Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11666399 . C A CCDS5985.1:NM_004462.3:c.196Cgc>Agc_NP_004453.3:p.66R>S Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:36 A:66 75.0 0.333 H -59.3 -54.2 75.0 0.333 0.0 D99
HOH
 9.211
2.879
 O
NH2
 CL2
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 ARG A:36 A:66 87.0 0.387 H -25.9 -68.2 87.0 0.387 0.0 B65
HOH
 8.390
7.788
 O
C
 CAG
O
ARG B:36 B:66 90.0 0.4 H -73.8 -55.8 NA NA NA
ARG C:36 C:66 80.0 0.356 H -48.6 -67.3 NA NA NA
ARG D:36 D:66 90.0 0.4 H -55.2 -62.2 NA NA NA
ARG E:36 E:66 78.0 0.347 H -53.8 -55.5 NA NA NA
ARG F:36 F:66 94.0 0.418 H -44.3 -73.2 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:36 A:66 47.0 NA H -57.9 -55.3 47.0 NA NA D9A
HOH
 8.860
3.844
 O
CB
 CL1
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:36 A:66 47.0 NA H -60.6 -50.7 47.0 NA NA D61
HOH
 8.623
3.272
 O
NE
 C33
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 ARG A:36 A:66 75.0 0.333 H -53.4 -65.1 75.0 0.333 0.0 D3A
HOH
 8.956
2.691
 O
NH1
 CL1
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:39 A:66 99.0 0.44 H -61.0 -55.0 99.0 0.44 0.0 HOH
 3.186
 CZ
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:39 A:66 84.0 0.373 H -60.9 -57.6 84.0 0.373 0.0 HOH
 3.612
 CB
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:39 A:66 65.0 0.289 H -57.7 -59.3 65.0 0.289 0.0 HOH
 3.240
 CD
 O
ARG B:39 B:66 70.0 0.311 H -58.0 -58.3 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:39 A:66 88.0 0.391 H -61.2 -57.1 19.0 0.084 0.307 B:P37268:0.307
 HOH
 3.264
 NH1
 O
ARG B:39 B:66 95.0 0.422 H -59.2 -57.6 18.0 0.08 0.342 C:P37268:0.342
 HOH
 3.103
 NH1
 O
ARG C:39 C:66 95.0 0.422 H -56.2 -60.9 24.0 0.107 0.315 A:P37268:0.316
 HOH
 3.066
 NE
 O
ARG D:39 D:66 95.0 0.422 H -57.3 -65.4 NA NA NA
ARG E:39 E:66 91.0 0.404 H -63.5 -56.9 NA NA NA
ARG F:39 F:66 89.0 0.396 H -52.5 -65.4 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:39 A:66 89.0 0.396 H -60.8 -59.4 18.0 0.08 0.316 B:P37268:0.316
 ZGA
HOH
 8.814
3.195
 O
NH2
 CAS
O
ARG B:39 B:66 88.0 0.391 H -61.6 -57.9 32.0 0.142 0.249 C:P37268:0.249
 ZGA
HOH
 9.005
3.031
 O
NH2
 CAS
O
ARG C:39 C:66 85.0 0.378 H -63.9 -50.1 15.0 0.067 0.311 A:P37268:0.311
 ZGA
HOH
 8.878
2.836
 O
NH2
 CAS
O
ARG D:39 D:66 90.0 0.4 H -57.9 -63.9 NA NA NA
ARG E:39 E:66 92.0 0.409 H -59.3 -57.1 NA NA NA
ARG F:39 F:66 91.0 0.404 H -49.3 -68.4 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 91.0 0.404 H -57.1 -60.6 17.0 0.076 0.328 B:P37268:0.329
 FPS
HOH
 8.877
2.960
 O
NH1
 C14
O
ARG B:39 B:66 90.0 0.4 H -55.6 -62.6 29.0 0.129 0.271 C:P37268:0.271
 FPS
HOH
 8.695
3.238
 O
NH1
 C15
O
ARG C:39 C:66 94.0 0.418 H -57.1 -65.6 15.0 0.067 0.351 A:P37268:0.351
 HOH
 3.190
 NE
 O
ARG D:39 D:66 87.0 0.387 H -55.9 -69.4 NA NA NA
ARG E:39 E:66 92.0 0.409 H -56.3 -66.3 NA NA NA
ARG F:39 F:66 93.0 0.413 H -37.5 -73.5 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 99.0 0.44 H -57.9 -58.4 99.0 0.44 0.0 FPS
HOH
 8.400
3.204
 O
CZ
 C14
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 101.0 0.449 H -59.1 -60.4 101.0 0.449 0.0 PS7
HOH
 9.177
3.024
 O
NH2
 CAB
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 97.0 0.431 H -53.5 -61.3 97.0 0.431 0.0 PS7
HOH
 9.063
2.931
 O
NH2
 CAB
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 99.0 0.44 H -59.3 -61.3 99.0 0.44 0.0 PS7
HOH
 9.098
2.834
 O
NH2
 CAA
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:39 A:66 73.0 0.324 H -55.9 -58.7 73.0 0.324 0.0 PS7
HOH
 8.305
3.448
 O
CB
 CAA
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 ARG A:36 A:66 88.0 0.391 H -58.6 -68.3 88.0 0.391 0.0 IN0
HOH
 8.780
2.896
 O
NE
 CL36
O
ARG B:36 B:66 92.0 0.409 H -52.3 -66.6 NA NA NA
ARG C:36 C:66 98.0 0.436 H -48.2 -66.6 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 87.0 0.387 H -51.5 -58.9 19.0 0.084 0.303 C:P37268:0.302
 HOH
 2.917
 CD
 O
ARG B:56 B:66 89.0 0.396 H -58.3 -68.2 30.0 0.133 0.263 A:P37268:0.262
 HOH
 4.029
 NH1
 O
ARG C:56 C:66 86.0 0.382 H -49.0 -68.4 25.0 0.111 0.271 B:P37268:0.271
 HOH
 3.134
 NH2
 O
ARG D:56 D:66 90.0 0.4 H -50.0 -61.0 15.0 0.067 0.333 F:P37268:0.333
 FPS
HOH
 9.505
5.699
 O
C
 C15
O
ARG E:56 E:66 92.0 0.409 H -51.3 -59.9 12.0 0.053 0.356 D:P37268:0.356
 HOH
 5.596
 NH2
 O
ARG F:56 F:66 80.0 0.356 H -59.1 -61.5 22.0 0.098 0.258 E:P37268:0.258
 HOH
 5.633
 NE
 O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 87.0 0.387 H -43.0 -61.4 15.0 0.067 0.32 C:P37268:0.32
 HOH
 3.093
 CD
 O
ARG B:56 B:66 93.0 0.413 H -48.5 -67.5 22.0 0.098 0.315 A:P37268:0.316
 HOH
 3.626
 NE
 O
ARG C:56 C:66 94.0 0.418 H -49.9 -75.3 19.0 0.084 0.334 B:P37268:0.333
 HOH
 3.029
 NE
 O
ARG D:56 D:66 83.0 0.369 H -67.7 -63.5 14.0 0.062 0.307 F:P37268:0.307
 HOH
 3.380
 NE
 O
ARG E:56 E:66 80.0 0.356 H -64.6 -67.3 14.0 0.062 0.294 D:P37268:0.293
 HOH
 3.668
 CD
 O
ARG F:56 F:66 89.0 0.396 H -47.7 -66.4 20.0 0.089 0.307 E:P37268:0.307
 HOH
 3.073
 CD
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 89.0 0.396 H -48.8 -67.3 18.0 0.08 0.316 C:P37268:0.316
 HOH
 3.058
 NH2
 O
ARG B:56 B:66 93.0 0.413 H -55.6 -64.3 16.0 0.071 0.342 A:P37268:0.342
 HOH
 3.120
 NE
 O
ARG C:56 C:66 94.0 0.418 H -49.7 -58.3 24.0 0.107 0.311 B:P37268:0.311
 HOH
 3.185
 NE
 O
ARG D:56 D:66 90.0 0.4 H -55.7 -62.1 17.0 0.076 0.324 F:P37268:0.324
 HOH
 3.573
 NE
 O
ARG E:56 E:66 87.0 0.387 H -56.0 -68.7 19.0 0.084 0.303 D:P37268:0.302
 HOH
 3.059
 NE
 O
ARG F:56 F:66 83.0 0.369 H -51.3 -73.8 17.0 0.076 0.293 E:P37268:0.293
 HOH
 5.330
 NE
 O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 86.0 0.382 H -56.1 -60.4 19.0 0.084 0.298 C:P37268:0.298
 8PH
HOH
 8.365
3.160
 O
NH2
 CAA
O
ARG B:56 B:66 91.0 0.404 H -47.3 -70.8 15.0 0.067 0.337 A:P37268:0.338
 8PH
HOH
 8.895
2.930
 O
CD
 CAL
O
ARG C:56 C:66 90.0 0.4 H -53.2 -70.6 20.0 0.089 0.311 B:P37268:0.311
 HOH
 3.176
 CD
 O
ARG D:56 D:66 93.0 0.413 H -55.3 -62.6 17.0 0.076 0.337 F:P37268:0.338
 HOH
 3.471
 NE
 O
ARG E:56 E:66 88.0 0.391 H -50.3 -65.6 17.0 0.076 0.315 D:P37268:0.316
 HOH
 2.696
 NH2
 O
ARG F:56 F:66 90.0 0.4 H -49.4 -65.7 16.0 0.071 0.329 E:P37268:0.329
 8PH
HOH
 9.256
3.077
 O
NH2
 CAA
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 88.0 0.391 H -50.9 -63.9 18.0 0.08 0.311 C:P37268:0.311
 HOH
 3.060
 NH2
 O
ARG B:56 B:66 92.0 0.409 H -53.2 -65.5 19.0 0.084 0.325 A:P37268:0.324
 HOH
 3.075
 NE
 O
ARG C:56 C:66 92.0 0.409 H -53.6 -66.9 20.0 0.089 0.32 B:P37268:0.32
 HOH
 2.653
 NH2
 O
ARG D:56 D:66 87.0 0.387 H -57.7 -62.2 19.0 0.084 0.303 F:P37268:0.302
 HOH
 3.378
 NE
 O
ARG E:56 E:66 90.0 0.4 H -52.6 -62.9 20.0 0.089 0.311 D:P37268:0.311
 HOH
 2.922
 NH2
 O
ARG F:56 F:66 89.0 0.396 H -54.8 -65.0 17.0 0.076 0.32 E:P37268:0.32
 HOH
 3.192
 CB
 O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 90.0 0.4 H -51.2 -62.9 3.0 0.013 0.387 C:P37268:0.387
 E5S
HOH
 8.380
3.040
 O
NH2
 CAF
O
ARG B:56 B:66 94.0 0.418 H -50.2 -66.7 21.0 0.093 0.325 A:P37268:0.324
 E5S
HOH
 8.375
3.021
 O
NE
 CAF
O
ARG C:56 C:66 97.0 0.431 H -51.7 -61.1 8.0 0.036 0.395 B:P37268:0.396
 E5S
HOH
 8.485
2.697
 O
NH2
 CAF
O
ARG D:56 D:66 88.0 0.391 H -54.1 -63.6 15.0 0.067 0.324 F:P37268:0.324
 E5S
HOH
 8.438
3.256
 O
CD
 CAF
O
ARG E:56 E:66 88.0 0.391 H -51.3 -63.1 2.0 0.009 0.382 D:P37268:0.382
 E5S
HOH
 8.468
3.195
 O
NE
 CAF
O
ARG F:56 F:66 91.0 0.404 H -45.4 -73.8 2.0 0.009 0.395 E:P37268:0.396
 E5S
HOH
 8.228
3.214
 O
NE
 CAF
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 88.0 0.391 H -47.0 -65.6 16.0 0.071 0.32 C:P37268:0.32
 HOH
 2.764
 NH2
 O
ARG B:56 B:66 97.0 0.431 H -51.5 -64.0 16.0 0.071 0.36 A:P37268:0.36
 HOH
 2.973
 NE
 O
ARG C:56 C:66 92.0 0.409 H -51.4 -64.8 7.0 0.031 0.378 B:P37268:0.378
 HOH
 2.650
 NH2
 O
ARG D:56 D:66 89.0 0.396 H -55.3 -63.7 18.0 0.08 0.316 F:P37268:0.316
 HOH
 3.132
 NH2
 O
ARG E:56 E:66 89.0 0.396 H -53.4 -64.3 6.0 0.027 0.369 D:P37268:0.369
 HOH
 2.912
 NH2
 O
ARG F:56 F:66 84.0 0.373 H -46.9 -66.4 4.0 0.018 0.355 E:P37268:0.356
 HOH
 3.126
 CD
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:56 A:66 89.0 0.396 H -51.9 -66.3 3.0 0.013 0.383 C:P37268:0.382
 ER4
HOH
 8.193
3.326
 O
CB
 CAE
O
ARG B:56 B:66 90.0 0.4 H -51.8 -62.0 19.0 0.084 0.316 A:P37268:0.316
 ER4
HOH
 8.257
3.085
 O
NE
 CAE
O
ARG C:56 C:66 86.0 0.382 H -51.7 -63.9 9.0 0.04 0.342 B:P37268:0.342
 ER4
HOH
 8.315
2.832
 O
NH2
 CAE
O
ARG D:56 D:66 86.0 0.382 H -54.0 -63.1 18.0 0.08 0.302 F:P37268:0.302
 ER4
HOH
 8.315
2.927
 O
NH2
 CAE
O
ARG E:56 E:66 90.0 0.4 H -51.3 -63.9 0.0 0.0 0.4 D:P37268:0.4
 ER4
HOH
 8.335
2.850
 O
NH2
 CAE
O
ARG F:56 F:66 86.0 0.382 H -46.3 -68.6 3.0 0.013 0.369 E:P37268:0.369
 ER4
HOH
 8.329
3.223
 O
NE
 CAE
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 ARG A:56 A:66 82.0 0.364 H -45.6 -68.6 2.0 0.009 0.355 C:P37268:0.356
 HOH
 3.207
 CB
 O
ARG B:56 B:66 67.0 0.298 H -47.7 -73.7 30.0 0.133 0.165 A:P37268:0.164
 HOH
 7.442
 CD
 O
ARG C:56 C:66 77.0 0.342 H -48.2 -59.8 4.0 0.018 0.324 B:P37268:0.324
 HOH
 5.617
 N
 O
ARG D:56 D:66 83.0 0.369 H -48.9 -63.3 17.0 0.076 0.293 F:P37268:0.293
 HOH
 3.836
 NE
 O
ARG E:56 E:66 77.0 0.342 H -56.4 -69.2 0.0 0.0 0.342 D:P37268:0.342
 HOH
 7.994
 NH2
 O
ARG F:56 F:66 79.0 0.351 H -45.9 -60.0 4.0 0.018 0.333 E:P37268:0.333
 HOH
 7.602
 CD
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 ARG A:66 A:66 40.0 0.178 H -54.2 -47.6