Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6441973 . G A CCDS5348.1:NM_006908.4:c.475Gcg>Acg_NP_008839.2:p.159A>T Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ALA C:159 D:159 12.0 0.104 T -67.3 -10.2 12.0 0.104 0.0 GDP
HOH
 2.848
7.049
 N
N
 O6
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 ALA C:159 D:159 13.0 0.113 T -70.9 -12.3 13.0 0.113 0.0 GDP
HOH
 3.294
7.227
 N
O
 O6
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 ALA C:159 C:159 0.0 0.0 T -78.6 -24.6 0.0 0.0 0.0
ALA F:159 F:159 0.0 0.0 T -78.6 -24.6 0.0 0.0 0.0
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 ALA B:162 B:159 13.0 0.113 T -67.3 -29.2 13.0 0.113 0.0
ALA D:162 D:159 14.0 0.122 T -65.2 -27.5 NA NA NA
ALA F:162 F:159 14.0 0.122 T -66.3 -29.1 NA NA NA
ALA H:162 H:159 14.0 0.122 T -67.0 -28.5 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 ALA C:159 D:159 16.0 0.139 T -75.0 -11.2 16.0 0.139 0.0 GNP
HOH
 3.110
4.618
 N
O
 O6
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 ALA A:159 A:159 12.0 0.104 T -76.0 -21.5 11.0 0.096 0.008 B:P19878:0.009
 GTP
HOH
 3.052
3.225
 N
N
 O6
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 ALA A:159 A:159 15.0 0.13 T -80.9 -37.9 15.0 0.13 0.0 GDP
HOH
 2.921
7.284
 N
N
 O6
O
ALA B:159 B:159 14.0 0.122 T -87.1 -38.3 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 ALA A:159 A:159 21.0 0.183 T -63.7 -37.7 21.0 0.183 0.0 HOH
 2.845
 N
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 ALA B:159 R:159 16.0 0.139 T -74.2 -34.9 16.0 0.139 0.0 GDP
HOH
 2.850
3.361
 N
CB
 O6
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 ALA A:163 A:159 12.0 0.104 T -53.7 -35.8 12.0 0.104 0.0 GDP
 3.149
 N
 O6
ALA B:163 B:159 12.0 0.104 T -62.6 -27.1 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 ALA A:163 A:159 12.0 0.104 T -63.8 -33.6 12.0 0.104 0.0 GDP
HOH
 2.976
2.951
 N
N
 O6
O
ALA B:163 B:159 13.0 0.113 T -66.8 -34.9 13.0 0.113 0.0 GDP
HOH
 2.919
3.022
 N
N
 O6
O
ALA C:163 C:159 12.0 0.104 T -65.9 -32.6 12.0 0.104 0.0 GDP
HOH
 3.030
2.973
 N
N
 O6
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 ALA A:161 A:159 12.0 0.104 T -64.9 -28.7 12.0 0.104 0.0 GNP
HOH
 2.976
3.053
 N
N
 O6
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 ALA A:159 A:159 14.0 0.122 T -73.6 -29.3 14.0 0.122 0.0 GDP
HOH
 2.944
3.048
 N
N
 O6
O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 ALA C:178 C:159 13.0 0.113 T -64.7 -43.5 NA NA NA
ALA D:178 D:159 14.0 0.122 T -54.4 -33.8 14.0 0.122 0.0 HOH
 3.022
 N
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 ALA A:159 A:159 8.0 0.07 T -70.2 -36.1 8.0 0.07 0.0 GNP
 2.760
 N
 O6
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 ALA A:159 A:159 6.0 0.052 T -78.4 -37.7 6.0 0.052 0.0 GNP
 2.683
 N
 O6
ALA B:159 B:159 6.0 0.052 T -77.7 -38.4 NA NA NA
ALA C:159 C:159 11.0 0.096 T -78.4 -38.5 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 ALA C:159 B:159 21.0 0.183 T -60.9 -36.2 21.0 0.183 0.0 HOH
 2.917
 N
 O
ALA D:159 D:159 23.0 0.2 T -58.3 -36.1 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 ALA A:159 A:159 10.0 0.087 T -75.3 -30.7 10.0 0.087 0.0 GSP
HOH
 2.855
3.083
 N
N
 O6
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 13.0 0.113 T -66.1 -26.6 13.0 0.113 0.0 JGA
HOH
 2.981
3.873
 N
O
 N11
O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 13.0 0.113 T -58.9 -36.5 13.0 0.113 0.0 N5S
HOH
 2.973
3.562
 N
O
 O3
O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 13.0 0.113 T -66.6 -33.9 13.0 0.113 0.0 N5V
HOH
 2.856
3.724
 N
O
 N2
O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 14.0 0.122 T -60.7 -32.6 14.0 0.122 0.0 N64
HOH
 2.979
3.714
 N
O
 N4
O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 14.0 0.122 T -60.7 -42.0 14.0 0.122 0.0 N67
HOH
 2.983
3.688
 N
O
 N3
O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 11.0 0.096 T -82.9 -26.7 11.0 0.096 0.0 N6D
HOH
 3.365
3.339
 N
O
 N2
O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 14.0 0.122 T -61.4 -36.6 14.0 0.122 0.0 N6J
HOH
 3.122
3.779
 N
O
 N6
O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 14.0 0.122 T -62.6 -36.2 14.0 0.122 0.0 N6V
HOH
 2.941
3.716
 N
O
 N4
O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 13.0 0.113 T -64.2 -30.6 13.0 0.113 0.0 N71
HOH
 2.927
5.643
 N
O
 O3
O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 13.0 0.113 T -62.9 -33.8 13.0 0.113 0.0 N74
HOH
 2.948
3.699
 N
O
 N4
O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 ALA A:160 A:159 14.0 0.122 T -59.8 -39.4 14.0 0.122 0.0 N5D
HOH
 3.040
3.701
 N
O
 C2
O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 ALA A:160 A:159 15.0 0.13 T -68.7 -27.9 15.0 0.13 0.0 HOH
 2.989
 N
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 ALA B:159 B:159 14.0 0.122 T -65.6 -21.4 14.0 0.122 0.0 SO4
HOH
 9.517
5.759
 CB
N
 O4
O
ALA D:159 D:159 15.0 0.13 T -65.4 -21.7 NA NA NA
ALA F:159 F:159 15.0 0.13 T -64.7 -22.1 NA NA NA
ALA H:159 H:159 15.0 0.13 T -65.4 -21.3 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 ALA A:159 A:159 15.0 0.13 T -56.3 -40.3 15.0 0.13 0.0 HOH
 2.923
 N
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 ALA C:159 C:159 20.0 0.174 S -91.8 -19.7 NA NA NA
ALA D:159 D:159 19.0 0.165 T -78.8 -34.5 19.0 0.165 0.0
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 ALA A:159 A:159 16.0 0.139 T -65.4 -29.4 16.0 0.139 0.0 GDP
HOH
 2.829
3.055
 N
N
 O6
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 ALA B:166 B:159 14.0 0.122 T -72.7 -29.4 14.0 0.122 0.0
ALA D:166 D:159 14.0 0.122 T -73.7 -27.7 14.0 0.122 0.0
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 ALA B:166 B:159 43.0 0.374 S -131.5 -19.3 43.0 0.374 0.0
ALA E:166 E:159 44.0 0.383 S -131.4 -19.4 44.0 0.383 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ALA A:180 A:178 12.0 0.104 T -66.6 -29.7 12.0 0.104 0.0 GDP
HOH
 2.885
2.934
 N
N
 O6
O
ALA B:180 B:178 12.0 0.104 T -58.8 -34.7 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 ALA A:180 A:178 13.0 0.113 T -67.1 -31.1 13.0 0.113 0.0 GNP
HOH
 2.903
2.969
 N
N
 O6
O
ALA B:180 B:178 13.0 0.113 T -62.2 -32.5 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 ALA A:186 A:159 10.0 0.087 T -64.2 -23.4 10.0 0.087 0.0 GNP
HOH
 2.828
7.609
 N
N
 O6
O
ALA B:186 B:159 12.0 0.104 T -70.1 -24.1 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 ALA A:159 A:159 13.0 0.113 T -70.7 -30.6 13.0 0.113 0.0 GSP
HOH
 2.092
7.508
 H
N
 O6
O
ALA C:159 B:159 12.0 0.104 T -76.4 -20.7 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 ALA A:158 A:159 13.0 0.113 T -77.6 -25.3 13.0 0.113 0.0 GDP
HOH
 2.937
7.350
 N
N
 O6
O
ALA B:158 B:159 12.0 0.104 T -79.1 -25.0 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 ALA B:161 B:159 16.0 0.139 T -66.1 -34.4 16.0 0.139 0.0 HOH
 2.887
 N
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 ALA C:162 C:159 7.0 0.061 T -59.6 -19.9 7.0 0.061 0.0 GNP
 2.756
 N
 O6
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 ALA A:186 A:159 12.0 0.104 T -72.3 -23.2 12.0 0.104 0.0 GSP
 2.662
 N
 O6
ALA B:186 B:159 13.0 0.113 T -72.6 -21.8 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ALA A:169 A:159 11.0 0.096 T -66.6 -31.9 11.0 0.096 0.0 GNP
HOH
 2.992
3.026
 N
N
 O6
O
ALA B:169 B:159 13.0 0.113 T -66.3 -28.8 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 ALA A:169 A:159 11.0 0.096 T -69.4 -26.2 11.0 0.096 0.0 GNP
HOH
 2.781
8.280
 N
N
 O6
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 ALA A:159 A:159 20.0 0.174 T -75.2 -20.5 20.0 0.174 0.0 GDP
 2.121
 H
 O6
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 ALA C:159 C:159 11.0 0.096 T -72.7 -30.1 11.0 0.096 0.0 GDP
HOH
 2.811
3.107
 N
N
 O6
O
ALA D:159 D:159 12.0 0.104 T -71.5 -30.8 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 ALA A:186 A:159 11.0 0.096 T -62.3 -35.2 11.0 0.096 0.0 GNP
IPA
HOH
 3.042
7.593
2.998
 N
N
N
 O6
O2
O
ALA B:186 B:159 11.0 0.096 T -60.6 -27.5 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 ALA A:162 BBB:159 12.0 0.104 T -71.3 -30.0 12.0 0.104 0.0 GNP
HOH
 3.275
7.571
 N
N
 O6
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ALA A:311 A:702 13.0 0.113 T -61.0 -35.3 13.0 0.113 0.0 GTP
CL
HOH
 2.918
7.348
3.016
 N
N
N
 O6
CL
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 ALA A:311 A:702 12.0 0.104 T -64.1 -32.6 12.0 0.104 0.0 GTP
CL
HOH
 2.969
7.327
2.773
 N
N
O
 O6
CL
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 ALA A:311 A:702 12.0 0.104 T -69.6 -25.6 12.0 0.104 0.0 GTP
HOH
 2.855
3.075
 N
N
 O6
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 ALA B:159 A:159 28.0 0.243 S -63.6 -83.3 28.0 0.243 0.0
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 ALA A:160 A:159 13.0 0.113 T -64.7 -32.6 13.0 0.113 0.0 GDP
HOH
 2.944
2.932
 N
N
 O6
O
ALA B:160 B:159 13.0 0.113 T -71.4 -29.0 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 ALA A:160 A:159 12.0 0.104 T -60.5 -32.3 12.0 0.104 0.0 GCP
HOH
 2.912
2.831
 N
N
 O6
O
ALA B:160 F:159 13.0 0.113 T -60.7 -33.9 NA NA NA
ALA C:160 B:159 12.0 0.104 T -64.3 -27.0 NA NA NA
ALA D:160 C:159 12.0 0.104 T -68.2 -27.4 NA NA NA
ALA E:160 G:159 13.0 0.113 T -60.8 -34.1 NA NA NA
ALA F:160 D:159 11.0 0.096 T -67.2 -34.3 NA NA NA
ALA G:160 E:159 12.0 0.104 T -68.1 -33.7 NA NA NA
ALA H:160 H:159 12.0 0.104 T -65.8 -26.5 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 ALA A:160 A:159 12.0 0.104 T -62.4 -30.7 12.0 0.104 0.0 GCP
GOL
HOH
 2.918
9.785
2.974
 N
N
N
 O6
O3
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 ALA A:160 A:159 12.0 0.104 T -61.4 -30.7 12.0 0.104 0.0 GNP
HOH
 2.981
2.963
 N
N
 O6
O
ALA B:160 B:159 13.0 0.113 T -66.3 -28.6 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 ALA A:159 A:159 13.0 0.113 T -60.3 -32.6 13.0 0.113 0.0 GDP
HOH
 2.935
3.036
 N
N
 O6
O
ALA B:159 B:159 11.0 0.096 T -70.0 -30.9 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ALA A:165 A:159 13.0 0.113 T -68.8 -34.5 13.0 0.113 0.0 GDP
HOH
 2.899
3.116
 N
N
 O6
O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 ALA A:165 A:159 14.0 0.122 T -75.1 -29.1 14.0 0.122 0.0 GSP
HOH
 2.962
8.614
 N
O
 O6
O
ALA B:165 B:159 14.0 0.122 T -70.9 -29.5 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 ALA A:166 A:159 15.0 0.13 T -69.7 -20.6 15.0 0.13 0.0 GTP
HOH
 2.862
3.087
 N
N
 O6
O
ALA B:166 B:159 14.0 0.122 T -76.9 -30.6 NA NA NA
ALA C:166 C:159 13.0 0.113 T -64.5 -33.0 NA NA NA
ALA D:166 D:159 13.0 0.113 T -66.4 -32.9 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 ALA A:311 A:308 12.0 0.104 T -70.1 -22.9 12.0 0.104 0.0 GTP
HOH
 2.751
2.888
 N
N
 O6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 ALA A:159 A:159 11.0 0.096 T -70.2 -29.1
af-p15153-f1 1 P15153 92.19 1e-133 ALA A:159 A:159 11.0 0.096 T -70.1 -30.2
af-p60763-f1 1 P60763 95.51 1e-128 ALA A:159 A:159 11.0 0.096 T -71.0 -28.8