Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683543 . A C CCDS5985.1:NM_004462.3:c.521tAt>tCt_NP_004453.3:p.174Y>S Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:144 A:174 36.0 0.157 I -61.4 -41.9 36.0 0.157 0.0 PO4
D99
HOH
 3.512
8.176
2.533
 CE2
O
OH
 O4
C28
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 TYR A:144 A:174 37.0 0.161 I -60.6 -56.8 37.0 0.161 0.0 B65
MG
HOH
 6.914
9.239
7.021
 O
C
N
 CAQ
MG
O
TYR B:144 B:174 32.0 0.139 I -73.5 -41.6 NA NA NA
TYR C:144 C:174 40.0 0.174 I -81.7 -34.1 NA NA NA
TYR D:144 D:174 34.0 0.148 I -57.1 -61.1 NA NA NA
TYR E:144 E:174 39.0 0.17 I -75.5 -37.1 NA NA NA
TYR F:144 F:174 43.0 0.187 I -57.7 -49.9 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:144 A:174 34.0 0.148 I -67.7 -37.3 34.0 0.148 0.0 PO4
D9A
HOH
 3.514
8.069
2.897
 CE2
C
OH
 O4
C25
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 TYR A:144 A:174 34.0 0.148 I -55.0 -44.6 34.0 0.148 0.0 MG
D61
PO4
HOH
 8.879
6.106
3.531
2.777
 C
O
CE2
OH
 MG
C22
O4
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 TYR A:144 A:174 30.0 0.13 I -64.7 -37.5 30.0 0.13 0.0 PO4
D3A
HOH
 3.526
9.211
3.032
 CE2
O
OH
 O4
C12
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:147 A:174 35.0 0.152 I -68.7 -32.5 35.0 0.152 0.0 HOH
 2.843
 OH
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:147 A:174 34.0 0.148 I -64.2 -38.0 34.0 0.148 0.0 CA
HOH
 9.015
2.892
 C
OH
 CA
O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:147 A:174 39.0 0.17 I -62.7 -37.5 39.0 0.17 0.0 HOH
 2.765
 OH
 O
TYR B:147 B:174 39.0 0.17 I -58.1 -39.8 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:147 A:174 31.0 0.135 I -64.2 -39.8 31.0 0.135 0.0 HOH
 2.901
 OH
 O
TYR B:147 B:174 35.0 0.152 I -61.7 -39.4 35.0 0.152 0.0 HOH
 2.760
 OH
 O
TYR C:147 C:174 33.0 0.143 I -63.9 -42.9 33.0 0.143 0.0 HOH
 2.612
 OH
 O
TYR D:147 D:174 40.0 0.174 I -64.7 -36.7 NA NA NA
TYR E:147 E:174 37.0 0.161 I -61.6 -42.5 NA NA NA
TYR F:147 F:174 32.0 0.139 I -66.1 -39.6 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 TYR A:147 A:174 32.0 0.139 I -62.3 -39.6 32.0 0.139 0.0 ZGA
PO4
HOH
 5.789
3.529
2.928
 O
CE1
OH
 CAC
O1
O
TYR B:147 B:174 33.0 0.143 I -59.6 -40.4 33.0 0.143 0.0 ZGA
PO4
HOH
 5.841
3.622
3.144
 O
CE1
OH
 CAC
O1
O
TYR C:147 C:174 35.0 0.152 I -62.2 -39.9 35.0 0.152 0.0 ZGA
PO4
HOH
 5.960
3.460
2.878
 O
CE1
OH
 CAC
O1
O
TYR D:147 D:174 36.0 0.157 I -65.5 -38.6 NA NA NA
TYR E:147 E:174 39.0 0.17 I -71.5 -36.9 NA NA NA
TYR F:147 F:174 37.0 0.161 I -72.9 -40.8 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 26.0 0.113 I -63.5 -36.1 26.0 0.113 0.0 FPS
FPS
HOH
 8.509
6.663
6.246
 O
O
N
 C5
C2
O
TYR B:147 B:174 38.0 0.165 I -64.7 -38.3 38.0 0.165 0.0 FPS
FPS
HOH
 8.205
5.963
8.454
 O
O
N
 C5
C4
O
TYR C:147 C:174 33.0 0.143 I -67.6 -36.6 33.0 0.143 0.0 FPS
HOH
 9.056
7.705
 C
CB
 C6
O
TYR D:147 D:174 41.0 0.178 I -66.4 -32.8 NA NA NA
TYR E:147 E:174 27.0 0.117 I -64.7 -37.3 NA NA NA
TYR F:147 F:174 29.0 0.126 I -77.1 -40.4 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 36.0 0.157 I -62.9 -34.7 36.0 0.157 0.0 MG
FPS
FPS
HOH
 8.851
9.076
6.802
2.958
 O
C
O
OH
 MG
C7
C5
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 35.0 0.152 I -62.7 -40.3 35.0 0.152 0.0 MG
PS7
HOH
 9.421
6.472
2.860
 C
O
OH
 MG
CAY
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 32.0 0.139 I -61.9 -42.1 32.0 0.139 0.0 MG
PS7
HOH
 8.921
6.242
3.282
 C
O
OH
 MG
CAY
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 34.0 0.148 I -65.7 -35.2 34.0 0.148 0.0 MN
PS7
HOH
 8.874
5.639
3.134
 C
O
OH
 MN
CAG
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 TYR A:147 A:174 36.0 0.157 I -65.6 -39.5 36.0 0.157 0.0 MG
PS7
HOH
 8.963
8.276
2.635
 O
O
OH
 MG
CAR
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 TYR A:144 A:174 31.0 0.135 I -59.0 -40.7 31.0 0.135 0.0 IN0
HOH
 8.267
5.879
 O
O
 C24
O
TYR B:144 B:174 42.0 0.183 I -61.5 -47.5 NA NA NA
TYR C:144 C:174 33.0 0.143 I -65.2 -54.4 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 37.0 0.161 I -68.0 -30.9 37.0 0.161 0.0 FPS
HOH
 8.808
4.251
 O
CE1
 C6
O
TYR B:164 B:174 37.0 0.161 I -67.7 -28.7 37.0 0.161 0.0 FPS
HOH
 8.999
3.465
 C
CE1
 C6
O
TYR C:164 C:174 43.0 0.187 I -61.9 -17.8 43.0 0.187 0.0 FPS
HOH
 8.795
3.012
 C
CE1
 C6
O
TYR D:164 D:174 38.0 0.165 I -70.3 -26.2 38.0 0.165 0.0 FPS
FPS
HOH
 8.749
8.163
5.694
 C
O
CE1
 C6
C7
O
TYR E:164 E:174 40.0 0.174 I -57.4 -32.3 40.0 0.174 0.0 FPS
HOH
 8.852
4.930
 O
OH
 C6
O
TYR F:164 F:174 38.0 0.165 I -77.5 -40.8 38.0 0.165 0.0 FPS
HOH
 8.454
4.026
 O
OH
 C6
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 32.0 0.139 I -74.3 -43.1 32.0 0.139 0.0 RWY
HOH
 7.677
3.652
 O
OH
 SAP
O
TYR B:164 B:174 38.0 0.165 I -66.4 -26.7 38.0 0.165 0.0 RWY
HOH
 8.269
4.596
 C
CE1
 OAN
O
TYR C:164 C:174 34.0 0.148 I -63.4 -32.5 34.0 0.148 0.0 HOH
 2.999
 OH
 O
TYR D:164 D:174 44.0 0.191 I -75.2 -21.4 44.0 0.191 0.0 RWY
HOH
 8.174
5.624
 C
CE1
 CAH
O
TYR E:164 E:174 43.0 0.187 I -77.0 -21.5 43.0 0.187 0.0 RWY
HOH
 8.667
4.496
 O
CE1
 SAP
O
TYR F:164 F:174 40.0 0.174 I -68.1 -30.6 40.0 0.174 0.0 HOH
 6.612
 N
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 37.0 0.161 I -68.5 -38.8 37.0 0.161 0.0 BH8
HOH
 7.201
2.803
 O
OH
 OAC
O
TYR B:164 B:174 33.0 0.143 I -66.0 -42.0 33.0 0.143 0.0 BH8
HOH
 8.936
4.086
 O
CE1
 CAP
O
TYR C:164 C:174 39.0 0.17 I -63.4 -38.6 39.0 0.17 0.0 BH8
HOH
 8.392
6.295
 O
CE1
 CAQ
O
TYR D:164 D:174 41.0 0.178 I -57.8 -39.2 41.0 0.178 0.0 BH8
HOH
 8.503
5.050
 O
CE1
 CAQ
O
TYR E:164 E:174 38.0 0.165 I -62.3 -40.5 38.0 0.165 0.0 BH8
HOH
 8.780
5.119
 O
CE1
 CAP
O
TYR F:164 F:174 41.0 0.178 I -73.5 -32.3 41.0 0.178 0.0 BH8
 8.889
 O
 CAP
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 38.0 0.165 I -70.9 -39.7 38.0 0.165 0.0 8PH
HOH
 7.316
3.830
 C
CE1
 CAI
O
TYR B:164 B:174 37.0 0.161 I -61.1 -42.6 37.0 0.161 0.0 8PH
HOH
 7.184
4.496
 O
CE1
 CAI
O
TYR C:164 C:174 40.0 0.174 I -67.2 -42.4 40.0 0.174 0.0 8PH
HOH
 6.950
4.338
 O
CE1
 CAI
O
TYR D:164 D:174 40.0 0.174 I -71.4 -35.4 40.0 0.174 0.0 8PH
HOH
 7.218
4.499
 O
CE1
 CAI
O
TYR E:164 E:174 41.0 0.178 I -69.5 -37.5 41.0 0.178 0.0 8PH
HOH
 9.025
4.596
 O
CE1
 CAR
O
TYR F:164 F:174 31.0 0.135 I -72.7 -37.7 31.0 0.135 0.0 8PH
HOH
 7.848
4.306
 O
CE1
 CAI
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 38.0 0.165 I -71.5 -37.1 38.0 0.165 0.0 BH5
HOH
 7.692
3.781
 O
CE1
 CAS
O
TYR B:164 B:174 38.0 0.165 I -64.9 -41.8 38.0 0.165 0.0 BH5
HOH
 7.793
3.400
 O
CE1
 CAS
O
TYR C:164 C:174 42.0 0.183 I -71.1 -35.9 42.0 0.183 0.0 BH5
HOH
 7.707
4.458
 O
CE1
 CAU
O
TYR D:164 D:174 42.0 0.183 I -70.4 -26.5 42.0 0.183 0.0 BH5
HOH
 7.558
4.535
 O
CE1
 CAU
O
TYR E:164 E:174 39.0 0.17 I -71.1 -37.3 39.0 0.17 0.0 BH5
HOH
 7.941
4.250
 O
CE1
 CAU
O
TYR F:164 F:174 38.0 0.165 I -77.8 -40.4 38.0 0.165 0.0 BH5
HOH
 7.708
3.834
 O
OH
 CAS
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 32.0 0.139 I -64.3 -41.4 32.0 0.139 0.0 E5S
HOH
 6.119
2.802
 O
OH
 OAC
O
TYR B:164 B:174 35.0 0.152 I -64.9 -44.3 35.0 0.152 0.0 E5S
HOH
 5.988
3.475
 O
CE1
 OAC
O
TYR C:164 C:174 29.0 0.126 I -58.3 -46.2 29.0 0.126 0.0 E5S
HOH
 6.303
2.780
 O
OH
 OAC
O
TYR D:164 D:174 40.0 0.174 I -61.0 -37.9 40.0 0.174 0.0 E5S
HOH
 6.253
4.708
 O
CE1
 OAC
O
TYR E:164 E:174 44.0 0.191 I -66.3 -32.4 44.0 0.191 0.0 E5S
HOH
 6.127
7.088
 O
OH
 OAC
O
TYR F:164 F:174 42.0 0.183 I -71.2 -48.6 42.0 0.183 0.0 E5S
HOH
 6.008
9.350
 O
CE1
 OAC
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 35.0 0.152 I -64.3 -44.1 35.0 0.152 0.0 BH3
HOH
 7.499
3.079
 O
OH
 CAT
O
TYR B:164 B:174 33.0 0.143 I -59.7 -42.0 33.0 0.143 0.0 HOH
 3.830
 CE1
 O
TYR C:164 C:174 32.0 0.139 I -62.2 -38.8 32.0 0.139 0.0 HOH
 2.786
 OH
 O
TYR D:164 D:174 39.0 0.17 I -64.9 -32.8 39.0 0.17 0.0 HOH
 3.485
 CE1
 O
TYR E:164 E:174 34.0 0.148 I -67.7 -32.1 34.0 0.148 0.0 HOH
 3.726
 CE1
 O
TYR F:164 F:174 39.0 0.17 I -74.0 -37.8 39.0 0.17 0.0 HOH
 4.781
 CE1
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 TYR A:164 A:174 34.0 0.148 I -61.2 -45.0 34.0 0.148 0.0 ER4
HOH
 7.974
2.687
 O
OH
 OAB
O
TYR B:164 B:174 35.0 0.152 I -61.2 -45.8 35.0 0.152 0.0 ER4
HOH
 8.002
3.976
 O
CE1
 OAB
O
TYR C:164 C:174 30.0 0.13 I -63.2 -38.5 30.0 0.13 0.0 ER4
HOH
 7.943
2.918
 O
OH
 OAB
O
TYR D:164 D:174 39.0 0.17 I -60.7 -36.1 39.0 0.17 0.0 ER4
HOH
 7.916
3.492
 O
CE1
 OAB
O
TYR E:164 E:174 43.0 0.187 I -65.2 -36.2 43.0 0.187 0.0 ER4
HOH
 8.088
4.833
 O
CE1
 OAB
O
TYR F:164 F:174 39.0 0.17 I -70.1 -49.7 39.0 0.17 0.0 ER4
HOH
 7.519
6.533
 O
N
 OAB
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 TYR A:164 A:174 37.0 0.161 I -78.6 -37.5 37.0 0.161 0.0 RWZ
HOH
 7.768
9.258
 O
CE1
 CAW
O
TYR B:164 B:174 34.0 0.148 I -63.9 -37.1 34.0 0.148 0.0 RWZ
HOH
 7.617
4.806
 O
CE1
 CAN
O
TYR C:164 C:174 43.0 0.187 I -71.7 -31.0 43.0 0.187 0.0 RWZ
HOH
 7.928
4.729
 O
CE1
 CAW
O
TYR D:164 D:174 52.0 0.226 I -70.0 -14.3 52.0 0.226 0.0 HOH
 8.763
 C
 O
TYR E:164 E:174 48.0 0.209 I -78.7 -46.9 48.0 0.209 0.0 RWZ
HOH
 7.795
4.059
 O
CE1
 CAW
O
TYR F:164 F:174 44.0 0.191 I -84.1 -28.8 44.0 0.191 0.0 HOH
 8.394
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 TYR A:174 A:174 41.0 0.178 I -63.8 -45.3