Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683630 . G A CCDS5985.1:NM_004462.3:c.608cGt>cAt_NP_004453.3:p.203R>H Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:173 A:203 69.0 0.307 H -65.7 -45.7 69.0 0.307 0.0 D99
HOH
 8.214
2.875
 O
NH1
 C10
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 ARG A:173 A:203 89.0 0.396 H -89.0 -36.5 89.0 0.396 0.0 HOH
 9.121
 N
 O
ARG B:173 B:203 64.0 0.284 H -77.8 -44.9 NA NA NA
ARG C:173 C:203 74.0 0.329 H -73.7 -48.0 NA NA NA
ARG D:173 D:203 73.0 0.324 H -71.5 -27.8 NA NA NA
ARG E:173 E:203 74.0 0.329 H -71.6 -60.8 NA NA NA
ARG F:173 F:203 90.0 0.4 H -83.2 -35.0 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:173 A:203 70.0 0.311 H -70.4 -43.3 70.0 0.311 0.0 D9A
HOH
 6.873
2.919
 O
NH2
 C19
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 ARG A:173 A:203 73.0 0.324 H -63.7 -46.1 73.0 0.324 0.0 D61
HOH
 7.445
3.117
 O
NH2
 C6
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 ARG A:173 A:203 72.0 0.32 H -67.5 -43.9 72.0 0.32 0.0 D3A
HOH
 7.102
2.929
 O
NH1
 C35
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:176 A:203 58.0 0.258 H -67.9 -41.0 58.0 0.258 0.0 HOH
 2.910
 NH1
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:176 A:203 67.0 0.298 H -65.8 -41.5 67.0 0.298 0.0 HOH
 3.085
 NH1
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:176 A:203 61.0 0.271 H -63.3 -40.9 61.0 0.271 0.0 HOH
 2.966
 NH2
 O
ARG B:176 B:203 64.0 0.284 H -68.6 -39.9 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:176 A:203 66.0 0.293 H -76.5 -31.8 66.0 0.293 0.0 HOH
 3.059
 NE
 O
ARG B:176 B:203 69.0 0.307 H -62.0 -43.7 69.0 0.307 0.0 HOH
 2.992
 NH1
 O
ARG C:176 C:203 72.0 0.32 H -68.8 -38.4 72.0 0.32 0.0 HOH
 2.963
 NH1
 O
ARG D:176 D:203 64.0 0.284 H -70.0 -42.2 NA NA NA
ARG E:176 E:203 70.0 0.311 H -62.9 -42.5 NA NA NA
ARG F:176 F:203 65.0 0.289 H -81.4 -32.2 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 ARG A:176 A:203 81.0 0.36 H -76.7 -30.9 81.0 0.36 0.0 HOH
 2.934
 NE
 O
ARG B:176 B:203 73.0 0.324 H -63.9 -45.5 73.0 0.324 0.0 HOH
 2.820
 NH1
 O
ARG C:176 C:203 70.0 0.311 H -62.1 -42.2 70.0 0.311 0.0 HOH
 2.985
 NH1
 O
ARG D:176 D:203 61.0 0.271 H -65.7 -37.8 NA NA NA
ARG E:176 E:203 69.0 0.307 H -67.9 -41.0 NA NA NA
ARG F:176 F:203 77.0 0.342 H -74.2 -29.9 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 81.0 0.36 H -73.0 -31.7 81.0 0.36 0.0 FPS
HOH
 5.701
3.229
 O
NE
 C15
O
ARG B:176 B:203 69.0 0.307 H -65.5 -40.9 69.0 0.307 0.0 FPS
HOH
 5.820
3.243
 O
NH2
 C15
O
ARG C:176 C:203 75.0 0.333 H -68.0 -40.2 75.0 0.333 0.0 FPS
HOH
 6.110
2.830
 O
NH1
 C15
O
ARG D:176 D:203 64.0 0.284 H -68.9 -46.8 NA NA NA
ARG E:176 E:203 71.0 0.316 H -65.2 -48.4 NA NA NA
ARG F:176 F:203 86.0 0.382 H -70.9 -23.2 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 61.0 0.271 H -66.8 -40.9 61.0 0.271 0.0 FPS
HOH
 5.746
2.960
 O
NH2
 C15
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 57.0 0.253 H -71.9 -40.4 57.0 0.253 0.0 PS7
HOH
 5.539
2.799
 O
NH2
 CAC
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 62.0 0.276 H -64.0 -40.7 62.0 0.276 0.0 PS7
HOH
 5.882
2.983
 O
NE
 CAC
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 59.0 0.262 H -63.4 -42.2 59.0 0.262 0.0 PS7
HOH
 5.667
2.938
 O
NH2
 CAC
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 ARG A:176 A:203 71.0 0.316 H -63.9 -42.6 71.0 0.316 0.0 PS7
HOH
 5.710
2.726
 O
NH1
 CAC
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 ARG A:173 A:203 55.0 0.244 H -67.2 -47.7 55.0 0.244 0.0 IN0
HOH
 7.165
3.241
 O
NH1
 C30
O
ARG B:173 B:203 60.0 0.267 H -59.9 -50.2 NA NA NA
ARG C:173 C:203 60.0 0.267 H -57.9 -46.4 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 65.0 0.289 H -72.1 -38.7 19.0 0.084 0.205 D:P37268:0.204
 FPS
HOH
 6.067
4.032
 O
NH1
 C15
O
ARG B:193 B:203 69.0 0.307 H -61.5 -44.8 69.0 0.307 0.0 FPS
HOH
 5.722
3.928
 O
NH2
 C15
O
ARG C:193 C:203 70.0 0.311 H -65.9 -33.2 70.0 0.311 0.0 FPS
HOH
 5.906
3.190
 O
NH1
 C15
O
ARG D:193 D:203 69.0 0.307 H -69.0 -31.8 69.0 0.307 0.0 FPS
HOH
 5.985
4.090
 O
NH1
 C15
O
ARG E:193 E:203 66.0 0.293 H -54.2 -44.3 66.0 0.293 0.0 FPS
HOH
 5.977
4.471
 O
CB
 C15
O
ARG F:193 F:203 84.0 0.373 H -84.0 -39.6 32.0 0.142 0.231 B:P37268:0.231
 FPS
HOH
 5.849
3.475
 O
NH1
 C15
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 65.0 0.289 H -68.0 -35.8 14.0 0.062 0.227 D:P37268:0.227
 RWY
HOH
 7.552
4.015
 O
NH1
 CAF
O
ARG B:193 B:203 67.0 0.298 H -68.9 -44.0 67.0 0.298 0.0 RWY
HOH
 7.730
3.712
 O
NH1
 CAF
O
ARG C:193 C:203 65.0 0.289 H -67.8 -45.0 65.0 0.289 0.0 HOH
 3.062
 NH1
 O
ARG D:193 D:203 66.0 0.293 H -66.7 -37.8 66.0 0.293 0.0 RWY
HOH
 7.636
5.879
 O
NH2
 CAF
O
ARG E:193 E:203 57.0 0.253 H -62.6 -49.2 57.0 0.253 0.0 RWY
HOH
 7.606
5.575
 O
NH1
 CAF
O
ARG F:193 F:203 77.0 0.342 H -71.4 -28.5 33.0 0.147 0.195 B:P37268:0.196
 HOH
 4.725
 N
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 69.0 0.307 H -63.0 -41.5 16.0 0.071 0.236 D:P37268:0.236
 BH8
HOH
 6.834
3.602
 O
NH1
 CAK
O
ARG B:193 B:203 71.0 0.316 H -63.0 -41.6 71.0 0.316 0.0 BH8
HOH
 7.063
2.811
 O
NH1
 CAK
O
ARG C:193 C:203 67.0 0.298 H -63.4 -46.8 67.0 0.298 0.0 BH8
HOH
 6.978
2.739
 O
NH2
 CAK
O
ARG D:193 D:203 68.0 0.302 H -62.6 -40.5 67.0 0.298 0.004 A:P37268:0.004
 BH8
HOH
 6.800
3.120
 O
NH1
 CAA
O
ARG E:193 E:203 69.0 0.307 H -56.8 -45.7 69.0 0.307 0.0 BH8
HOH
 7.423
3.851
 O
CB
 CAK
O
ARG F:193 F:203 83.0 0.369 H -76.1 -33.5 30.0 0.133 0.236 B:P37268:0.236
 BH8
HOH
 6.956
5.126
 O
NH1
 CAA
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 64.0 0.284 H -66.8 -44.0 13.0 0.058 0.226 D:P37268:0.227
 8PH
HOH
 7.079
3.999
 O
NH1
 CAL
O
ARG B:193 B:203 68.0 0.302 H -70.4 -36.5 68.0 0.302 0.0 8PH
HOH
 6.879
3.205
 O
NH1
 CAL
O
ARG C:193 C:203 69.0 0.307 H -69.2 -43.5 69.0 0.307 0.0 8PH
HOH
 7.032
4.889
 O
N
 CAA
O
ARG D:193 D:203 67.0 0.298 H -63.1 -40.8 67.0 0.298 0.0 8PH
HOH
 6.959
3.285
 O
NH1
 CAL
O
ARG E:193 E:203 62.0 0.276 H -69.4 -35.0 62.0 0.276 0.0 8PH
HOH
 6.678
4.428
 O
NE
 CAL
O
ARG F:193 F:203 77.0 0.342 H -72.4 -38.0 17.0 0.076 0.266 B:P37268:0.267
 8PH
HOH
 7.416
8.065
 O
NH1
 CAL
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 65.0 0.289 H -77.6 -28.8 13.0 0.058 0.231 D:P37268:0.231
 BH5
HOH
 7.322
3.361
 O
NH1
 CAL
O
ARG B:193 B:203 75.0 0.333 H -60.8 -40.6 75.0 0.333 0.0 BH5
HOH
 7.449
2.783
 O
NH1
 CAA
O
ARG C:193 C:203 64.0 0.284 H -69.7 -42.0 64.0 0.284 0.0 BH5
HOH
 7.219
2.896
 O
NH1
 CAA
O
ARG D:193 D:203 68.0 0.302 H -67.5 -40.7 68.0 0.302 0.0 BH5
HOH
 7.325
2.927
 O
NH1
 CAA
O
ARG E:193 E:203 67.0 0.298 H -60.2 -40.0 67.0 0.298 0.0 BH5
HOH
 7.242
3.583
 O
CB
 CAA
O
ARG F:193 F:203 83.0 0.369 H -68.8 -30.0 27.0 0.12 0.249 B:P37268:0.249
 BH5
HOH
 7.255
3.236
 O
NH1
 CAL
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 68.0 0.302 H -74.0 -29.7 16.0 0.071 0.231 D:P37268:0.231
 E5S
HOH
 6.495
3.312
 O
NH1
 CAA
O
ARG B:193 B:203 74.0 0.329 H -64.0 -43.0 74.0 0.329 0.0 E5S
HOH
 6.415
2.879
 O
NH1
 CAA
O
ARG C:193 C:203 70.0 0.311 H -67.9 -36.3 70.0 0.311 0.0 E5S
HOH
 6.258
2.720
 O
NH1
 CAA
O
ARG D:193 D:203 71.0 0.316 H -68.0 -40.5 71.0 0.316 0.0 E5S
HOH
 6.073
3.144
 O
NH1
 CAA
O
ARG E:193 E:203 66.0 0.293 H -56.1 -43.0 66.0 0.293 0.0 E5S
HOH
 6.234
5.216
 O
N
 CAA
O
ARG F:193 F:203 80.0 0.356 H -86.0 -27.3 33.0 0.147 0.209 B:P37268:0.209
 E5S
HOH
 6.477
2.984
 O
NE
 CAA
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 66.0 0.293 H -73.9 -30.3 16.0 0.071 0.222 D:P37268:0.222
 BH3
HOH
 7.402
3.477
 O
NH1
 CAA
O
ARG B:193 B:203 71.0 0.316 H -63.9 -41.5 71.0 0.316 0.0 HOH
 3.083
 NH1
 O
ARG C:193 C:203 64.0 0.284 H -68.9 -40.6 64.0 0.284 0.0 HOH
 2.782
 NH2
 O
ARG D:193 D:203 68.0 0.302 H -65.3 -41.7 68.0 0.302 0.0 HOH
 2.850
 NH1
 O
ARG E:193 E:203 64.0 0.284 H -59.1 -44.1 64.0 0.284 0.0 HOH
 3.061
 NE
 O
ARG F:193 F:203 81.0 0.36 H -77.6 -21.3 32.0 0.142 0.218 B:P37268:0.218
 HOH
 3.090
 NE
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 ARG A:193 A:203 65.0 0.289 H -75.2 -28.2 22.0 0.098 0.191 D:P37268:0.191
 ER4
HOH
 6.930
3.077
 O
NE
 OAV
O
ARG B:193 B:203 70.0 0.311 H -67.7 -39.2 70.0 0.311 0.0 ER4
HOH
 6.982
3.172
 O
NH1
 OAV
O
ARG C:193 C:203 65.0 0.289 H -67.9 -40.2 65.0 0.289 0.0 ER4
HOH
 7.151
2.628
 O
NH1
 CAA
O
ARG D:193 D:203 66.0 0.293 H -65.6 -41.1 66.0 0.293 0.0 ER4
HOH
 7.277
3.174
 O
NH1
 CAA
O
ARG E:193 E:203 66.0 0.293 H -58.7 -41.6 66.0 0.293 0.0 ER4
HOH
 6.871
3.189
 O
NH1
 OAV
O
ARG F:193 F:203 82.0 0.364 H -74.6 -31.0 31.0 0.138 0.226 B:P37268:0.227
 ER4
HOH
 6.594
3.093
 O
NE
 CAA
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 ARG A:193 A:203 72.0 0.32 H -78.2 -24.4 24.0 0.107 0.213 D:P37268:0.213
 RWZ
HOH
 5.725
3.514
 O
NE
 CAA
O
ARG B:193 B:203 66.0 0.293 H -69.2 -36.1 66.0 0.293 0.0 RWZ
HOH
 6.159
4.406
 O
NH2
 CAA
O
ARG C:193 C:203 67.0 0.298 H -64.1 -41.7 67.0 0.298 0.0 RWZ
HOH
 5.792
5.049
 O
N
 CAA
O
ARG D:193 D:203 61.0 0.271 H -84.3 -47.1 61.0 0.271 0.0 HOH
 4.687
 CB
 O
ARG E:193 E:203 70.0 0.311 H -59.7 -46.6 70.0 0.311 0.0 RWZ
HOH
 5.345
6.592
 O
N
 CAA
O
ARG F:193 F:203 84.0 0.373 H -79.2 -25.3 26.0 0.116 0.257 B:P37268:0.258
 HOH
 6.743
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 ARG A:203 A:203 63.0 0.28 H -69.5 -37.9