Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11687883 . C A CCDS5985.1:NM_004462.3:c.833tCg>tAg_NP_004453.3:p.278S>* Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 SER A:248 A:278 50.0 0.435 H -62.3 -21.2 50.0 0.435 0.0 HOH
 2.673
 OG
 O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 SER A:248 A:278 43.0 0.374 T -61.6 -9.7 43.0 0.374 0.0 HOH
 8.033
 O
 O
SER B:248 B:278 40.0 0.348 H -64.8 -28.5 NA NA NA
SER C:248 C:278 50.0 0.435 T -78.0 0.8 NA NA NA
SER D:248 D:278 48.0 0.417 H -81.5 -16.6 NA NA NA
SER E:248 E:278 58.0 0.504 H -51.5 -41.4 NA NA NA
SER F:248 F:278 39.0 0.339 T -68.2 -10.2 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 SER A:248 A:278 65.0 0.565 H -69.9 -15.2 65.0 0.565 0.0 HOH
 3.458
 O
 O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 SER A:248 A:278 48.0 0.417 H -64.5 -20.4 48.0 0.417 0.0 HOH
 3.618
 O
 O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 SER A:248 A:278 45.0 0.391 H -73.4 -14.0 45.0 0.391 0.0 HOH
 3.532
 O
 O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 SER A:251 A:278 66.0 0.574 H -69.0 -17.2 66.0 0.574 0.0 HOH
 3.191
 O
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 SER A:251 A:278 66.0 0.574 H -67.5 -20.0 66.0 0.574 0.0 HOH
 2.872
 OG
 O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 SER A:251 A:278 67.0 0.583 H -65.4 -19.0 67.0 0.583 0.0 HOH
 3.548
 O
 O
SER B:251 B:278 68.0 0.591 H -66.9 -21.8 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 SER A:251 A:278 40.0 0.348 H -67.7 -21.7 40.0 0.348 0.0 HOH
 3.061
 O
 O
SER B:251 B:278 42.0 0.365 H -71.9 -10.3 42.0 0.365 0.0 HOH
 3.241
 O
 O
SER C:251 C:278 49.0 0.426 H -69.9 -15.2 49.0 0.426 0.0 HOH
 2.301
 OG
 O
SER D:251 D:278 59.0 0.513 H -60.5 -15.2 NA NA NA
SER E:251 E:278 43.0 0.374 H -74.5 -7.9 NA NA NA
SER F:251 F:278 41.0 0.357 H -60.3 -25.0 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 SER A:251 A:278 41.0 0.357 H -61.2 -23.4 41.0 0.357 0.0 HOH
 2.740
 OG
 O
SER B:251 B:278 63.0 0.548 H -68.4 -18.4 63.0 0.548 0.0 HOH
 3.126
 OG
 O
SER C:251 C:278 50.0 0.435 H -65.9 -16.9 50.0 0.435 0.0 HOH
 2.738
 O
 O
SER D:251 D:278 60.0 0.522 H -69.3 -17.2 NA NA NA
SER E:251 E:278 45.0 0.391 H -68.8 -15.2 NA NA NA
SER F:251 F:278 42.0 0.365 H -67.4 -20.8 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 SER A:251 A:278 36.0 0.313 H -70.6 -21.3 36.0 0.313 0.0 HOH
 3.261
 O
 O
SER B:251 B:278 44.0 0.383 H -72.3 -9.0 44.0 0.383 0.0 HOH
 3.527
 O
 O
SER C:251 C:278 50.0 0.435 H -65.6 -15.7 50.0 0.435 0.0 HOH
 2.955
 O
 O
SER D:251 D:278 59.0 0.513 H -67.0 -21.1 NA NA NA
SER E:251 E:278 44.0 0.383 H -76.2 -9.7 NA NA NA
SER F:251 F:278 42.0 0.365 H -63.3 -20.9 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 SER A:251 A:278 66.0 0.574 H -67.8 -17.4 66.0 0.574 0.0 HOH
 3.350
 O
 O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 SER A:251 A:278 65.0 0.565 H -70.5 -14.7 65.0 0.565 0.0 HOH
 3.411
 CB
 O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 SER A:251 A:278 65.0 0.565 H -69.8 -18.8 65.0 0.565 0.0 HOH
 2.352
 OG
 O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 SER A:251 A:278 67.0 0.583 H -64.2 -21.6 67.0 0.583 0.0 HOH
 3.328
 O
 O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 SER A:251 A:278 68.0 0.591 H -64.1 -18.7 68.0 0.591 0.0 HOH
 3.490
 O
 O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 SER A:248 A:278 42.0 0.365 H -67.9 -15.4 42.0 0.365 0.0 HOH
 2.676
 O
 O
SER B:248 B:278 61.0 0.53 H -73.6 -17.7 NA NA NA
SER C:248 C:278 64.0 0.557 H -68.6 -19.3 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 43.0 0.374 H -53.0 -38.3 41.0 0.357 0.017 D:P37268:0.017
 HOH
 3.445
 OG
 O
SER B:268 B:278 42.0 0.365 T -77.8 2.0 42.0 0.365 0.0 HOH
 3.787
 OG
 O
SER C:268 C:278 46.0 0.4 H -67.6 -14.6 46.0 0.4 0.0 HOH
 3.379
 O
 O
SER D:268 D:278 42.0 0.365 T -71.4 -7.9 42.0 0.365 0.0 HOH
 3.129
 C
 O
SER E:268 E:278 49.0 0.426 H -77.2 -11.8 49.0 0.426 0.0 HOH
 6.602
 O
 O
SER F:268 F:278 51.0 0.443 H -67.0 -16.3 43.0 0.374 0.069 B:P37268:0.07
 HOH
 3.619
 OG
 O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 42.0 0.365 T -57.9 -11.2 42.0 0.365 0.0 HOH
 4.007
 O
 O
SER B:268 B:278 46.0 0.4 T -75.8 -1.0 46.0 0.4 0.0 HOH
 2.810
 O
 O
SER C:268 C:278 39.0 0.339 H -63.9 -27.5 39.0 0.339 0.0 HOH
 3.405
 O
 O
SER D:268 D:278 42.0 0.365 H -73.2 -15.1 42.0 0.365 0.0 HOH
 3.158
 O
 O
SER E:268 E:278 41.0 0.357 H -61.2 -33.9 41.0 0.357 0.0 HOH
 5.639
 N
 O
SER F:268 F:278 46.0 0.4 H -65.0 -17.5 38.0 0.33 0.07 B:P37268:0.07
 HOH
 5.355
 O
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 42.0 0.365 H -65.7 -27.4 42.0 0.365 0.0 HOH
 2.838
 O
 O
SER B:268 B:278 45.0 0.391 T -72.5 -1.9 45.0 0.391 0.0 HOH
 3.610
 C
 O
SER C:268 C:278 44.0 0.383 H -68.8 -14.3 44.0 0.383 0.0 HOH
 3.427
 O
 O
SER D:268 D:278 39.0 0.339 H -66.9 -24.9 39.0 0.339 0.0 HOH
 3.197
 O
 O
SER E:268 E:278 41.0 0.357 H -58.9 -15.2 41.0 0.357 0.0 HOH
 3.544
 O
 O
SER F:268 F:278 42.0 0.365 H -59.9 -26.4 36.0 0.313 0.052 B:P37268:0.052
 HOH
 3.486
 O
 O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 56.0 0.487 H -66.1 -18.5 56.0 0.487 0.0 HOH
 3.294
 OG
 O
SER B:268 B:278 50.0 0.435 T -67.0 -11.6 50.0 0.435 0.0 HOH
 2.985
 O
 O
SER C:268 C:278 41.0 0.357 T -72.7 -8.8 41.0 0.357 0.0 HOH
 3.645
 C
 O
SER D:268 D:278 39.0 0.339 H -66.3 -23.5 39.0 0.339 0.0 HOH
 3.327
 O
 O
SER E:268 E:278 60.0 0.522 H -66.7 -13.1 60.0 0.522 0.0 HOH
 3.114
 CB
 O
SER F:268 F:278 60.0 0.522 H -63.8 -25.7 58.0 0.504 0.018 B:P37268:0.017
 HOH
 3.281
 O
 O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 43.0 0.374 H -66.6 -21.0 43.0 0.374 0.0 HOH
 3.540
 O
 O
SER B:268 B:278 48.0 0.417 H -69.4 -17.2 48.0 0.417 0.0 HOH
 2.730
 OG
 O
SER C:268 C:278 44.0 0.383 H -64.4 -17.0 44.0 0.383 0.0 HOH
 3.429
 O
 O
SER D:268 D:278 41.0 0.357 H -66.4 -23.6 41.0 0.357 0.0 HOH
 3.279
 O
 O
SER E:268 E:278 62.0 0.539 H -69.3 -17.7 62.0 0.539 0.0 HOH
 3.049
 O
 O
SER F:268 F:278 44.0 0.383 H -64.7 -32.0 40.0 0.348 0.035 B:P37268:0.035
 HOH
 3.093
 O
 O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 45.0 0.391 H -65.6 -24.5 39.0 0.339 0.052 D:P37268:0.052
 HOH
 3.168
 OG
 O
SER B:268 B:278 49.0 0.426 T -69.8 -9.8 49.0 0.426 0.0 HOH
 2.809
 O
 O
SER C:268 C:278 48.0 0.417 H -63.2 -15.8 48.0 0.417 0.0 HOH
 3.346
 O
 O
SER D:268 D:278 41.0 0.357 H -61.2 -20.4 41.0 0.357 0.0 HOH
 3.191
 O
 O
SER E:268 E:278 48.0 0.417 T -66.4 -6.8 48.0 0.417 0.0 HOH
 3.487
 C
 O
SER F:268 F:278 42.0 0.365 H -60.2 -29.7 33.0 0.287 0.078 B:P37268:0.078
 HOH
 2.655
 OG
 O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 43.0 0.374 H -65.5 -23.4 43.0 0.374 0.0 HOH
 3.095
 OG
 O
SER B:268 B:278 47.0 0.409 T -69.3 -12.6 47.0 0.409 0.0 HOH
 2.801
 O
 O
SER C:268 C:278 44.0 0.383 H -65.4 -15.0 44.0 0.383 0.0 HOH
 3.587
 O
 O
SER D:268 D:278 38.0 0.33 H -65.6 -16.9 38.0 0.33 0.0 HOH
 3.099
 O
 O
SER E:268 E:278 47.0 0.409 T -64.9 -6.4 47.0 0.409 0.0 HOH
 3.758
 C
 O
SER F:268 F:278 42.0 0.365 H -67.2 -25.2 36.0 0.313 0.052 B:P37268:0.052
 HOH
 3.117
 OG
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 SER A:268 A:278 42.0 0.365 H -63.5 -20.4 42.0 0.365 0.0 HOH
 2.905
 OG
 O
SER B:268 B:278 49.0 0.426 H -68.4 -15.9 49.0 0.426 0.0 HOH
 3.074
 OG
 O
SER C:268 C:278 45.0 0.391 H -61.7 -19.2 45.0 0.391 0.0 HOH
 3.378
 O
 O
SER D:268 D:278 40.0 0.348 H -64.9 -19.1 40.0 0.348 0.0 HOH
 3.049
 O
 O
SER E:268 E:278 44.0 0.383 T -68.2 -8.7 44.0 0.383 0.0 HOH
 3.316
 CB
 O
SER F:268 F:278 41.0 0.357 H -64.1 -17.4 37.0 0.322 0.035 B:P37268:0.035
 HOH
 2.860
 OG
 O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 SER A:268 A:278 48.0 0.417 T -69.9 -7.9 48.0 0.417 0.0 HOH
 3.842
 OG
 O
SER B:268 B:278 48.0 0.417 T -59.0 -7.7 48.0 0.417 0.0 HOH
 3.129
 O
 O
SER C:268 C:278 47.0 0.409 H -72.1 -23.4 47.0 0.409 0.0 HOH
 2.952
 O
 O
SER D:268 D:278 42.0 0.365 T -65.3 -17.7 42.0 0.365 0.0 HOH
 3.479
 O
 O
SER E:268 E:278 50.0 0.435 T -75.6 -11.5 50.0 0.435 0.0 HOH
 7.958
 O
 O
SER F:268 F:278 46.0 0.4 T -68.5 -3.3 43.0 0.374 0.026 B:P37268:0.026
 HOH
 4.259
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 SER A:278 A:278 58.0 0.504 H -68.4 -17.7