Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6441604 . A C CCDS5348.1:NM_006908.4:c.394Aag>Cag_NP_008839.2:p.132K>Q Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 LYS C:132 D:132 133.0 0.665 T -88.1 20.0 133.0 0.665 0.0 HOH
 2.601
 NZ
 O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 LYS C:132 D:132 120.0 0.6 T -103.2 9.0 120.0 0.6 0.0 HOH
 5.816
 NZ
 O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 LYS C:132 C:132 61.0 0.305 T -87.5 -10.4 61.0 0.305 0.0
LYS F:132 F:132 60.0 0.3 T -87.5 -10.4 60.0 0.3 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 LYS B:135 B:132 153.0 0.765 T -103.2 32.4 153.0 0.765 0.0
LYS D:135 D:132 165.0 0.825 T -105.7 35.8 NA NA NA
LYS F:135 F:132 166.0 0.83 T -101.6 32.1 NA NA NA
LYS H:135 H:132 154.0 0.77 T -102.9 33.8 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 LYS C:132 D:132 120.0 0.6 T -104.7 2.2 120.0 0.6 0.0 HOH
 6.674
 N
 O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 LYS A:132 A:132 159.0 0.795 T -96.3 14.1 159.0 0.795 0.0 HOH
 6.884
 CG
 O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 LYS A:132 A:132 144.0 0.72 T -122.4 17.9 144.0 0.72 0.0 HOH
 6.625
 CD
 O
LYS B:132 B:132 137.0 0.685 G -104.3 12.9 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 LYS A:132 A:132 143.0 0.715 T -92.5 15.9 143.0 0.715 0.0 HOH
 6.562
 O
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 LYS B:132 R:132 145.0 0.725 T -71.6 16.7 85.0 0.425 0.3 A:P74873:0.3
 HOH
 3.436
 CG
 O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 LYS A:136 A:132 114.0 0.57 T -142.9 43.9 114.0 0.57 0.0
LYS B:136 B:132 160.0 0.8 T -108.1 30.1 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 LYS A:136 A:132 135.0 0.675 T -97.2 14.2 135.0 0.675 0.0 ZN
HOH
 7.792
2.613
 N
O
 ZN
O
LYS B:136 B:132 143.0 0.715 T -99.1 11.1 143.0 0.715 0.0 HOH
 3.781
 O
 O
LYS C:136 C:132 124.0 0.62 T -92.8 14.2 124.0 0.62 0.0 HOH
 2.778
 O
 O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 LYS A:134 A:132 83.0 NA T -105.6 11.7 83.0 NA NA HOH
 2.619
 O
 O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 LYS A:132 A:132 127.0 0.635 T -93.4 10.8 127.0 0.635 0.0 HOH
 2.643
 NZ
 O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 LYS C:151 C:132 136.0 0.68 T -106.0 4.9 NA NA NA
LYS D:151 D:132 153.0 0.765 T -89.5 6.2 153.0 0.765 0.0
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 LYS A:132 A:132 160.0 0.8 T -90.8 -0.4 160.0 0.8 0.0
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 LYS A:132 A:132 179.0 0.895 T -98.7 13.9 179.0 0.895 0.0
LYS B:132 B:132 170.0 0.85 T -98.9 14.4 NA NA NA
LYS C:132 C:132 180.0 0.9 T -98.9 14.2 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 LYS C:132 B:132 117.0 0.585 T -116.3 11.3 117.0 0.585 0.0
LYS D:132 D:132 105.0 0.525 T -117.2 9.8 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 LYS A:132 A:132 153.0 0.765 T -91.7 10.1 153.0 0.765 0.0 HOH
 7.115
 O
 O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 107.0 NA T -103.4 10.9 107.0 NA NA HOH
 3.004
 O
 O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 107.0 NA T -107.1 15.7 107.0 NA NA HOH
 3.198
 CG
 O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 99.0 NA T -94.0 17.8 99.0 NA NA HOH
 2.914
 O
 O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 108.0 NA T -101.4 24.6 108.0 NA NA HOH
 3.213
 O
 O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 106.0 NA T -110.4 11.7 106.0 NA NA HOH
 2.893
 O
 O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 103.0 NA T -106.5 17.3 103.0 NA NA HOH
 3.089
 O
 O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 107.0 NA T -106.2 7.9 107.0 NA NA HOH
 3.049
 O
 O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 105.0 NA T -97.7 12.7 105.0 NA NA HOH
 3.094
 O
 O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 111.0 NA T -92.3 17.5 111.0 NA NA HOH
 2.793
 O
 O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 106.0 NA T -95.5 9.3 106.0 NA NA HOH
 3.184
 O
 O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LYS A:133 A:132 111.0 NA T -99.6 11.9 111.0 NA NA HOH
 2.972
 O
 O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 LYS A:133 A:132 104.0 NA T -107.3 14.9 104.0 NA NA HOH
 3.384
 O
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 LYS B:132 B:132 107.0 0.535 T -110.0 23.2 107.0 0.535 0.0
LYS D:132 D:132 108.0 0.54 T -111.8 23.6 NA NA NA
LYS F:132 F:132 108.0 0.54 T -110.5 23.1 NA NA NA
LYS H:132 H:132 106.0 0.53 T -108.3 22.4 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 LYS A:132 A:132 137.0 0.685 T -104.5 15.1 137.0 0.685 0.0 HOH
 5.978
 CD
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 LYS C:132 C:132 67.0 NA T -81.6 -6.4 NA NA NA
LYS D:132 D:132 77.0 NA S -83.7 27.1 77.0 NA NA
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 LYS A:132 A:132 60.0 NA T -107.7 16.7 60.0 NA NA HOH
 5.577
 CB
 O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 LYS B:139 B:132 165.0 0.825 T -89.1 10.0 165.0 0.825 0.0
LYS D:139 D:132 167.0 0.835 T -94.3 10.0 167.0 0.835 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 LYS B:139 B:132 130.0 0.65 T -94.9 23.4 130.0 0.65 0.0
LYS E:139 E:132 130.0 0.65 T -94.8 23.4 130.0 0.65 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 LYS A:153 A:151 173.0 0.865 T -97.1 13.9 173.0 0.865 0.0 HOH
 6.581
 CE
 O
LYS B:153 B:151 167.0 0.835 T -107.5 23.2 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 LYS A:153 A:151 79.0 NA T -101.8 13.2 79.0 NA NA HOH
 6.508
 O
 O
LYS B:153 B:151 158.0 0.79 T -116.6 29.8 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 LYS A:159 A:132 140.0 0.7 T -109.8 11.0 140.0 0.7 0.0
LYS B:159 B:132 123.0 0.615 T -118.0 13.5 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 LYS A:132 A:132 141.0 0.705 T -80.7 5.1 141.0 0.705 0.0 HOH
 7.260
 HZ2
 O
LYS C:132 B:132 140.0 0.7 T -86.7 6.1 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 LYS A:131 A:132 157.0 0.785 T -90.1 15.6 157.0 0.785 0.0 HOH
 6.791
 CD
 O
LYS B:131 B:132 121.0 0.605 T -84.3 4.7 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 LYS B:134 B:132 129.0 0.645 T -105.9 14.0 129.0 0.645 0.0 HOH
 2.585
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 LYS C:135 C:132 153.0 0.765 T -77.0 5.3 153.0 0.765 0.0
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 LYS A:159 A:132 121.0 0.605 G -98.5 15.5 121.0 0.605 0.0
LYS B:159 B:132 121.0 0.605 G -98.5 15.3 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 LYS A:142 A:132 168.0 0.84 T -82.1 21.6 168.0 0.84 0.0 HOH
 6.738
 O
 O
LYS B:142 B:132 163.0 0.815 T -90.1 4.9 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 LYS A:142 A:132 142.0 0.71 T -92.7 33.1 142.0 0.71 0.0 HOH
 7.193
 CD
 O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 LYS A:132 A:132 126.0 0.63 T -95.5 9.4 126.0 0.63 0.0
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 LYS C:132 C:132 143.0 0.715 T -98.8 11.4 113.0 0.565 0.15 A:Q51451:0.15
 HOH
 3.429
 CD
 O
LYS D:132 D:132 145.0 0.725 T -108.2 8.3 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 LYS A:159 A:132 166.0 0.83 T -84.9 10.0 166.0 0.83 0.0 HOH
 3.973
 CG
 O
LYS B:159 B:132 136.0 0.68 T -102.1 15.7 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 LYS A:135 BBB:132 67.0 NA T -91.4 17.5 67.0 NA NA
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 LYS A:284 A:675 141.0 0.705 T -93.8 3.7 141.0 0.705 0.0 CL
HOH
 7.617
2.886
 NZ
NZ
 CL
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 LYS A:284 A:675 135.0 0.675 T -83.8 0.1 135.0 0.675 0.0 CL
HOH
 7.652
2.761
 NZ
NZ
 CL
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 LYS A:284 A:675 143.0 0.715 T -91.5 4.1 143.0 0.715 0.0 HOH
 2.834
 NZ
 O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 LYS B:132 A:132 99.0 NA H -103.7 -2.9 99.0 NA NA
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 LYS A:133 A:132 79.0 NA T -104.2 21.2 79.0 NA NA HOH
 2.546
 O
 O
LYS B:133 B:132 89.0 NA T -102.2 17.2 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 LYS A:133 A:132 91.0 NA T -98.4 17.8 91.0 NA NA HOH
 5.078
 O
 O
LYS B:133 F:132 88.0 NA T -98.1 15.0 NA NA NA
LYS C:133 B:132 83.0 NA T -100.8 15.2 NA NA NA
LYS D:133 C:132 88.0 NA T -104.6 26.5 NA NA NA
LYS E:133 G:132 88.0 NA T -91.1 16.5 NA NA NA
LYS F:133 D:132 85.0 NA T -94.7 16.1 NA NA NA
LYS G:133 E:132 88.0 NA T -86.0 9.3 NA NA NA
LYS H:133 H:132 77.0 NA T -87.0 11.0 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 LYS A:133 A:132 146.0 0.73 T -108.7 20.5 146.0 0.73 0.0 HOH
 2.827
 NZ
 O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 LYS A:133 A:132 83.0 NA T -106.6 21.5 83.0 NA NA HOH
 2.643
 O
 O
LYS B:133 B:132 87.0 NA T -102.1 20.0 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 LYS A:132 A:132 86.0 NA T -106.9 27.0 86.0 NA NA
LYS B:132 B:132 104.0 NA T -83.1 4.1 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 LYS A:138 A:132 115.0 0.575 T -118.3 13.2 115.0 0.575 0.0 HOH
 6.154
 CD
 O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 LYS A:138 A:132 62.0 NA T -106.3 19.9 62.0 NA NA
LYS B:138 B:132 63.0 NA T -105.2 19.7 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 LYS A:139 A:132 128.0 0.64 T -115.7 10.7 128.0 0.64 0.0 HOH
 2.764
 O
 O
LYS B:139 NA:NA DO NA DO DO DO NA NA NA
LYS C:139 NA:NA DO NA DO DO DO NA NA NA
LYS D:139 D:132 140.0 0.7 G -103.9 7.5 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 LYS A:284 A:281 152.0 0.76 T -108.7 15.2 152.0 0.76 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 LYS A:132 A:132 155.0 0.775 T -94.1 8.6
af-p15153-f1 1 P15153 92.19 1e-133 LYS A:132 A:132 154.0 0.77 T -92.9 8.8
af-p60763-f1 1 P60763 95.51 1e-128 LYS A:132 A:132 157.0 0.785 T -95.1 8.5