Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 6441991 . C A CCDS5348.1:NM_006908.4:c.493Ctc>Atc_NP_008839.2:p.165L>I Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1i4d 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 LEU C:165 D:165 1.0 0.006 H -43.6 -76.8 1.0 0.006 0.0 GDP
HOH
 7.624
3.517
 CD1
N
 O6
O
1i4l 2 P63000 100.0 4e-143 X-RAY
 2001-05-16 LEU C:165 D:165 2.0 0.012 H -63.6 -70.0 2.0 0.012 0.0 GDP
HOH
 8.001
3.792
 CD1
N
 O6
O
6tgc 3 P63000 100.0 4e-143 EM
 2020-07-29 LEU C:165 C:165 15.0 0.088 H -81.8 -71.2 8.0 0.047 0.041 A:Q92608:0.041
LEU F:165 F:165 16.0 0.094 H -81.7 -71.3 9.0 0.053 0.041 D:Q92608:0.041
5fi0 2 P63000 100.0 6e-143 X-RAY
 2016-04-20 LEU B:168 B:165 4.0 0.024 H -74.4 -45.4 4.0 0.024 0.0
LEU D:168 D:165 3.0 0.018 H -72.5 -43.4 NA NA NA
LEU F:168 F:165 3.0 0.018 H -74.0 -45.8 NA NA NA
LEU H:168 H:165 3.0 0.018 H -74.9 -45.9 NA NA NA
1i4t 2 P63000 99.48 7e-142 X-RAY
 2001-05-16 LEU C:165 D:165 3.0 0.018 H -76.4 -58.4 3.0 0.018 0.0 GNP
HOH
 7.984
5.029
 CD1
N
 O6
O
1e96 1 P15154 99.48 9e-141 X-RAY
 2000-11-17 LEU A:165 A:165 5.0 0.029 H -69.5 -51.3 5.0 0.029 0.0 GTP
HOH
 7.736
3.449
 CD1
N
 O6
O
1hh4 1 P15154 99.48 9e-141 X-RAY
 2001-08-28 LEU A:165 A:165 5.0 0.029 H -65.1 -22.7 5.0 0.029 0.0 GDP
HOH
 7.474
4.643
 CD1
N
 O6
O
LEU B:165 B:165 5.0 0.029 H -59.5 -26.6 NA NA NA
2vrw 1 P63000 100.0 5e-137 X-RAY
 2008-06-17 LEU A:165 A:165 3.0 0.018 H -72.0 -52.8 3.0 0.018 0.0 HOH
 3.445
 N
 O
1g4u 2 P63000 99.46 6e-136 X-RAY
 2001-01-24 LEU B:165 R:165 7.0 0.041 H -62.8 -58.5 7.0 0.041 0.0 GDP
HOH
 7.241
3.276
 CD1
N
 O6
O
2h7v 1 P63000 99.46 7e-136 X-RAY
 2006-09-19 LEU A:169 A:165 1.0 0.006 H -66.0 -49.3 1.0 0.006 0.0 GDP
 7.871
 CD1
 O6
LEU B:169 B:165 6.0 0.035 H -91.5 -36.8 NA NA NA
2p2l 1 P63000 99.46 7e-136 X-RAY
 2007-05-01 LEU A:169 A:165 3.0 0.018 H -71.7 -46.9 3.0 0.018 0.0 GDP
HOH
 7.613
3.362
 CD1
N
 O6
O
LEU B:169 B:165 8.0 0.047 H -67.4 -49.2 8.0 0.047 0.0 GDP
HOH
 6.567
3.206
 CD1
N
 O6
O
LEU C:169 C:165 3.0 0.018 H -70.0 -46.2 3.0 0.018 0.0 GDP
HOH
 7.627
3.380
 CD1
N
 O6
O
1mh1 1 P63000 99.45 9e-135 X-RAY
 1998-01-21 LEU A:167 A:165 5.0 0.029 H -68.3 -55.4 5.0 0.029 0.0 GNP
HOH
 7.634
3.390
 CD1
N
 O6
O
1ds6 1 P15153 92.19 3e-133 X-RAY
 2000-07-12 LEU A:165 A:165 3.0 0.018 H -64.6 -50.6 3.0 0.018 0.0 GDP
HOH
 7.536
3.502
 CD1
N
 O6
O
2yin 2 P63000 100.0 6e-132 X-RAY
 2011-05-25 LEU C:184 C:165 3.0 0.018 H -75.7 -47.5 NA NA NA
LEU D:184 D:165 3.0 0.018 H -73.7 -58.7 3.0 0.018 0.0 HOH
 5.707
 CD2
 O
3su8 1 P63000 100.0 1e-131 X-RAY
 2011-09-28 LEU A:165 A:165 0.0 0.0 H -56.3 -43.6 0.0 0.0 0.0 GNP
 7.568
 CD1
 O6
3sua 1 P63000 100.0 1e-131 X-RAY
 2011-09-07 LEU A:165 A:165 1.0 0.006 H -77.6 -38.1 1.0 0.006 0.0 GNP
 7.678
 CD2
 O6
LEU B:165 B:165 0.0 0.0 H -77.3 -37.1 NA NA NA
LEU C:165 C:165 0.0 0.0 H -77.4 -37.5 NA NA NA
6x1g 2 P63000 100.0 1e-131 X-RAY
 2020-11-25 LEU C:165 B:165 1.0 0.006 H -70.9 -43.2 1.0 0.006 0.0 HOH
 4.745
 N
 O
LEU D:165 D:165 1.0 0.006 H -74.1 -44.1 NA NA NA
2fju 1 P63000 100.0 1e-131 X-RAY
 2006-11-21 LEU A:165 A:165 0.0 0.0 H -61.6 -54.8 0.0 0.0 0.0 GSP
HOH
 7.557
3.426
 CD1
N
 O6
O
5qqd 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -71.2 -54.6 1.0 0.006 0.0 JGA
HOH
 6.447
3.365
 CD1
CD2
 O10
O
5qqe 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -75.1 -59.1 1.0 0.006 0.0 N5S
HOH
 6.534
3.164
 CD1
CD2
 O3
O
5qqf 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -74.6 -60.3 1.0 0.006 0.0 N5V
HOH
 5.659
3.452
 CD1
N
 C4
O
5qqg 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 3.0 0.018 H -75.9 -51.5 3.0 0.018 0.0 N64
HOH
 6.470
3.488
 CD1
CD2
 O1
O
5qqh 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 0.0 0.0 H -75.9 -55.5 0.0 0.0 0.0 N67
HOH
 6.493
3.165
 CD1
CD2
 O3
O
5qqi 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -75.4 -53.6 1.0 0.006 0.0 N6D
HOH
 6.781
3.505
 CD1
N
 O2
O
5qqj 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -73.3 -53.8 1.0 0.006 0.0 N6J
HOH
 6.693
3.172
 CD1
CG
 O1
O
5qqk 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -82.0 -49.7 1.0 0.006 0.0 N6V
HOH
 6.421
3.314
 CD1
N
 O1
O
5qql 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -77.8 -56.4 1.0 0.006 0.0 N71
HOH
 6.686
3.629
 CD1
N
 O3
O
5qqm 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -80.2 -49.3 1.0 0.006 0.0 N74
HOH
 6.474
3.323
 CD1
CG
 O1
O
5qqn 1 P63000 100.0 1e-131 X-RAY
 2019-12-18 LEU A:166 A:165 1.0 0.006 H -74.3 -53.0 1.0 0.006 0.0 N5D
HOH
 5.807
3.323
 CD1
CG
 C
O
5qu9 1 P63000 100.0 1e-131 X-RAY
 2020-01-29 LEU A:166 A:165 1.0 0.006 H -73.8 -52.1 1.0 0.006 0.0 HOH
 3.552
 CD2
 O
1foe 2 P63000 100.0 2e-131 X-RAY
 2001-01-17 LEU B:165 B:165 2.0 0.012 H -62.1 -62.6 2.0 0.012 0.0 HOH
 4.058
 N
 O
LEU D:165 D:165 1.0 0.006 H -59.2 -63.0 NA NA NA
LEU F:165 F:165 1.0 0.006 H -61.1 -62.6 NA NA NA
LEU H:165 H:165 2.0 0.012 H -60.6 -62.5 NA NA NA
2nz8 1 P63000 100.0 2e-131 X-RAY
 2007-04-10 LEU A:165 A:165 4.0 0.024 H -65.7 -52.4 4.0 0.024 0.0 HOH
 3.482
 N
 O
3bji 2 P63000 100.0 2e-131 X-RAY
 2008-07-15 LEU C:165 C:165 1.0 0.006 H -53.6 -33.1 NA NA NA
LEU D:165 D:165 6.0 0.035 H -45.3 -45.7 6.0 0.035 0.0 HOH
 9.789
 O
 O
5o33 1 P63000 100.0 2e-131 X-RAY
 2017-05-31 LEU A:165 A:165 2.0 0.012 H -70.3 -47.8 2.0 0.012 0.0 GDP
HOH
 7.530
3.429
 CD1
N
 O6
O
3b13 2 P63000 99.44 4e-131 X-RAY
 2012-03-14 LEU B:172 B:165 4.0 0.024 H -70.1 -52.6 1.0 0.006 0.018 A:Q92608:0.018
LEU D:172 D:165 5.0 0.029 H -71.2 -63.9 2.0 0.012 0.017 C:Q92608:0.018
7dpa 2 P63000 99.44 6e-131 EM
 2021-08-04 LEU B:172 B:165 3.0 0.018 H -58.4 -51.2 3.0 0.018 0.0
LEU E:172 E:165 3.0 0.018 H -58.4 -51.2 3.0 0.018 0.0
1ryf 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 LEU A:186 A:184 3.0 0.018 H -69.3 -49.2 3.0 0.018 0.0 GDP
HOH
 7.590
3.997
 CD1
CD2
 O6
O
LEU B:186 B:184 2.0 0.012 H -70.9 -49.1 NA NA NA
1ryh 1 P63000 90.55 6e-131 X-RAY
 2004-01-27 LEU A:186 A:184 1.0 0.006 H -72.9 -48.2 1.0 0.006 0.0 GNP
HOH
 7.786
4.705
 CD1
N
 O6
O
LEU B:186 B:184 2.0 0.012 H -73.0 -48.2 NA NA NA
3th5 1 P63000 100.0 8e-131 X-RAY
 2012-07-18 LEU A:192 A:165 3.0 0.018 H -80.2 -43.2 3.0 0.018 0.0 GNP
HOH
 7.496
4.770
 CD1
N
 O6
O
LEU B:192 B:165 1.0 0.006 H -67.1 -51.0 NA NA NA
6bc1 1 P63000 100.0 1e-130 X-RAY
 2017-12-13 LEU A:165 A:165 5.0 0.029 H -69.5 -44.8 5.0 0.029 0.0 GSP
HOH
 6.990
5.912
 HD13
O
 O6
O
LEU C:165 B:165 3.0 0.018 H -80.5 -31.9 NA NA NA
5n6o 1 P63000 100.0 2e-130 X-RAY
 2017-12-27 LEU A:164 A:165 1.0 0.006 H -65.1 -50.4 1.0 0.006 0.0 GDP
HOH
 7.861
4.873
 CD1
N
 O6
O
LEU B:164 B:165 4.0 0.024 H -66.9 -46.6 NA NA NA
4yon 2 P63000 99.44 3e-130 X-RAY
 2015-07-01 LEU B:167 B:165 4.0 0.024 H -69.8 -47.5 4.0 0.024 0.0 HOH
 3.432
 N
 O
3ryt 2 P63000 99.44 5e-130 X-RAY
 2012-01-18 LEU C:168 C:165 3.0 0.018 H -69.7 -42.5 3.0 0.018 0.0 GNP
 7.772
 CD2
 O6
4gzm 1 P63000 99.43 6e-130 X-RAY
 2012-12-12 LEU A:192 A:165 5.0 0.029 H -75.4 -38.6 5.0 0.029 0.0 GSP
 7.554
 CD1
 O6
LEU B:192 B:165 3.0 0.018 H -74.0 -39.9 NA NA NA
3sbd 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 LEU A:175 A:165 4.0 0.024 H -74.8 -52.7 4.0 0.024 0.0 GNP
HOH
 8.028
4.580
 CD1
N
 O6
O
LEU B:175 B:165 4.0 0.024 H -67.5 -53.1 NA NA NA
3sbe 1 P63000 99.43 9e-130 X-RAY
 2012-07-18 LEU A:175 A:165 2.0 0.012 H -59.7 -60.4 2.0 0.012 0.0 GNP
HOH
 7.694
4.681
 CD1
N
 O6
O
6agp 1 P63000 97.79 1e-129 NMR
 2019-03-20 LEU A:165 A:165 3.0 0.018 H -66.2 -46.1 3.0 0.018 0.0 GDP
 6.825
 HD13
 O6
1he1 2 P15154 100.0 1e-129 X-RAY
 2001-01-02 LEU C:165 C:165 4.0 0.024 H -65.5 -53.3 4.0 0.024 0.0 GDP
HOH
 7.899
3.509
 CD1
N
 O6
O
LEU D:165 D:165 3.0 0.018 H -65.8 -47.8 NA NA NA
4gzl 1 P63000 99.43 1e-129 X-RAY
 2012-12-12 LEU A:192 A:165 3.0 0.018 H -74.9 -43.9 3.0 0.018 0.0 GNP
IPA
HOH
 7.815
9.046
4.775
 CD1
N
N
 O6
O2
O
LEU B:192 B:165 4.0 0.024 H -74.6 -42.9 NA NA NA
7ajk 1 P63000 99.43 3e-129 X-RAY
 2020-11-18 LEU A:168 BBB:165 3.0 0.018 H -73.2 -44.4 3.0 0.018 0.0 GNP
HOH
 8.264
8.864
 CD1
N
 O6
O
2wkr 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 LEU A:317 A:708 3.0 0.018 H -69.9 -53.7 3.0 0.018 0.0 GTP
CL
HOH
 7.520
8.672
3.202
 CD1
N
N
 O6
CL
O
2wkq 1 O49003,P63000 97.21 1e-128 X-RAY
 2009-08-18 LEU A:317 A:708 3.0 0.018 H -71.6 -48.4 3.0 0.018 0.0 GTP
CL
HOH
 7.819
8.780
3.354
 CD1
N
N
 O6
CL
O
2wkp 1 O49003,P63000 97.21 3e-128 X-RAY
 2009-08-18 LEU A:317 A:708 3.0 0.018 H -68.9 -45.8 3.0 0.018 0.0 GTP
HOH
 7.694
3.298
 CD1
N
 O6
O
6tm1 2 P60763 95.51 3e-128 X-RAY
 2020-01-22 LEU B:165 A:165 10.0 0.059 T -75.3 -174.9 6.0 0.035 0.024 A:Q96BY6:0.024
2g0n 1 P60763 95.48 1e-127 X-RAY
 2006-05-30 LEU A:166 A:165 4.0 0.024 H -68.7 -46.7 4.0 0.024 0.0 GDP
HOH
 7.579
3.603
 CG
CD1
 O6
O
LEU B:166 B:165 5.0 0.029 H -71.0 -54.4 NA NA NA
2ov2 1 P60763 95.48 1e-127 X-RAY
 2007-03-13 LEU A:166 A:165 4.0 0.024 H -70.7 -51.0 4.0 0.024 0.0 CL
GCP
HOH
 6.988
7.817
3.338
 N
CD1
N
 CL
O6
O
LEU B:166 F:165 4.0 0.024 H -72.3 -53.6 NA NA NA
LEU C:166 B:165 3.0 0.018 H -64.7 -56.5 NA NA NA
LEU D:166 C:165 5.0 0.029 H -77.7 -50.3 NA NA NA
LEU E:166 G:165 3.0 0.018 H -78.1 -50.4 NA NA NA
LEU F:166 D:165 4.0 0.024 H -71.0 -52.1 NA NA NA
LEU G:166 E:165 4.0 0.024 H -70.4 -51.5 NA NA NA
LEU H:166 H:165 3.0 0.018 H -69.8 -48.2 NA NA NA
2qme 1 P60763 95.48 1e-127 X-RAY
 2007-08-28 LEU A:166 A:165 4.0 0.024 H -70.5 -53.0 4.0 0.024 0.0 GCP
GOL
HOH
 7.602
3.392
3.513
 CD1
N
N
 O6
O3
O
2ic5 1 P60763 95.48 1e-127 X-RAY
 2006-10-10 LEU A:166 A:165 4.0 0.024 H -74.0 -48.7 4.0 0.024 0.0 GNP
BTB
HOH
 7.572
7.090
3.746
 CG
C
CB
 O6
C1
O
LEU B:166 B:165 5.0 0.029 H -71.1 -52.8 NA NA NA
2c2h 1 P60763 95.48 4e-127 X-RAY
 2005-10-13 LEU A:165 A:165 3.0 0.018 H -76.7 -44.6 3.0 0.018 0.0 GDP
GDP
HOH
 7.233
7.985
3.277
 CD1
N
N
 O6
O3'
O
LEU B:165 B:165 5.0 0.029 H -72.5 -52.1 NA NA NA
2w2t 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 LEU A:171 A:165 4.0 0.024 H -63.3 -46.9 4.0 0.024 0.0 GDP
HOH
 7.530
3.335
 CD1
N
 O6
O
2w2x 1 P15153 94.94 2e-125 X-RAY
 2009-05-05 LEU A:171 A:165 3.0 0.018 H -68.3 -57.0 3.0 0.018 0.0 GSP
HOH
 7.535
4.669
 CD1
N
 O6
O
LEU B:171 B:165 3.0 0.018 H -70.4 -58.3 NA NA NA
2w2v 1 P15153 94.92 1e-124 X-RAY
 2009-05-05 LEU A:172 A:165 3.0 0.018 H -61.6 -53.2 3.0 0.018 0.0 GTP
HOH
 7.949
3.969
 CD1
CD2
 O6
O
LEU B:172 B:165 3.0 0.018 H -76.7 -45.8 NA NA NA
LEU C:172 C:165 0.0 0.0 H -51.3 -57.4 NA NA NA
LEU D:172 D:165 0.0 0.0 H -60.1 -40.6 NA NA NA
5hzh 1 P63000,O49003 92.36 2e-94 X-RAY
 2016-12-21 LEU A:317 A:314 3.0 0.018 H -72.1 -39.4 3.0 0.018 0.0 GTP
HOH
 7.550
5.413
 CD1
CD1
 O6
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p63000-f1 1 P63000 100.0 2e-143 LEU A:165 A:165 6.0 0.035 H -62.3 -52.1
af-p15153-f1 1 P15153 92.19 1e-133 LEU A:165 A:165 6.0 0.035 H -61.4 -52.1
af-p60763-f1 1 P60763 95.51 1e-128 LEU A:165 A:165 6.0 0.035 H -61.6 -53.0