Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11667274 . A C CCDS5985.1:NM_004462.3:c.296aAc>aCc_NP_004453.3:p.99N>T Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ASN A:69 A:99 74.0 0.463 H -94.1 0.2 74.0 0.463 0.0 HOH
 3.054
 OD1
 O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 ASN A:69 A:99 78.0 0.487 H -87.9 5.4 78.0 0.487 0.0 HOH
 4.497
 C
 O
ASN B:69 B:99 83.0 0.519 T -109.0 9.7 NA NA NA
ASN C:69 C:99 73.0 0.456 T -100.7 17.4 NA NA NA
ASN D:69 D:99 70.0 0.438 T -121.6 23.4 NA NA NA
ASN E:69 E:99 82.0 0.512 T -100.0 34.7 NA NA NA
ASN F:69 F:99 71.0 0.444 T -104.8 44.2 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ASN A:69 A:99 75.0 0.469 H -99.4 0.1 75.0 0.469 0.0 HOH
 3.529
 ND2
 O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ASN A:69 A:99 72.0 0.45 H -99.9 -2.7 72.0 0.45 0.0 HOH
 2.926
 ND2
 O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 ASN A:69 A:99 75.0 0.469 H -95.4 -0.0 75.0 0.469 0.0 HOH
 2.949
 ND2
 O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ASN A:72 A:99 75.0 0.469 H -100.1 0.7 75.0 0.469 0.0 HOH
 2.921
 ND2
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ASN A:72 A:99 86.0 0.537 H -107.2 10.7 86.0 0.537 0.0 HOH
 3.161
 OD1
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ASN A:72 A:99 85.0 0.531 T -110.7 10.7 85.0 0.531 0.0 NI
HOH
 5.881
2.881
 OD1
OD1
 NI
O
ASN B:72 B:99 83.0 0.519 H -101.3 4.6 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ASN A:72 A:99 73.0 0.456 H -100.6 -2.0 73.0 0.456 0.0 HOH
 2.593
 ND2
 O
ASN B:72 B:99 74.0 0.463 H -97.9 -7.7 74.0 0.463 0.0 HOH
 3.031
 ND2
 O
ASN C:72 C:99 74.0 0.463 H -97.8 -1.0 74.0 0.463 0.0 HOH
 2.659
 OD1
 O
ASN D:72 D:99 75.0 0.469 H -93.4 -3.9 NA NA NA
ASN E:72 E:99 80.0 0.5 H -102.1 2.7 NA NA NA
ASN F:72 F:99 78.0 0.487 T -89.8 2.7 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ASN A:72 A:99 77.0 0.481 H -97.6 -0.6 77.0 0.481 0.0 HOH
 2.866
 ND2
 O
ASN B:72 B:99 72.0 0.45 H -96.7 -2.8 72.0 0.45 0.0 HOH
 4.110
 OD1
 O
ASN C:72 C:99 75.0 0.469 H -96.8 1.4 75.0 0.469 0.0 HOH
 2.691
 OD1
 O
ASN D:72 D:99 73.0 0.456 H -93.0 -2.0 NA NA NA
ASN E:72 E:99 75.0 0.469 H -96.7 -9.1 NA NA NA
ASN F:72 F:99 69.0 0.431 T -100.8 -0.5 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 73.0 0.456 H -97.1 -1.1 73.0 0.456 0.0 HOH
 2.937
 ND2
 O
ASN B:72 B:99 74.0 0.463 H -94.0 -0.7 74.0 0.463 0.0 HOH
 3.421
 ND2
 O
ASN C:72 C:99 76.0 0.475 H -98.9 1.3 76.0 0.475 0.0 HOH
 3.027
 ND2
 O
ASN D:72 D:99 78.0 0.487 T -96.7 19.4 NA NA NA
ASN E:72 E:99 76.0 0.475 H -103.1 -2.3 NA NA NA
ASN F:72 F:99 78.0 0.487 H -85.0 -5.9 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 76.0 0.475 H -96.9 -1.6 76.0 0.475 0.0 HOH
 4.259
 C
 O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 74.0 0.463 H -100.7 -7.0 74.0 0.463 0.0 HOH
 3.153
 ND2
 O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 76.0 0.475 H -111.2 4.7 76.0 0.475 0.0 HOH
 3.284
 OD1
 O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 74.0 0.463 H -99.5 -0.3 74.0 0.463 0.0 HOH
 4.029
 CB
 O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ASN A:72 A:99 74.0 0.463 S -97.7 -0.4 74.0 0.463 0.0 HOH
 3.809
 CB
 O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 ASN A:69 A:99 76.0 0.475 H -90.4 3.5 76.0 0.475 0.0 HOH
 3.226
 OD1
 O
ASN B:69 B:99 73.0 0.456 H -97.7 5.4 NA NA NA
ASN C:69 C:99 73.0 0.456 H -88.0 -5.0 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 77.0 0.481 H -101.7 7.2 77.0 0.481 0.0 HOH
 3.316
 ND2
 O
ASN B:89 B:99 73.0 0.456 H -96.6 0.9 73.0 0.456 0.0 HOH
 5.320
 N
 O
ASN C:89 C:99 70.0 0.438 H -103.2 5.3 70.0 0.438 0.0 HOH
 6.523
 OD1
 O
ASN D:89 D:99 76.0 0.475 T -106.8 22.3 76.0 0.475 0.0 HOH
 6.835
 ND2
 O
ASN E:89 E:99 89.0 0.556 T -80.4 33.1 89.0 0.556 0.0
ASN F:89 F:99 63.0 0.394 H -96.4 2.5 63.0 0.394 0.0
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 76.0 0.475 H -95.4 -1.5 76.0 0.475 0.0 HOH
 2.969
 ND2
 O
ASN B:89 B:99 77.0 0.481 H -98.1 1.9 77.0 0.481 0.0 HOH
 4.182
 C
 O
ASN C:89 C:99 76.0 0.475 H -96.2 0.1 76.0 0.475 0.0 HOH
 4.473
 CG
 O
ASN D:89 D:99 77.0 0.481 H -109.2 0.4 77.0 0.481 0.0 HOH
 3.102
 ND2
 O
ASN E:89 E:99 79.0 0.494 T -96.2 23.3 79.0 0.494 0.0
ASN F:89 F:99 72.0 0.45 H -107.7 5.8 72.0 0.45 0.0 HOH
 6.030
 ND2
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 76.0 0.475 H -96.6 3.9 76.0 0.475 0.0 HOH
 2.624
 OD1
 O
ASN B:89 B:99 74.0 0.463 H -97.2 -2.9 74.0 0.463 0.0 HOH
 2.606
 OD1
 O
ASN C:89 C:99 74.0 0.463 H -95.3 2.3 74.0 0.463 0.0 HOH
 2.636
 ND2
 O
ASN D:89 D:99 79.0 0.494 H -99.9 4.3 79.0 0.494 0.0 HOH
 2.875
 OD1
 O
ASN E:89 E:99 77.0 0.481 T -100.5 16.3 77.0 0.481 0.0
ASN F:89 F:99 76.0 0.475 H -96.0 -4.8 76.0 0.475 0.0
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 75.0 0.469 T -106.1 13.9 75.0 0.469 0.0 HOH
 3.133
 OD1
 O
ASN B:89 B:99 78.0 0.487 H -104.9 0.4 78.0 0.487 0.0 HOH
 4.120
 C
 O
ASN C:89 C:99 77.0 0.481 H -94.8 -5.6 77.0 0.481 0.0 HOH
 4.103
 ND2
 O
ASN D:89 D:99 74.0 0.463 H -105.6 2.6 74.0 0.463 0.0 HOH
 4.187
 C
 O
ASN E:89 E:99 79.0 0.494 H -104.7 10.8 79.0 0.494 0.0 HOH
 4.140
 C
 O
ASN F:89 F:99 77.0 0.481 H -103.4 0.5 77.0 0.481 0.0 HOH
 4.076
 C
 O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 74.0 0.463 H -98.8 -0.8 74.0 0.463 0.0 HOH
 2.970
 ND2
 O
ASN B:89 B:99 75.0 0.469 H -98.5 -1.6 75.0 0.469 0.0 HOH
 2.715
 OD1
 O
ASN C:89 C:99 73.0 0.456 H -97.4 -2.5 73.0 0.456 0.0 HOH
 2.907
 ND2
 O
ASN D:89 D:99 75.0 0.469 H -105.0 8.3 75.0 0.469 0.0 HOH
 4.424
 C
 O
ASN E:89 E:99 80.0 0.5 S -104.0 18.0 80.0 0.5 0.0 HOH
 3.458
 OD1
 O
ASN F:89 F:99 72.0 0.45 H -106.3 3.8 72.0 0.45 0.0 HOH
 4.233
 C
 O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 75.0 0.469 H -100.9 5.2 75.0 0.469 0.0 HOH
 2.536
 OD1
 O
ASN B:89 B:99 75.0 0.469 H -101.8 -0.7 75.0 0.469 0.0 HOH
 2.619
 OD1
 O
ASN C:89 C:99 77.0 0.481 H -101.2 -5.3 77.0 0.481 0.0 HOH
 3.098
 ND2
 O
ASN D:89 D:99 76.0 0.475 H -102.3 2.0 76.0 0.475 0.0 HOH
 4.210
 C
 O
ASN E:89 E:99 81.0 0.506 T -109.4 24.6 81.0 0.506 0.0
ASN F:89 F:99 74.0 0.463 H -99.8 -5.0 74.0 0.463 0.0
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 75.0 0.469 H -98.0 4.2 75.0 0.469 0.0 HOH
 2.709
 OD1
 O
ASN B:89 B:99 75.0 0.469 H -99.9 1.3 75.0 0.469 0.0 HOH
 2.663
 OD1
 O
ASN C:89 C:99 74.0 0.463 H -101.7 -1.1 74.0 0.463 0.0 HOH
 3.355
 ND2
 O
ASN D:89 D:99 76.0 0.475 H -101.9 1.4 76.0 0.475 0.0 HOH
 4.084
 C
 O
ASN E:89 E:99 76.0 0.475 T -102.6 10.4 76.0 0.475 0.0 HOH
 4.375
 C
 O
ASN F:89 F:99 74.0 0.463 H -109.2 5.9 74.0 0.463 0.0 HOH
 2.746
 ND2
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ASN A:89 A:99 76.0 0.475 H -94.7 -3.0 76.0 0.475 0.0 HOH
 2.798
 ND2
 O
ASN B:89 B:99 75.0 0.469 H -98.2 0.7 75.0 0.469 0.0 HOH
 2.541
 OD1
 O
ASN C:89 C:99 75.0 0.469 H -100.7 -2.5 75.0 0.469 0.0 HOH
 2.937
 ND2
 O
ASN D:89 D:99 80.0 0.5 H -100.7 3.5 80.0 0.5 0.0 HOH
 2.752
 OD1
 O
ASN E:89 E:99 79.0 0.494 H -103.2 8.1 79.0 0.494 0.0 HOH
 2.672
 OD1
 O
ASN F:89 F:99 75.0 0.469 H -105.3 -0.1 75.0 0.469 0.0
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 ASN A:89 A:99 78.0 0.487 H -105.7 4.0 78.0 0.487 0.0 HOH
 3.863
 OD1
 O
ASN B:89 B:99 77.0 0.481 H -110.2 7.4 77.0 0.481 0.0 HOH
 7.096
 O
 O
ASN C:89 C:99 80.0 0.5 H -102.1 8.3 80.0 0.5 0.0
ASN D:89 D:99 73.0 0.456 H -120.0 9.2 73.0 0.456 0.0 HOH
 8.488
 ND2
 O
ASN E:89 E:99 83.0 0.519 T -109.4 40.3 83.0 0.519 0.0
ASN F:89 F:99 75.0 0.469 H -104.2 -5.1 75.0 0.469 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 ASN A:99 A:99 77.0 0.481 H -98.1 2.3