Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6431563 . A C CCDS5348.1:NM_006908.4:c.116aAt>aCt_NP_008839.2:p.39N>T Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ASN C:39 D:39 73.0 0.456 -101.5 175.4 19.0 0.119 0.337 A:P53365:0.338
 MG
HOH
 9.770
2.702
 OD1
O
 MG
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ASN C:39 D:39 73.0 0.456 -112.2 163.6 21.0 0.131 0.325 A:P53365:0.325
 HOH
 4.289
 O
 O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 ASN C:39 C:39 108.0 0.675 -48.5 109.7 16.0 0.1 0.575 A:Q92608:0.575
ASN F:39 F:39 108.0 0.675 -48.5 109.8 17.0 0.106 0.569 D:Q92608:0.569
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 ASN B:42 B:39 112.0 0.7 -52.1 120.0 31.0 0.194 0.506 A:Q8TCU6:0.506
ASN D:42 D:39 109.0 0.681 -52.2 118.3 NA NA NA
ASN F:42 F:39 103.0 0.644 -52.1 123.7 NA NA NA
ASN H:42 H:39 104.0 0.65 -50.6 124.2 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 ASN C:39 D:39 76.0 0.475 -117.7 158.0 24.0 0.15 0.325 A:P53365:0.325
 MG
HOH
 9.864
2.613
 OD1
ND2
 MG
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 ASN A:39 A:39 82.0 0.512 E -134.9 136.3 82.0 0.512 0.0 HOH
 9.302
 N
 O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 ASN A:39 A:39 76.0 0.475 -53.7 133.5 69.0 0.431 0.044 C:P52565:0.044
 HOH
 6.512
 CB
 O
ASN B:39 B:39 100.0 0.625 -58.2 94.0 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 ASN A:39 A:39 96.0 0.6 -43.1 134.7 19.0 0.119 0.481 B:P27870:0.481
 HOH
 2.746
 OD1
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 ASN B:39 R:39 90.0 0.562 E -131.4 137.5 90.0 0.562 0.0 HOH
 3.035
 OD1
 O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 ASN A:43 A:39 92.0 0.575 -59.3 142.0 33.0 0.206 0.369 C:Q05608:0.369
 HOH
 3.135
 CB
 O
ASN B:43 B:39 99.0 0.619 -65.2 126.3 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 ASN A:43 A:39 93.0 0.581 -61.0 124.0 47.0 0.294 0.287 B:P63000:0.287
 ZN
ZN
GDP
HOH
 7.017
7.912
9.100
2.499
 N
O
O
ND2
 ZN
ZN
O2A
O
ASN B:43 B:39 84.0 0.525 -63.7 126.2 39.0 0.244 0.281 C:P63000:0.281
 ZN
ZN
GDP
HOH
 6.953
7.938
9.079
2.428
 N
O
O
ND2
 ZN
ZN
O2A
O
ASN C:43 C:39 91.0 0.569 -67.0 124.1 45.0 0.281 0.288 A:P63000:0.287
 ZN
ZN
GDP
HOH
 7.974
6.936
9.155
2.610
 O
N
O
OD1
 ZN
ZN
O2A
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 ASN A:41 A:39 84.0 0.525 E -117.1 138.7 84.0 0.525 0.0 HOH
 3.599
 ND2
 O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 ASN A:39 A:39 89.0 0.556 -72.1 121.6 62.0 0.388 0.168 B:P52566:0.169
 HOH
 2.792
 OD1
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 ASN C:58 C:39 92.0 0.575 -81.6 155.5 NA NA NA
ASN D:58 D:39 98.0 0.613 -101.1 143.4 31.0 0.194 0.419 B:Q92608:0.419
 HOH
 4.110
 O
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 ASN A:39 A:39 78.0 0.487 E -132.9 137.3 15.0 0.094 0.393 B:O43157:0.394
 MG
 9.627
 N
 MG
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 ASN A:39 A:39 89.0 0.556 B -113.3 137.4 19.0 0.119 0.437 D:O43157:0.438
ASN B:39 B:39 95.0 0.594 B -115.2 138.2 NA NA NA
ASN C:39 C:39 86.0 0.537 B -116.6 137.2 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 ASN C:39 B:39 50.0 0.312 65.4 30.3 1.0 0.006 0.306 A:B3CVM3:0.306
 HOH
 2.865
 O
 O
ASN D:39 D:39 50.0 0.312 62.0 32.4 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 ASN A:39 A:39 85.0 0.531 E -140.5 136.0 50.0 0.312 0.219 B:Q00722:0.219
 HOH
 2.816
 ND2
 O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 102.0 0.637 -38.2 129.5 13.0 0.081 0.556 B:O60229:0.556
 HOH
 2.693
 O
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 102.0 0.637 -46.2 132.2 11.0 0.069 0.568 B:O60229:0.569
 HOH
 2.675
 O
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 99.0 0.619 -47.7 134.8 11.0 0.069 0.55 B:O60229:0.55
 HOH
 2.684
 O
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 102.0 0.637 -42.5 133.0 11.0 0.069 0.568 B:O60229:0.569
 HOH
 2.653
 O
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 102.0 0.637 -46.7 132.6 11.0 0.069 0.568 B:O60229:0.569
 HOH
 2.615
 O
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 99.0 0.619 -45.7 136.6 13.0 0.081 0.538 B:O60229:0.537
 HOH
 2.609
 O
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 100.0 0.625 -43.4 132.7 11.0 0.069 0.556 B:O60229:0.556
 HOH
 2.630
 O
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 102.0 0.637 -36.9 131.6 11.0 0.069 0.568 B:O60229:0.569
 HOH
 2.590
 O
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 100.0 0.625 -42.0 134.0 11.0 0.069 0.556 B:O60229:0.556
 HOH
 2.681
 O
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 99.0 0.619 -42.3 131.6 11.0 0.069 0.55 B:O60229:0.55
 HOH
 2.582
 O
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ASN A:40 A:39 101.0 0.631 -40.2 136.0 12.0 0.075 0.556 B:O60229:0.556
 HOH
 2.609
 O
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 ASN A:40 A:39 104.0 0.65 -46.3 134.1 13.0 0.081 0.569 B:O60229:0.569
 HOH
 2.724
 O
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 ASN B:39 B:39 111.0 0.694 -56.3 123.0 12.0 0.075 0.619 A:Q60610:0.619
 HOH
 5.131
 N
 O
ASN D:39 D:39 114.0 0.713 -57.3 124.6 NA NA NA
ASN F:39 F:39 112.0 0.7 -57.4 123.5 NA NA NA
ASN H:39 H:39 115.0 0.719 -58.9 123.9 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 ASN A:39 A:39 103.0 0.644 -45.8 130.1 16.0 0.1 0.544 B:O75962:0.544
 HOH
 2.595
 OD1
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 ASN C:39 C:39 87.0 0.544 -60.4 119.5 NA NA NA
ASN D:39 D:39 92.0 0.575 -50.2 127.0 21.0 0.131 0.444 A:P15498:0.444
 HOH
 4.106
 O
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 ASN A:39 A:39 108.0 0.675 -47.1 132.6 14.0 0.087 0.588 B:P97924:0.588
 EDO
HOH
 4.362
2.806
 N
O
 HO2
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 ASN B:46 B:39 66.0 0.412 56.3 -164.5 15.0 0.094 0.318 A:Q92608:0.319
ASN D:46 D:39 64.0 0.4 50.4 -169.5 15.0 0.094 0.306 C:Q92608:0.306
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 ASN B:46 B:39 101.0 0.631 61.6 67.6 14.0 0.087 0.544 A:Q9H7D0:0.544
ASN E:46 E:39 100.0 0.625 61.7 67.6 12.0 0.075 0.55 D:Q9H7D0:0.55
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ASN A:41 A:39 63.0 0.394 E -145.8 152.6 63.0 0.394 0.0 MG
HOH
 9.984
3.961
 N
OD1
 MG
O
ASN B:41 B:39 64.0 0.4 E -156.4 158.1 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ASN A:41 A:39 63.0 0.394 E -150.5 151.1 63.0 0.394 0.0 HOH
 2.860
 OD1
 O
ASN B:41 B:39 71.0 0.444 E -147.5 156.9 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 ASN A:66 A:39 100.0 0.625 E -133.6 109.6 100.0 0.625 0.0 HOH
 9.358
 N
 O
ASN B:66 B:39 91.0 0.569 E -145.3 113.9 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 ASN A:39 A:39 80.0 0.5 E -118.5 131.7 22.0 0.138 0.362 B:Q8N1W1:0.362
 MG
HOH
 9.987
2.092
 N
H
 MG
O
ASN C:39 B:39 80.0 0.5 E -126.4 134.5 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 ASN A:38 A:39 70.0 0.438 E -119.4 147.8 70.0 0.438 0.0 HOH
 5.527
 N
 O
ASN B:38 B:39 84.0 0.525 E -115.2 132.5 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 ASN B:41 B:39 110.0 0.688 -49.4 130.5 32.0 0.2 0.488 A:Q8TCU6:0.487
 HOH
 2.689
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 ASN C:42 C:39 72.0 0.45 -149.8 130.1 21.0 0.131 0.319 A:P70206:0.319
 MG
 9.610
 N
 MG
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 ASN A:66 A:39 84.0 0.525 -158.3 95.6 84.0 0.525 0.0
ASN B:66 B:39 83.0 0.519 -158.1 95.7 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ASN A:49 A:39 92.0 0.575 E -118.6 134.5 92.0 0.575 0.0 HOH
 7.409
 N
 O
ASN B:49 B:39 92.0 0.575 E -116.2 131.6 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ASN A:49 A:39 77.0 0.481 E -142.2 124.5 77.0 0.481 0.0 MG
HOH
 9.488
9.150
 N
N
 MG
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 ASN A:39 A:39 120.0 0.75 152.9 163.3 120.0 0.75 0.0
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 ASN C:39 C:39 78.0 0.487 E -154.8 144.9 47.0 0.294 0.193 A:Q51451:0.194
 MG
HOH
 9.878
2.627
 N
ND2
 MG
O
ASN D:39 D:39 72.0 0.45 E -146.8 132.5 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 ASN A:66 A:39 92.0 0.575 E -115.8 120.8 92.0 0.575 0.0 HOH
 7.417
 N
 O
ASN B:66 B:39 86.0 0.537 E -116.0 132.9 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 ASN A:42 BBB:39 105.0 0.656 E -147.4 141.8 4.0 0.025 0.631 B:Q9NUQ9:0.631
 MG
HOH
 8.874
6.723
 N
N
 MG
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ASN A:191 A:582 3.0 0.019 E -136.7 146.8 3.0 0.019 0.0 MG
HOH
 9.746
2.589
 N
ND2
 MG
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ASN A:191 A:582 3.0 0.019 E -134.7 150.4 3.0 0.019 0.0 MG
HOH
 9.741
2.626
 N
ND2
 MG
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 ASN A:191 A:582 1.0 0.006 E -131.7 151.2 1.0 0.006 0.0 MG
CA
HOH
 9.789
4.508
2.640
 N
O
ND2
 MG
CA
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 ASN B:39 A:39 84.0 0.525 58.7 96.8 12.0 0.075 0.45 A:Q96BY6:0.45
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 ASN A:40 A:39 85.0 0.531 E -112.1 128.0 85.0 0.531 0.0 HOH
 3.270
 CB
 O
ASN B:40 B:39 78.0 0.487 E -108.9 119.5 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 ASN A:40 A:39 85.0 0.531 E -124.3 121.9 17.0 0.106 0.425 I:O96013:0.425
 HOH
 3.042
 OD1
 O
ASN B:40 F:39 84.0 0.525 E -124.7 129.4 NA NA NA
ASN C:40 B:39 82.0 0.512 E -129.3 126.9 NA NA NA
ASN D:40 C:39 83.0 0.519 E -123.4 120.8 NA NA NA
ASN E:40 G:39 81.0 0.506 E -123.0 123.6 NA NA NA
ASN F:40 D:39 79.0 0.494 E -124.9 129.6 NA NA NA
ASN G:40 E:39 79.0 0.494 E -126.1 122.8 NA NA NA
ASN H:40 H:39 78.0 0.487 E -122.6 129.1 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 ASN A:40 A:39 86.0 0.537 E -119.9 131.2 19.0 0.119 0.418 B:Q13153:0.419
 HOH
 2.924
 OD1
 O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 ASN A:40 A:39 68.0 0.425 E -110.2 120.8 68.0 0.425 0.0 HOH
 3.302
 N
 O
ASN B:40 B:39 76.0 0.475 E -110.6 116.6 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 ASN A:39 A:39 68.0 0.425 E -135.8 143.6 68.0 0.425 0.0 HOH
 5.003
 ND2
 O
ASN B:39 B:39 73.0 0.456 E -118.2 144.4 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ASN A:45 A:39 82.0 0.512 E -117.4 154.4 82.0 0.512 0.0 HOH
 2.932
 O
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ASN A:45 A:39 80.0 0.5 E -123.5 148.0 31.0 0.194 0.306 D:P16885:0.306
 MG
HOH
 9.797
3.977
 N
N
 MG
O
ASN B:45 B:39 81.0 0.506 E -124.4 145.6 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 ASN A:46 A:39 83.0 0.519 E -117.9 148.9 83.0 0.519 0.0 GTP
HOH
 9.578
2.766
 N
OD1
 O2G
O
ASN B:46 B:39 108.0 0.675 E -130.7 150.1 NA NA NA
ASN C:46 C:39 84.0 0.525 E -121.5 157.5 NA NA NA
ASN D:46 D:39 66.0 0.412 E -126.1 156.7 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 GLU A:191 A:188 107.0 0.563 H -71.4 -32.8 107.0 0.563 0.0
5hzh 1 P63000,O49003 100.0 3e-26 X-RAY
 2016-12-21 ASN A:42 A:39 90.0 0.562 E -101.0 145.4 90.0 0.562 0.0 HOH
 6.510
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 ASN A:39 A:39 86.0 0.537 E -122.2 132.3
af-p15153-f1 1 P15153 92.19 1e-133 ASN A:39 A:39 78.0 0.487 E -127.0 130.4
af-p60763-f1 1 P60763 95.51 1e-128 ASN A:39 A:39 88.0 0.55 E -120.6 132.6