Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11667207 . C A CCDS5985.1:NM_004462.3:c.229Cga>Aga_NP_004453.3:p.77R>R Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:47 A:77 65.0 0.289 H -58.5 -43.9 65.0 0.289 0.0 D99
HOH
 6.510
3.493
 NH2
CD
 C26
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 ARG A:47 A:77 59.0 0.262 H -64.6 -42.8 59.0 0.262 0.0 B65
MG
HOH
 3.027
7.036
4.268
 NH2
NH1
NH2
 OAD
MG
O
ARG B:47 B:77 65.0 0.289 H -66.9 -50.6 NA NA NA
ARG C:47 C:77 48.0 0.213 H -62.2 -42.8 NA NA NA
ARG D:47 D:77 49.0 0.218 H -78.1 -48.7 NA NA NA
ARG E:47 E:77 18.0 NA H -56.2 -62.1 NA NA NA
ARG F:47 F:77 65.0 0.289 H -63.2 -46.4 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:47 A:77 50.0 0.222 H -56.4 -46.3 50.0 0.222 0.0 D9A
HOH
 6.785
3.641
 N
CD
 C9
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:47 A:77 86.0 0.382 H -66.1 -35.3 86.0 0.382 0.0 MG
MG
D61
HOH
 6.112
3.906
2.622
3.541
 NH1
NH1
NH2
CD
 MG
MG
O18
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 ARG A:47 A:77 48.0 0.213 H -56.6 -47.3 48.0 0.213 0.0 D3A
HOH
 6.664
2.675
 N
NE
 C14
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:50 A:77 68.0 0.302 H -65.4 -39.9 68.0 0.302 0.0 HOH
 3.600
 N
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:50 A:77 49.0 0.218 H -63.0 -41.2 49.0 0.218 0.0 CA
HOH
 6.141
2.985
 NH2
NH2
 CA
O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:50 A:77 44.0 0.196 H -64.1 -40.3 44.0 0.196 0.0 HOH
 3.329
 NH1
 O
ARG B:50 B:77 56.0 0.249 H -63.3 -38.7 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:50 A:77 48.0 0.213 H -58.1 -42.0 48.0 0.213 0.0 HOH
 2.944
 NH2
 O
ARG B:50 B:77 64.0 0.284 H -63.3 -44.2 64.0 0.284 0.0 HOH
 3.200
 NE
 O
ARG C:50 C:77 57.0 0.253 H -60.0 -43.1 57.0 0.253 0.0 HOH
 5.033
 CD
 O
ARG D:50 D:77 65.0 0.289 H -56.6 -39.3 NA NA NA
ARG E:50 E:77 66.0 0.293 H -67.9 -38.6 NA NA NA
ARG F:50 F:77 48.0 0.213 H -67.4 -32.5 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:50 A:77 45.0 0.2 H -60.2 -40.6 45.0 0.2 0.0 ZGA
HOH
 2.832
2.957
 NH1
NE
 OAP
O
ARG B:50 B:77 44.0 0.196 H -63.2 -41.9 44.0 0.196 0.0 ZGA
HOH
 2.653
3.364
 NH1
NE
 OAP
O
ARG C:50 C:77 42.0 0.187 H -60.3 -42.6 42.0 0.187 0.0 ZGA
HOH
 2.652
3.120
 NH2
NH2
 OAI
O
ARG D:50 D:77 41.0 0.182 H -60.7 -40.2 NA NA NA
ARG E:50 E:77 62.0 0.276 H -59.0 -41.5 NA NA NA
ARG F:50 F:77 52.0 0.231 H -65.5 -42.1 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 45.0 0.2 H -66.1 -37.5 45.0 0.2 0.0 FPS
FPS
HOH
 3.607
3.576
2.648
 NH2
NH2
NH1
 O3A
C9
O
ARG B:50 B:77 47.0 0.209 H -61.8 -45.2 47.0 0.209 0.0 FPS
FPS
HOH
 2.593
3.695
6.828
 NH2
CZ
NH1
 O1A
C9
O
ARG C:50 C:77 58.0 0.258 H -60.8 -41.5 58.0 0.258 0.0 FPS
 2.980
 NH2
 O1A
ARG D:50 D:77 47.0 0.209 H -61.0 -43.0 NA NA NA
ARG E:50 E:77 63.0 0.28 H -62.6 -44.1 NA NA NA
ARG F:50 F:77 68.0 0.302 H -69.6 -32.2 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 61.0 0.271 H -59.8 -43.5 61.0 0.271 0.0 MG
MG
MG
FPS
FPS
HOH
 8.791
6.683
3.755
2.610
3.597
3.546
 NH1
NH1
NH1
NH2
NH2
NE
 MG
MG
MG
O2B
C9
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 64.0 0.284 H -62.4 -41.9 64.0 0.284 0.0 MG
MG
PS7
HOH
 4.549
6.984
2.591
2.958
 NH1
NH1
NH2
NH1
 MG
MG
OAM
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 66.0 0.293 H -60.9 -42.7 66.0 0.293 0.0 MG
PS7
HOH
 6.825
3.615
2.879
 NH1
N
NE
 MG
CAE
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 66.0 0.293 H -62.1 -46.9 66.0 0.293 0.0 MN
MN
MN
PS7
HOH
 8.755
6.564
4.197
3.524
3.797
 NH1
NH1
NH1
NH1
NH1
 MN
MN
MN
OAJ
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:50 A:77 72.0 0.32 H -67.6 -39.4 72.0 0.32 0.0 MG
MG
PS7
HOH
 5.813
7.877
2.751
4.064
 CZ
O
NH2
NH2
 MG
MG
OAL
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 ARG A:47 A:77 64.0 0.284 H -72.4 -42.4 64.0 0.284 0.0 IN0
HOH
 5.361
6.245
 NH2
N
 O63
O
ARG B:47 B:77 60.0 0.267 H -60.7 -43.3 NA NA NA
ARG C:47 C:77 75.0 0.333 H -61.7 -37.5 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 53.0 0.236 H -54.8 -40.8 53.0 0.236 0.0 FPS
HOH
 3.027
3.356
 NH1
CZ
 O1A
O
ARG B:67 B:77 56.0 0.249 H -68.1 -41.9 56.0 0.249 0.0 FPS
HOH
 3.220
3.272
 NH1
NH1
 O1A
O
ARG C:67 C:77 68.0 0.302 H -56.6 -45.7 68.0 0.302 0.0 FPS
HOH
 3.225
3.930
 NH2
NH2
 O1A
O
ARG D:67 D:77 60.0 0.267 H -62.4 -41.4 60.0 0.267 0.0 FPS
FPS
HOH
 3.003
3.406
7.088
 NH2
NH1
NH1
 O1A
C2
O
ARG E:67 E:77 53.0 0.236 H -68.0 -52.7 53.0 0.236 0.0 FPS
HOH
 3.476
4.562
 NH2
NH2
 O1A
O
ARG F:67 F:77 54.0 0.24 H -76.7 -40.2 54.0 0.24 0.0 FPS
HOH
 3.023
4.000
 NH2
NH2
 O1A
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 42.0 0.187 H -62.4 -38.4 42.0 0.187 0.0 RWY
HOH
 3.976
4.351
 NH1
CB
 NAA
O
ARG B:67 B:77 51.0 0.227 H -62.7 -38.7 51.0 0.227 0.0 RWY
HOH
 4.133
4.858
 NH1
NH2
 NAA
O
ARG C:67 C:77 50.0 0.222 H -64.9 -49.6 50.0 0.222 0.0 HOH
 4.100
 CG
 O
ARG D:67 D:77 74.0 0.329 H -67.7 -46.8 74.0 0.329 0.0 RWY
HOH
 4.283
4.082
 NH1
NH2
 NAA
O
ARG E:67 E:77 53.0 0.236 H -67.3 -39.6 53.0 0.236 0.0 RWY
HOH
 3.400
6.351
 NH1
NH1
 NAA
O
ARG F:67 F:77 48.0 0.213 H -75.7 -29.6 48.0 0.213 0.0 HOH
 3.660
 NH1
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 30.0 0.133 H -60.1 -42.7 30.0 0.133 0.0 BH8
HOH
 2.711
5.642
 NH1
NH1
 OAB
O
ARG B:67 B:77 49.0 0.218 H -65.1 -35.8 49.0 0.218 0.0 BH8
HOH
 3.866
2.706
 NH2
NH1
 OAC
O
ARG C:67 C:77 51.0 0.227 H -65.5 -38.0 51.0 0.227 0.0 BH8
HOH
 4.897
4.265
 NH2
NH1
 OAE
O
ARG D:67 D:77 51.0 0.227 H -70.2 -38.0 51.0 0.227 0.0 BH8
HOH
 4.169
3.630
 NH2
NH2
 OAG
O
ARG E:67 E:77 46.0 0.204 H -64.1 -44.1 46.0 0.204 0.0 BH8
HOH
 4.727
5.093
 NH2
N
 OAC
O
ARG F:67 F:77 49.0 0.218 H -70.2 -37.4 49.0 0.218 0.0 BH8
HOH
 4.247
8.720
 NH2
NH2
 CAT
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 34.0 0.151 H -66.9 -42.5 34.0 0.151 0.0 8PH
8PH
8PH
HOH
 2.598
7.493
5.312
3.110
 NH1
N
NH1
NH1
 OAG
CAL
OAH
O
ARG B:67 B:77 46.0 0.204 H -62.2 -41.1 46.0 0.204 0.0 8PH
8PH
HOH
 3.945
7.513
3.514
 NH2
N
N
 OAG
CAA
O
ARG C:67 C:77 36.0 0.16 H -67.6 -46.2 36.0 0.16 0.0 8PH
HOH
 3.484
3.651
 NH2
NH1
 OAG
O
ARG D:67 D:77 46.0 0.204 H -64.3 -46.8 46.0 0.204 0.0 8PH
HOH
 3.862
2.916
 NH1
NH2
 OAC
O
ARG E:67 E:77 56.0 0.249 H -60.9 -43.1 56.0 0.249 0.0 8PH
HOH
 5.271
3.413
 NH2
NH2
 CAU
O
ARG F:67 F:77 35.0 0.156 H -67.6 -45.9 35.0 0.156 0.0 8PH
8PH
HOH
 3.196
6.685
5.143
 NH1
NH1
NH1
 OAG
OAB
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 35.0 0.156 H -64.8 -37.6 35.0 0.156 0.0 BH5
HOH
 2.885
3.206
 NH1
NH1
 CAY
O
ARG B:67 B:77 50.0 0.222 H -68.5 -31.0 50.0 0.222 0.0 BH5
HOH
 2.879
3.124
 NH1
NH2
 CAY
O
ARG C:67 C:77 62.0 0.276 H -64.7 -39.1 62.0 0.276 0.0 BH5
HOH
 2.840
4.035
 NH2
NH1
 NBA
O
ARG D:67 D:77 52.0 0.231 H -63.3 -48.3 52.0 0.231 0.0 BH5
HOH
 2.753
4.075
 NH2
NH1
 NBA
O
ARG E:67 E:77 49.0 0.218 H -51.0 -49.7 49.0 0.218 0.0 BH5
HOH
 3.054
7.614
 NE
NH2
 CAY
O
ARG F:67 F:77 41.0 0.182 H -66.1 -46.0 41.0 0.182 0.0 BH5
HOH
 2.965
3.470
 NE
NH2
 CAY
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 30.0 0.133 H -60.0 -43.6 30.0 0.133 0.0 E5S
HOH
 4.347
5.006
 N
NH1
 CAN
O
ARG B:67 B:77 50.0 0.222 H -61.7 -39.7 50.0 0.222 0.0 E5S
HOH
 4.397
3.058
 NH1
NH2
 CAO
O
ARG C:67 C:77 46.0 0.204 H -62.9 -38.4 46.0 0.204 0.0 E5S
HOH
 4.034
3.658
 NH2
NH2
 CAO
O
ARG D:67 D:77 46.0 0.204 H -62.4 -41.8 46.0 0.204 0.0 E5S
HOH
 4.303
3.889
 N
NH2
 CAN
O
ARG E:67 E:77 35.0 0.156 H -61.3 -49.4 35.0 0.156 0.0 E5S
HOH
 3.957
3.251
 NH2
NH1
 CAM
O
ARG F:67 F:77 55.0 0.244 H -66.7 -49.1 55.0 0.244 0.0 E5S
HOH
 4.198
4.159
 NH1
NH1
 CAM
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 31.0 0.138 H -64.4 -40.0 31.0 0.138 0.0 BH3
HOH
 2.970
3.248
 NH1
CD
 CAX
O
ARG B:67 B:77 55.0 0.244 H -65.5 -42.1 55.0 0.244 0.0 HOH
 2.629
 NE
 O
ARG C:67 C:77 44.0 0.196 H -61.3 -46.7 44.0 0.196 0.0 HOH
 3.830
 CA
 O
ARG D:67 D:77 49.0 0.218 H -71.7 -46.3 49.0 0.218 0.0 HOH
 3.639
 NH1
 O
ARG E:67 E:77 48.0 0.213 H -61.7 -42.2 48.0 0.213 0.0 HOH
 4.319
 NH1
 O
ARG F:67 F:77 47.0 0.209 H -61.2 -47.0 47.0 0.209 0.0 HOH
 3.574
 N
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:67 A:77 31.0 0.138 H -61.1 -42.4 31.0 0.138 0.0 ER4
HOH
 3.233
2.965
 NH1
NH1
 CAR
O
ARG B:67 B:77 37.0 0.164 H -64.2 -40.2 37.0 0.164 0.0 ER4
HOH
 3.375
2.830
 CD
CD
 CAP
O
ARG C:67 C:77 38.0 0.169 H -66.0 -42.2 38.0 0.169 0.0 ER4
HOH
 3.344
2.560
 NH1
NH1
 CAR
O
ARG D:67 D:77 44.0 0.196 H -68.5 -40.0 44.0 0.196 0.0 ER4
HOH
 3.424
4.819
 CD
NH1
 CAP
O
ARG E:67 E:77 30.0 0.133 H -60.6 -46.7 30.0 0.133 0.0 ER4
HOH
 3.360
3.595
 CD
NE
 CAP
O
ARG F:67 F:77 36.0 0.16 H -68.2 -42.0 36.0 0.16 0.0 ER4
HOH
 3.489
3.910
 NH2
NH2
 CAR
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 ARG A:67 A:77 42.0 0.187 H -61.8 -41.2 42.0 0.187 0.0 RWZ
HOH
 4.010
8.157
 N
N
 CAK
O
ARG B:67 B:77 33.0 0.147 H -78.6 -35.8 33.0 0.147 0.0 RWZ
HOH
 3.780
8.208
 N
N
 CAK
O
ARG C:67 C:77 62.0 0.276 H -69.2 -55.1 62.0 0.276 0.0 RWZ
HOH
 3.831
6.565
 NE
NH1
 CAU
O
ARG D:67 D:77 66.0 0.293 H -68.5 -54.9 66.0 0.293 0.0 HOH
 5.523
 N
 O
ARG E:67 E:77 62.0 0.276 H -66.2 -47.0 62.0 0.276 0.0 RWZ
HOH
 3.217
7.328
 NH1
NH1
 CAM
O
ARG F:67 F:77 36.0 0.16 H -69.1 -44.1 36.0 0.16 0.0 HOH
 4.367
 NE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 ARG A:77 A:77 49.0 0.218 H -62.5 -38.5