Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683612 . T A CCDS5985.1:NM_004462.3:c.590gTt>gAt_NP_004453.3:p.197V>D Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 VAL A:167 A:197 5.0 0.032 H -58.5 -47.2 5.0 0.032 0.0 D99
HOH
 9.041
2.673
 CG1
O
 C11
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 VAL A:167 A:197 0.0 0.0 H -71.2 -46.2 0.0 0.0 0.0 HOH
 6.887
 C
 O
VAL B:167 B:197 5.0 0.032 H -55.6 -36.9 NA NA NA
VAL C:167 C:197 3.0 0.019 H -47.4 -47.6 NA NA NA
VAL D:167 D:197 1.0 0.006 H -57.5 -57.5 NA NA NA
VAL E:167 E:197 4.0 0.026 H -71.6 -13.7 NA NA NA
VAL F:167 F:197 0.0 0.0 H -75.5 -48.4 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 VAL A:167 A:197 6.0 0.039 H -62.7 -42.1 6.0 0.039 0.0 D9A
HOH
 7.548
2.805
 CG1
O
 C19
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 VAL A:167 A:197 7.0 0.045 H -56.2 -49.3 7.0 0.045 0.0 D61
HOH
 8.812
2.855
 CG1
O
 C1
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 VAL A:167 A:197 7.0 0.045 H -54.4 -52.9 7.0 0.045 0.0 D3A
HOH
 7.157
2.694
 CG1
O
 C35
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 VAL A:170 A:197 5.0 0.032 H -63.2 -47.4 5.0 0.032 0.0 HOH
 2.694
 O
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 VAL A:170 A:197 6.0 0.039 H -61.3 -48.1 6.0 0.039 0.0 HOH
 2.707
 O
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 VAL A:170 A:197 5.0 0.032 H -59.7 -47.2 5.0 0.032 0.0 HOH
 2.695
 O
 O
VAL B:170 B:197 7.0 0.045 H -59.4 -50.6 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 VAL A:170 A:197 0.0 0.0 H -61.7 -55.8 0.0 0.0 0.0 HOH
 2.590
 O
 O
VAL B:170 B:197 7.0 0.045 H -64.6 -45.6 7.0 0.045 0.0 HOH
 2.713
 O
 O
VAL C:170 C:197 4.0 0.026 H -54.7 -49.4 4.0 0.026 0.0 HOH
 2.808
 O
 O
VAL D:170 D:197 8.0 0.052 H -62.4 -52.0 NA NA NA
VAL E:170 E:197 4.0 0.026 H -58.8 -50.6 NA NA NA
VAL F:170 F:197 0.0 0.0 H -68.1 -56.6 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 VAL A:170 A:197 0.0 0.0 H -67.3 -51.8 0.0 0.0 0.0 HOH
 2.754
 O
 O
VAL B:170 B:197 4.0 0.026 H -59.5 -50.8 4.0 0.026 0.0 HOH
 2.645
 O
 O
VAL C:170 C:197 4.0 0.026 H -60.8 -50.3 4.0 0.026 0.0 HOH
 2.673
 O
 O
VAL D:170 D:197 6.0 0.039 H -60.9 -48.9 NA NA NA
VAL E:170 E:197 4.0 0.026 H -54.8 -50.8 NA NA NA
VAL F:170 F:197 0.0 0.0 H -68.4 -53.9 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 0.0 0.0 H -68.9 -48.7 0.0 0.0 0.0 FPS
HOH
 7.704
3.486
 CG1
O
 C15
O
VAL B:170 B:197 7.0 0.045 H -66.0 -48.6 7.0 0.045 0.0 FPS
HOH
 7.208
3.010
 CG1
O
 C15
O
VAL C:170 C:197 3.0 0.019 H -62.2 -46.1 3.0 0.019 0.0 FPS
HOH
 7.701
2.562
 CG1
O
 C15
O
VAL D:170 D:197 9.0 0.058 H -54.2 -44.0 NA NA NA
VAL E:170 E:197 2.0 0.013 H -65.2 -48.7 NA NA NA
VAL F:170 F:197 1.0 0.006 H -73.3 -48.4 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 5.0 0.032 H -59.1 -48.5 5.0 0.032 0.0 FPS
HOH
 6.841
2.711
 CG1
O
 C15
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 5.0 0.032 H -54.4 -47.8 5.0 0.032 0.0 PS7
HOH
 6.920
2.665
 CG1
O
 CAC
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 5.0 0.032 H -57.0 -46.3 5.0 0.032 0.0 PS7
HOH
 6.776
2.631
 CG1
O
 CAC
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 5.0 0.032 H -55.8 -51.2 5.0 0.032 0.0 PS7
HOH
 6.845
2.679
 CG1
O
 CAC
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 VAL A:170 A:197 3.0 0.019 H -59.4 -44.4 3.0 0.019 0.0 PS7
HOH
 6.980
2.666
 CG1
O
 CAC
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 VAL A:167 A:197 6.0 0.039 H -52.7 -43.9 6.0 0.039 0.0 IN0
HOH
 9.499
2.659
 CG1
O
 C26
O
VAL B:167 B:197 4.0 0.026 H -53.2 -49.3 NA NA NA
VAL C:167 C:197 6.0 0.039 H -57.1 -50.3 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 0.0 0.0 H -68.0 -54.7 0.0 0.0 0.0 FPS
HOH
 6.971
3.614
 CG1
O
 C15
O
VAL B:187 B:197 6.0 0.039 H -45.3 -48.3 6.0 0.039 0.0 FPS
HOH
 6.714
3.490
 CG1
O
 C15
O
VAL C:187 C:197 7.0 0.045 H -56.8 -37.4 7.0 0.045 0.0 FPS
HOH
 6.917
4.122
 CG1
CA
 C15
O
VAL D:187 D:197 4.0 0.026 H -57.1 -39.2 3.0 0.019 0.007 A:P37268:0.006
 FPS
HOH
 6.681
2.795
 CG1
O
 C15
O
VAL E:187 E:197 3.0 0.019 H -54.5 -56.7 3.0 0.019 0.0 FPS
HOH
 6.906
3.481
 CG1
CA
 C15
O
VAL F:187 F:197 1.0 0.006 H -68.5 -35.8 1.0 0.006 0.0 FPS
HOH
 6.879
7.228
 CG1
CG2
 C15
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 0.0 0.0 H -49.8 -56.0 0.0 0.0 0.0 RWY
HOH
 8.908
3.653
 CG1
CG1
 CAF
O
VAL B:187 B:197 2.0 0.013 H -52.2 -47.4 2.0 0.013 0.0 RWY
HOH
 9.044
7.289
 CG1
CG2
 CAF
O
VAL C:187 C:197 7.0 0.045 H -61.3 -43.3 7.0 0.045 0.0 HOH
 2.913
 O
 O
VAL D:187 D:197 2.0 0.013 H -43.9 -42.6 2.0 0.013 0.0 RWY
HOH
 9.070
7.042
 CG1
N
 CAF
O
VAL E:187 E:197 5.0 0.032 H -55.2 -44.8 5.0 0.032 0.0 RWY
HOH
 8.907
3.891
 CG1
CG2
 CAF
O
VAL F:187 F:197 1.0 0.006 H -55.7 -52.8 1.0 0.006 0.0 HOH
 3.993
 CA
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -62.5 -55.3 1.0 0.006 0.0 BH8
HOH
 7.256
3.573
 CG1
O
 CAA
O
VAL B:187 B:197 4.0 0.026 H -61.5 -45.0 3.0 0.019 0.007 F:P37268:0.006
 BH8
HOH
 7.622
2.694
 CG1
O
 CAA
O
VAL C:187 C:197 5.0 0.032 H -60.1 -42.2 5.0 0.032 0.0 BH8
HOH
 6.944
2.906
 CG1
O
 CAA
O
VAL D:187 D:197 4.0 0.026 H -62.1 -43.1 4.0 0.026 0.0 BH8
HOH
 7.438
2.769
 CG1
O
 CAA
O
VAL E:187 E:197 6.0 0.039 H -63.0 -55.0 6.0 0.039 0.0 BH8
HOH
 8.167
2.668
 CG1
O
 CAK
O
VAL F:187 F:197 1.0 0.006 H -77.9 -46.4 1.0 0.006 0.0 BH8
HOH
 7.736
3.704
 CG1
CG1
 CAA
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -59.2 -54.1 1.0 0.006 0.0 8PH
HOH
 7.691
3.662
 CG1
CG2
 CAA
O
VAL B:187 B:197 2.0 0.013 H -53.2 -48.6 2.0 0.013 0.0 8PH
HOH
 7.808
2.465
 CG1
O
 CAA
O
VAL C:187 C:197 5.0 0.032 H -59.4 -44.9 5.0 0.032 0.0 8PH
HOH
 7.744
3.332
 CG1
O
 CAA
O
VAL D:187 D:197 3.0 0.019 H -61.9 -38.9 3.0 0.019 0.0 8PH
HOH
 7.234
3.780
 CG1
CA
 CAA
O
VAL E:187 E:197 4.0 0.026 H -61.2 -47.5 4.0 0.026 0.0 8PH
HOH
 7.526
5.398
 CG1
C
 CAA
O
VAL F:187 F:197 0.0 0.0 H -55.4 -50.7 0.0 0.0 0.0 8PH
HOH
 8.088
3.897
 CG1
CG2
 CAA
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -65.7 -48.5 1.0 0.006 0.0 BH5
HOH
 7.583
3.654
 CG1
CG1
 CAA
O
VAL B:187 B:197 3.0 0.019 H -58.7 -44.7 3.0 0.019 0.0 BH5
HOH
 7.153
2.612
 CG1
O
 CAA
O
VAL C:187 C:197 6.0 0.039 H -58.8 -49.7 6.0 0.039 0.0 BH5
HOH
 7.115
2.883
 CG1
O
 CAA
O
VAL D:187 D:197 3.0 0.019 H -60.7 -40.9 3.0 0.019 0.0 BH5
HOH
 6.971
2.712
 CG1
O
 CAA
O
VAL E:187 E:197 2.0 0.013 H -59.3 -41.3 2.0 0.013 0.0 BH5
HOH
 7.023
3.132
 CG1
O
 CAA
O
VAL F:187 F:197 1.0 0.006 H -65.1 -47.6 1.0 0.006 0.0 BH5
HOH
 7.466
3.824
 CG1
CG2
 CAA
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -65.4 -53.5 1.0 0.006 0.0 E5S
HOH
 7.011
3.747
 CG1
O
 CAA
O
VAL B:187 B:197 3.0 0.019 H -52.8 -48.1 3.0 0.019 0.0 E5S
HOH
 7.025
2.601
 CG1
O
 CAA
O
VAL C:187 C:197 6.0 0.039 H -57.7 -43.9 6.0 0.039 0.0 E5S
HOH
 7.047
2.976
 CG1
O
 CAA
O
VAL D:187 D:197 3.0 0.019 H -62.3 -45.1 3.0 0.019 0.0 E5S
HOH
 7.026
2.781
 CG1
O
 CAA
O
VAL E:187 E:197 6.0 0.039 H -44.5 -50.8 6.0 0.039 0.0 E5S
HOH
 6.949
3.626
 CG1
CG2
 CAA
O
VAL F:187 F:197 0.0 0.0 H -65.5 -52.8 0.0 0.0 0.0 E5S
HOH
 7.188
3.984
 CG1
CG1
 CAA
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -61.6 -54.3 1.0 0.006 0.0 BH3
HOH
 7.624
3.386
 CG1
O
 CAA
O
VAL B:187 B:197 5.0 0.032 H -60.2 -52.8 5.0 0.032 0.0 HOH
 2.589
 O
 O
VAL C:187 C:197 6.0 0.039 H -57.0 -46.0 6.0 0.039 0.0 HOH
 2.916
 O
 O
VAL D:187 D:197 2.0 0.013 H -59.6 -43.9 2.0 0.013 0.0 HOH
 2.608
 O
 O
VAL E:187 E:197 8.0 0.052 H -58.4 -46.1 8.0 0.052 0.0 HOH
 3.031
 O
 O
VAL F:187 F:197 0.0 0.0 H -63.6 -56.7 0.0 0.0 0.0 HOH
 3.443
 O
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 VAL A:187 A:197 1.0 0.006 H -65.4 -55.3 1.0 0.006 0.0 ER4
HOH
 6.685
3.730
 CG1
O
 CAA
O
VAL B:187 B:197 5.0 0.032 H -56.1 -48.4 5.0 0.032 0.0 ER4
HOH
 6.767
2.656
 CG1
O
 CAA
O
VAL C:187 C:197 5.0 0.032 H -57.4 -44.5 5.0 0.032 0.0 ER4
HOH
 6.502
2.734
 CG1
O
 CAA
O
VAL D:187 D:197 3.0 0.019 H -54.6 -48.7 3.0 0.019 0.0 ER4
HOH
 6.596
2.600
 CG1
O
 CAA
O
VAL E:187 E:197 7.0 0.045 H -48.8 -57.9 7.0 0.045 0.0 ER4
HOH
 6.635
2.647
 CG1
O
 CAA
O
VAL F:187 F:197 0.0 0.0 H -63.2 -56.1 0.0 0.0 0.0 ER4
HOH
 6.660
3.505
 CG1
O
 CAA
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 VAL A:187 A:197 0.0 0.0 H -62.3 -44.8 0.0 0.0 0.0 RWZ
HOH
 7.049
6.735
 CG1
CG2
 CAA
O
VAL B:187 B:197 4.0 0.026 H -57.6 -51.4 4.0 0.026 0.0 RWZ
HOH
 6.922
7.767
 CG1
C
 CAA
O
VAL C:187 C:197 6.0 0.039 H -52.7 -50.8 6.0 0.039 0.0 RWZ
HOH
 6.846
5.439
 CG1
C
 CAA
O
VAL D:187 D:197 5.0 0.032 H -58.8 -32.0 5.0 0.032 0.0 HOH
 3.794
 CA
 O
VAL E:187 E:197 8.0 0.052 H -56.6 -46.5 8.0 0.052 0.0 RWZ
HOH
 6.647
7.443
 CG1
CG2
 CAA
O
VAL F:187 F:197 1.0 0.006 H -65.1 -40.1 1.0 0.006 0.0 HOH
 7.396
 CG2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 VAL A:197 A:197 5.0 0.032 H -63.6 -44.7