Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6431659 . C A CCDS5348.1:NM_006908.4:c.212tCc>tAc_NP_008839.2:p.71S>Y Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 SER C:71 D:71 15.0 0.13 G -94.9 -13.7 0.0 0.0 0.13 A:P53365:0.13
 HOH
 3.475
 O
 O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 SER C:71 D:71 13.0 0.113 G -102.4 -8.6 0.0 0.0 0.113 A:P53365:0.113
 HOH
 5.996
 OG
 O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 SER C:71 C:71 5.0 0.043 T -120.1 -6.7 5.0 0.043 0.0
SER F:71 F:71 5.0 0.043 T -120.1 -6.6 5.0 0.043 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 SER B:74 B:71 20.0 0.174 G -86.9 -13.1 1.0 0.009 0.165 A:Q8TCU6:0.165
SER D:74 D:71 24.0 0.209 G -84.9 -12.5 NA NA NA
SER F:74 F:71 17.0 0.148 G -85.8 -12.4 NA NA NA
SER H:74 H:71 24.0 0.209 G -85.5 -12.9 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 SER C:71 D:71 16.0 0.139 G -93.8 -12.3 0.0 0.0 0.139 A:P53365:0.139
 HOH
 3.327
 CA
 O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 SER A:71 A:71 9.0 0.078 G -90.4 -13.4 9.0 0.078 0.0 HOH
 8.234
 OG
 O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 SER A:71 A:71 19.0 0.165 G -94.8 -13.1 2.0 0.017 0.148 C:P52565:0.148
 HOH
 3.015
 OG
 O
SER B:71 B:71 23.0 0.2 G -96.4 -14.7 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 SER A:71 A:71 10.0 0.087 G -72.5 -18.0 0.0 0.0 0.087 B:P27870:0.087
 HOH
 2.645
 OG
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 SER B:71 R:71 17.0 0.148 G -91.3 -20.8 17.0 0.148 0.0 HOH
 3.065
 O
 O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 SER A:75 A:71 9.0 0.078 G -86.8 -17.7 0.0 0.0 0.078 C:Q05608:0.078
 HOH
 7.574
 CB
 O
SER B:75 B:71 8.0 0.07 G -79.8 -15.2 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 SER A:75 A:71 27.0 0.235 T -96.8 -30.7 27.0 0.235 0.0 ZN
HOH
 7.307
2.527
 OG
O
 ZN
O
SER B:75 B:71 25.0 0.217 T -94.1 -33.1 25.0 0.217 0.0 ZN
HOH
 7.265
2.497
 OG
O
 ZN
O
SER C:75 C:71 26.0 0.226 T -98.4 -30.2 26.0 0.226 0.0 ZN
HOH
 7.401
2.650
 OG
O
 ZN
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 SER A:73 A:71 7.0 0.061 G -84.4 -15.7 7.0 0.061 0.0 HOH
 2.746
 OG
 O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 SER A:71 A:71 21.0 0.183 G -92.1 -7.7 2.0 0.017 0.166 B:P52566:0.165
 HOH
 4.698
 N
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 SER C:90 C:71 33.0 0.287 G -98.0 14.9 NA NA NA
SER D:90 D:71 32.0 0.278 G -90.5 1.1 11.0 0.096 0.182 B:Q92608:0.183
 HOH
 4.722
 N
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 SER A:71 A:71 12.0 0.104 S -83.3 -24.9 3.0 0.026 0.078 B:O43157:0.078
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 SER A:71 A:71 6.0 0.052 G -72.6 -30.5 1.0 0.009 0.043 D:O43157:0.043
SER B:71 B:71 5.0 0.043 G -72.5 -30.4 NA NA NA
SER C:71 C:71 5.0 0.043 G -73.1 -30.8 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 SER C:71 B:71 31.0 0.27 G -83.5 -13.3 2.0 0.017 0.253 A:B3CVM3:0.252
 HOH
 2.705
 OG
 O
SER D:71 D:71 31.0 0.27 G -81.1 -17.9 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 SER A:71 A:71 26.0 0.226 G -92.4 -9.5 5.0 0.043 0.183 B:Q00722:0.183
 HOH
 2.642
 OG
 O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -85.7 -14.3 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.550
 OG
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 19.0 0.165 G -82.3 -15.8 0.0 0.0 0.165 B:O60229:0.165
 HOH
 2.653
 OG
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 17.0 0.148 G -78.3 -11.7 0.0 0.0 0.148 B:O60229:0.148
 HOH
 2.578
 OG
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -77.6 -14.0 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.679
 OG
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 17.0 0.148 G -80.2 -14.2 0.0 0.0 0.148 B:O60229:0.148
 HOH
 2.732
 OG
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 17.0 0.148 G -84.4 -12.0 0.0 0.0 0.148 B:O60229:0.148
 HOH
 2.645
 OG
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -82.3 -14.0 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.737
 OG
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -77.4 -13.1 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.625
 OG
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -77.0 -10.3 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.562
 OG
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 18.0 0.157 G -83.2 -11.4 0.0 0.0 0.157 B:O60229:0.157
 HOH
 2.744
 OG
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 SER A:72 A:71 19.0 0.165 G -82.7 -12.9 0.0 0.0 0.165 B:O60229:0.165
 HOH
 2.707
 OG
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 SER A:72 A:71 21.0 0.183 G -84.1 -9.6 0.0 0.0 0.183 B:O60229:0.183
 HOH
 2.745
 OG
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 SER B:71 B:71 23.0 0.2 S -91.3 -16.1 0.0 0.0 0.2 A:Q60610:0.2
 HOH
 6.465
 CA
 O
SER D:71 D:71 24.0 0.209 S -92.0 -17.1 NA NA NA
SER F:71 F:71 25.0 0.217 S -94.5 -16.3 NA NA NA
SER H:71 H:71 24.0 0.209 S -93.0 -16.1 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 SER A:71 A:71 19.0 0.165 G -85.3 -13.0 0.0 0.0 0.165 B:O75962:0.165
 HOH
 2.660
 OG
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 SER C:71 C:71 13.0 0.113 G -71.8 -12.9 NA NA NA
SER D:71 D:71 11.0 0.096 G -83.6 -17.2 0.0 0.0 0.096 A:P15498:0.096
 HOH
 6.263
 O
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 SER A:71 A:71 18.0 0.157 G -84.5 -11.5 0.0 0.0 0.157 B:P97924:0.157
 EDO
HOH
 9.280
2.833
 OG
OG
 H21
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 SER B:78 B:71 36.0 0.313 G -85.8 -15.5 16.0 0.139 0.174 A:Q92608:0.174
SER D:78 D:71 35.0 0.304 G -70.0 -25.2 14.0 0.122 0.182 C:Q92608:0.183
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 SER B:78 B:71 63.0 0.548 T -74.1 -42.2 48.0 0.417 0.131 A:Q9H7D0:0.13
SER E:78 E:71 64.0 0.557 T -74.1 -42.2 50.0 0.435 0.122 D:Q9H7D0:0.122
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 SER A:73 NA:NA DO NA DO DO DO NA NA NA
SER B:73 NA:NA DO NA DO DO DO NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 SER A:73 NA:NA DO NA DO DO DO NA NA NA
SER B:73 NA:NA DO NA DO DO DO NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 SER A:98 A:71 11.0 0.096 G -83.3 -9.0 11.0 0.096 0.0 HOH
 4.832
 OG
 O
SER B:98 B:71 11.0 0.096 G -79.7 -11.4 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 SER A:71 A:71 3.0 0.026 G -97.6 0.0 3.0 0.026 0.0 HOH
 7.760
 HG
 O
SER C:71 B:71 3.0 0.026 G -100.6 3.1 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 SER A:70 A:71 37.0 0.322 G -86.5 -13.2 37.0 0.322 0.0 HOH
 2.120
 OG
 O
SER B:70 B:71 29.0 0.252 G -87.9 -11.7 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 SER B:73 B:71 20.0 0.174 G -85.2 -15.4 0.0 0.0 0.174 A:Q8TCU6:0.174
 HOH
 2.643
 OG
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 SER C:74 C:71 14.0 0.122 G -112.0 -12.1 9.0 0.078 0.044 A:P70206:0.043
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 SER A:98 A:71 13.0 0.113 G -74.6 -21.2 13.0 0.113 0.0
SER B:98 B:71 14.0 0.122 G -75.2 -20.5 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 SER A:81 A:71 14.0 0.122 G -73.1 -15.0 14.0 0.122 0.0 HOH
 4.805
 OG
 O
SER B:81 B:71 15.0 0.13 G -84.1 -6.8 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 SER A:81 A:71 11.0 0.096 G -69.8 -18.4 11.0 0.096 0.0 HOH
 5.334
 OG
 O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 SER A:71 A:71 21.0 0.183 G -92.0 -8.1 21.0 0.183 0.0
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 SER C:71 C:71 1.0 0.009 G -88.8 -10.2 1.0 0.009 0.0 HOH
 2.588
 OG
 O
SER D:71 D:71 2.0 0.017 G -91.6 -12.1 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 SER A:98 A:71 17.0 0.148 G -74.6 -17.3 17.0 0.148 0.0 HOH
 6.247
 O
 O
SER B:98 B:71 17.0 0.148 G -68.7 -22.5 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 SER A:74 BBB:71 7.0 0.061 S -99.2 0.7 7.0 0.061 0.0
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 SER A:223 A:614 0.0 0.0 G -83.6 -13.1 0.0 0.0 0.0 HOH
 3.380
 CA
 O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 SER A:223 A:614 0.0 0.0 G -85.5 -9.1 0.0 0.0 0.0 HOH
 3.481
 CA
 O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 SER A:223 A:614 0.0 0.0 G -81.3 -10.1 0.0 0.0 0.0 HOH
 3.394
 CA
 O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 SER B:71 A:71 43.0 0.374 G -89.5 -15.6 10.0 0.087 0.287 A:Q96BY6:0.287
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 SER A:72 A:71 38.0 0.33 G -88.0 -8.6 38.0 0.33 0.0 HOH
 2.692
 OG
 O
SER B:72 B:71 37.0 0.322 G -97.0 -4.4 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 SER A:72 A:71 7.0 0.061 G -79.0 -14.7 1.0 0.009 0.052 I:O96013:0.052
 HOH
 4.854
 N
 O
SER B:72 F:71 6.0 0.052 G -79.6 -14.4 NA NA NA
SER C:72 B:71 7.0 0.061 G -79.8 -12.1 NA NA NA
SER D:72 C:71 7.0 0.061 G -77.8 -14.6 NA NA NA
SER E:72 G:71 7.0 0.061 G -83.1 -14.7 NA NA NA
SER F:72 D:71 7.0 0.061 G -79.2 -10.4 NA NA NA
SER G:72 E:71 6.0 0.052 G -80.5 -20.2 NA NA NA
SER H:72 H:71 6.0 0.052 G -76.7 -16.9 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 SER A:72 A:71 1.0 0.009 G -74.0 -16.4 1.0 0.009 0.0 HOH
 2.530
 OG
 O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 SER A:72 A:71 36.0 0.313 G -84.7 -8.5 36.0 0.313 0.0 HOH
 2.764
 OG
 O
SER B:72 B:71 38.0 0.33 G -90.4 -5.5 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 SER A:71 A:71 40.0 0.348 G -84.2 -11.0 40.0 0.348 0.0 GDP
HOH
 8.927
3.434
 N
O
 C4'
O
SER B:71 B:71 42.0 0.365 G -88.3 -12.8 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 SER A:77 A:71 26.0 0.226 G -90.5 9.8 26.0 0.226 0.0 HOH
 2.939
 OG
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 SER A:77 A:71 9.0 0.078 G -72.1 -16.1 2.0 0.017 0.061 D:P16885:0.061
 HOH
 5.185
 OG
 O
SER B:77 B:71 9.0 0.078 G -77.6 -17.9 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 SER A:78 A:71 36.0 0.313 G -89.4 -17.5 36.0 0.313 0.0 HOH
 3.310
 O
 O
SER B:78 B:71 47.0 0.409 G -83.7 -7.0 NA NA NA
SER C:78 C:71 34.0 0.296 G -82.7 -13.9 NA NA NA
SER D:78 D:71 42.0 0.365 G -86.6 -17.1 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 SER A:223 A:220 10.0 0.087 G -106.9 7.6 10.0 0.087 0.0 HOH
 8.440
 OG
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 SER A:71 A:71 14.0 0.122 G -82.2 -13.7
af-p15153-f1 1 P15153 92.19 1e-133 SER A:71 A:71 16.0 0.139 G -82.3 -11.5
af-p60763-f1 1 P60763 95.51 1e-128 SER A:71 A:71 15.0 0.13 G -82.5 -13.4