Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6431637 . T A CCDS5348.1:NM_006908.4:c.190Tat>Aat_NP_008839.2:p.64Y>N Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 TYR C:64 D:64 75.0 0.326 G -101.1 5.1 21.0 0.091 0.235 A:P53365:0.235
B:P53365:0.004
 MG
HOH
 9.792
4.668
 CE1
CD2
 MG
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 TYR C:64 D:64 77.0 0.335 G -103.2 8.7 25.0 0.109 0.226 A:P53365:0.226
 MG
HOH
 9.611
3.040
 CE1
C
 MG
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 TYR C:64 C:64 66.0 0.287 G -113.1 21.5 25.0 0.109 0.178 A:Q92608:0.178
TYR F:64 F:64 67.0 0.291 G -113.1 21.6 24.0 0.104 0.187 D:Q92608:0.187
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 TYR B:67 B:64 140.0 0.609 -113.7 90.2 22.0 0.096 0.513 A:Q8TCU6:0.513
TYR D:67 D:64 138.0 0.6 -114.4 90.6 NA NA NA
TYR F:67 F:64 145.0 0.63 -115.4 91.7 NA NA NA
TYR H:67 H:64 141.0 0.613 -114.9 90.2 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 TYR C:64 D:64 86.0 0.374 G -100.1 12.2 26.0 0.113 0.261 A:P53365:0.261
 MG
GNP
HOH
 9.472
7.362
3.179
 CE1
CE1
C
 MG
O3G
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 TYR A:64 A:64 70.0 0.304 G -103.5 23.3 70.0 0.304 0.0 GTP
MG
HOH
 6.821
9.366
4.227
 CE2
CE2
CD2
 O2G
MG
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 TYR A:64 A:64 114.0 0.496 G -110.0 21.0 2.0 0.009 0.487 C:P52565:0.487
 HOH
 6.496
 O
 O
TYR B:64 B:64 113.0 0.491 S -96.6 18.4 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 TYR A:64 A:64 134.0 0.583 -119.0 94.5 9.0 0.039 0.544 B:P27870:0.543
 HOH
 2.739
 OH
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 TYR B:64 R:64 79.0 0.343 G -105.0 8.1 5.0 0.022 0.321 A:P74873:0.322
 AF3
HOH
 8.037
3.362
 CD1
C
 AL
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 TYR A:68 A:64 63.0 0.274 H -62.6 -19.6 2.0 0.009 0.265 C:Q05608:0.265
 MG
GDP
HOH
 7.912
9.305
7.456
 CZ
CD1
CD1
 MG
O1B
O
TYR B:68 B:64 71.0 0.309 H -87.5 -11.5 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 TYR A:68 A:64 191.0 0.83 G -116.6 7.3 191.0 0.83 0.0 ZN
HOH
 6.785
2.897
 N
OH
 ZN
O
TYR B:68 B:64 189.0 0.822 G -116.2 17.0 189.0 0.822 0.0 ZN
HOH
 6.735
3.289
 N
C
 ZN
O
TYR C:68 C:64 192.0 0.835 G -115.4 8.6 192.0 0.835 0.0 ZN
HOH
 6.765
2.828
 N
OH
 ZN
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 TYR A:66 A:64 63.0 0.274 G -101.6 11.4 63.0 0.274 0.0 MG
GNP
HOH
 8.561
6.149
3.309
 OH
CE1
C
 MG
O3G
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 TYR A:64 A:64 106.0 0.461 G -106.3 20.0 0.0 0.0 0.461 B:P52566:0.461
 HOH
 3.657
 C
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 TYR C:83 C:64 108.0 0.47 G -91.7 12.5 NA NA NA
TYR D:83 D:64 109.0 0.474 G -93.5 8.7 60.0 0.261 0.213 B:Q92608:0.213
 HOH
 5.029
 OH
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 TYR A:64 A:64 93.0 0.404 G -92.3 24.4 71.0 0.309 0.095 B:O43157:0.096
 MG
GNP
 9.498
6.921
 CD2
CD2
 MG
O3G
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 TYR A:64 A:64 91.0 0.396 G -93.6 61.6 52.0 0.226 0.17 D:O43157:0.17
 MG
GNP
 8.075
7.063
 CD2
CD2
 MG
O3G
TYR B:64 B:64 92.0 0.4 G -94.0 61.5 NA NA NA
TYR C:64 C:64 93.0 0.404 G -93.8 61.5 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 TYR C:64 B:64 97.0 0.422 G -103.3 16.3 2.0 0.009 0.413 A:B3CVM3:0.413
 HOH
 2.610
 OH
 O
TYR D:64 D:64 94.0 0.409 G -104.7 14.7 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 TYR A:64 A:64 60.0 0.261 G -101.8 12.1 40.0 0.174 0.087 B:Q00722:0.087
 GSP
HOH
 7.701
3.067
 CE2
OH
 S1G
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 130.0 0.565 -122.1 83.1 13.0 0.057 0.508 B:O60229:0.509
 HOH
 2.706
 OH
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 127.0 0.552 -119.3 83.6 11.0 0.048 0.504 B:O60229:0.504
 HOH
 2.793
 OH
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 125.0 0.543 -109.4 89.8 9.0 0.039 0.504 B:O60229:0.504
 HOH
 2.643
 OH
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 125.0 0.543 -119.2 83.3 8.0 0.035 0.508 B:O60229:0.509
 HOH
 3.052
 OH
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 134.0 0.583 -116.8 85.2 13.0 0.057 0.526 B:O60229:0.526
 HOH
 2.715
 OH
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 132.0 0.574 -121.4 82.3 10.0 0.043 0.531 B:O60229:0.53
 HOH
 2.717
 OH
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 131.0 0.57 -118.3 83.1 11.0 0.048 0.522 B:O60229:0.522
 HOH
 2.735
 OH
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 128.0 0.557 -115.3 82.4 11.0 0.048 0.509 B:O60229:0.509
 HOH
 2.989
 OH
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 125.0 0.543 -117.3 85.2 8.0 0.035 0.508 B:O60229:0.509
 HOH
 2.722
 OH
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 129.0 0.561 -120.5 84.7 10.0 0.043 0.518 B:O60229:0.517
 HOH
 2.603
 OH
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 TYR A:65 A:64 128.0 0.557 -115.8 85.2 9.0 0.039 0.518 B:O60229:0.517
 HOH
 2.838
 OH
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 TYR A:65 A:64 136.0 0.591 -118.9 87.7 14.0 0.061 0.53 B:O60229:0.53
 HOH
 2.891
 OH
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 TYR B:64 B:64 127.0 0.552 -113.1 82.7 25.0 0.109 0.443 A:Q60610:0.443
 HOH
 3.870
 CE2
 O
TYR D:64 D:64 127.0 0.552 -113.9 82.1 NA NA NA
TYR F:64 F:64 127.0 0.552 -113.0 83.2 NA NA NA
TYR H:64 H:64 130.0 0.565 -111.9 83.7 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 TYR A:64 A:64 128.0 0.557 -125.8 86.0 14.0 0.061 0.496 B:O75962:0.496
 HOH
 2.606
 OH
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 TYR C:64 C:64 120.0 0.522 -121.1 86.6 NA NA NA
TYR D:64 D:64 132.0 0.574 -120.6 98.2 18.0 0.078 0.496 A:P15498:0.496
 HOH
 2.632
 OH
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 TYR A:64 A:64 130.0 0.565 -123.2 88.2 13.0 0.057 0.508 B:P97924:0.509
 HOH
 2.874
 OH
 O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 TYR B:71 B:64 102.0 0.443 G -95.0 5.5 54.0 0.235 0.208 A:Q92608:0.209
TYR D:71 D:64 122.0 0.53 G -94.0 2.2 57.0 0.248 0.282 C:Q92608:0.283
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 TYR B:71 B:64 114.0 0.496 G -75.9 13.7 88.0 0.383 0.113 A:Q9H7D0:0.113
TYR E:71 E:64 112.0 0.487 G -75.9 13.7 91.0 0.396 0.091 D:Q9H7D0:0.091
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 TYR A:66 NA:NA DO NA DO DO DO NA NA NA
TYR B:66 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 TYR A:66 NA:NA DO NA DO DO DO NA NA NA
TYR B:66 NA:NA DO NA DO DO DO NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 TYR A:91 A:64 60.0 0.261 G -92.1 18.4 60.0 0.261 0.0 GNP
MG
HOH
 7.545
9.721
5.167
 CE1
CE1
CB
 O3G
MG
O
TYR B:91 B:64 57.0 0.248 G -91.9 12.0 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 TYR A:64 A:64 74.0 0.322 G -108.5 26.7 74.0 0.322 0.0 GSP
MG
HOH
 7.128
9.729
2.679
 HE2
HD2
HA
 S1G
MG
O
TYR C:64 B:64 72.0 0.313 G -107.4 28.3 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 TYR A:63 A:64 79.0 0.343 G -100.5 12.4 79.0 0.343 0.0 GDP
MG
HOH
 8.865
8.875
5.462
 CE2
CE2
CB
 O3B
MG
O
TYR B:63 B:64 83.0 0.361 G -110.3 20.6 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 TYR B:66 B:64 131.0 0.57 -120.5 87.9 17.0 0.074 0.496 A:Q8TCU6:0.496
 HOH
 2.720
 OH
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 TYR C:67 C:64 91.0 0.396 T -109.0 23.5 68.0 0.296 0.1 A:P70206:0.1
 MG
GNP
 9.083
7.240
 CD2
CD2
 MG
O3G
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 TYR A:91 A:64 77.0 0.335 G -99.1 21.7 77.0 0.335 0.0 GSP
MG
 7.732
9.864
 CE1
CE1
 S1G
MG
TYR B:91 B:64 78.0 0.339 G -99.4 21.3 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 TYR A:74 A:64 56.0 0.243 G -98.6 8.5 56.0 0.243 0.0 GNP
MG
HOH
 7.601
9.708
3.570
 CD1
CE1
CE1
 O3G
MG
O
TYR B:74 B:64 60.0 0.261 G -98.9 6.4 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 TYR A:74 A:64 65.0 0.283 G -97.1 9.3 65.0 0.283 0.0 GNP
MG
HOH
 7.323
9.397
4.983
 CE1
CE1
CB
 O3G
MG
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 TYR A:64 A:64 107.0 0.465 G -96.2 19.8 107.0 0.465 0.0 GDP
MG
 9.973
9.467
 HD1
HD1
 O3B
MG
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 TYR C:64 C:64 96.0 0.417 G -110.5 22.2 4.0 0.017 0.4 A:Q51451:0.4
 GDP
AF3
HOH
 9.796
7.600
2.721
 CD2
CD2
OH
 O3B
F2
O
TYR D:64 D:64 99.0 0.43 G -105.5 21.9 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 TYR A:91 A:64 71.0 0.309 G -110.5 10.2 71.0 0.309 0.0 GNP
MG
HOH
 7.309
9.592
3.628
 CE2
CE2
C
 O3G
MG
O
TYR B:91 B:64 72.0 0.313 G -102.1 6.1 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 TYR A:67 BBB:64 70.0 0.304 G -112.8 36.4 70.0 0.304 0.0 MG
GNP
HOH
 9.138
6.912
3.918
 CE2
CD2
CE2
 MG
O1G
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 TYR A:216 A:607 78.0 0.339 G -105.0 9.3 78.0 0.339 0.0 GTP
MG
HOH
 7.519
9.788
3.108
 CE2
CE2
C
 O2G
MG
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 TYR A:216 A:607 74.0 0.322 G -99.6 11.6 74.0 0.322 0.0 HOH
 3.543
 C
 O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 TYR A:216 A:607 86.0 0.374 G -99.6 12.4 86.0 0.374 0.0 HOH
 3.434
 C
 O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 TYR B:64 A:64 133.0 0.578 T -111.8 17.8 114.0 0.496 0.082 A:Q96BY6:0.083
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 TYR A:65 A:64 84.0 0.365 G -103.7 14.1 84.0 0.365 0.0 MG
CL
HOH
 9.756
7.111
3.108
 CE1
CD1
OH
 MG
CL
O
TYR B:65 B:64 86.0 0.374 G -105.2 15.1 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 TYR A:65 A:64 87.0 0.378 G -103.8 22.7 24.0 0.104 0.274 I:O96013:0.274
 MG
GCP
HOH
 9.822
7.431
2.517
 CD1
CD1
OH
 MG
O3G
O
TYR B:65 F:64 75.0 0.326 G -100.7 21.6 NA NA NA
TYR C:65 B:64 75.0 0.326 G -102.1 21.1 NA NA NA
TYR D:65 C:64 93.0 0.404 G -103.7 28.0 NA NA NA
TYR E:65 G:64 73.0 0.317 G -98.6 18.0 NA NA NA
TYR F:65 D:64 76.0 0.33 G -103.1 20.8 NA NA NA
TYR G:65 E:64 70.0 0.304 G -102.3 26.3 NA NA NA
TYR H:65 H:64 72.0 0.313 G -101.2 20.3 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 TYR A:65 A:64 68.0 0.296 G -101.3 16.5 26.0 0.113 0.183 B:Q13153:0.183
 MG
GCP
HOH
 9.664
7.442
2.458
 CD1
CD1
OH
 MG
O3G
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 TYR A:65 A:64 86.0 0.374 G -102.2 15.2 86.0 0.374 0.0 MG
GNP
HOH
 9.659
7.570
3.087
 CE1
CD1
OH
 MG
O2G
O
TYR B:65 B:64 86.0 0.374 G -102.1 12.4 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 TYR A:64 A:64 106.0 0.461 G -99.9 9.9 106.0 0.461 0.0 MG
HOH
 9.789
3.290
 CE1
C
 MG
O
TYR B:64 B:64 114.0 0.496 G -105.8 13.7 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 TYR A:70 A:64 99.0 0.43 G -106.3 14.9 99.0 0.43 0.0 HOH
 5.262
 N
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 TYR A:70 A:64 87.0 0.378 G -94.0 24.5 58.0 0.252 0.126 D:P16885:0.126
 GSP
MG
HOH
 8.024
9.692
4.847
 CD1
CD1
CD1
 S1G
MG
O
TYR B:70 B:64 85.0 0.37 G -90.6 21.3 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 TYR A:71 A:64 89.0 0.387 G -113.8 20.8 89.0 0.387 0.0 HOH
 5.257
 N
 O
TYR B:71 B:64 91.0 0.396 G -107.6 21.8 NA NA NA
TYR C:71 C:64 87.0 0.378 G -107.0 17.0 NA NA NA
TYR D:71 D:64 90.0 0.391 G -117.8 21.2 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 TYR A:216 A:213 74.0 0.322 G -103.5 19.0 74.0 0.322 0.0 GTP
MG
CA
HOH
 6.917
9.007
7.771
7.539
 CE2
CE2
N
O
 O2G
MG
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 TYR A:64 A:64 62.0 0.27 G -101.6 9.1
af-p15153-f1 1 P15153 92.19 1e-133 TYR A:64 A:64 62.0 0.27 G -102.2 9.8
af-p60763-f1 1 P60763 95.51 1e-128 TYR A:64 A:64 63.0 0.274 G -101.8 9.2