO B:56 B:29 93.0 0.641 -63.2 360.0 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 PRO A:29 A:29 37.0 0.255 -65.6 167.5 37.0 0.255 0.0 GSP
MG
HOH
 4.576
7.727
3.292
 HG2
HG3
HG3
 H2'
MG
O
PRO C:29 B:29 34.0 0.234 -67.8 140.4 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 PRO A:28 A:29 30.0 0.207 -65.7 2.5 30.0 0.207 0.0 GDP
MG
HOH
 6.126
9.468
8.354
 CG
CG
CG
 H2'
MG
O
PRO B:28 B:29 20.0 0.138 -87.3 76.3 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 PRO B:31 B:29 59.0 0.407 S -81.3 -40.7 59.0 0.407 0.0 HOH
 2.277
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 PRO C:32 C:29 66.0 0.455 -66.4 -126.0 66.0 0.455 0.0 GNP
 6.448
 C
 O2'
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 PRO A:56 A:29 52.0 0.359 -58.4 133.3 52.0 0.359 0.0 GSP
MG
 4.702
9.521
 O
CG
 O2'
MG
PRO B:56 B:29 52.0 0.359 -58.4 133.1 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 SER A:39 A:29 70.0 0.609 -113.4 141.6 70.0 0.609 0.0 GNP
HOH
 2.889
2.970
 O
N
 O2'
O
SER B:39 B:29 70.0 0.609 -113.8 140.9 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 SER A:39 A:29 72.0 0.626 -113.3 137.9 72.0 0.626 0.0 GNP
HOH
 2.630
5.132
 O
CB
 O2'
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 PRO A:29 A:29 107.0 0.738 G -66.6 -17.3 107.0 0.738 0.0
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 PRO C:29 C:29 26.0 0.179 -51.6 136.5 26.0 0.179 0.0 GDP
MG
HOH
 6.397
8.748
2.999
 CG
CG
O
 O1A
MG
O
PRO D:29 D:29 29.0 0.2 -48.1 132.9 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 PRO A:56 A:29 42.0 0.29 -49.6 152.8 42.0 0.29 0.0 GNP
MG
HOH
 4.482
8.327
4.449
 O
CG
CB
 O2'
MG
O
PRO B:56 B:29 61.0 0.421 -50.0 360.0 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 PRO A:32 BBB:29 45.0 0.31 -82.6 115.2 6.0 0.041 0.269 B:Q9NUQ9:0.269
 MG
GNP
HOH
 9.385
3.300
7.601
 CG
O
CG
 MG
O2'
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 PRO A:181 A:572 33.0 0.228 -74.7 153.2 33.0 0.228 0.0 GTP
MG
HOH
 5.645
9.072
3.497
 O
CG
O
 C2'
MG
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 PRO A:181 A:572 33.0 0.228 -67.4 155.6 33.0 0.228 0.0 GTP
MG
HOH
 5.539
9.036
4.745
 O
CG
C
 C2'
MG
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 PRO A:181 A:572 60.0 0.414 -69.1 -35.5 60.0 0.414 0.0 GTP
MG
HOH
 6.135
8.762
5.022
 CG
CG
CG
 O2A
MG
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 PRO B:29 A:29 25.0 0.172 T -63.2 163.8 12.0 0.083 0.089 A:Q96BY6:0.09
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 PRO A:30 A:29 13.0 0.09 -60.0 142.7 13.0 0.09 0.0 MG
GDP
HOH
 9.294
5.420
2.903
 CG
O
O
 MG
O2'
O
PRO B:30 B:29 22.0 0.152 -44.1 -63.9 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 PRO A:30 A:29 37.0 0.255 -51.1 135.4 37.0 0.255 0.0 MG
GCP
HOH
 8.557
4.790
2.647
 CG
O
O
 MG
O2'
O
PRO B:30 F:29 37.0 0.255 -54.0 131.4 NA NA NA
PRO C:30 B:29 40.0 0.276 -54.3 130.1 NA NA NA
PRO D:30 C:29 39.0 0.269 -51.8 139.0 NA NA NA
PRO E:30 G:29 38.0 0.262 -52.6 135.8 NA NA NA
PRO F:30 D:29 39.0 0.269 -54.6 134.3 NA NA NA
PRO G:30 E:29 40.0 0.276 -53.1 137.2 NA NA NA
PRO H:30 H:29 37.0 0.255 -48.3 135.2 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 PRO A:30 A:29 33.0 0.228 -51.1 134.4 33.0 0.228 0.0 MG
GCP
HOH
 8.661
4.722
2.747
 CG
O
O
 MG
O2'
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 PRO A:30 A:29 13.0 0.09 -53.3 143.1 13.0 0.09 0.0 MG
GNP
HOH
 9.305
5.596
4.103
 CG
O
CA
 MG
O2'
O
PRO B:30 B:29 24.0 0.166 -44.2 -60.6 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 PRO A:29 A:29 41.0 0.283 -60.3 144.5 41.0 0.283 0.0 GDP
MG
HOH
 5.137
8.732
2.897
 O
CG
O
 O2'
MG
O
PRO B:29 B:29 31.0 0.214 -61.2 139.3 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 PRO A:35 A:29 22.0 0.152 -66.5 -47.8 22.0 0.152 0.0 MG
GDP
HOH
 9.906
5.662
3.786
 CG
C
CA
 MG
O2'
O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 PRO A:35 A:29 32.0 0.221 -77.0 136.6 32.0 0.221 0.0 GSP
MG
 4.385
9.556
 O
CG
 O2'
MG
PRO B:35 B:29 29.0 0.2 -77.7 138.0 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 PRO A:36 A:29 61.0 0.421 -66.0 360.0 61.0 0.421 0.0 GTP
HOH
 6.092
6.802
 C
O
 O2'
O
PRO B:36 B:29 51.0 0.352 -64.6 -62.5 NA NA NA
PRO C:36 C:29 59.0 0.407 -59.7 360.0 NA NA NA
PRO D:36 D:29 36.0 0.248 -58.1 -71.7 NA NA NA
5hzh 1 P63000,O49003 100.0 3e-26 X-RAY
 2016-12-21 PRO A:32 A:29 90.0 0.621 -60.3 360.0 90.0 0.621 0.0 GTP
MG
HOH
 4.970
8.650
6.875
 O
CG
CG
 O2'
MG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 PRO A:29 A:29 33.0 0.228 -68.8 132.8
af-p15153-f1 1 P15153 92.19 1e-133 PRO A:29 A:29 33.0 0.228 -69.4 131.1
af-p60763-f1 1 P60763 95.51 1e-128 PRO A:29 A:29 34.0 0.234 -68.7 131.9