Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 11689070 | . | A | C | CCDS5985.1:NM_004462.3:c.923cAg>cCg_NP_004453.3:p.308Q>P | Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3asx | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:278 | A:308 | 71.0 | NA | G | -59.7 | -21.7 | 71.0 | NA | NA |
HOH |
3.642 |
CB |
O |
||
| 3lee | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2010-12-08 | GLN | A:278 | A:308 | 91.0 | 0.506 | G | -60.1 | -14.4 | 91.0 | 0.506 | 0.0 |
HOH |
3.996 |
OE1 |
O |
||
| GLN | B:278 | B:308 | 101.0 | 0.561 | G | -87.5 | 4.8 | NA | NA | NA | |||||||||||||
| GLN | C:278 | C:308 | 95.0 | 0.528 | G | -87.2 | -12.5 | NA | NA | NA | |||||||||||||
| GLN | D:278 | D:308 | 25.0 | NA | S | -116.4 | -31.4 | NA | NA | NA | |||||||||||||
| GLN | E:278 | E:308 | 77.0 | 0.428 | G | -62.5 | -14.5 | NA | NA | NA | |||||||||||||
| GLN | F:278 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3q2z | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:278 | A:308 | 104.0 | 0.578 | G | -62.8 | -23.4 | 104.0 | 0.578 | 0.0 |
HOH |
4.763 |
O |
O |
||
| 3q30 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:278 | A:308 | 101.0 | 0.561 | G | -65.9 | -24.1 | 101.0 | 0.561 | 0.0 |
HOH |
2.803 |
NE2 |
O |
||
| 3v66 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-12-19 | GLN | A:278 | A:308 | 104.0 | 0.578 | G | -61.3 | -23.8 | 104.0 | 0.578 | 0.0 |
HOH |
2.771 |
O |
O |
||
| 3vj8 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:281 | A:308 | 87.0 | 0.483 | G | -64.7 | -17.7 | 87.0 | 0.483 | 0.0 |
HOH |
3.456 |
CG |
O |
||
| 3vj9 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:281 | A:308 | 82.0 | 0.456 | H | -62.3 | -21.9 | 82.0 | 0.456 | 0.0 |
HOH |
2.684 |
OE1 |
O |
||
| 3vja | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:281 | A:308 | 111.0 | 0.617 | G | -65.2 | -18.0 | 111.0 | 0.617 | 0.0 |
HOH |
3.024 |
NE2 |
O |
||
| GLN | B:281 | B:308 | 81.0 | 0.45 | H | -59.7 | -24.6 | NA | NA | NA | |||||||||||||
| 3vjb | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:281 | A:308 | 89.0 | 0.494 | G | -60.2 | -22.1 | 89.0 | 0.494 | 0.0 |
HOH |
4.831 |
N |
O |
||
| GLN | B:281 | B:308 | 59.0 | 0.328 | G | -64.1 | -6.1 | 59.0 | 0.328 | 0.0 |
HOH |
4.319 |
CG |
O |
|||||||||
| GLN | C:281 | C:308 | 75.0 | 0.417 | H | -54.6 | -19.6 | 75.0 | 0.417 | 0.0 | |||||||||||||
| GLN | D:281 | D:308 | 82.0 | 0.456 | G | -52.1 | -22.7 | NA | NA | NA | |||||||||||||
| GLN | E:281 | E:308 | 65.0 | 0.361 | G | -45.2 | -38.8 | NA | NA | NA | |||||||||||||
| GLN | F:281 | F:308 | 127.0 | 0.706 | G | -50.3 | -17.8 | NA | NA | NA | |||||||||||||
| 3vjc | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:281 | A:308 | 89.0 | 0.494 | G | -59.3 | -21.9 | 89.0 | 0.494 | 0.0 |
HOH |
3.461 |
CG |
O |
||
| GLN | B:281 | B:308 | 68.0 | 0.378 | G | -62.6 | -26.0 | 68.0 | 0.378 | 0.0 |
HOH |
4.839 |
N |
O |
|||||||||
| GLN | C:281 | C:308 | 79.0 | 0.439 | G | -56.0 | -31.6 | 79.0 | 0.439 | 0.0 |
HOH |
4.988 |
O |
O |
|||||||||
| GLN | D:281 | D:308 | 76.0 | 0.422 | G | -56.7 | -26.5 | NA | NA | NA | |||||||||||||
| GLN | E:281 | E:308 | 85.0 | 0.472 | G | -58.4 | -21.0 | NA | NA | NA | |||||||||||||
| GLN | F:281 | F:308 | 84.0 | 0.467 | G | -56.2 | -16.9 | NA | NA | NA | |||||||||||||
| 3wef | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 94.0 | 0.522 | G | -55.9 | -30.7 | 94.0 | 0.522 | 0.0 |
HOH |
4.873 |
N |
O |
||
| GLN | B:281 | B:308 | 71.0 | 0.394 | G | -62.2 | -25.1 | 71.0 | 0.394 | 0.0 |
HOH |
5.903 |
NE2 |
O |
|||||||||
| GLN | C:281 | C:308 | 90.0 | 0.5 | G | -65.9 | -16.5 | 90.0 | 0.5 | 0.0 | |||||||||||||
| GLN | D:281 | D:308 | 82.0 | 0.456 | G | -61.1 | -30.3 | NA | NA | NA | |||||||||||||
| GLN | E:281 | E:308 | 98.0 | 0.544 | G | -63.2 | -13.9 | NA | NA | NA | |||||||||||||
| GLN | F:281 | F:308 | 85.0 | 0.472 | G | -52.4 | -26.7 | NA | NA | NA | |||||||||||||
| 3weg | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 95.0 | 0.528 | G | -67.2 | -20.0 | 95.0 | 0.528 | 0.0 |
HOH |
3.580 |
CG |
O |
||
| 3weh | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 101.0 | 0.561 | G | -65.7 | -21.2 | 101.0 | 0.561 | 0.0 |
HOH |
2.575 |
OE1 |
O |
||
| 3wek | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 115.0 | 0.639 | G | -68.3 | -15.2 | 115.0 | 0.639 | 0.0 |
HOH |
3.735 |
CB |
O |
||
| 3wei | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 106.0 | 0.589 | G | -69.2 | -16.6 | 106.0 | 0.589 | 0.0 |
HOH |
3.592 |
CG |
O |
||
| 3wej | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:281 | A:308 | 75.0 | 0.417 | G | -68.6 | -20.9 | 75.0 | 0.417 | 0.0 |
HOH |
3.594 |
CB |
O |
||
| 1ezf | 1 | P37268 | 99.12 | 0.0 |
X-RAY |
2000-10-18 | GLN | A:278 | A:308 | 99.0 | 0.55 | G | -58.1 | -19.3 | 99.0 | 0.55 | 0.0 |
HOH |
4.371 |
O |
O |
||
| GLN | B:278 | B:308 | 82.0 | 0.456 | G | -66.5 | -24.8 | NA | NA | NA | |||||||||||||
| GLN | C:278 | C:308 | 96.0 | 0.533 | G | -52.4 | -24.6 | NA | NA | NA | |||||||||||||
| 3wc9 | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 85.0 | 0.472 | G | -40.4 | -37.5 | 85.0 | 0.472 | 0.0 |
HOH |
4.621 |
OE1 |
O |
||
| GLN | B:298 | B:308 | 72.0 | 0.4 | G | -54.2 | -38.6 | 72.0 | 0.4 | 0.0 | |||||||||||||
| GLN | C:298 | C:308 | 92.0 | 0.511 | G | -77.0 | -10.9 | 92.0 | 0.511 | 0.0 |
HOH |
3.899 |
CG |
O |
|||||||||
| GLN | D:298 | D:308 | 87.0 | 0.483 | G | -37.0 | -25.5 | 87.0 | 0.483 | 0.0 |
HOH |
5.691 |
O |
O |
|||||||||
| GLN | E:298 | E:308 | 70.0 | 0.389 | H | -54.7 | -22.9 | 70.0 | 0.389 | 0.0 |
HOH |
5.338 |
N |
O |
|||||||||
| GLN | F:298 | F:308 | 80.0 | 0.444 | H | -42.2 | -23.6 | 80.0 | 0.444 | 0.0 |
HOH |
6.474 |
OE1 |
O |
|||||||||
| 3wcd | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 83.0 | 0.461 | G | -48.3 | -37.6 | 83.0 | 0.461 | 0.0 |
HOH |
3.645 |
OE1 |
O |
||
| GLN | B:298 | B:308 | 103.0 | 0.572 | G | -63.9 | -18.8 | 103.0 | 0.572 | 0.0 | |||||||||||||
| GLN | C:298 | C:308 | 88.0 | 0.489 | G | -65.3 | -29.8 | 88.0 | 0.489 | 0.0 |
HOH |
3.549 |
O |
O |
|||||||||
| GLN | D:298 | D:308 | 92.0 | 0.511 | G | -49.3 | -4.1 | 92.0 | 0.511 | 0.0 |
HOH |
4.259 |
OE1 |
O |
|||||||||
| GLN | E:298 | E:308 | 75.0 | 0.417 | G | -62.5 | -33.0 | 75.0 | 0.417 | 0.0 |
HOH |
4.690 |
N |
O |
|||||||||
| GLN | F:298 | F:308 | 103.0 | 0.572 | T | -64.8 | 18.1 | 103.0 | 0.572 | 0.0 |
HOH |
6.298 |
CG |
O |
|||||||||
| 3wcf | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 75.0 | 0.417 | H | -57.1 | -19.9 | 75.0 | 0.417 | 0.0 |
HOH |
4.534 |
N |
O |
||
| GLN | B:298 | B:308 | 70.0 | 0.389 | G | -51.0 | -27.9 | 70.0 | 0.389 | 0.0 | |||||||||||||
| GLN | C:298 | C:308 | 63.0 | 0.35 | G | -57.8 | -22.8 | 63.0 | 0.35 | 0.0 |
HOH |
8.588 |
N |
O |
|||||||||
| GLN | D:298 | D:308 | 72.0 | 0.4 | G | -51.7 | -28.2 | 72.0 | 0.4 | 0.0 |
HOH |
3.300 |
N |
O |
|||||||||
| GLN | E:298 | E:308 | 78.0 | 0.433 | H | -51.7 | -31.5 | 78.0 | 0.433 | 0.0 |
HOH |
5.809 |
O |
O |
|||||||||
| GLN | F:298 | F:308 | 74.0 | 0.411 | H | -42.7 | -32.3 | 74.0 | 0.411 | 0.0 | |||||||||||||
| 3wch | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 79.0 | 0.439 | G | -47.5 | -23.0 | 79.0 | 0.439 | 0.0 | ||||||
| GLN | B:298 | B:308 | 81.0 | 0.45 | G | -55.4 | -21.4 | 81.0 | 0.45 | 0.0 | |||||||||||||
| GLN | C:298 | C:308 | 90.0 | 0.5 | G | -59.2 | -23.7 | 90.0 | 0.5 | 0.0 |
HOH |
6.341 |
O |
O |
|||||||||
| GLN | D:298 | D:308 | 95.0 | 0.528 | G | -54.1 | -17.2 | 95.0 | 0.528 | 0.0 | |||||||||||||
| GLN | E:298 | E:308 | 92.0 | 0.511 | G | -51.5 | -28.1 | 92.0 | 0.511 | 0.0 |
HOH |
4.662 |
N |
O |
|||||||||
| GLN | F:298 | F:308 | 83.0 | 0.461 | G | -49.5 | -8.6 | 83.0 | 0.461 | 0.0 |
HOH |
4.618 |
OE1 |
O |
|||||||||
| 3wci | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 83.0 | 0.461 | G | -58.7 | -30.4 | 83.0 | 0.461 | 0.0 |
HOH |
4.139 |
NE2 |
O |
||
| GLN | B:298 | B:308 | 70.0 | 0.389 | G | -63.7 | -23.1 | 70.0 | 0.389 | 0.0 |
HOH |
6.133 |
CB |
O |
|||||||||
| GLN | C:298 | C:308 | 95.0 | 0.528 | G | -61.2 | -21.2 | 95.0 | 0.528 | 0.0 |
HOH |
3.789 |
CG |
O |
|||||||||
| GLN | D:298 | D:308 | 94.0 | 0.522 | G | -52.7 | -15.9 | 94.0 | 0.522 | 0.0 | |||||||||||||
| GLN | E:298 | E:308 | 90.0 | 0.5 | G | -52.9 | -30.6 | 90.0 | 0.5 | 0.0 |
HOH |
4.029 |
CB |
O |
|||||||||
| GLN | F:298 | F:308 | 84.0 | 0.467 | G | -50.5 | -17.0 | 84.0 | 0.467 | 0.0 |
HOH |
5.667 |
O |
O |
|||||||||
| 3wcj | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 91.0 | 0.506 | G | -57.9 | -18.8 | 91.0 | 0.506 | 0.0 |
HOH |
3.897 |
CB |
O |
||
| GLN | B:298 | B:308 | 72.0 | 0.4 | G | -52.8 | -34.3 | 72.0 | 0.4 | 0.0 |
HOH |
4.855 |
O |
O |
|||||||||
| GLN | C:298 | C:308 | 96.0 | 0.533 | G | -58.4 | -17.4 | 96.0 | 0.533 | 0.0 |
HOH |
5.714 |
O |
O |
|||||||||
| GLN | D:298 | D:308 | 98.0 | 0.544 | G | -58.7 | -19.8 | 98.0 | 0.544 | 0.0 |
HOH |
4.409 |
CG |
O |
|||||||||
| GLN | E:298 | E:308 | 87.0 | 0.483 | G | -55.2 | -29.4 | 87.0 | 0.483 | 0.0 |
HOH |
4.265 |
CG |
O |
|||||||||
| GLN | F:298 | F:308 | 95.0 | 0.528 | H | -47.1 | -20.4 | 95.0 | 0.528 | 0.0 |
HOH |
6.401 |
OE1 |
O |
|||||||||
| 3wcl | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 77.0 | 0.428 | G | -58.2 | -29.0 | 77.0 | 0.428 | 0.0 |
HOH |
4.779 |
N |
O |
||
| GLN | B:298 | B:308 | 81.0 | 0.45 | G | -66.3 | -18.6 | 81.0 | 0.45 | 0.0 |
HOH |
3.802 |
CB |
O |
|||||||||
| GLN | C:298 | C:308 | 89.0 | 0.494 | G | -59.9 | -16.9 | 89.0 | 0.494 | 0.0 |
HOH |
3.717 |
NE2 |
O |
|||||||||
| GLN | D:298 | D:308 | 82.0 | 0.456 | G | -64.9 | -9.9 | 82.0 | 0.456 | 0.0 |
HOH |
8.595 |
O |
O |
|||||||||
| GLN | E:298 | E:308 | 73.0 | 0.406 | G | -53.6 | -31.6 | 73.0 | 0.406 | 0.0 |
HOH |
4.505 |
CG |
O |
|||||||||
| GLN | F:298 | F:308 | 84.0 | 0.467 | G | -39.3 | -33.3 | 84.0 | 0.467 | 0.0 |
HOH |
3.728 |
CG |
O |
|||||||||
| 3wcm | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:298 | A:308 | 87.0 | 0.483 | G | -59.2 | -24.0 | 87.0 | 0.483 | 0.0 |
HOH |
4.486 |
N |
O |
||
| GLN | B:298 | B:308 | 85.0 | 0.472 | G | -60.1 | -20.8 | 85.0 | 0.472 | 0.0 |
HOH |
3.360 |
CB |
O |
|||||||||
| GLN | C:298 | C:308 | 80.0 | 0.444 | G | -55.6 | -26.0 | 80.0 | 0.444 | 0.0 |
HOH |
4.928 |
O |
O |
|||||||||
| GLN | D:298 | D:308 | 120.0 | 0.667 | G | -49.0 | -22.6 | 120.0 | 0.667 | 0.0 |
HOH |
5.440 |
O |
O |
|||||||||
| GLN | E:298 | E:308 | 77.0 | 0.428 | G | -53.8 | -28.5 | 77.0 | 0.428 | 0.0 |
HOH |
2.605 |
OE1 |
O |
|||||||||
| GLN | F:298 | F:308 | 93.0 | 0.517 | G | -45.9 | -27.1 | 93.0 | 0.517 | 0.0 | |||||||||||||
| 3wsa | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2015-04-01 | GLN | A:298 | A:308 | 102.0 | 0.567 | G | -58.0 | -24.5 | 102.0 | 0.567 | 0.0 |
HOH |
6.726 |
O |
O |
||
| GLN | B:298 | B:308 | 90.0 | 0.5 | G | -56.7 | -15.8 | 90.0 | 0.5 | 0.0 | |||||||||||||
| GLN | C:298 | C:308 | 81.0 | 0.45 | G | -70.8 | -22.6 | 81.0 | 0.45 | 0.0 | |||||||||||||
| GLN | D:298 | D:308 | 121.0 | 0.672 | G | -55.8 | -11.5 | 121.0 | 0.672 | 0.0 |
HOH |
3.759 |
O |
O |
|||||||||
| GLN | E:298 | E:308 | 73.0 | 0.406 | H | -58.8 | -25.4 | 73.0 | 0.406 | 0.0 | |||||||||||||
| GLN | F:298 | F:308 | 106.0 | 0.589 | G | -60.7 | -6.2 | 106.0 | 0.589 | 0.0 | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p37268-f1 | 1 | P37268 | 100.0 | 0.0 | GLN | A:308 | A:308 | 84.0 | 0.467 | G | -61.1 | -28.1 | |