Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6441968 . G A CCDS5348.1:NM_006908.4:c.470tGc>tAc_NP_008839.2:p.157C>Y Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 CYS C:157 D:157 0.0 0.0 -160.6 174.2 0.0 0.0 0.0 GDP
HOH
 4.822
5.952
 O
C
 O6
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 CYS C:157 D:157 0.0 0.0 E -169.9 175.1 0.0 0.0 0.0 GDP
HOH
 5.575
7.153
 O
O
 O6
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 CYS C:157 C:157 14.0 0.104 -166.3 148.8 14.0 0.104 0.0
CYS F:157 F:157 15.0 0.111 -166.4 148.8 15.0 0.111 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 CYS B:160 B:157 0.0 0.0 -165.6 166.6 0.0 0.0 0.0
CYS D:160 D:157 0.0 0.0 -164.5 166.6 NA NA NA
CYS F:160 F:157 0.0 0.0 -163.8 165.3 NA NA NA
CYS H:160 H:157 0.0 0.0 -163.3 166.5 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 CYS C:157 D:157 1.0 0.007 E -160.3 168.3 1.0 0.007 0.0 GNP
HOH
 4.916
4.248
 O
CB
 O6
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 CYS A:157 A:157 0.0 0.0 -161.8 170.0 0.0 0.0 0.0 GTP
HOH
 5.128
2.929
 O
O
 O6
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 CYS A:157 A:157 2.0 0.015 -157.8 169.3 2.0 0.015 0.0 GDP
HOH
 5.090
4.247
 O
CB
 O6
O
CYS B:157 B:157 0.0 0.0 -156.5 171.9 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 CYS A:157 A:157 1.0 0.007 -152.7 167.3 1.0 0.007 0.0 HOH
 4.005
 O
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 CYS B:157 R:157 3.0 0.022 -158.8 175.4 3.0 0.022 0.0 GDP
HOH
 5.193
3.376
 O
O
 O6
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 CYS A:161 A:157 0.0 0.0 -163.6 167.6 0.0 0.0 0.0 GDP
 5.382
 O
 O6
CYS B:161 B:157 0.0 0.0 -175.8 159.1 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 CYS A:161 A:157 1.0 0.007 -151.4 164.1 1.0 0.007 0.0 GDP
HOH
 5.108
3.179
 O
O
 O6
O
CYS B:161 B:157 2.0 0.015 -153.4 161.6 2.0 0.015 0.0 GDP
HOH
 5.074
3.227
 O
O
 O6
O
CYS C:161 C:157 1.0 0.007 -151.0 165.0 1.0 0.007 0.0 GDP
HOH
 5.143
3.164
 O
O
 O6
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 CYS A:159 A:157 0.0 0.0 -157.1 166.6 0.0 0.0 0.0 GNP
HOH
 5.119
3.180
 O
O
 O6
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 CYS A:157 A:157 1.0 0.007 -149.2 173.0 1.0 0.007 0.0 GDP
HOH
 5.059
3.332
 O
O
 O6
O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 CYS C:176 C:157 0.0 0.0 -154.1 166.0 NA NA NA
CYS D:176 D:157 0.0 0.0 -145.0 172.0 0.0 0.0 0.0 HOH
 4.137
 O
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 CYS A:157 A:157 0.0 0.0 -145.6 162.0 0.0 0.0 0.0 GNP
 4.992
 O
 O6
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 CYS A:157 A:157 0.0 0.0 -166.0 176.0 0.0 0.0 0.0 GNP
 5.227
 O
 O6
CYS B:157 B:157 0.0 0.0 -166.4 177.0 NA NA NA
CYS C:157 C:157 0.0 0.0 -166.2 177.1 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 CYS C:157 B:157 0.0 0.0 -149.1 165.5 0.0 0.0 0.0 HOH
 3.990
 O
 O
CYS D:157 D:157 1.0 0.007 -149.9 164.3 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 CYS A:157 A:157 0.0 0.0 -160.7 172.7 0.0 0.0 0.0 GSP
HOH
 4.971
3.171
 O
O
 O6
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -152.1 163.2 0.0 0.0 0.0 JGA
HOH
 4.280
4.453
 O
CB
 N11
O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -144.8 162.2 0.0 0.0 0.0 N5S
HOH
 4.423
4.335
 O
CB
 N2
O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -156.3 165.2 0.0 0.0 0.0 N5V
HOH
 4.341
4.329
 O
CB
 N2
O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -146.8 159.0 0.0 0.0 0.0 N64
HOH
 4.515
4.527
 O
CB
 O1
O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -150.8 161.8 0.0 0.0 0.0 N67
HOH
 4.348
4.401
 O
CB
 O3
O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 1.0 0.007 -151.1 162.8 1.0 0.007 0.0 N6D
HOH
 4.677
4.263
 O
CB
 N2
O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -149.0 160.3 0.0 0.0 0.0 N6J
HOH
 4.432
4.395
 O
CB
 N6
O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -159.6 162.9 0.0 0.0 0.0 N6V
HOH
 4.266
4.389
 O
CB
 N4
O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -156.0 162.6 0.0 0.0 0.0 N71
HOH
 4.398
4.388
 O
N
 O3
O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -146.5 162.9 0.0 0.0 0.0 N74
HOH
 4.378
4.479
 O
CB
 N4
O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 CYS A:158 A:157 0.0 0.0 -153.7 157.1 0.0 0.0 0.0 N5D
HOH
 4.614
4.289
 O
CB
 C2
O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 CYS A:158 A:157 0.0 0.0 -157.8 167.9 0.0 0.0 0.0 HOH
 4.277
 O
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 CYS B:157 B:157 2.0 0.015 -151.1 -179.3 2.0 0.015 0.0 HOH
 7.476
 CB
 O
CYS D:157 D:157 1.0 0.007 -153.0 179.4 NA NA NA
CYS F:157 F:157 0.0 0.0 -151.1 -178.3 NA NA NA
CYS H:157 H:157 1.0 0.007 -150.4 -178.9 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 CYS A:157 A:157 0.0 0.0 -153.2 166.8 0.0 0.0 0.0 HOH
 4.051
 O
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 CYS C:157 C:157 2.0 0.015 -179.2 177.8 NA NA NA
CYS D:157 D:157 9.0 0.067 E -178.4 -178.1 9.0 0.067 0.0 HOH
 6.388
 N
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 CYS A:157 A:157 0.0 0.0 -155.4 169.7 0.0 0.0 0.0 GDP
HOH
 5.142
3.180
 O
O
 O6
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 CYS B:164 B:157 0.0 0.0 -159.6 177.1 0.0 0.0 0.0
CYS D:164 D:157 0.0 0.0 -177.1 164.7 0.0 0.0 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 CYS B:164 B:157 0.0 0.0 -123.8 -169.1 0.0 0.0 0.0
CYS E:164 E:157 1.0 0.007 -123.8 -169.0 1.0 0.007 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 CYS A:178 A:176 1.0 0.007 -154.2 160.7 1.0 0.007 0.0 GDP
HOH
 5.019
3.112
 O
O
 O6
O
CYS B:178 B:176 1.0 0.007 -150.9 163.6 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 CYS A:178 A:176 1.0 0.007 -153.7 160.6 1.0 0.007 0.0 GNP
HOH
 4.969
3.075
 O
O
 O6
O
CYS B:178 B:176 1.0 0.007 -152.4 164.6 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 CYS A:184 A:157 0.0 0.0 -152.6 161.2 0.0 0.0 0.0 GNP
HOH
 4.994
4.482
 O
CB
 O6
O
CYS B:184 B:157 1.0 0.007 -151.2 163.6 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 CYS A:157 A:157 1.0 0.007 -150.8 168.8 1.0 0.007 0.0 GSP
HOH
 5.278
5.634
 O
N
 O6
O
CYS C:157 B:157 0.0 0.0 -144.9 166.6 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 CYS A:156 A:157 0.0 0.0 -164.7 168.9 0.0 0.0 0.0 GDP
HOH
 4.758
4.775
 O
CB
 O6
O
CYS B:156 B:157 0.0 0.0 -142.1 169.4 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 CYS B:159 B:157 1.0 0.007 -155.3 166.5 1.0 0.007 0.0 HOH
 4.119
 O
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 CYS C:160 C:157 0.0 0.0 -150.6 178.6 0.0 0.0 0.0 GNP
 5.071
 O
 O6
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 CYS A:184 A:157 0.0 0.0 -155.4 146.8 0.0 0.0 0.0 GSP
 4.733
 O
 O6
CYS B:184 B:157 0.0 0.0 -156.2 146.2 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 CYS A:167 A:157 1.0 0.007 -154.9 164.1 1.0 0.007 0.0 GNP
HOH
 4.920
3.054
 O
O
 O6
O
CYS B:167 B:157 1.0 0.007 -154.3 161.7 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 CYS A:167 A:157 0.0 0.0 -148.2 174.9 0.0 0.0 0.0 GNP
HOH
 5.062
4.725
 O
CB
 O6
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 CYS A:157 A:157 1.0 0.007 -148.4 165.8 1.0 0.007 0.0 GDP
 5.009
 O
 O6
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 CYS C:157 C:157 1.0 0.007 -155.4 165.1 1.0 0.007 0.0 GDP
HOH
 4.898
3.033
 O
O
 O6
O
CYS D:157 D:157 1.0 0.007 -156.4 167.2 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 CYS A:184 A:157 1.0 0.007 -148.6 162.4 1.0 0.007 0.0 GNP
IPA
HOH
 5.147
6.498
3.270
 O
C
O
 O6
O2
O
CYS B:184 B:157 1.0 0.007 -147.6 166.0 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 CYS A:160 BBB:157 1.0 0.007 -150.4 170.2 1.0 0.007 0.0 GNP
HOH
 5.136
5.713
 O
C
 O6
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 CYS A:309 A:700 1.0 0.007 -162.5 167.0 1.0 0.007 0.0 GTP
CL
HOH
 5.237
6.176
3.229
 O
C
O
 O6
CL
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 CYS A:309 A:700 1.0 0.007 -153.9 168.1 1.0 0.007 0.0 GTP
CL
HOH
 5.169
6.162
3.153
 O
C
O
 O6
CL
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 CYS A:309 A:700 1.0 0.007 -156.1 163.8 1.0 0.007 0.0 GTP
HOH
 5.066
3.014
 O
O
 O6
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 CYS B:157 A:157 1.0 0.007 -113.6 159.6 1.0 0.007 0.0
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 CYS A:158 A:157 0.0 0.0 -158.9 167.7 0.0 0.0 0.0 GDP
HOH
 5.016
3.295
 O
O
 O6
O
CYS B:158 B:157 1.0 0.007 -153.1 165.2 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 CYS A:158 A:157 0.0 0.0 -156.0 166.8 0.0 0.0 0.0 CL
GCP
HOH
 5.691
5.063
3.413
 N
O
O
 CL
O6
O
CYS B:158 F:157 1.0 0.007 -151.2 173.4 NA NA NA
CYS C:158 B:157 0.0 0.0 -156.7 163.0 NA NA NA
CYS D:158 C:157 1.0 0.007 -153.4 168.3 NA NA NA
CYS E:158 G:157 0.0 0.0 -159.9 170.0 NA NA NA
CYS F:158 D:157 0.0 0.0 -149.4 159.3 NA NA NA
CYS G:158 E:157 1.0 0.007 -156.8 166.6 NA NA NA
CYS H:158 H:157 1.0 0.007 -148.5 164.4 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 CYS A:158 A:157 1.0 0.007 -157.0 164.4 1.0 0.007 0.0 GCP
GOL
HOH
 5.053
6.754
3.111
 O
CB
O
 O6
O3
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 CYS A:158 A:157 0.0 0.0 -153.6 165.8 0.0 0.0 0.0 GNP
HOH
 5.033
3.254
 O
O
 O6
O
CYS B:158 B:157 1.0 0.007 -155.7 164.9 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 CYS A:157 A:157 1.0 0.007 -154.4 169.6 1.0 0.007 0.0 GDP
GDP
HOH
 5.020
5.763
3.174
 O
N
O
 O6
O2'
O
CYS B:157 B:157 0.0 0.0 -156.5 171.1 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 CYS A:163 A:157 1.0 0.007 -150.8 167.7 1.0 0.007 0.0 GDP
HOH
 5.121
3.225
 O
O
 O6
O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 CYS A:163 A:157 1.0 0.007 -173.4 159.8 1.0 0.007 0.0 GSP
HOH
 4.951
4.178
 O
CB
 O6
O
CYS B:163 B:157 0.0 0.0 E -176.0 158.3 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 CYS A:164 A:157 1.0 0.007 -145.9 174.5 1.0 0.007 0.0 GTP
HOH
 5.437
2.843
 O
SG
 O6
O
CYS B:164 B:157 3.0 NA -124.2 155.7 NA NA NA
CYS C:164 C:157 1.0 0.007 -150.9 173.8 NA NA NA
CYS D:164 D:157 1.0 0.007 -160.7 169.0 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 CYS A:309 A:306 2.0 0.015 -152.3 167.1 2.0 0.015 0.0 GTP
HOH
 5.197
3.259
 O
O
 O6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 CYS A:157 A:157 0.0 0.0 -151.1 164.2
af-p15153-f1 1 P15153 92.19 1e-133 CYS A:157 A:157 1.0 0.007 -150.2 163.7
af-p60763-f1 1 P60763 95.51 1e-128 CYS A:157 A:157 0.0 0.0 -150.3 162.3