Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11687833 . A C CCDS5985.1:NM_004462.3:c.783gaA>gaC_NP_004453.3:p.261E>D Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLU A:231 A:261 10.0 0.053 H -70.5 -40.8 10.0 0.053 0.0 HOH
 2.531
 OE2
 O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 GLU A:231 A:261 5.0 0.026 H -55.4 -49.7 5.0 0.026 0.0 HOH
 4.349
 CG
 O
GLU B:231 B:261 44.0 0.232 H -64.8 -53.6 NA NA NA
GLU C:231 C:261 46.0 0.242 H -64.8 -56.0 NA NA NA
GLU D:231 D:261 29.0 0.153 H -56.4 -57.1 NA NA NA
GLU E:231 E:261 14.0 0.074 H -54.3 -40.6 NA NA NA
GLU F:231 NA:NA DO NA DO DO DO NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLU A:231 A:261 13.0 0.068 H -68.8 -42.0 13.0 0.068 0.0 HOH
 2.684
 OE2
 O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLU A:231 A:261 23.0 0.121 H -60.9 -47.7 23.0 0.121 0.0 HOH
 2.623
 OE2
 O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 GLU A:231 A:261 9.0 0.047 H -65.2 -46.5 9.0 0.047 0.0 HOH
 2.631
 OE2
 O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLU A:234 A:261 17.0 0.089 H -67.2 -41.2 17.0 0.089 0.0 HOH
 2.691
 OE2
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLU A:234 A:261 30.0 0.158 H -62.9 -44.4 30.0 0.158 0.0 HOH
 2.677
 OE2
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLU A:234 A:261 31.0 0.163 H -62.5 -45.1 31.0 0.163 0.0 HOH
 2.629
 OE2
 O
GLU B:234 B:261 31.0 0.163 H -65.6 -41.8 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLU A:234 A:261 28.0 0.147 H -64.3 -40.1 28.0 0.147 0.0 HOH
 2.719
 O
 O
GLU B:234 B:261 14.0 0.074 H -67.4 -41.8 14.0 0.074 0.0 HOH
 2.280
 OE2
 O
GLU C:234 C:261 32.0 0.168 H -64.8 -41.1 32.0 0.168 0.0 HOH
 2.889
 OE2
 O
GLU D:234 D:261 19.0 0.1 H -63.3 -41.6 NA NA NA
GLU E:234 E:261 29.0 0.153 H -59.0 -41.7 NA NA NA
GLU F:234 F:261 36.0 0.189 H -62.7 -44.8 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLU A:234 A:261 27.0 0.142 H -61.5 -47.1 27.0 0.142 0.0 HOH
 2.598
 OE2
 O
GLU B:234 B:261 18.0 0.095 H -59.5 -46.6 18.0 0.095 0.0 HOH
 2.679
 OE2
 O
GLU C:234 C:261 9.0 0.047 H -63.7 -46.2 9.0 0.047 0.0 HOH
 2.696
 O
 O
GLU D:234 D:261 15.0 0.079 H -61.4 -45.4 NA NA NA
GLU E:234 E:261 29.0 0.153 H -65.5 -40.5 NA NA NA
GLU F:234 F:261 15.0 0.079 H -58.2 -46.4 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 31.0 0.163 H -68.7 -45.8 31.0 0.163 0.0 HOH
 3.853
 N
 O
GLU B:234 B:261 16.0 0.084 H -64.0 -47.2 16.0 0.084 0.0 HOH
 7.584
 O
 O
GLU C:234 C:261 17.0 0.089 H -65.0 -44.0 17.0 0.089 0.0 HOH
 5.353
 N
 O
GLU D:234 D:261 10.0 0.053 H -67.4 -39.6 NA NA NA
GLU E:234 E:261 26.0 0.137 H -65.6 -44.8 NA NA NA
GLU F:234 F:261 30.0 0.158 H -60.0 -53.9 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 31.0 0.163 H -65.8 -43.8 31.0 0.163 0.0 HOH
 2.779
 O
 O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 28.0 0.147 H -59.6 -46.2 28.0 0.147 0.0 HOH
 2.797
 OE2
 O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 29.0 0.153 H -68.6 -44.8 29.0 0.153 0.0 HOH
 2.701
 O
 O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 29.0 0.153 H -64.1 -46.3 29.0 0.153 0.0 HOH
 2.775
 OE2
 O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLU A:234 A:261 12.0 0.063 H -67.4 -35.9 12.0 0.063 0.0 HOH
 2.442
 O
 O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 GLU A:231 A:261 11.0 0.058 H -69.1 -37.7 11.0 0.058 0.0 HOH
 2.785
 OE2
 O
GLU B:231 B:261 12.0 0.063 H -72.7 -41.0 NA NA NA
GLU C:231 C:261 29.0 0.153 H -66.1 -44.8 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 23.0 0.121 H -63.5 -46.2 23.0 0.121 0.0 HOH
 3.044
 O
 O
GLU B:251 B:261 22.0 0.116 H -69.0 -47.4 22.0 0.116 0.0 HOH
 3.180
 OE2
 O
GLU C:251 C:261 35.0 0.184 H -51.4 -54.6 35.0 0.184 0.0 HOH
 2.925
 O
 O
GLU D:251 D:261 22.0 0.116 H -64.9 -44.8 22.0 0.116 0.0 HOH
 6.356
 O
 O
GLU E:251 E:261 17.0 0.089 H -66.6 -48.9 17.0 0.089 0.0 HOH
 6.163
 O
 O
GLU F:251 F:261 27.0 0.142 H -56.1 -14.8 27.0 0.142 0.0 HOH
 3.949
 OE2
 O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 20.0 0.105 H -73.7 -44.6 20.0 0.105 0.0 HOH
 3.366
 OE1
 O
GLU B:251 B:261 15.0 0.079 H -74.9 -38.0 15.0 0.079 0.0 HOH
 5.760
 O
 O
GLU C:251 C:261 27.0 0.142 H -58.8 -60.7 27.0 0.142 0.0 HOH
 3.355
 CG
 O
GLU D:251 D:261 19.0 0.1 H -78.2 -30.8 19.0 0.1 0.0 HOH
 8.763
 O
 O
GLU E:251 E:261 18.0 0.095 H -74.4 -38.7 18.0 0.095 0.0 HOH
 3.202
 O
 O
GLU F:251 F:261 26.0 0.137 H -54.2 -42.3 26.0 0.137 0.0 HOH
 4.836
 O
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 11.0 0.058 H -70.3 -41.1 11.0 0.058 0.0 HOH
 2.728
 O
 O
GLU B:251 B:261 16.0 0.084 H -69.5 -40.2 16.0 0.084 0.0 HOH
 7.734
 O
 O
GLU C:251 C:261 11.0 0.058 H -64.5 -45.3 11.0 0.058 0.0 HOH
 2.779
 O
 O
GLU D:251 D:261 13.0 0.068 H -67.0 -43.2 13.0 0.068 0.0 HOH
 2.505
 O
 O
GLU E:251 E:261 10.0 0.053 H -69.2 -41.6 10.0 0.053 0.0 HOH
 2.559
 OE2
 O
GLU F:251 F:261 16.0 0.084 H -64.2 -29.5 16.0 0.084 0.0 HOH
 8.319
 O
 O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 18.0 0.095 H -66.9 -43.5 18.0 0.095 0.0 HOH
 3.040
 O
 O
GLU B:251 B:261 16.0 0.084 H -77.5 -30.0 16.0 0.084 0.0 HOH
 7.640
 OE2
 O
GLU C:251 C:261 14.0 0.074 H -71.5 -40.0 14.0 0.074 0.0 HOH
 3.151
 O
 O
GLU D:251 D:261 20.0 0.105 H -75.9 -35.3 20.0 0.105 0.0 HOH
 7.852
 OE2
 O
GLU E:251 E:261 14.0 0.074 H -69.6 -36.1 14.0 0.074 0.0 HOH
 2.920
 O
 O
GLU F:251 F:261 24.0 0.126 H -66.6 -24.6 24.0 0.126 0.0 HOH
 7.195
 OE2
 O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 20.0 0.105 H -70.3 -44.5 20.0 0.105 0.0 HOH
 2.840
 O
 O
GLU B:251 B:261 11.0 0.058 H -69.2 -38.6 11.0 0.058 0.0 HOH
 3.288
 O
 O
GLU C:251 C:261 16.0 0.084 H -66.9 -42.3 16.0 0.084 0.0 HOH
 2.619
 O
 O
GLU D:251 D:261 15.0 0.079 H -64.7 -40.7 15.0 0.079 0.0 HOH
 5.001
 N
 O
GLU E:251 E:261 12.0 0.063 H -66.8 -38.4 12.0 0.063 0.0 HOH
 2.714
 O
 O
GLU F:251 F:261 17.0 0.089 H -69.8 -36.8 17.0 0.089 0.0 HOH
 6.363
 O
 O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 20.0 0.105 H -71.2 -39.6 20.0 0.105 0.0 HOH
 2.659
 OE2
 O
GLU B:251 B:261 22.0 0.116 H -71.2 -40.3 22.0 0.116 0.0 HOH
 2.584
 O
 O
GLU C:251 C:261 11.0 0.058 H -71.4 -45.6 11.0 0.058 0.0 HOH
 3.627
 N
 O
GLU D:251 D:261 11.0 0.058 H -69.1 -50.1 11.0 0.058 0.0 HOH
 8.833
 O
 O
GLU E:251 E:261 17.0 0.089 H -68.8 -43.3 17.0 0.089 0.0 HOH
 2.724
 OE2
 O
GLU F:251 F:261 23.0 0.121 H -57.8 -41.0 23.0 0.121 0.0 HOH
 5.129
 OE1
 O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 21.0 0.111 H -73.4 -42.5 21.0 0.111 0.0 HOH
 2.512
 O
 O
GLU B:251 B:261 15.0 0.079 H -68.4 -40.9 15.0 0.079 0.0 HOH
 2.482
 O
 O
GLU C:251 C:261 15.0 0.079 H -62.4 -48.0 15.0 0.079 0.0 HOH
 2.607
 O
 O
GLU D:251 D:261 16.0 0.084 H -68.7 -46.4 16.0 0.084 0.0 HOH
 2.630
 O
 O
GLU E:251 E:261 31.0 0.163 H -70.7 -37.7 31.0 0.163 0.0 HOH
 2.658
 OE2
 O
GLU F:251 F:261 16.0 0.084 H -64.4 -46.7 16.0 0.084 0.0 HOH
 2.564
 O
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLU A:251 A:261 22.0 0.116 H -67.1 -42.8 22.0 0.116 0.0 HOH
 2.788
 O
 O
GLU B:251 B:261 18.0 0.095 H -69.2 -38.4 18.0 0.095 0.0 HOH
 2.926
 O
 O
GLU C:251 C:261 21.0 0.111 H -69.0 -40.8 21.0 0.111 0.0 HOH
 2.789
 O
 O
GLU D:251 D:261 21.0 0.111 H -70.5 -36.3 21.0 0.111 0.0 HOH
 4.800
 O
 O
GLU E:251 E:261 11.0 0.058 H -68.9 -40.7 11.0 0.058 0.0 HOH
 2.677
 O
 O
GLU F:251 F:261 13.0 0.068 H -65.9 -36.1 13.0 0.068 0.0 HOH
 5.014
 O
 O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 GLU A:251 A:261 27.0 0.142 H -75.0 -44.3 27.0 0.142 0.0 HOH
 3.378
 OE1
 O
GLU B:251 B:261 27.0 0.142 H -70.7 -38.0 27.0 0.142 0.0 HOH
 8.925
 OE2
 O
GLU C:251 C:261 18.0 0.095 H -63.4 -44.8 18.0 0.095 0.0 HOH
 5.110
 OE2
 O
GLU D:251 D:261 20.0 0.105 H -62.8 -46.2 20.0 0.105 0.0
GLU E:251 E:261 14.0 0.074 H -68.0 -37.8 14.0 0.074 0.0
GLU F:251 F:261 11.0 0.058 H -66.6 -46.0 11.0 0.058 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 GLU A:261 A:261 20.0 0.105 H -62.6 -46.6