Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683575 . C A CCDS5985.1:NM_004462.3:c.553Cgt>Agt_NP_004453.3:p.185R>S Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:155 A:185 57.0 0.253 H -66.0 -36.0 57.0 0.253 0.0 PO4
D99
HOH
 9.050
9.432
2.339
 NH2
N
NH2
 O3
C11
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 ARG A:155 A:185 65.0 0.289 H -84.0 -25.4 65.0 0.289 0.0 HOH
 3.626
 CD
 O
ARG B:155 B:185 58.0 0.258 H -91.1 -18.2 NA NA NA
ARG C:155 C:185 66.0 0.293 H -64.8 -20.3 NA NA NA
ARG D:155 D:185 68.0 0.302 H -52.2 -34.2 NA NA NA
ARG E:155 E:185 71.0 0.316 H -80.0 -35.8 NA NA NA
ARG F:155 F:185 74.0 0.329 H -75.2 -44.7 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:155 A:185 59.0 0.262 H -70.0 -30.3 59.0 0.262 0.0 PO4
D9A
HOH
 8.732
7.961
1.856
 NH1
N
NH2
 O3
C19
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:155 A:185 53.0 0.236 H -72.4 -34.3 53.0 0.236 0.0 D61
HOH
 9.449
7.429
 N
N
 C6
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 ARG A:155 A:185 60.0 0.267 H -65.4 -35.1 60.0 0.267 0.0 PO4
D3A
HOH
 7.856
7.504
2.649
 NH1
N
NH1
 O3
C35
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:158 A:185 62.0 0.276 H -69.3 -32.9 62.0 0.276 0.0 HOH
 2.793
 O
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:158 A:185 64.0 0.284 H -64.6 -38.6 64.0 0.284 0.0 HOH
 2.803
 O
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:158 A:185 64.0 0.284 H -65.6 -34.9 64.0 0.284 0.0 HOH
 2.794
 O
 O
ARG B:158 B:185 91.0 0.404 H -68.0 -37.6 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:158 A:185 68.0 0.302 H -65.5 -36.9 68.0 0.302 0.0 HOH
 2.288
 NH2
 O
ARG B:158 B:185 55.0 0.244 H -67.3 -36.8 55.0 0.244 0.0 HOH
 2.676
 O
 O
ARG C:158 C:185 63.0 0.28 H -67.4 -33.3 63.0 0.28 0.0 HOH
 2.581
 O
 O
ARG D:158 D:185 61.0 0.271 H -60.1 -36.1 NA NA NA
ARG E:158 E:185 61.0 0.271 H -71.2 -35.6 NA NA NA
ARG F:158 F:185 67.0 0.298 H -72.0 -31.7 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:158 A:185 62.0 0.276 H -66.3 -36.5 62.0 0.276 0.0 PO4
HOH
 8.504
2.821
 NH1
O
 O2
O
ARG B:158 B:185 61.0 0.271 H -61.9 -36.6 61.0 0.271 0.0 PO4
HOH
 8.546
2.802
 NH1
O
 O2
O
ARG C:158 C:185 61.0 0.271 H -66.5 -37.8 61.0 0.271 0.0 PO4
HOH
 8.510
2.717
 NH1
O
 O3
O
ARG D:158 D:185 62.0 0.276 H -63.1 -41.8 NA NA NA
ARG E:158 E:185 60.0 0.267 H -65.7 -34.9 NA NA NA
ARG F:158 F:185 66.0 0.293 H -67.6 -28.2 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 65.0 0.289 H -65.6 -32.3 65.0 0.289 0.0 FPS
HOH
 7.923
2.573
 N
O
 C15
O
ARG B:158 B:185 61.0 0.271 H -70.0 -31.0 61.0 0.271 0.0 FPS
HOH
 7.629
2.728
 N
O
 C15
O
ARG C:158 C:185 61.0 0.271 H -67.6 -29.7 61.0 0.271 0.0 FPS
HOH
 8.363
2.618
 N
O
 C15
O
ARG D:158 D:185 71.0 0.316 H -65.8 -34.2 NA NA NA
ARG E:158 E:185 60.0 0.267 H -67.2 -37.3 NA NA NA
ARG F:158 F:185 67.0 0.298 H -63.0 -38.1 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 63.0 0.28 H -67.8 -35.6 63.0 0.28 0.0 FPS
HOH
 7.585
2.667
 N
O
 C15
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 66.0 0.293 H -63.8 -36.4 66.0 0.293 0.0 PS7
HOH
 7.766
2.581
 N
O
 CAC
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 62.0 0.276 H -68.4 -29.7 62.0 0.276 0.0 PS7
HOH
 7.481
2.552
 N
O
 CAC
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 63.0 0.28 H -69.1 -32.4 63.0 0.28 0.0 PS7
HOH
 7.595
2.677
 N
O
 CAC
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:158 A:185 65.0 0.289 H -72.8 -32.0 65.0 0.289 0.0 PS7
HOH
 7.803
2.605
 N
O
 CAC
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 ARG A:155 A:185 96.0 0.427 H -66.7 -36.5 96.0 0.427 0.0 IN0
HOH
 9.513
2.694
 N
NH1
 C29
O
ARG B:155 B:185 67.0 0.298 H -69.7 -31.3 NA NA NA
ARG C:155 C:185 66.0 0.293 H -62.5 -38.0 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 69.0 0.307 H -63.7 -32.0 69.0 0.307 0.0 FPS
HOH
 7.726
2.986
 N
NH1
 C15
O
ARG B:175 B:185 68.0 0.302 H -73.4 -21.5 68.0 0.302 0.0 FPS
HOH
 7.758
3.112
 N
NE
 C15
O
ARG C:175 C:185 57.0 0.253 H -53.3 -31.1 57.0 0.253 0.0 FPS
HOH
 7.652
3.279
 N
NH2
 C15
O
ARG D:175 D:185 73.0 0.324 H -55.1 -36.4 73.0 0.324 0.0 FPS
HOH
 7.587
2.817
 N
CD
 C15
O
ARG E:175 E:185 69.0 0.307 H -67.5 -52.3 69.0 0.307 0.0 FPS
HOH
 7.865
4.258
 N
NH1
 C15
O
ARG F:175 F:185 80.0 0.356 H -66.3 -28.9 80.0 0.356 0.0 FPS
HOH
 7.835
4.790
 N
NH2
 C15
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 72.0 0.32 H -63.8 -31.3 72.0 0.32 0.0 RWY
HOH
 9.559
3.079
 N
NH2
 CAF
O
ARG B:175 B:185 64.0 0.284 H -63.4 -28.5 64.0 0.284 0.0 RWY
HOH
 9.904
2.563
 N
O
 OAO
O
ARG C:175 C:185 63.0 0.28 H -59.1 -24.4 63.0 0.28 0.0 HOH
 2.885
 NH1
 O
ARG D:175 D:185 72.0 0.32 H -73.0 -32.6 72.0 0.32 0.0 RWY
HOH
 9.540
2.386
 N
O
 CAF
O
ARG E:175 E:185 57.0 0.253 H -65.4 -31.8 57.0 0.253 0.0 RWY
HOH
 9.782
7.271
 N
NH2
 OAO
O
ARG F:175 F:185 81.0 0.36 H -64.9 -42.9 81.0 0.36 0.0 HOH
 3.277
 NH2
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 67.0 0.298 H -71.8 -33.4 67.0 0.298 0.0 BH8
HOH
 7.892
2.533
 N
NH1
 CAA
O
ARG B:175 B:185 65.0 0.289 H -68.8 -27.5 65.0 0.289 0.0 BH8
HOH
 8.728
2.773
 N
O
 CAA
O
ARG C:175 C:185 59.0 0.262 H -63.7 -29.7 59.0 0.262 0.0 BH8
HOH
 7.835
2.761
 N
NH1
 CAA
O
ARG D:175 D:185 67.0 0.298 H -66.4 -34.6 67.0 0.298 0.0 BH8
HOH
 7.782
2.702
 N
O
 CAA
O
ARG E:175 E:185 59.0 0.262 H -67.0 -25.1 59.0 0.262 0.0 BH8
HOH
 8.402
7.389
 N
N
 CAK
O
ARG F:175 F:185 66.0 0.293 H -68.4 -34.8 66.0 0.293 0.0 BH8
HOH
 7.883
3.341
 N
O
 CAA
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 70.0 0.311 H -77.1 -28.1 70.0 0.311 0.0 8PH
HOH
 8.596
3.156
 N
O
 CAA
O
ARG B:175 B:185 66.0 0.293 H -83.4 -20.2 66.0 0.293 0.0 8PH
HOH
 8.772
3.413
 N
CG
 CAA
O
ARG C:175 C:185 60.0 0.267 H -67.2 -27.4 60.0 0.267 0.0 8PH
HOH
 8.517
2.760
 N
O
 CAA
O
ARG D:175 D:185 65.0 0.289 H -70.5 -29.8 65.0 0.289 0.0 8PH
HOH
 8.275
2.611
 N
O
 CAA
O
ARG E:175 E:185 57.0 0.253 H -79.9 -30.7 57.0 0.253 0.0 8PH
HOH
 8.237
4.366
 N
CG
 CAA
O
ARG F:175 F:185 74.0 0.329 H -70.8 -31.1 74.0 0.329 0.0 8PH
HOH
 8.700
8.196
 N
NH2
 CAA
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 65.0 0.289 H -67.7 -29.9 65.0 0.289 0.0 BH5
HOH
 8.318
2.572
 N
NH1
 CAA
O
ARG B:175 B:185 67.0 0.298 H -65.6 -26.6 67.0 0.298 0.0 BH5
HOH
 8.197
2.545
 N
O
 CAA
O
ARG C:175 C:185 62.0 0.276 H -64.3 -29.5 62.0 0.276 0.0 BH5
HOH
 8.007
2.710
 N
NH1
 CAA
O
ARG D:175 D:185 69.0 0.307 H -69.9 -32.4 69.0 0.307 0.0 BH5
HOH
 8.073
2.702
 N
O
 CAA
O
ARG E:175 E:185 62.0 0.276 H -69.2 -34.7 62.0 0.276 0.0 BH5
HOH
 8.153
3.057
 N
O
 CAA
O
ARG F:175 F:185 70.0 0.311 H -69.0 -36.6 70.0 0.311 0.0 BH5
HOH
 8.080
2.900
 N
O
 CAA
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 73.0 0.324 H -64.2 -36.4 73.0 0.324 0.0 E5S
HOH
 7.933
2.809
 N
O
 CAA
O
ARG B:175 B:185 60.0 0.267 H -65.2 -33.3 60.0 0.267 0.0 E5S
HOH
 8.276
2.665
 N
O
 CAA
O
ARG C:175 C:185 58.0 0.258 H -70.1 -32.3 58.0 0.258 0.0 E5S
HOH
 8.016
2.794
 N
NH1
 CAA
O
ARG D:175 D:185 65.0 0.289 H -66.3 -33.6 65.0 0.289 0.0 E5S
HOH
 8.115
2.680
 N
NH1
 CAA
O
ARG E:175 E:185 63.0 0.28 H -67.9 -32.4 63.0 0.28 0.0 E5S
HOH
 8.111
3.685
 N
CD
 CAA
O
ARG F:175 F:185 80.0 0.356 H -62.4 -37.2 80.0 0.356 0.0 E5S
HOH
 8.060
3.940
 N
CD
 CAA
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 75.0 0.333 H -68.2 -34.6 75.0 0.333 0.0 BH3
HOH
 8.533
2.960
 N
NH1
 CAA
O
ARG B:175 B:185 62.0 0.276 H -66.3 -32.5 62.0 0.276 0.0 HOH
 2.667
 O
 O
ARG C:175 C:185 60.0 0.267 H -67.5 -33.4 60.0 0.267 0.0 HOH
 2.714
 NE
 O
ARG D:175 D:185 66.0 0.293 H -68.4 -31.2 66.0 0.293 0.0 HOH
 2.644
 O
 O
ARG E:175 E:185 60.0 0.267 H -73.8 -24.8 60.0 0.267 0.0 HOH
 2.646
 O
 O
ARG F:175 F:185 70.0 0.311 H -68.7 -33.2 70.0 0.311 0.0 HOH
 2.753
 O
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:175 A:185 74.0 0.329 H -67.4 -34.4 74.0 0.329 0.0 ER4
HOH
 7.209
2.789
 N
O
 CAA
O
ARG B:175 B:185 63.0 0.28 H -67.2 -33.7 63.0 0.28 0.0 ER4
HOH
 7.243
2.808
 N
NH2
 CAA
O
ARG C:175 C:185 62.0 0.276 H -67.6 -34.8 62.0 0.276 0.0 ER4
HOH
 7.295
2.728
 N
O
 CAA
O
ARG D:175 D:185 67.0 0.298 H -67.2 -32.2 67.0 0.298 0.0 ER4
HOH
 7.235
2.644
 N
O
 CAA
O
ARG E:175 E:185 60.0 0.267 H -68.5 -33.9 60.0 0.267 0.0 ER4
HOH
 7.116
2.851
 N
NH1
 CAA
O
ARG F:175 F:185 76.0 0.338 H -66.4 -35.7 76.0 0.338 0.0 ER4
HOH
 6.889
3.938
 N
CG
 CAA
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 ARG A:175 A:185 76.0 0.338 H -71.2 -33.7 76.0 0.338 0.0 RWZ
HOH
 8.072
4.161
 N
CG
 CAA
O
ARG B:175 B:185 68.0 0.302 H -62.1 -27.0 68.0 0.302 0.0 RWZ
HOH
 8.226
2.572
 N
O
 CAA
O
ARG C:175 C:185 64.0 0.284 H -70.0 -16.2 64.0 0.284 0.0 RWZ
HOH
 7.803
3.673
 N
CA
 CAA
O
ARG D:175 D:185 73.0 0.324 H -71.6 -18.7 73.0 0.324 0.0 HOH
 6.814
 O
 O
ARG E:175 E:185 56.0 0.249 H -76.6 -24.8 56.0 0.249 0.0 RWZ
HOH
 7.848
8.592
 N
NH1
 CAA
O
ARG F:175 F:185 84.0 0.373 H -80.0 -22.0 84.0 0.373 0.0 HOH
 3.114
 NH2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 ARG A:185 A:185 67.0 0.298 H -66.9 -37.7