Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11683653 . T A CCDS5985.1:NM_004462.3:c.631Ttg>Atg_NP_004453.3:p.211L>M Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 LEU A:181 A:211 49.0 0.288 H -70.6 -45.9 49.0 0.288 0.0 D99
HOH
 3.837
3.627
 CD1
CD2
 CL1
O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 LEU A:181 A:211 38.0 0.224 H -52.3 -46.5 38.0 0.224 0.0 B65
HOH
 7.169
3.715
 CD1
CD1
 CAL
O
LEU B:181 B:211 40.0 0.235 H -48.4 -52.7 NA NA NA
LEU C:181 C:211 52.0 0.306 H -47.4 -45.3 NA NA NA
LEU D:181 D:211 34.0 0.2 H -52.8 -43.4 NA NA NA
LEU E:181 E:211 37.0 0.218 H -72.9 -39.2 NA NA NA
LEU F:181 F:211 43.0 0.253 H -47.9 -43.0 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 LEU A:181 A:211 48.0 0.282 H -68.8 -47.7 48.0 0.282 0.0 D9A
HOH
 3.698
2.870
 CB
O
 C26
O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 LEU A:181 A:211 60.0 0.353 H -62.0 -45.5 60.0 0.353 0.0 D61
HOH
 3.784
3.704
 CD1
CD1
 C12
O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 LEU A:181 A:211 48.0 0.282 H -63.6 -47.9 48.0 0.282 0.0 D3A
HOH
 3.666
2.877
 CD1
O
 O6
O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 LEU A:184 A:211 47.0 0.276 H -65.1 -44.2 47.0 0.276 0.0 HOH
 2.948
 O
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 LEU A:184 A:211 47.0 0.276 H -64.3 -45.2 47.0 0.276 0.0 HOH
 2.984
 O
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 LEU A:184 A:211 47.0 0.276 H -62.4 -42.1 47.0 0.276 0.0 HOH
 4.038
 CD2
 O
LEU B:184 B:211 48.0 0.282 H -63.6 -42.8 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 LEU A:184 A:211 38.0 0.224 H -61.3 -44.7 38.0 0.224 0.0 HOH
 2.987
 O
 O
LEU B:184 B:211 38.0 0.224 H -58.7 -49.8 38.0 0.224 0.0 HOH
 3.692
 CD2
 O
LEU C:184 C:211 40.0 0.235 H -56.7 -47.2 40.0 0.235 0.0 HOH
 3.954
 CD2
 O
LEU D:184 D:211 34.0 0.2 H -67.5 -40.2 NA NA NA
LEU E:184 E:211 48.0 0.282 H -62.8 -42.5 NA NA NA
LEU F:184 F:211 47.0 0.276 H -60.2 -44.3 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 LEU A:184 A:211 42.0 0.247 H -65.4 -42.1 42.0 0.247 0.0 ZGA
HOH
 3.946
3.869
 CD2
CD1
 CAE
O
LEU B:184 B:211 44.0 0.259 H -64.5 -47.0 44.0 0.259 0.0 ZGA
HOH
 3.892
7.727
 CD2
O
 CAE
O
LEU C:184 C:211 41.0 0.241 H -64.8 -45.8 41.0 0.241 0.0 ZGA
HOH
 3.305
3.971
 O
CD1
 CAB
O
LEU D:184 D:211 48.0 0.282 H -64.3 -42.9 NA NA NA
LEU E:184 E:211 44.0 0.259 H -66.7 -44.7 NA NA NA
LEU F:184 F:211 42.0 0.247 H -67.7 -41.9 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 37.0 0.218 H -69.4 -44.6 37.0 0.218 0.0 FPS
FPS
HOH
 3.626
6.652
3.084
 CD1
CD1
O
 C7
C11
O
LEU B:184 B:211 39.0 0.229 H -67.9 -42.3 39.0 0.229 0.0 FPS
FPS
HOH
 3.526
7.509
4.046
 CD1
CD1
CD1
 C7
C14
O
LEU C:184 C:211 39.0 0.229 H -53.1 -52.1 39.0 0.229 0.0 FPS
HOH
 3.520
3.881
 CD2
CD2
 C8
O
LEU D:184 D:211 39.0 0.229 H -64.3 -48.5 NA NA NA
LEU E:184 E:211 42.0 0.247 H -64.1 -48.1 NA NA NA
LEU F:184 F:211 44.0 0.259 H -60.6 -49.8 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 35.0 0.206 H -63.4 -43.1 35.0 0.206 0.0 MG
FPS
FPS
HOH
 8.072
3.802
7.342
2.916
 O
CD1
CD1
O
 MG
C8
C15
O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 36.0 0.212 H -68.1 -41.2 36.0 0.212 0.0 PS7
HOH
 3.902
3.806
 CD1
CD1
 CAQ
O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 38.0 0.224 H -73.0 -32.3 38.0 0.224 0.0 PS7
HOH
 3.880
3.499
 CD1
O
 CAF
O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 46.0 0.271 H -64.3 -41.2 46.0 0.271 0.0 MN
PS7
HOH
 7.964
3.621
2.535
 O
CD1
O
 MN
CBG
O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 LEU A:184 A:211 38.0 0.224 H -64.7 -41.4 38.0 0.224 0.0 PS7
HOH
 3.921
3.905
 CD1
CD1
 CAF
O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 LEU A:181 A:211 48.0 0.282 H -63.5 -46.5 48.0 0.282 0.0 IN0
HOH
 3.457
3.727
 CD1
CD1
 C33
O
LEU B:181 B:211 49.0 0.288 H -67.4 -41.3 NA NA NA
LEU C:181 C:211 47.0 0.276 H -61.3 -44.5 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 39.0 0.229 H -56.2 -45.7 39.0 0.229 0.0 FPS
HOH
 3.840
3.944
 CD1
CD1
 C5
O
LEU B:201 B:211 45.0 0.265 H -69.3 -49.8 45.0 0.265 0.0 FPS
HOH
 3.659
4.994
 CD1
CD1
 C11
O
LEU C:201 C:211 41.0 0.241 H -63.1 -46.8 41.0 0.241 0.0 FPS
HOH
 3.817
4.721
 CD1
CB
 C5
O
LEU D:201 D:211 44.0 0.259 H -70.7 -38.3 44.0 0.259 0.0 FPS
FPS
HOH
 3.629
7.495
3.653
 CB
CD1
CD1
 C5
C12
O
LEU E:201 E:211 39.0 0.229 H -71.4 -38.9 39.0 0.229 0.0 FPS
HOH
 3.587
3.778
 CD1
CD2
 C11
O
LEU F:201 F:211 37.0 0.218 H -60.8 -52.1 37.0 0.218 0.0 FPS
HOH
 3.868
9.244
 CB
O
 C5
O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 39.0 0.229 H -66.3 -36.9 39.0 0.229 0.0 RWY
HOH
 3.530
4.162
 CD1
CB
 CAK
O
LEU B:201 B:211 33.0 0.194 H -72.3 -54.3 33.0 0.194 0.0 RWY
HOH
 3.486
4.040
 CD1
CD2
 CAK
O
LEU C:201 C:211 37.0 0.218 H -55.1 -50.3 37.0 0.218 0.0 HOH
 3.622
 CD2
 O
LEU D:201 D:211 47.0 0.276 H -66.5 -33.2 47.0 0.276 0.0 RWY
HOH
 3.458
3.311
 CD1
CB
 CAK
O
LEU E:201 E:211 32.0 0.188 H -71.6 -55.0 32.0 0.188 0.0 RWY
HOH
 3.829
4.574
 CD1
CD2
 CAI
O
LEU F:201 F:211 40.0 0.235 H -69.1 -56.3 40.0 0.235 0.0 HOH
 4.201
 CD1
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 38.0 0.224 H -62.8 -42.0 38.0 0.224 0.0 BH8
HOH
 3.608
3.707
 CD1
CD1
 CAP
O
LEU B:201 B:211 38.0 0.224 H -67.5 -42.6 38.0 0.224 0.0 BH8
HOH
 3.757
3.642
 CD1
CD2
 CAN
O
LEU C:201 C:211 38.0 0.224 H -67.6 -46.3 38.0 0.224 0.0 BH8
HOH
 3.654
4.036
 CD1
CD1
 CAO
O
LEU D:201 D:211 47.0 0.276 H -62.4 -47.1 47.0 0.276 0.0 BH8
HOH
 3.217
3.710
 CD1
CD2
 CAN
O
LEU E:201 E:211 35.0 0.206 H -64.9 -47.4 35.0 0.206 0.0 BH8
HOH
 3.197
3.815
 CD1
CD2
 CAN
O
LEU F:201 F:211 37.0 0.218 H -63.2 -50.6 37.0 0.218 0.0 BH8
HOH
 3.552
3.999
 CD1
CD1
 CAQ
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 47.0 0.276 H -67.2 -46.2 47.0 0.276 0.0 8PH
8PH
8PH
HOH
 3.748
4.530
4.680
4.196
 CD2
CD2
CG
CG
 CAO
CAQ
CAS
O
LEU B:201 B:211 48.0 0.282 H -73.2 -48.6 48.0 0.282 0.0 8PH
8PH
HOH
 3.412
4.372
4.201
 CD2
CD2
CD2
 CAP
CAP
O
LEU C:201 C:211 41.0 0.241 H -59.8 -50.5 41.0 0.241 0.0 8PH
HOH
 3.218
4.161
 CD2
CD2
 CAP
O
LEU D:201 D:211 50.0 0.294 H -66.4 -44.3 50.0 0.294 0.0 8PH
HOH
 3.370
3.796
 CD2
CD2
 CAQ
O
LEU E:201 E:211 38.0 0.224 H -65.4 -46.1 38.0 0.224 0.0 8PH
HOH
 4.104
4.369
 CD2
CD2
 CAO
O
LEU F:201 F:211 52.0 0.306 H -74.0 -45.5 52.0 0.306 0.0 8PH
8PH
HOH
 3.536
4.328
9.692
 CD2
CD2
O
 CAP
CAP
O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 39.0 0.229 H -68.5 -45.5 39.0 0.229 0.0 BH5
HOH
 3.325
3.942
 CD1
CD1
 CAP
O
LEU B:201 B:211 50.0 0.294 H -67.2 -45.0 50.0 0.294 0.0 BH5
HOH
 3.313
3.753
 CD1
CD2
 CAP
O
LEU C:201 C:211 37.0 0.218 H -67.2 -47.5 37.0 0.218 0.0 BH5
HOH
 3.337
3.951
 CD1
CD1
 CAP
O
LEU D:201 D:211 47.0 0.276 H -63.9 -47.9 47.0 0.276 0.0 BH5
HOH
 3.331
3.647
 CD1
CD2
 CAP
O
LEU E:201 E:211 37.0 0.218 H -70.1 -43.1 37.0 0.218 0.0 BH5
HOH
 3.308
3.753
 CD1
CD2
 CAP
O
LEU F:201 F:211 49.0 0.288 H -66.9 -45.9 49.0 0.288 0.0 BH5
HOH
 3.366
3.962
 CD1
CD1
 CAP
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 39.0 0.229 H -63.5 -45.2 39.0 0.229 0.0 E5S
HOH
 3.426
4.084
 CD1
CB
 CAY
O
LEU B:201 B:211 36.0 0.212 H -66.8 -45.7 36.0 0.212 0.0 E5S
HOH
 3.445
4.186
 CD1
CB
 CAY
O
LEU C:201 C:211 37.0 0.218 H -63.0 -46.2 37.0 0.218 0.0 E5S
HOH
 3.582
3.894
 CD1
CB
 CAY
O
LEU D:201 D:211 40.0 0.235 H -68.5 -48.9 40.0 0.235 0.0 E5S
HOH
 3.519
4.402
 CD1
CD2
 CAY
O
LEU E:201 E:211 35.0 0.206 H -68.2 -45.5 35.0 0.206 0.0 E5S
HOH
 3.432
3.987
 CD1
CD2
 CAY
O
LEU F:201 F:211 36.0 0.212 H -63.3 -51.0 36.0 0.212 0.0 E5S
HOH
 3.541
4.434
 CD1
CD2
 NBE
O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 37.0 0.218 H -68.1 -42.1 37.0 0.218 0.0 BH3
HOH
 3.174
3.088
 CD1
O
 CAO
O
LEU B:201 B:211 39.0 0.229 H -65.6 -43.4 39.0 0.229 0.0 HOH
 3.740
 CD1
 O
LEU C:201 C:211 40.0 0.235 H -62.0 -45.9 40.0 0.235 0.0 HOH
 3.709
 CD1
 O
LEU D:201 D:211 41.0 0.241 H -68.3 -43.0 41.0 0.241 0.0 HOH
 3.587
 CD1
 O
LEU E:201 E:211 36.0 0.212 H -69.5 -46.4 36.0 0.212 0.0 HOH
 3.548
 CD1
 O
LEU F:201 F:211 47.0 0.276 H -65.6 -48.4 47.0 0.276 0.0 HOH
 3.999
 CD1
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 LEU A:201 A:211 37.0 0.218 H -64.4 -42.7 37.0 0.218 0.0 ER4
HOH
 3.502
2.730
 CD1
O
 OAW
O
LEU B:201 B:211 35.0 0.206 H -63.0 -41.7 35.0 0.206 0.0 ER4
HOH
 3.641
3.996
 CD1
CD1
 OAW
O
LEU C:201 C:211 37.0 0.218 H -64.5 -47.6 37.0 0.218 0.0 ER4
HOH
 3.556
3.702
 CD1
CD1
 OAW
O
LEU D:201 D:211 39.0 0.229 H -63.4 -47.8 39.0 0.229 0.0 ER4
HOH
 3.472
3.891
 CD1
CD1
 OAW
O
LEU E:201 E:211 37.0 0.218 H -69.8 -46.4 37.0 0.218 0.0 ER4
HOH
 3.449
3.889
 CD1
CD1
 OAW
O
LEU F:201 F:211 37.0 0.218 H -60.8 -44.4 37.0 0.218 0.0 ER4
HOH
 3.466
3.864
 CD1
CD1
 OAW
O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 LEU A:201 A:211 39.0 0.229 H -75.8 -40.5 39.0 0.229 0.0 RWZ
HOH
 3.572
4.808
 CD1
O
 CAJ
O
LEU B:201 B:211 53.0 0.312 H -67.6 -46.7 53.0 0.312 0.0 RWZ
HOH
 3.487
5.163
 CD1
CD2
 CAJ
O
LEU C:201 C:211 44.0 0.259 H -62.6 -44.7 44.0 0.259 0.0 RWZ
HOH
 3.487
4.410
 CD1
CD2
 CAJ
O
LEU D:201 D:211 45.0 0.265 H -72.9 -42.5 45.0 0.265 0.0 HOH
 3.434
 CD1
 O
LEU E:201 E:211 37.0 0.218 H -72.6 -38.9 37.0 0.218 0.0 RWZ
HOH
 3.592
7.910
 CD1
O
 CAJ
O
LEU F:201 F:211 56.0 0.329 H -79.7 -43.3 56.0 0.329 0.0 HOH
 5.269
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 LEU A:211 A:211 37.0 0.218 H -66.8 -45.7