Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683535 . C A CCDS5985.1:NM_004462.3:c.513taC>taA_NP_004453.3:p.171Y>* Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:141 A:171 19.0 0.083 H -51.5 -54.5 19.0 0.083 0.0 PO4
D99
HOH
 8.754
9.411
2.536
 O
CE2
OH
 O4
C27
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 TYR A:141 A:171 13.0 0.057 H -65.8 -41.2 13.0 0.057 0.0 B65
MG
HOH
 4.278
3.712
5.992
 OH
OH
OH
 OAA
MG
O
TYR B:141 B:171 21.0 0.091 H -64.4 -51.0 NA NA NA
TYR C:141 C:171 12.0 0.052 H -37.8 -54.7 NA NA NA
TYR D:141 D:171 24.0 0.104 H -61.8 -61.3 NA NA NA
TYR E:141 E:171 14.0 0.061 H -52.7 -38.5 NA NA NA
TYR F:141 F:171 50.0 0.217 H -65.8 -50.7 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:141 A:171 13.0 0.057 H -56.3 -52.8 13.0 0.057 0.0 PO4
D9A
HOH
 8.988
8.539
2.635
 O
OH
OH
 O4
C25
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:141 A:171 13.0 0.057 H -49.0 -52.5 13.0 0.057 0.0 MG
MG
D61
PO4
HOH
 4.593
6.937
3.528
8.695
2.535
 OH
OH
OH
O
OH
 MG
MG
O44
O4
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 TYR A:141 A:171 13.0 0.057 H -53.3 -50.8 13.0 0.057 0.0 PO4
HOH
 8.944
2.435
 O
OH
 O4
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:144 A:171 12.0 0.052 H -57.4 -46.6 12.0 0.052 0.0 HOH
 3.786
 CE2
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:144 A:171 10.0 0.043 H -58.1 -46.2 10.0 0.043 0.0 CA
HOH
 4.774
3.502
 OH
OH
 CA
O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:144 A:171 19.0 0.083 H -54.9 -50.6 19.0 0.083 0.0 HOH
 2.411
 OH
 O
TYR B:144 B:171 10.0 0.043 H -58.7 -49.9 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:144 A:171 15.0 0.065 H -62.1 -43.7 15.0 0.065 0.0 HOH
 3.893
 CE1
 O
TYR B:144 B:171 24.0 0.104 H -51.8 -48.2 24.0 0.104 0.0 HOH
 3.570
 CE1
 O
TYR C:144 C:171 21.0 0.091 H -59.7 -45.8 21.0 0.091 0.0 HOH
 3.514
 CE1
 O
TYR D:144 D:171 15.0 0.065 H -58.1 -45.7 NA NA NA
TYR E:144 E:171 19.0 0.083 H -59.3 -54.5 NA NA NA
TYR F:144 F:171 29.0 0.126 H -60.8 -51.4 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:144 A:171 19.0 0.083 H -59.9 -46.2 19.0 0.083 0.0 ZGA
PO4
HOH
 7.835
8.845
2.792
 OH
O
OH
 OAG
O1
O
TYR B:144 B:171 22.0 0.096 H -60.7 -50.2 22.0 0.096 0.0 ZGA
PO4
HOH
 7.792
8.887
2.925
 OH
O
OH
 OAG
O1
O
TYR C:144 C:171 19.0 0.083 H -59.4 -46.8 19.0 0.083 0.0 ZGA
PO4
HOH
 7.717
8.716
2.706
 OH
O
OH
 OAG
O1
O
TYR D:144 D:171 19.0 0.083 H -57.4 -45.8 NA NA NA
TYR E:144 E:171 27.0 0.117 H -55.1 -50.1 NA NA NA
TYR F:144 F:171 18.0 0.078 H -64.9 -48.1 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 16.0 0.07 H -56.6 -44.8 16.0 0.07 0.0 FPS
FPS
HOH
 9.471
4.760
3.940
 CE2
OH
CE1
 C4
S1
O
TYR B:144 B:171 29.0 0.126 H -58.6 -51.2 29.0 0.126 0.0 FPS
FPS
HOH
 9.269
2.956
6.541
 CE2
OH
N
 C4
O2A
O
TYR C:144 C:171 16.0 0.07 H -63.2 -46.2 16.0 0.07 0.0 FPS
HOH
 9.420
4.134
 CE2
CE1
 C4
O
TYR D:144 D:171 17.0 0.074 H -59.3 -52.2 NA NA NA
TYR E:144 E:171 24.0 0.104 H -62.9 -50.6 NA NA NA
TYR F:144 F:171 13.0 0.057 H -64.2 -56.4 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 16.0 0.07 H -60.6 -45.0 16.0 0.07 0.0 MG
MG
MG
FPS
FPS
HOH
 9.402
4.250
8.092
9.033
4.720
3.773
 OH
OH
OH
CE2
OH
CE1
 MG
MG
MG
C4
O2B
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 16.0 0.07 H -55.4 -46.8 16.0 0.07 0.0 MG
MG
PS7
HOH
 7.273
4.602
7.190
3.392
 OH
OH
OH
OH
 MG
MG
CAY
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 15.0 0.065 H -60.6 -48.6 15.0 0.065 0.0 MG
PS7
HOH
 4.196
7.402
2.814
 OH
OH
OH
 MG
CAY
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 9.0 0.039 H -61.1 -46.0 9.0 0.039 0.0 MN
MN
MN
PS7
HOH
 8.431
4.289
7.663
4.595
3.064
 OH
OH
OH
OH
OH
 MN
MN
MN
OAL
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:144 A:171 21.0 0.091 H -51.4 -49.1 21.0 0.091 0.0 MG
MG
PS7
HOH
 7.777
4.732
8.665
2.632
 OH
OH
CE2
OH
 MG
MG
CAH
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 TYR A:141 A:171 7.0 0.03 H -62.3 -51.0 7.0 0.03 0.0 IN0
HOH
 8.341
2.852
 OH
OH
 C25
O
TYR B:141 B:171 17.0 0.074 H -62.6 -44.4 NA NA NA
TYR C:141 C:171 9.0 0.039 H -58.7 -55.7 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 13.0 0.057 H -65.0 -50.6 13.0 0.057 0.0 FPS
HOH
 9.109
3.446
 CE2
CE1
 C4
O
TYR B:161 B:171 16.0 0.07 H -55.0 -52.4 16.0 0.07 0.0 FPS
HOH
 9.092
4.467
 CE2
OH
 C4
O
TYR C:161 C:171 25.0 0.109 H -75.6 -56.7 25.0 0.109 0.0 FPS
HOH
 9.256
4.824
 CE2
CE1
 C4
O
TYR D:161 D:171 24.0 0.104 H -72.3 -43.2 24.0 0.104 0.0 FPS
FPS
HOH
 8.657
5.739
4.381
 OH
OH
OH
 C4
C4
O
TYR E:161 E:171 15.0 0.065 H -75.7 -47.7 15.0 0.065 0.0 FPS
HOH
 8.993
3.805
 CE2
OH
 C4
O
TYR F:161 F:171 14.0 0.061 H -61.4 -56.5 14.0 0.061 0.0 FPS
HOH
 8.690
4.926
 CE2
OH
 C4
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 14.0 0.061 H -60.6 -35.8 14.0 0.061 0.0 RWY
HOH
 9.377
3.866
 O
CE1
 OAN
O
TYR B:161 B:171 19.0 0.083 H -64.3 -44.1 19.0 0.083 0.0 RWY
HOH
 9.389
4.182
 O
OH
 OAN
O
TYR C:161 C:171 28.0 0.122 H -62.8 -50.4 28.0 0.122 0.0 HOH
 4.004
 OH
 O
TYR D:161 D:171 25.0 0.109 H -64.9 -55.0 25.0 0.109 0.0 RWY
HOH
 9.459
4.891
 O
OH
 OAN
O
TYR E:161 E:171 18.0 0.078 H -71.6 -44.4 18.0 0.078 0.0 HOH
 3.822
 CE1
 O
TYR F:161 F:171 15.0 0.065 H -57.1 -60.6 15.0 0.065 0.0 HOH
 4.653
 CE1
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 13.0 0.057 H -60.8 -48.0 13.0 0.057 0.0 BH8
HOH
 9.130
3.912
 OH
CE1
 CAT
O
TYR B:161 B:171 19.0 0.083 H -64.9 -43.0 19.0 0.083 0.0 BH8
HOH
 9.202
4.250
 OH
CE1
 CAH
O
TYR C:161 C:171 21.0 0.091 H -62.8 -49.4 21.0 0.091 0.0 BH8
HOH
 9.401
4.626
 OH
CE1
 CAH
O
TYR D:161 D:171 28.0 0.122 H -64.2 -44.4 28.0 0.122 0.0 BH8
HOH
 9.122
4.048
 OH
CE1
 CAH
O
TYR E:161 E:171 18.0 0.078 H -62.8 -43.4 18.0 0.078 0.0 BH8
 9.983
 CE2
 CAH
TYR F:161 F:171 16.0 0.07 H -60.4 -58.6 16.0 0.07 0.0 BH8
 9.397
 OH
 CAH
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 12.0 0.052 H -55.8 -52.7 12.0 0.052 0.0 8PH
HOH
 5.620
2.944
 OH
OH
 OAF
O
TYR B:161 B:171 17.0 0.074 H -60.8 -42.8 17.0 0.074 0.0 8PH
HOH
 5.884
4.819
 OH
OH
 OAF
O
TYR C:161 C:171 25.0 0.109 H -61.1 -58.4 25.0 0.109 0.0 8PH
HOH
 5.198
5.086
 OH
OH
 OAB
O
TYR D:161 D:171 20.0 0.087 H -59.5 -46.2 20.0 0.087 0.0 8PH
HOH
 6.183
5.527
 OH
OH
 CAU
O
TYR E:161 E:171 19.0 0.083 H -58.9 -44.0 19.0 0.083 0.0 8PH
HOH
 9.590
6.652
 CE2
N
 CAT
O
TYR F:161 F:171 12.0 0.052 H -54.2 -55.1 12.0 0.052 0.0 8PH
HOH
 5.933
9.896
 OH
O
 OAF
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 12.0 0.052 H -64.0 -40.1 12.0 0.052 0.0 BH5
HOH
 8.858
3.772
 O
CE1
 CAS
O
TYR B:161 B:171 14.0 0.061 H -66.5 -42.4 14.0 0.061 0.0 BH5
HOH
 9.173
3.177
 O
OH
 CAS
O
TYR C:161 C:171 21.0 0.091 H -63.0 -47.4 21.0 0.091 0.0 BH5
HOH
 9.110
2.506
 O
OH
 CAS
O
TYR D:161 D:171 22.0 0.096 H -60.5 -51.0 22.0 0.096 0.0 BH5
HOH
 9.137
5.971
 O
OH
 CAS
O
TYR E:161 E:171 15.0 0.065 H -60.9 -42.9 15.0 0.065 0.0 BH5
HOH
 9.340
3.290
 O
OH
 CAS
O
TYR F:161 F:171 13.0 0.057 H -56.5 -52.8 13.0 0.057 0.0 BH5
HOH
 9.080
5.684
 O
CE1
 CAS
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 12.0 0.052 H -66.9 -43.8 12.0 0.052 0.0 E5S
HOH
 8.223
3.973
 OH
CE1
 CAT
O
TYR B:161 B:171 17.0 0.074 H -63.4 -45.6 17.0 0.074 0.0 E5S
HOH
 8.041
3.949
 OH
CE1
 CAP
O
TYR C:161 C:171 29.0 0.126 H -62.9 -47.3 29.0 0.126 0.0 E5S
HOH
 8.551
4.602
 OH
OH
 CAT
O
TYR D:161 D:171 24.0 0.104 H -63.5 -45.4 24.0 0.104 0.0 E5S
HOH
 8.206
4.386
 OH
CE1
 CAT
O
TYR E:161 E:171 18.0 0.078 H -59.4 -43.5 18.0 0.078 0.0 E5S
HOH
 7.827
3.326
 OH
OH
 CAT
O
TYR F:161 F:171 15.0 0.065 H -56.5 -57.6 15.0 0.065 0.0 E5S
HOH
 7.730
5.209
 OH
OH
 CAT
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 11.0 0.048 H -62.5 -38.5 11.0 0.048 0.0 BH3
HOH
 8.963
3.288
 O
OH
 CAR
O
TYR B:161 B:171 17.0 0.074 H -61.7 -48.7 17.0 0.074 0.0 HOH
 4.240
 CE1
 O
TYR C:161 C:171 28.0 0.122 H -59.3 -46.9 28.0 0.122 0.0 HOH
 3.665
 OH
 O
TYR D:161 D:171 27.0 0.117 H -62.0 -49.9 27.0 0.117 0.0 HOH
 4.238
 OH
 O
TYR E:161 E:171 15.0 0.065 H -60.4 -48.4 15.0 0.065 0.0 HOH
 3.188
 OH
 O
TYR F:161 F:171 15.0 0.065 H -62.8 -60.3 15.0 0.065 0.0 HOH
 5.469
 CE1
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:161 A:171 14.0 0.061 H -62.8 -44.0 14.0 0.061 0.0 ER4
HOH
 8.970
4.045
 OH
CE1
 CAT
O
TYR B:161 B:171 18.0 0.078 H -63.1 -45.7 18.0 0.078 0.0 ER4
HOH
 8.822
2.678
 OH
OH
 CAT
O
TYR C:161 C:171 32.0 0.139 H -61.0 -48.3 32.0 0.139 0.0 ER4
HOH
 8.787
2.746
 OH
OH
 CAT
O
TYR D:161 D:171 28.0 0.122 H -64.8 -46.4 28.0 0.122 0.0 ER4
HOH
 8.769
3.065
 OH
OH
 CAT
O
TYR E:161 E:171 20.0 0.087 H -59.4 -44.4 20.0 0.087 0.0 ER4
HOH
 8.751
4.324
 OH
OH
 CAT
O
TYR F:161 F:171 14.0 0.061 H -59.1 -44.6 14.0 0.061 0.0 ER4
HOH
 8.764
3.929
 OH
OH
 CAT
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 TYR A:161 A:171 13.0 0.057 H -63.1 -47.6 13.0 0.057 0.0 RWZ
HOH
 9.420
4.086
 O
OH
 NAP
O
TYR B:161 B:171 19.0 0.083 H -64.3 -55.6 19.0 0.083 0.0 RWZ
HOH
 8.911
4.400
 OH
OH
 CAI
O
TYR C:161 C:171 21.0 0.091 H -71.5 -54.8 21.0 0.091 0.0 RWZ
HOH
 9.122
4.260
 OH
CZ
 CAI
O
TYR D:161 D:171 30.0 0.13 H -62.5 -51.6 30.0 0.13 0.0 HOH
 3.895
 OH
 O
TYR E:161 E:171 16.0 0.07 H -63.0 -49.8 16.0 0.07 0.0 RWZ
HOH
 9.338
4.530
 CE2
CE1
 CAI
O
TYR F:161 F:171 17.0 0.074 H -62.8 -54.2 17.0 0.074 0.0 HOH
 5.227
 OH
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 TYR A:171 A:171 14.0 0.061 H -59.1 -51.2