Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 73117176 . T A CCDS34655.1:NM_004603.3:c.677cAg>cTg_NP_004594.1:p.226Q>L Homo sapiens syntaxin 1A (STX1A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3c98 2 P32851 99.63 0.0 X-RAY
 2008-03-25 GLN B:238 B:226 52.0 0.289 H -85.5 -36.6 52.0 0.289 0.0 HOH
 2.639
 O
 O
6mdm 3 P32851 99.22 0.0 EM
 2018-09-19 GLN H:226 I:226 96.0 0.533 H -63.6 -31.2 23.0 0.128 0.405 G:P60881:0.006
I:P63045:0.4
6mdn 3 P32851 99.22 0.0 EM
 2018-09-19 GLN H:226 I:226 131.0 0.728 H -63.7 -30.9 21.0 0.117 0.611 I:P63045:0.594
G:P60881:0.05
6ip1 2 P32851 99.6 0.0 EM
 2019-04-24 GLN B:227 B:226 115.0 0.639 H -87.4 -23.7 0.0 0.0 0.639 D:P60881:0.106
C:P60881:0.089
A:P63045:0.628
4jeh 2 P32851 99.59 5e-177 X-RAY
 2013-07-17 GLN B:203 B:226 44.0 0.244 H -61.9 -40.5 44.0 0.244 0.0 HOH
 2.924
 O
 O
4jeu 2 P32851 99.59 2e-176 X-RAY
 2013-07-17 GLN B:225 B:226 48.0 0.267 S -64.9 -37.8 48.0 0.267 0.0
2m8r 1 P32851 97.17 8e-70 NMR
 2013-11-20 GLN A:47 A:226 105.0 0.583 T -73.2 14.1 105.0 0.583 0.0
3hd7 2 P32851 97.17 8e-70 X-RAY
 2009-07-14 GLN B:47 B:226 114.0 0.633 H -79.0 -16.7 1.0 0.006 0.627 C:P60881:0.044
A:P63045:0.628
GLN F:47 F:226 108.0 0.6 H -79.1 -26.1 NA NA NA
3ipd 2 P32851 97.17 8e-70 X-RAY
 2009-09-01 GLN B:47 B:226 120.0 0.667 H -74.0 -9.5 12.0 0.067 0.6 A:P63045:0.589
C:P60881:0.028
GLN F:47 F:226 119.0 0.661 H -75.0 -8.6 NA NA NA
1sfc 2 P32851 100.0 7e-53 X-RAY
 1998-10-28 GLN B:47 B:226 98.0 0.544 H -63.1 -26.2 0.0 0.0 0.544 D:P60881:0.022
C:P60881:0.044
A:P63045:0.544
GLN F:47 F:226 95.0 0.528 H -61.5 -33.9 NA NA NA
GLN J:47 J:226 101.0 0.561 H -76.2 -29.9 NA NA NA
1jth 2 P32851 100.0 2e-48 X-RAY
 2001-11-28 GLN B:36 B:226 116.0 0.644 H -69.2 -26.6 13.0 0.072 0.572 D:P32851:0.044
C:P60881:0.039
A:P60881:0.533
 HOH
 2.793
 OE1
 O
GLN D:36 D:226 105.0 0.583 H -63.8 -29.6 9.0 0.05 0.533 B:P32851:0.039
C:P60881:0.494
A:P60881:0.044
 HOH
 2.601
 OE1
 O
1hvv 1 P32851 100.0 4e-47 X-RAY
 2001-01-31 GLN A:37 A:226 117.0 0.65 H -65.5 -37.6 16.0 0.089 0.561 C:P32851:0.056
D:P32851:0.094
B:P32851:0.522
 TAR
HOH
 5.367
3.080
 O
OE1
 O11
O
GLN B:37 B:226 111.0 0.617 H -62.7 -51.0 0.0 0.0 0.617 C:P32851:0.183
D:P32851:0.45
A:P32851:0.178
 HOH
 5.658
 C
 O
GLN C:37 C:226 139.0 0.772 H -65.2 -40.0 12.0 0.067 0.705 D:P32851:0.606
A:P32851:0.133
B:P32851:0.183
 HOH
 3.576
 CA
 O
GLN D:37 D:226 103.0 0.572 H -66.9 -27.1 0.0 0.0 0.572 C:P32851:0.106
A:P32851:0.144
B:P32851:0.517
 HOH
 5.501
 O
 O
1urq 2 P32851 98.65 9e-45 X-RAY
 2004-08-26 GLN B:42 B:226 124.0 0.689 H -63.1 -31.1 23.0 0.128 0.561 C:P13795:0.028
A:Q9Z152:0.561
 HOH
 2.868
 NE2
 O
2n1t 2 P32851 100.0 1e-44 NMR
 2015-06-03 GLN B:39 B:226 97.0 0.539 H -60.0 -37.4 3.0 0.017 0.522 A:P63045:0.522
C:P60880:0.022
1n7s 2 P32851 100.0 7e-40 X-RAY
 2002-12-27 GLN B:38 B:226 93.0 0.517 H -68.8 -24.2 0.0 0.0 0.517 A:P63045:0.517
C:P60881:0.044
 HOH
 4.524
 CG
 O
3j96 4 P32851 100.0 7e-40 EM
 2015-01-28 GLN L:37 L:226 103.0 0.572 H -70.8 -13.7 7.0 0.039 0.533 M:None:0.017
K:P63045:0.533
3j97 4 P32851 100.0 7e-40 EM
 2015-01-28 GLN L:37 L:226 100.0 0.556 H -65.8 -38.9 1.0 0.006 0.55 M:None:0.067
K:P63045:0.494
3j98 4 P32851 100.0 7e-40 EM
 2015-01-28 GLN L:37 L:226 108.0 0.6 H -93.8 -28.7 10.0 0.056 0.544 K:P63045:0.544
3j99 4 P32851 100.0 7e-40 EM
 2015-01-28 GLN L:37 L:226 108.0 0.6 H -93.8 -28.8 9.0 0.05 0.55 K:P63045:0.544
5ccg 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 GLN B:37 B:226 121.0 0.672 H -56.2 -36.0 0.0 0.0 0.672 F:P21707:0.006
C:P60881:0.061
A:P63045:0.672
GLN H:37 H:226 115.0 0.639 H -55.6 -37.4 NA NA NA
5cch 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 GLN B:37 B:226 105.0 0.583 H -61.1 -28.2 0.0 0.0 0.583 F:P21707:0.033
C:P60881:0.039
A:P63045:0.583
5cci 2 P32851 100.0 7e-40 X-RAY
 2015-08-12 GLN B:37 B:226 107.0 0.594 H -58.0 -32.8 0.0 0.0 0.594 F:P21707:0.017
C:P60881:0.039
A:P63045:0.594
5w5c 2 P32851 100.0 7e-40 X-RAY
 2017-08-23 GLN B:37 B:226 89.0 0.494 H -62.7 -28.5 0.0 0.0 0.494 E:P63041:0.017
C:P60881:0.044
A:P63045:0.494
 HOH
 5.675
 O
 O
5w5d 2 P32851 100.0 7e-40 X-RAY
 2017-08-23 GLN B:37 B:226 94.0 0.522 H -60.4 -25.2 0.0 0.0 0.522 E:P63041:0.017
C:P60881:0.056
A:P63045:0.522
 HOH
 6.142
 OE1
 O
6mti 4 P32851 100.0 7e-40 EM
 2019-04-24 GLN H:37 B:226 107.0 0.594 H -57.9 -32.8 0.0 0.0 0.594 G:P63045:0.594
I:P60881:0.039
GLN L:37 F:226 107.0 0.594 H -57.9 -32.8 0.0 0.0 0.594 K:P63045:0.594
M:P60881:0.039
GLN P:37 J:226 106.0 0.589 H -58.0 -32.8 0.0 0.0 0.589 O:P63045:0.589
Q:P60881:0.039
GLN T:37 N:226 108.0 0.6 H -57.9 -32.8 0.0 0.0 0.6 U:P60881:0.039
S:P63045:0.6
GLN X:37 R:226 109.0 0.606 H -57.9 -32.8 0.0 0.0 0.606 Y:P60881:0.039
W:P63045:0.606
GLN BA:37 V:226 107.0 0.594 H -58.0 -32.8 0.0 0.0 0.594 AA:P63045:0.594
CA:P60881:0.039
5kj7 2 P32851 100.0 8e-40 X-RAY
 2016-10-19 GLN B:36 B:226 120.0 0.667 H -56.5 -34.2 0.0 0.0 0.667 D:P60881:0.006
A:P63025:0.667
C:P60881:0.067
GLN H:36 H:226 112.0 0.622 H -56.0 -36.0 NA NA NA
5kj8 2 P32851 100.0 8e-40 X-RAY
 2016-10-19 GLN B:36 B:226 119.0 0.661 H -54.5 -34.8 0.0 0.0 0.661 A:P63025:0.661
C:P60881:0.072
GLN H:36 H:226 113.0 0.628 H -54.7 -34.6 NA NA NA
6wvw 2 P32851 100.0 8e-40 X-RAY
 2021-03-17 GLN B:36 B:226 92.0 0.511 H -70.5 -26.4 0.0 0.0 0.511 C:P60881:0.044
A:P63045:0.511
 HOH
 3.889
 HA
 O
GLN F:36 F:226 101.0 0.561 H -70.4 -22.6 NA NA NA
3rk2 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 GLN B:38 B:226 94.0 0.522 H -64.4 -21.1 0.0 0.0 0.522 C:P60880:0.039
A:P63027:0.522
 CA
CA
HOH
 7.343
8.750
4.424
 O
O
NE2
 CA
CA
O
GLN F:38 F:226 95.0 0.528 H -62.8 -25.2 NA NA NA
3rk3 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 GLN B:38 B:226 99.0 0.55 H -66.4 -40.8 0.0 0.0 0.55 A:P63027:0.55
C:P60880:0.039
3rl0 2 P32851 100.0 9e-38 X-RAY
 2011-07-27 GLN B:38 B:226 110.0 0.611 H -51.1 -41.9 0.0 0.0 0.611 D:P60880:0.017
A:P63027:0.611
C:P60880:0.006
GLN F:38 F:226 109.0 0.606 H -51.7 -41.5 NA NA NA
GLN J:38 J:226 109.0 0.606 H -52.5 -40.3 NA NA NA
GLN N:38 N:226 110.0 0.611 H -51.9 -40.6 NA NA NA
GLN R:38 R:226 111.0 0.617 H -51.3 -41.4 NA NA NA
GLN V:38 V:226 110.0 0.611 H -51.0 -42.3 NA NA NA
GLN Z:38 Z:226 108.0 0.6 H -51.8 -40.4 NA NA NA
GLN DA:38 d:226 108.0 0.6 H -52.9 -40.7 NA NA NA
1kil 2 P32851 100.0 2e-35 X-RAY
 2002-03-13 GLN B:38 B:226 92.0 0.511 H -60.0 -25.0 0.0 0.0 0.511 A:P63045:0.511
E:P63041:0.033
C:P60880:0.033
 HOH
 5.489
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q16623-f1 1 Q16623 100.0 0.0 GLN A:226 A:226 8.0 0.044 T -96.9 -14.8
af-p61266-f1 1 P61266 83.33 3e-178 GLN A:225 A:225 6.0 0.033 T -104.0 -12.2