Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6439812 . G A CCDS5348.1:NM_006908.4:c.281cGt>cAt_NP_008839.2:p.94R>H Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ARG C:94 D:94 92.0 0.409 I -73.3 -33.5 92.0 0.409 0.0 HOH
 4.957
 NH1
 O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ARG C:94 D:94 84.0 0.373 I -108.6 -28.2 84.0 0.373 0.0 HOH
 9.079
 O
 O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 ARG C:94 C:94 46.0 0.204 I -66.2 -11.3 46.0 0.204 0.0
ARG F:94 F:94 44.0 0.196 I -66.2 -11.3 44.0 0.196 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 ARG B:97 B:94 98.0 0.436 I -76.0 -50.4 98.0 0.436 0.0
ARG D:97 D:94 99.0 0.44 I -78.6 -43.4 NA NA NA
ARG F:97 F:94 92.0 0.409 I -79.8 -39.7 NA NA NA
ARG H:97 H:94 87.0 0.387 I -80.4 -38.6 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 ARG C:94 D:94 73.0 0.324 I -98.0 -34.6 73.0 0.324 0.0
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 ARG A:94 A:94 96.0 0.427 I -66.5 -53.7 96.0 0.427 0.0 HOH
 4.687
 NH2
 O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 ARG A:94 A:94 94.0 0.418 I -82.3 -28.4 94.0 0.418 0.0 HOH
 9.665
 O
 O
ARG B:94 B:94 96.0 0.427 I -80.3 -33.6 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 ARG A:94 A:94 93.0 0.413 I -76.4 -34.5 93.0 0.413 0.0 HOH
 4.094
 NE
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 ARG B:94 R:94 88.0 0.391 I -92.2 -27.2 88.0 0.391 0.0 HOH
 3.665
 NH2
 O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 ARG A:98 A:94 91.0 0.404 I -68.2 -44.0 91.0 0.404 0.0 HOH
 7.340
 N
 O
ARG B:98 B:94 122.0 0.542 I -77.4 -43.1 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 ARG A:98 A:94 95.0 0.422 I -70.2 -46.1 95.0 0.422 0.0 HOH
 2.642
 O
 O
ARG B:98 B:94 96.0 0.427 I -75.9 -40.2 96.0 0.427 0.0 HOH
 2.629
 O
 O
ARG C:98 C:94 93.0 0.413 I -81.0 -39.6 93.0 0.413 0.0 HOH
 2.716
 O
 O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 ARG A:96 A:94 97.0 0.431 I -82.3 -32.7 97.0 0.431 0.0 HOH
 2.693
 O
 O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 ARG A:94 A:94 88.0 0.391 I -66.9 -46.6 88.0 0.391 0.0 HOH
 2.861
 O
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 ARG C:113 C:94 93.0 0.413 I -75.2 -42.8 NA NA NA
ARG D:113 D:94 94.0 0.418 I -74.5 -41.5 94.0 0.418 0.0 HOH
 8.952
 O
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 ARG A:94 A:94 95.0 0.422 I -70.2 -40.9 95.0 0.422 0.0
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 ARG A:94 A:94 89.0 0.396 I -74.8 -30.9 89.0 0.396 0.0
ARG B:94 B:94 90.0 0.4 I -75.2 -30.6 NA NA NA
ARG C:94 C:94 92.0 0.409 I -75.1 -30.9 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 ARG C:94 B:94 119.0 0.529 I -91.7 -25.9 119.0 0.529 0.0 HOH
 2.635
 O
 O
ARG D:94 D:94 122.0 0.542 I -93.4 -27.9 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 ARG A:94 A:94 92.0 0.409 I -82.7 -37.9 92.0 0.409 0.0 HOH
 2.721
 O
 O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 88.0 0.391 I -81.8 -40.8 88.0 0.391 0.0 HOH
 2.232
 O
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 97.0 0.431 I -81.7 -45.2 97.0 0.431 0.0 HOH
 2.587
 O
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 90.0 0.4 I -74.2 -44.0 90.0 0.4 0.0 HOH
 2.580
 O
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 90.0 0.4 I -76.5 -47.3 90.0 0.4 0.0 HOH
 3.008
 O
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 92.0 0.409 I -87.5 -40.4 92.0 0.409 0.0 HOH
 2.668
 O
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 90.0 0.4 I -80.9 -45.3 90.0 0.4 0.0 HOH
 2.615
 O
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 91.0 0.404 I -84.5 -43.4 91.0 0.404 0.0 HOH
 2.624
 O
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 93.0 0.413 I -70.7 -45.0 93.0 0.413 0.0 HOH
 2.680
 O
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 87.0 0.387 I -70.8 -45.3 87.0 0.387 0.0 HOH
 2.800
 O
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 90.0 0.4 I -81.1 -45.4 90.0 0.4 0.0 HOH
 2.661
 O
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ARG A:95 A:94 87.0 0.387 I -79.8 -43.9 87.0 0.387 0.0 HOH
 2.639
 O
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 ARG A:95 A:94 92.0 0.409 I -78.1 -36.1 92.0 0.409 0.0 HOH
 2.738
 O
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 ARG B:94 B:94 87.0 0.387 I -90.9 -26.1 87.0 0.387 0.0
ARG D:94 D:94 86.0 0.382 I -89.9 -28.3 NA NA NA
ARG F:94 F:94 86.0 0.382 I -88.5 -29.4 NA NA NA
ARG H:94 H:94 87.0 0.387 I -90.2 -24.6 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 ARG A:94 A:94 87.0 0.387 I -80.1 -31.6 87.0 0.387 0.0 HOH
 4.552
 NH2
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 ARG C:94 C:94 93.0 0.413 I -75.9 -42.2 NA NA NA
ARG D:94 D:94 146.0 0.649 I -73.3 -38.7 146.0 0.649 0.0
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 ARG A:94 A:94 90.0 0.4 I -81.2 -37.4 90.0 0.4 0.0 HOH
 2.678
 O
 O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 ARG B:101 B:94 96.0 0.427 I -74.9 -32.7 96.0 0.427 0.0
ARG D:101 D:94 95.0 0.422 I -71.2 -45.3 95.0 0.422 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 ARG B:101 B:94 110.0 0.489 I -71.1 -19.4 110.0 0.489 0.0
ARG E:101 E:94 110.0 0.489 I -71.1 -19.4 110.0 0.489 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ARG A:115 A:113 110.0 0.489 I -88.5 -31.0 110.0 0.489 0.0 HOH
 2.781
 O
 O
ARG B:115 B:113 112.0 0.498 I -91.7 -30.1 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ARG A:115 A:113 113.0 0.502 I -86.4 -29.9 113.0 0.502 0.0 HOH
 2.638
 O
 O
ARG B:115 B:113 113.0 0.502 I -89.0 -29.2 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 ARG A:121 A:94 120.0 0.533 I -86.7 -25.4 120.0 0.533 0.0 HOH
 6.762
 NH2
 O
ARG B:121 B:94 120.0 0.533 I -88.2 -24.4 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 ARG A:94 A:94 93.0 0.413 I -83.6 -24.4 93.0 0.413 0.0 HOH
 3.404
 HH21
 O
ARG C:94 B:94 94.0 0.418 I -88.7 -20.8 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 ARG A:93 A:94 122.0 0.542 I -77.4 -34.9 122.0 0.542 0.0 HOH
 7.902
 N
 O
ARG B:93 B:94 135.0 0.6 I -69.1 -42.5 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 ARG B:96 B:94 90.0 0.4 I -75.1 -41.6 90.0 0.4 0.0 HOH
 2.499
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 ARG C:97 C:94 129.0 0.573 I -87.6 -27.9 129.0 0.573 0.0
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 ARG A:121 A:94 112.0 0.498 I -68.0 -35.8 112.0 0.498 0.0
ARG B:121 B:94 111.0 0.493 I -69.4 -34.9 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ARG A:104 A:94 115.0 0.511 I -88.0 -31.5 115.0 0.511 0.0 HOH
 2.960
 NE
 O
ARG B:104 B:94 115.0 0.511 I -85.3 -34.9 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ARG A:104 A:94 133.0 0.591 I -87.6 -22.4 133.0 0.591 0.0 HOH
 3.255
 NH2
 O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 ARG A:94 A:94 92.0 0.409 I -64.8 -48.7 92.0 0.409 0.0
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 ARG C:94 C:94 91.0 0.404 I -77.0 -46.3 91.0 0.404 0.0 HOH
 2.632
 O
 O
ARG D:94 D:94 86.0 0.382 I -79.5 -34.5 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 ARG A:121 A:94 116.0 0.516 I -96.2 -28.0 116.0 0.516 0.0 HOH
 3.004
 O
 O
ARG B:121 B:94 114.0 0.507 I -94.4 -25.2 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 ARG A:97 BBB:94 37.0 NA I -76.0 -30.8 37.0 NA NA HOH
 7.763
 N
 O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ARG A:246 A:637 100.0 0.444 I -70.0 -43.1 100.0 0.444 0.0 HOH
 3.817
 CB
 O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ARG A:246 A:637 98.0 0.436 I -76.5 -39.4 98.0 0.436 0.0 HOH
 4.652
 O
 O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 ARG A:246 A:637 101.0 0.449 I -68.9 -41.2 101.0 0.449 0.0 HOH
 2.629
 O
 O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 ARG B:94 A:94 181.0 0.804 H -56.6 -35.8 181.0 0.804 0.0
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 ARG A:95 A:94 105.0 0.467 I -78.1 -42.3 105.0 0.467 0.0 HOH
 3.013
 NH1
 O
ARG B:95 B:94 91.0 0.404 I -81.3 -38.5 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 ARG A:95 A:94 107.0 0.476 I -68.3 -51.9 107.0 0.476 0.0 HOH
 2.876
 O
 O
ARG B:95 F:94 113.0 0.502 I -74.7 -43.9 NA NA NA
ARG C:95 B:94 126.0 0.56 I -86.1 -37.4 NA NA NA
ARG D:95 C:94 115.0 0.511 I -74.0 -44.6 NA NA NA
ARG E:95 G:94 113.0 0.502 I -77.0 -45.9 NA NA NA
ARG F:95 D:94 132.0 0.587 I -89.3 -37.7 NA NA NA
ARG G:95 E:94 109.0 0.484 I -72.4 -45.1 NA NA NA
ARG H:95 H:94 109.0 0.484 I -81.0 -44.3 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 ARG A:95 A:94 95.0 0.422 I -78.2 -45.3 95.0 0.422 0.0 HOH
 2.774
 O
 O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 ARG A:95 A:94 101.0 0.449 I -79.4 -37.4 101.0 0.449 0.0 HOH
 2.719
 O
 O
ARG B:95 B:94 91.0 0.404 I -77.9 -39.9 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 ARG A:94 A:94 114.0 0.507 I -73.0 -39.7 114.0 0.507 0.0 GDP
HOH
 8.751
2.676
 O
O
 N2
O
ARG B:94 B:94 109.0 0.484 I -71.6 -39.8 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ARG A:100 A:94 76.0 0.338 I -88.5 -35.4 76.0 0.338 0.0 HOH
 2.706
 O
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ARG A:100 A:94 159.0 0.707 I -78.7 -36.9 159.0 0.707 0.0 HOH
 7.635
 N
 O
ARG B:100 B:94 41.0 NA I -77.0 -36.5 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 ARG A:101 A:94 94.0 0.418 I -89.4 -25.7 94.0 0.418 0.0 HOH
 2.612
 O
 O
ARG B:101 B:94 86.0 0.382 I -85.8 -27.9 NA NA NA
ARG C:101 C:94 118.0 0.524 I -89.2 -24.6 NA NA NA
ARG D:101 D:94 78.0 0.347 I -83.9 -29.5 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 ARG A:246 A:243 105.0 0.467 I -81.6 -32.4 105.0 0.467 0.0 HOH
 2.965
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 ARG A:94 A:94 104.0 0.462 I -80.0 -40.8
af-p15153-f1 1 P15153 92.19 1e-133 ARG A:94 A:94 67.0 0.298 I -73.6 -38.1
af-p60763-f1 1 P60763 95.51 1e-128 ARG A:94 A:94 119.0 0.529 I -77.5 -36.3