Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 11679320 | . | G | A | CCDS5985.1:NM_004462.3:c.443cGg>cAg_NP_004453.3:p.148R>Q | Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
3asx | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | ARG | A:118 | A:148 | 94.0 | 0.418 | H | -57.7 | -48.7 | 94.0 | 0.418 | 0.0 |
PO4 HOH |
5.652 2.563 |
NH1 NE |
O1 O |
||
3lee | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2010-12-08 | ARG | A:118 | A:148 | 98.0 | 0.436 | H | -66.1 | -31.2 | 98.0 | 0.436 | 0.0 |
HOH |
3.334 |
CA |
O |
||
ARG | B:118 | B:148 | 99.0 | 0.44 | H | -77.7 | -41.1 | NA | NA | NA | |||||||||||||
ARG | C:118 | C:148 | 95.0 | 0.422 | H | -67.9 | -56.8 | NA | NA | NA | |||||||||||||
ARG | D:118 | D:148 | 99.0 | 0.44 | H | -72.1 | -50.5 | NA | NA | NA | |||||||||||||
ARG | E:118 | E:148 | 98.0 | 0.436 | H | -58.8 | -45.9 | NA | NA | NA | |||||||||||||
ARG | F:118 | F:148 | 87.0 | 0.387 | H | -65.2 | -59.3 | NA | NA | NA | |||||||||||||
3q2z | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | ARG | A:118 | A:148 | 98.0 | 0.436 | H | -59.0 | -46.5 | 98.0 | 0.436 | 0.0 |
PO4 HOH |
5.681 2.680 |
NH1 NE |
O1 O |
||
3q30 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | ARG | A:118 | A:148 | 100.0 | 0.444 | H | -60.0 | -48.7 | 100.0 | 0.444 | 0.0 |
PO4 HOH |
5.596 2.594 |
NH1 NH1 |
O1 O |
||
3v66 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-12-19 | ARG | A:118 | A:148 | 98.0 | 0.436 | H | -64.8 | -46.5 | 98.0 | 0.436 | 0.0 |
PO4 HOH |
5.655 2.576 |
NH1 NH2 |
O1 O |
||
3vj8 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | ARG | A:121 | A:148 | 92.0 | 0.409 | H | -59.6 | -48.8 | 92.0 | 0.409 | 0.0 |
HOH |
2.863 |
O |
O |
||
3vj9 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | ARG | A:121 | A:148 | 102.0 | 0.453 | H | -59.5 | -51.8 | 102.0 | 0.453 | 0.0 |
HOH |
2.783 |
O |
O |
||
3vja | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | ARG | A:121 | A:148 | 102.0 | 0.453 | H | -58.1 | -51.6 | 102.0 | 0.453 | 0.0 |
NI HOH |
9.695 2.323 |
O NH1 |
NI O |
||
ARG | B:121 | B:148 | 84.0 | 0.373 | H | -62.1 | -50.9 | NA | NA | NA | |||||||||||||
3vjb | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | ARG | A:121 | A:148 | 100.0 | 0.444 | H | -58.7 | -47.4 | 100.0 | 0.444 | 0.0 |
HOH |
2.771 |
NH1 |
O |
||
ARG | B:121 | B:148 | 95.0 | 0.422 | H | -60.6 | -51.4 | 95.0 | 0.422 | 0.0 |
HOH |
2.930 |
NH1 |
O |
|||||||||
ARG | C:121 | C:148 | 95.0 | 0.422 | H | -62.0 | -50.5 | 95.0 | 0.422 | 0.0 |
HOH |
2.843 |
O |
O |
|||||||||
ARG | D:121 | D:148 | 89.0 | 0.396 | H | -67.1 | -53.4 | NA | NA | NA | |||||||||||||
ARG | E:121 | E:148 | 102.0 | 0.453 | H | -57.5 | -52.8 | NA | NA | NA | |||||||||||||
ARG | F:121 | F:148 | 107.0 | 0.476 | H | -63.9 | -52.2 | NA | NA | NA | |||||||||||||
3vjc | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | ARG | A:121 | A:148 | 103.0 | 0.458 | H | -57.1 | -51.7 | 103.0 | 0.458 | 0.0 |
PO4 HOH |
5.752 2.562 |
NH1 NE |
O2 O |
||
ARG | B:121 | B:148 | 97.0 | 0.431 | H | -63.5 | -49.6 | 97.0 | 0.431 | 0.0 |
PO4 HOH |
5.813 2.711 |
NH1 NH2 |
O2 O |
|||||||||
ARG | C:121 | C:148 | 95.0 | 0.422 | H | -64.9 | -46.1 | 95.0 | 0.422 | 0.0 |
PO4 HOH |
5.853 2.743 |
NH1 NE |
O2 O |
|||||||||
ARG | D:121 | D:148 | 96.0 | 0.427 | H | -61.0 | -54.5 | NA | NA | NA | |||||||||||||
ARG | E:121 | E:148 | 98.0 | 0.436 | H | -58.0 | -51.1 | NA | NA | NA | |||||||||||||
ARG | F:121 | F:148 | 88.0 | 0.391 | H | -70.0 | -58.4 | NA | NA | NA | |||||||||||||
3wef | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 101.0 | 0.449 | H | -53.7 | -55.4 | 101.0 | 0.449 | 0.0 |
HOH |
2.854 |
NE |
O |
||
ARG | B:121 | B:148 | 98.0 | 0.436 | H | -60.1 | -49.3 | 98.0 | 0.436 | 0.0 |
HOH |
2.996 |
NH1 |
O |
|||||||||
ARG | C:121 | C:148 | 96.0 | 0.427 | H | -62.5 | -52.7 | 96.0 | 0.427 | 0.0 |
HOH |
2.662 |
NH2 |
O |
|||||||||
ARG | D:121 | D:148 | 95.0 | 0.422 | H | -46.3 | -63.7 | NA | NA | NA | |||||||||||||
ARG | E:121 | E:148 | 102.0 | 0.453 | H | -68.8 | -44.7 | NA | NA | NA | |||||||||||||
ARG | F:121 | F:148 | 97.0 | 0.431 | H | -70.8 | -55.3 | NA | NA | NA | |||||||||||||
3weg | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 89.0 | 0.396 | H | -57.9 | -49.8 | 89.0 | 0.396 | 0.0 |
HOH |
2.903 |
O |
O |
||
3weh | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 93.0 | 0.413 | H | -62.5 | -48.7 | 93.0 | 0.413 | 0.0 |
HOH |
2.409 |
NH1 |
O |
||
3wek | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 90.0 | 0.4 | H | -60.6 | -47.9 | 90.0 | 0.4 | 0.0 |
HOH |
3.399 |
CA |
O |
||
3wei | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 94.0 | 0.418 | H | -60.9 | -49.6 | 94.0 | 0.418 | 0.0 |
HOH |
2.821 |
O |
O |
||
3wej | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | ARG | A:121 | A:148 | 109.0 | 0.484 | H | -62.4 | -47.4 | 109.0 | 0.484 | 0.0 |
HOH |
2.941 |
O |
O |
||
1ezf | 1 | P37268 | 99.12 | 0.0 |
X-RAY |
2000-10-18 | ARG | A:118 | A:148 | 94.0 | 0.418 | H | -65.7 | -53.0 | 94.0 | 0.418 | 0.0 |
HOH |
2.794 |
O |
O |
||
ARG | B:118 | B:148 | 88.0 | 0.391 | H | -64.7 | -48.4 | NA | NA | NA | |||||||||||||
ARG | C:118 | C:148 | 105.0 | 0.467 | H | -65.8 | -56.7 | NA | NA | NA | |||||||||||||
3wc9 | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 103.0 | 0.458 | H | -66.2 | -51.3 | 103.0 | 0.458 | 0.0 |
HOH |
3.672 |
NH1 |
O |
||
ARG | B:138 | B:148 | 88.0 | 0.391 | H | -65.7 | -46.7 | 88.0 | 0.391 | 0.0 |
HOH |
3.428 |
NH2 |
O |
|||||||||
ARG | C:138 | C:148 | 97.0 | 0.431 | H | -59.8 | -51.7 | 97.0 | 0.431 | 0.0 |
HOH |
3.390 |
CG |
O |
|||||||||
ARG | D:138 | D:148 | 96.0 | 0.427 | H | -78.5 | -41.5 | 96.0 | 0.427 | 0.0 |
HOH |
7.345 |
O |
O |
|||||||||
ARG | E:138 | E:148 | 97.0 | 0.431 | H | -70.9 | -65.0 | 97.0 | 0.431 | 0.0 | |||||||||||||
ARG | F:138 | F:148 | 99.0 | 0.44 | H | -47.1 | -59.1 | 99.0 | 0.44 | 0.0 |
HOH |
7.527 |
NH1 |
O |
|||||||||
3wcd | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 94.0 | 0.418 | H | -52.5 | -50.8 | 94.0 | 0.418 | 0.0 |
HOH |
3.533 |
NE |
O |
||
ARG | B:138 | B:148 | 97.0 | 0.431 | H | -62.4 | -65.2 | 97.0 | 0.431 | 0.0 |
HOH |
2.634 |
NH1 |
O |
|||||||||
ARG | C:138 | C:148 | 98.0 | 0.436 | H | -68.4 | -37.8 | 98.0 | 0.436 | 0.0 |
HOH |
3.046 |
NH2 |
O |
|||||||||
ARG | D:138 | D:148 | 104.0 | 0.462 | H | -63.7 | -51.1 | 104.0 | 0.462 | 0.0 |
HOH |
2.996 |
NE |
O |
|||||||||
ARG | E:138 | E:148 | 96.0 | 0.427 | H | -73.1 | -56.6 | 96.0 | 0.427 | 0.0 |
HOH |
3.783 |
NE |
O |
|||||||||
ARG | F:138 | F:148 | 94.0 | 0.418 | H | -60.7 | -61.2 | 94.0 | 0.418 | 0.0 |
HOH |
3.460 |
NH1 |
O |
|||||||||
3wcf | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 102.0 | 0.453 | H | -59.9 | -51.2 | 102.0 | 0.453 | 0.0 |
HOH |
2.770 |
NH2 |
O |
||
ARG | B:138 | B:148 | 94.0 | 0.418 | H | -61.2 | -56.1 | 94.0 | 0.418 | 0.0 |
HOH |
2.858 |
O |
O |
|||||||||
ARG | C:138 | C:148 | 97.0 | 0.431 | H | -60.7 | -54.8 | 97.0 | 0.431 | 0.0 |
HOH |
3.216 |
NH1 |
O |
|||||||||
ARG | D:138 | D:148 | 100.0 | 0.444 | H | -68.9 | -46.7 | 100.0 | 0.444 | 0.0 |
HOH |
3.557 |
CA |
O |
|||||||||
ARG | E:138 | E:148 | 91.0 | 0.404 | H | -72.0 | -55.5 | 91.0 | 0.404 | 0.0 |
HOH |
8.062 |
NH1 |
O |
|||||||||
ARG | F:138 | F:148 | 86.0 | 0.382 | H | -55.8 | -61.6 | 86.0 | 0.382 | 0.0 | |||||||||||||
3wch | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 99.0 | 0.44 | H | -63.1 | -44.4 | 99.0 | 0.44 | 0.0 |
HOH |
2.780 |
O |
O |
||
ARG | B:138 | B:148 | 92.0 | 0.409 | H | -59.1 | -53.4 | 92.0 | 0.409 | 0.0 |
HOH |
3.580 |
CA |
O |
|||||||||
ARG | C:138 | C:148 | 96.0 | 0.427 | H | -53.5 | -60.9 | 96.0 | 0.427 | 0.0 |
HOH |
2.809 |
NE |
O |
|||||||||
ARG | D:138 | D:148 | 100.0 | 0.444 | H | -57.6 | -52.9 | 100.0 | 0.444 | 0.0 |
HOH |
3.528 |
CA |
O |
|||||||||
ARG | E:138 | E:148 | 95.0 | 0.422 | H | -76.2 | -49.4 | 95.0 | 0.422 | 0.0 |
HOH |
3.976 |
CA |
O |
|||||||||
ARG | F:138 | F:148 | 101.0 | 0.449 | H | -63.7 | -54.6 | 101.0 | 0.449 | 0.0 |
HOH |
3.498 |
CA |
O |
|||||||||
3wci | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 99.0 | 0.44 | H | -60.4 | -53.6 | 99.0 | 0.44 | 0.0 |
HOH |
3.429 |
NH1 |
O |
||
ARG | B:138 | B:148 | 92.0 | 0.409 | H | -63.0 | -51.0 | 92.0 | 0.409 | 0.0 |
HOH |
2.744 |
O |
O |
|||||||||
ARG | C:138 | C:148 | 93.0 | 0.413 | H | -60.7 | -56.1 | 93.0 | 0.413 | 0.0 |
HOH |
2.761 |
NH2 |
O |
|||||||||
ARG | D:138 | D:148 | 107.0 | 0.476 | H | -63.6 | -50.3 | 107.0 | 0.476 | 0.0 |
HOH |
2.932 |
NE |
O |
|||||||||
ARG | E:138 | E:148 | 106.0 | 0.471 | H | -77.3 | -48.6 | 106.0 | 0.471 | 0.0 |
HOH |
2.656 |
NH2 |
O |
|||||||||
ARG | F:138 | F:148 | 96.0 | 0.427 | H | -64.6 | -56.9 | 96.0 | 0.427 | 0.0 |
HOH |
2.737 |
NH2 |
O |
|||||||||
3wcj | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 97.0 | 0.431 | H | -56.9 | -55.6 | 97.0 | 0.431 | 0.0 |
HOH |
2.552 |
NH2 |
O |
||
ARG | B:138 | B:148 | 96.0 | 0.427 | H | -67.0 | -54.1 | 96.0 | 0.427 | 0.0 |
HOH |
2.750 |
O |
O |
|||||||||
ARG | C:138 | C:148 | 95.0 | 0.422 | H | -64.0 | -50.9 | 95.0 | 0.422 | 0.0 |
HOH |
3.146 |
NE |
O |
|||||||||
ARG | D:138 | D:148 | 97.0 | 0.431 | H | -62.9 | -47.8 | 97.0 | 0.431 | 0.0 |
HOH |
3.327 |
NH2 |
O |
|||||||||
ARG | E:138 | E:148 | 96.0 | 0.427 | H | -68.8 | -58.5 | 96.0 | 0.427 | 0.0 |
HOH |
8.890 |
NH1 |
O |
|||||||||
ARG | F:138 | F:148 | 98.0 | 0.436 | H | -58.0 | -55.7 | 98.0 | 0.436 | 0.0 |
HOH |
4.652 |
NH1 |
O |
|||||||||
3wcl | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 101.0 | 0.449 | H | -58.1 | -56.7 | 101.0 | 0.449 | 0.0 |
HOH |
2.554 |
NH2 |
O |
||
ARG | B:138 | B:148 | 100.0 | 0.444 | H | -62.4 | -56.3 | 100.0 | 0.444 | 0.0 |
HOH |
2.868 |
NH2 |
O |
|||||||||
ARG | C:138 | C:148 | 95.0 | 0.422 | H | -59.2 | -57.5 | 95.0 | 0.422 | 0.0 |
HOH |
3.058 |
NH2 |
O |
|||||||||
ARG | D:138 | D:148 | 106.0 | 0.471 | H | -64.3 | -50.9 | 106.0 | 0.471 | 0.0 |
HOH |
3.632 |
CA |
O |
|||||||||
ARG | E:138 | E:148 | 99.0 | 0.44 | H | -65.7 | -58.9 | 99.0 | 0.44 | 0.0 |
HOH |
2.707 |
NH2 |
O |
|||||||||
ARG | F:138 | F:148 | 97.0 | 0.431 | H | -56.6 | -58.9 | 97.0 | 0.431 | 0.0 |
HOH |
3.287 |
CA |
O |
|||||||||
3wcm | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | ARG | A:138 | A:148 | 97.0 | 0.431 | H | -60.7 | -49.9 | 97.0 | 0.431 | 0.0 |
HOH |
2.511 |
NH2 |
O |
||
ARG | B:138 | B:148 | 94.0 | 0.418 | H | -61.9 | -51.7 | 94.0 | 0.418 | 0.0 |
HOH |
2.759 |
O |
O |
|||||||||
ARG | C:138 | C:148 | 97.0 | 0.431 | H | -63.7 | -48.1 | 97.0 | 0.431 | 0.0 |
HOH |
2.864 |
O |
O |
|||||||||
ARG | D:138 | D:148 | 98.0 | 0.436 | H | -64.3 | -46.3 | 98.0 | 0.436 | 0.0 |
HOH |
2.654 |
NE |
O |
|||||||||
ARG | E:138 | E:148 | 97.0 | 0.431 | H | -61.9 | -58.2 | 97.0 | 0.431 | 0.0 |
HOH |
3.125 |
O |
O |
|||||||||
ARG | F:138 | F:148 | 95.0 | 0.422 | H | -60.5 | -54.2 | 95.0 | 0.422 | 0.0 |
HOH |
8.307 |
NH1 |
O |
|||||||||
3wsa | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2015-04-01 | ARG | A:138 | A:148 | 99.0 | 0.44 | H | -61.2 | -44.9 | 99.0 | 0.44 | 0.0 |
HOH |
8.694 |
NH1 |
O |
||
ARG | B:138 | B:148 | 92.0 | 0.409 | H | -70.1 | -60.1 | 92.0 | 0.409 | 0.0 |
HOH |
5.579 |
NH1 |
O |
|||||||||
ARG | C:138 | C:148 | 96.0 | 0.427 | H | -63.2 | -56.4 | 96.0 | 0.427 | 0.0 |
HOH |
7.841 |
NH1 |
O |
|||||||||
ARG | D:138 | D:148 | 102.0 | 0.453 | H | -80.0 | -48.2 | 102.0 | 0.453 | 0.0 | |||||||||||||
ARG | E:138 | E:148 | 105.0 | 0.467 | H | -76.9 | -54.4 | 105.0 | 0.467 | 0.0 |
HOH |
5.818 |
NH2 |
O |
|||||||||
ARG | F:138 | F:148 | 98.0 | 0.436 | H | -66.2 | -63.0 | 98.0 | 0.436 | 0.0 |
HOH |
8.854 |
NH1 |
O |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p37268-f1 | 1 | P37268 | 100.0 | 0.0 | ARG | A:148 | A:148 | 92.0 | 0.409 | H | -63.0 | -50.2 |