Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6431649 . C A CCDS5348.1:NM_006908.4:c.202Cgc>Agc_NP_008839.2:p.68R>S Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ARG C:68 D:68 10.0 0.044 G -57.8 -42.5 0.0 0.0 0.044 A:P53365:0.044
 HOH
 3.683
 CA
 O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ARG C:68 D:68 8.0 0.036 S -86.3 -53.4 1.0 0.004 0.032 A:P53365:0.031
 HOH
 3.926
 CG
 O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 ARG C:68 C:68 10.0 0.044 T -66.4 -53.6 10.0 0.044 0.0
ARG F:68 F:68 11.0 0.049 T -66.4 -53.6 11.0 0.049 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 ARG B:71 B:68 16.0 0.071 G -45.6 -51.5 16.0 0.071 0.0
ARG D:71 D:68 19.0 0.084 G -45.2 -52.0 NA NA NA
ARG F:71 F:68 15.0 0.067 G -45.0 -52.6 NA NA NA
ARG H:71 H:68 18.0 0.08 G -45.5 -51.9 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 ARG C:68 D:68 8.0 0.036 S -93.7 -49.6 1.0 0.004 0.032 A:P53365:0.031
 MG
GNP
HOH
 9.816
7.030
3.389
 NE
NH2
CG
 MG
O1G
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 ARG A:68 A:68 5.0 0.022 G -55.7 -49.1 5.0 0.022 0.0 GTP
HOH
 7.680
3.553
 NE
NE
 O1G
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 ARG A:68 A:68 6.0 0.027 G -50.9 -50.0 0.0 0.0 0.027 C:P52565:0.027
 MG
HOH
 9.895
2.358
 NE
O
 MG
O
ARG B:68 B:68 10.0 0.044 G -44.4 -54.7 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 ARG A:68 A:68 30.0 0.133 G -32.8 -55.2 30.0 0.133 0.0 HOH
 2.637
 O
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 ARG B:68 R:68 9.0 0.04 G -51.7 -42.0 9.0 0.04 0.0 AF3
HOH
 7.264
3.548
 NE
NE
 F2
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 ARG A:72 A:68 13.0 0.058 G -52.2 -48.4 8.0 0.036 0.022 C:Q05608:0.022
 HOH
 8.137
 NH2
 O
ARG B:72 B:68 12.0 0.053 G -51.2 -56.1 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 ARG A:72 A:68 82.0 0.364 49.2 50.9 82.0 0.364 0.0 ZN
HOH
 7.382
2.863
 NE
NH1
 ZN
O
ARG B:72 B:68 84.0 0.373 45.5 53.2 84.0 0.373 0.0 ZN
HOH
 7.276
2.979
 NH2
NH1
 ZN
O
ARG C:72 C:68 82.0 0.364 43.4 55.3 82.0 0.364 0.0 ZN
HOH
 7.416
3.225
 NE
NH2
 ZN
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 ARG A:70 A:68 0.0 0.0 G -52.7 -42.8 0.0 0.0 0.0 GNP
HOH
 7.382
3.481
 NH2
O
 O1G
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 ARG A:68 A:68 12.0 0.053 G -50.1 -44.4 0.0 0.0 0.053 B:P52566:0.053
 HOH
 3.591
 CD
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 ARG C:87 C:68 9.0 0.04 G -65.1 -48.7 NA NA NA
ARG D:87 D:68 10.0 0.044 G -60.0 -41.8 10.0 0.044 0.0 HOH
 8.014
 N
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 ARG A:68 A:68 5.0 0.022 G -50.3 -46.5 5.0 0.022 0.0 GNP
 7.830
 NH2
 O1G
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 ARG A:68 A:68 3.0 0.013 G -43.4 -41.6 3.0 0.013 0.0 MG
GNP
 9.480
7.570
 NE
NH2
 MG
O1G
ARG B:68 B:68 3.0 0.013 G -42.8 -42.3 NA NA NA
ARG C:68 C:68 3.0 0.013 G -43.0 -42.4 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 ARG C:68 B:68 0.0 0.0 G -49.6 -42.1 0.0 0.0 0.0 HOH
 3.174
 O
 O
ARG D:68 D:68 0.0 0.0 G -56.4 -38.4 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 ARG A:68 A:68 10.0 0.044 G -45.6 -53.6 10.0 0.044 0.0 GSP
HOH
 7.512
2.789
 NH2
O
 O3G
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 12.0 0.053 G -55.6 -40.4 12.0 0.053 0.0 HOH
 2.786
 O
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 11.0 0.049 G -61.0 -45.5 11.0 0.049 0.0 HOH
 2.666
 O
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 10.0 0.044 G -54.9 -42.0 10.0 0.044 0.0 HOH
 2.677
 O
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 9.0 0.04 G -60.1 -41.7 9.0 0.04 0.0 HOH
 2.917
 O
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 12.0 0.053 G -55.8 -41.2 12.0 0.053 0.0 HOH
 2.493
 NH1
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 11.0 0.049 G -48.8 -46.1 11.0 0.049 0.0 HOH
 2.774
 O
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 11.0 0.049 G -52.6 -46.9 11.0 0.049 0.0 HOH
 2.673
 NH1
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 9.0 0.04 G -59.4 -42.9 9.0 0.04 0.0 HOH
 2.793
 NH1
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 10.0 0.044 G -55.4 -41.2 10.0 0.044 0.0 HOH
 2.706
 NH1
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 11.0 0.049 G -54.0 -44.1 11.0 0.049 0.0 HOH
 2.598
 NH1
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:69 A:68 10.0 0.044 G -60.0 -45.2 10.0 0.044 0.0 HOH
 2.830
 O
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 ARG A:69 A:68 13.0 0.058 G -53.0 -43.0 13.0 0.058 0.0 HOH
 2.796
 O
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 ARG B:68 B:68 18.0 0.08 G -45.4 -50.8 18.0 0.08 0.0 HOH
 8.000
 NH2
 O
ARG D:68 D:68 19.0 0.084 G -46.3 -49.9 NA NA NA
ARG F:68 F:68 18.0 0.08 G -45.5 -52.1 NA NA NA
ARG H:68 H:68 19.0 0.084 G -46.5 -49.8 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 ARG A:68 A:68 10.0 0.044 G -51.3 -48.7 10.0 0.044 0.0 HOH
 2.040
 NH2
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 ARG C:68 C:68 21.0 0.093 G -32.5 -60.6 NA NA NA
ARG D:68 D:68 25.0 0.111 G -64.6 -36.9 25.0 0.111 0.0 HOH
 9.574
 NH1
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 ARG A:68 A:68 11.0 0.049 G -56.4 -45.5 11.0 0.049 0.0 HOH
 2.536
 NH1
 O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 ARG B:75 B:68 11.0 0.049 G -50.7 -53.4 11.0 0.049 0.0
ARG D:75 D:68 8.0 0.036 G -65.3 -45.1 8.0 0.036 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 ARG B:75 B:68 30.0 0.133 S -76.5 -37.4 30.0 0.133 0.0
ARG E:75 E:68 30.0 0.133 S -76.5 -37.4 30.0 0.133 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ARG A:70 NA:NA DO NA DO DO DO NA NA NA
ARG B:70 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ARG A:70 NA:NA DO NA DO DO DO NA NA NA
ARG B:70 NA:NA DO NA DO DO DO NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 ARG A:95 A:68 8.0 0.036 G -66.8 -44.4 8.0 0.036 0.0 GNP
HOH
 7.854
4.764
 NH2
CA
 O1G
O
ARG B:95 B:68 8.0 0.036 G -69.2 -43.0 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 ARG A:68 A:68 5.0 0.022 G -50.0 -48.2 5.0 0.022 0.0 GSP
MG
HOH
 6.594
9.378
2.647
 HE
HE
HE
 HOG3
MG
O
ARG C:68 B:68 5.0 0.022 G -59.8 -43.6 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 ARG A:67 A:68 7.0 0.031 G -56.0 -48.2 7.0 0.031 0.0 HOH
 2.476
 O
 O
ARG B:67 B:68 8.0 0.036 G -56.1 -46.0 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 ARG B:70 B:68 12.0 0.053 G -57.0 -42.3 12.0 0.053 0.0 HOH
 2.858
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 ARG C:71 C:68 16.0 0.071 G -47.4 -49.8 16.0 0.071 0.0 MG
GNP
 8.863
7.504
 NE
NH2
 MG
O1G
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 ARG A:95 A:68 9.0 0.04 S -68.9 -47.3 9.0 0.04 0.0 GSP
MG
 8.094
9.989
 NH2
NE
 O2G
MG
ARG B:95 B:68 9.0 0.04 S -68.0 -47.8 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ARG A:78 A:68 8.0 0.036 G -58.3 -40.2 8.0 0.036 0.0 GNP
HOH
 7.403
3.445
 NH2
NE
 O1G
O
ARG B:78 B:68 11.0 0.049 G -53.7 -46.3 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ARG A:78 A:68 11.0 0.049 G -62.1 -44.8 11.0 0.049 0.0 GNP
MG
HOH
 7.663
9.416
3.169
 NE
NE
CD
 O1G
MG
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 ARG A:68 A:68 11.0 0.049 G -58.2 -39.7 11.0 0.049 0.0 GDP
MG
 9.937
9.604
 HD3
HD3
 O3B
MG
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 ARG C:68 C:68 6.0 0.027 G -51.4 -45.4 6.0 0.027 0.0 AF3
HOH
 7.156
3.255
 NE
CB
 F2
O
ARG D:68 D:68 6.0 0.027 G -51.8 -44.1 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 ARG A:95 A:68 10.0 0.044 G -51.8 -45.2 10.0 0.044 0.0 GNP
HOH
 7.356
3.533
 NH2
NE
 O1G
O
ARG B:95 B:68 9.0 0.04 G -53.4 -43.9 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 ARG A:71 BBB:68 5.0 0.022 G -68.1 -49.2 5.0 0.022 0.0 MG
GNP
HOH
 9.886
7.064
7.359
 NH1
NH1
NH1
 MG
O1G
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ARG A:220 A:611 2.0 0.009 G -47.1 -47.0 2.0 0.009 0.0 GTP
HOH
 7.624
3.623
 NE
NE
 O3G
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ARG A:220 A:611 2.0 0.009 G -49.7 -43.0 2.0 0.009 0.0 GTP
HOH
 7.603
3.566
 NE
NE
 O3G
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 ARG A:220 A:611 2.0 0.009 G -46.1 -45.8 2.0 0.009 0.0 GTP
HOH
 7.570
3.509
 NE
NE
 O3G
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 ARG B:68 A:68 16.0 0.071 S -95.1 -55.2 16.0 0.071 0.0
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 ARG A:69 A:68 10.0 0.044 G -59.4 -44.5 10.0 0.044 0.0 CL
HOH
 7.516
3.259
 NH2
O
 CL
O
ARG B:69 B:68 8.0 0.036 G -56.9 -53.2 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 ARG A:69 A:68 5.0 0.022 G -49.9 -52.8 5.0 0.022 0.0 GCP
HOH
 7.564
3.009
 NE
O
 O2G
O
ARG B:69 F:68 5.0 0.022 G -57.0 -41.9 NA NA NA
ARG C:69 B:68 5.0 0.022 G -53.6 -50.9 NA NA NA
ARG D:69 C:68 6.0 0.027 G -57.6 -52.4 NA NA NA
ARG E:69 G:68 5.0 0.022 G -52.1 -51.0 NA NA NA
ARG F:69 D:68 4.0 0.018 G -58.0 -47.5 NA NA NA
ARG G:69 E:68 5.0 0.022 G -52.5 -50.5 NA NA NA
ARG H:69 H:68 6.0 0.027 G -58.9 -50.9 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 ARG A:69 A:68 5.0 0.022 G -50.4 -42.9 5.0 0.022 0.0 GCP
HOH
 7.659
2.751
 NE
O
 O2G
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 ARG A:69 A:68 9.0 0.04 G -56.5 -45.7 9.0 0.04 0.0 GNP
HOH
 7.778
3.299
 NH2
O
 O2G
O
ARG B:69 B:68 8.0 0.036 G -56.8 -49.8 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 ARG A:68 A:68 7.0 0.031 G -57.3 -47.7 7.0 0.031 0.0 GDP
GDP
CA
HOH
 8.077
9.291
9.012
3.685
 NH1
C
NH1
O
 O6
O4'
CA
O
ARG B:68 B:68 8.0 0.036 G -51.7 -48.8 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ARG A:74 A:68 13.0 0.058 G -53.1 -48.4 13.0 0.058 0.0 HOH
 3.569
 CB
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ARG A:74 A:68 4.0 0.018 G -45.1 -52.6 4.0 0.018 0.0 GSP
MG
HOH
 7.934
9.539
4.254
 NE
NE
CA
 O3G
MG
O
ARG B:74 B:68 5.0 0.022 G -45.6 -53.0 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 ARG A:75 A:68 12.0 0.053 G -48.6 -50.9 12.0 0.053 0.0 HOH
 3.393
 CG
 O
ARG B:75 B:68 10.0 0.044 G -46.7 -47.0 NA NA NA
ARG C:75 C:68 10.0 0.044 G -43.6 -45.8 NA NA NA
ARG D:75 D:68 11.0 0.049 G -45.6 -48.6 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 ARG A:220 A:217 9.0 0.04 G -64.1 -44.4 9.0 0.04 0.0 GTP
HOH
 7.894
3.659
 NE
NE
 O3G
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 ARG A:68 A:68 7.0 0.031 G -52.9 -45.3
af-p15153-f1 1 P15153 92.19 1e-133 ARG A:68 A:68 8.0 0.036 G -53.5 -44.2
af-p60763-f1 1 P60763 95.51 1e-128 ARG A:68 A:68 7.0 0.031 G -53.1 -45.3