Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 11689165 . C A CCDS5985.1:NM_004462.3:c.1018Cag>Aag_NP_004453.3:p.340Q>K Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3asx 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLN A:310 A:340 130.0 0.722 H -59.4 -46.5 130.0 0.722 0.0 HOH
 2.642
 O
 O
3lee 1 P37268 100.0 0.0 X-RAY
 2010-12-08 GLN A:310 A:340 135.0 0.75 H -65.6 -55.1 135.0 0.75 0.0
GLN B:310 B:340 122.0 0.678 H -64.4 -43.0 NA NA NA
GLN C:310 C:340 130.0 0.722 H -78.6 -62.2 NA NA NA
GLN D:310 D:340 115.0 0.639 H -48.1 -44.9 NA NA NA
GLN E:310 E:340 138.0 0.767 H -57.4 -38.9 NA NA NA
GLN F:310 F:340 136.0 0.756 H -76.5 -15.9 NA NA NA
3q2z 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLN A:310 A:340 127.0 0.706 H -59.8 -42.5 127.0 0.706 0.0 HOH
 3.080
 OE1
 O
3q30 1 P37268 100.0 0.0 X-RAY
 2011-12-21 GLN A:310 A:340 144.0 0.8 H -63.3 -45.5 144.0 0.8 0.0 HOH
 2.567
 OE1
 O
3v66 1 P37268 100.0 0.0 X-RAY
 2012-12-19 GLN A:310 A:340 153.0 0.85 H -67.5 -38.0 153.0 0.85 0.0 HOH
 2.528
 OE1
 O
3vj8 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLN A:313 A:340 98.0 0.544 H -62.1 -48.2 98.0 0.544 0.0 HOH
 2.928
 O
 O
3vj9 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLN A:313 A:340 108.0 0.6 H -66.2 -42.5 108.0 0.6 0.0 NI
HOH
 8.311
2.733
 NE2
OE1
 NI
O
3vja 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLN A:313 A:340 108.0 0.6 H -59.0 -48.7 108.0 0.6 0.0 HOH
 2.978
 NE2
 O
GLN B:313 B:340 103.0 0.572 H -63.1 -45.6 NA NA NA
3vjb 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLN A:313 A:340 130.0 0.722 H -57.7 -45.2 116.0 0.644 0.078 C:P37268:0.078
 HOH
 3.602
 CA
 O
GLN B:313 B:340 46.0 0.256 H -71.3 -40.2 13.0 0.072 0.184 A:P37268:0.183
 HOH
 2.771
 NE2
 O
GLN C:313 C:340 68.0 0.378 H -74.1 -42.9 38.0 0.211 0.167 B:P37268:0.167
 HOH
 3.644
 NE2
 O
GLN D:313 D:340 50.0 0.278 H -58.9 -48.8 NA NA NA
GLN E:313 E:340 69.0 0.383 H -65.4 -41.6 NA NA NA
GLN F:313 F:340 54.0 0.3 H -63.0 -34.6 NA NA NA
3vjc 1 P37268 100.0 0.0 X-RAY
 2012-04-11 GLN A:313 A:340 43.0 0.239 H -59.9 -42.0 31.0 0.172 0.067 C:P37268:0.067
 HOH
 2.774
 O
 O
GLN B:313 B:340 41.0 0.228 H -62.9 -43.8 12.0 0.067 0.161 A:P37268:0.161
 ZGA
HOH
 8.585
2.943
 NE2
NE2
 OAK
O
GLN C:313 C:340 26.0 0.144 H -61.6 -45.1 17.0 0.094 0.05 B:P37268:0.05
 HOH
 3.836
 N
 O
GLN D:313 D:340 44.0 0.244 H -62.5 -40.1 NA NA NA
GLN E:313 E:340 46.0 0.256 H -62.0 -46.1 NA NA NA
GLN F:313 F:340 55.0 0.306 H -59.3 -51.3 NA NA NA
3wef 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 134.0 0.744 H -60.5 -43.5 112.0 0.622 0.122 C:P37268:0.122
 HOH
 4.315
 CG
 O
GLN B:313 B:340 39.0 0.217 H -63.1 -45.2 7.0 0.039 0.178 A:P37268:0.178
 FPS
HOH
 9.771
3.356
 OE1
NE2
 O2B
O
GLN C:313 C:340 44.0 0.244 H -57.8 -48.2 27.0 0.15 0.094 B:P37268:0.094
 HOH
 8.340
 OE1
 O
GLN D:313 D:340 69.0 0.383 H -63.1 -38.2 NA NA NA
GLN E:313 E:340 61.0 0.339 H -68.2 -51.1 NA NA NA
GLN F:313 F:340 141.0 0.783 H -65.3 -33.2 NA NA NA
3weg 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 99.0 0.55 H -60.4 -44.2 99.0 0.55 0.0 HOH
 2.505
 OE1
 O
3weh 1 P37268 100.0 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 88.0 0.489 H -57.3 -48.1 88.0 0.489 0.0 HOH
 3.106
 CG
 O
3wek 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 74.0 0.411 H -57.3 -49.9 74.0 0.411 0.0 HOH
 3.694
 N
 O
3wei 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 87.0 0.483 H -62.7 -45.2 87.0 0.483 0.0 HOH
 2.737
 O
 O
3wej 1 P37268 99.71 0.0 X-RAY
 2014-02-12 GLN A:313 A:340 91.0 0.506 H -51.0 -50.8 91.0 0.506 0.0 HOH
 2.690
 O
 O
1ezf 1 P37268 99.12 0.0 X-RAY
 2000-10-18 GLN A:310 A:340 112.0 0.622 H -62.3 -45.5 112.0 0.622 0.0 HOH
 4.676
 N
 O
GLN B:310 B:340 116.0 0.644 H -60.8 -47.6 NA NA NA
GLN C:310 C:340 128.0 0.711 H -67.4 -35.8 NA NA NA
3wc9 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 26.0 0.144 H -60.6 -35.9 18.0 0.1 0.044 B:P37268:0.044
 HOH
 4.956
 N
 O
GLN B:330 B:340 16.0 0.089 H -63.7 -46.7 4.0 0.022 0.067 C:P37268:0.067
 HOH
 4.617
 CG
 O
GLN C:330 C:340 45.0 0.25 H -64.3 -42.4 17.0 0.094 0.156 A:P37268:0.156
 HOH
 3.052
 NE2
 O
GLN D:330 D:340 43.0 0.239 H -62.9 -42.7 19.0 0.106 0.133 E:P37268:0.133
 HOH
 9.244
 NE2
 O
GLN E:330 E:340 32.0 0.178 H -82.7 -23.3 23.0 0.128 0.05 F:P37268:0.05
 HOH
 4.481
 N
 O
GLN F:330 F:340 34.0 0.189 H -63.5 -30.6 15.0 0.083 0.106 D:P37268:0.106
 HOH
 9.334
 NE2
 O
3wcd 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 41.0 0.228 H -67.6 -37.4 21.0 0.117 0.111 B:P37268:0.111
 HOH
 4.192
 CG
 O
GLN B:330 B:340 30.0 0.167 H -58.6 -52.9 15.0 0.083 0.084 C:P37268:0.083
 HOH
 6.906
 O
 O
GLN C:330 C:340 42.0 0.233 H -65.1 -37.9 25.0 0.139 0.094 A:P37268:0.094
 HOH
 6.475
 NE2
 O
GLN D:330 D:340 48.0 0.267 H -61.1 -40.0 27.0 0.15 0.117 E:P37268:0.117
GLN E:330 E:340 42.0 0.233 H -65.9 -50.3 27.0 0.15 0.083 F:P37268:0.083
 HOH
 7.300
 O
 O
GLN F:330 F:340 49.0 0.272 H -75.0 -47.2 15.0 0.083 0.189 D:P37268:0.189
 HOH
 4.501
 N
 O
3wcf 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 40.0 0.222 H -61.4 -43.7 27.0 0.15 0.072 B:P37268:0.072
 BH8
HOH
 9.977
3.662
 NE2
CA
 OAF
O
GLN B:330 B:340 40.0 0.222 H -64.7 -48.4 20.0 0.111 0.111 C:P37268:0.111
 BH8
HOH
 9.129
3.270
 NE2
NE2
 OAG
O
GLN C:330 C:340 31.0 0.172 H -63.8 -48.2 18.0 0.1 0.072 A:P37268:0.072
 HOH
 3.991
 CG
 O
GLN D:330 D:340 45.0 0.25 H -66.0 -41.8 24.0 0.133 0.117 E:P37268:0.117
 BH8
HOH
 8.857
9.266
 NE2
CG
 OAF
O
GLN E:330 E:340 42.0 0.233 H -68.3 -36.5 26.0 0.144 0.089 F:P37268:0.089
 BH8
HOH
 9.452
4.037
 NE2
NE2
 OAF
O
GLN F:330 F:340 39.0 0.217 H -70.4 -42.1 19.0 0.106 0.111 D:P37268:0.111
 BH8
HOH
 9.171
3.296
 NE2
NE2
 OAF
O
3wch 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 43.0 0.239 H -53.7 -52.7 28.0 0.156 0.083 B:P37268:0.083
 HOH
 4.594
 N
 O
GLN B:330 B:340 51.0 0.283 H -61.3 -39.3 22.0 0.122 0.161 C:P37268:0.161
 HOH
 9.503
 OE1
 O
GLN C:330 C:340 57.0 0.317 H -60.4 -44.5 15.0 0.083 0.234 A:P37268:0.233
 8PH
HOH
 8.773
8.577
 OE1
O
 OAG
O
GLN D:330 D:340 51.0 0.283 H -67.1 -24.3 26.0 0.144 0.139 E:P37268:0.139
 8PH
HOH
 9.269
3.238
 NE2
O
 OAG
O
GLN E:330 E:340 61.0 0.339 H -58.9 -47.6 26.0 0.144 0.195 F:P37268:0.194
 8PH
HOH
 8.577
7.873
 NE2
CG
 OAF
O
GLN F:330 F:340 60.0 0.333 H -58.8 -57.2 34.0 0.189 0.144 D:P37268:0.144
 HOH
 3.431
 OE1
 O
3wci 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 54.0 0.3 H -64.6 -43.3 33.0 0.183 0.117 B:P37268:0.117
 BH5
HOH
 9.807
2.951
 NE2
O
 OAE
O
GLN B:330 B:340 43.0 0.239 H -57.5 -55.1 15.0 0.083 0.156 C:P37268:0.156
 BH5
HOH
 8.904
3.403
 OE1
OE1
 OAB
O
GLN C:330 C:340 42.0 0.233 H -66.1 -49.5 4.0 0.022 0.211 A:P37268:0.211
 BH5
HOH
 9.367
4.658
 NE2
N
 OAE
O
GLN D:330 D:340 75.0 0.417 H -53.4 -50.4 40.0 0.222 0.195 E:P37268:0.194
 BH5
HOH
 8.738
2.785
 NE2
NE2
 OAE
O
GLN E:330 E:340 48.0 0.267 H -66.1 -37.2 28.0 0.156 0.111 F:P37268:0.111
 HOH
 2.885
 OE1
 O
GLN F:330 F:340 58.0 0.322 H -65.6 -48.2 26.0 0.144 0.178 D:P37268:0.178
 BH5
HOH
 9.387
3.409
 NE2
NE2
 OAE
O
3wcj 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 21.0 0.117 H -63.6 -42.0 10.0 0.056 0.061 B:P37268:0.061
 HOH
 3.586
 CA
 O
GLN B:330 B:340 40.0 0.222 H -59.4 -48.6 28.0 0.156 0.066 C:P37268:0.067
 HOH
 3.841
 CA
 O
GLN C:330 C:340 28.0 0.156 H -66.1 -42.1 15.0 0.083 0.073 A:P37268:0.072
 HOH
 4.791
 N
 O
GLN D:330 D:340 50.0 0.278 H -54.4 -51.3 24.0 0.133 0.145 E:P37268:0.144
 HOH
 2.651
 NE2
 O
GLN E:330 E:340 26.0 0.144 H -70.2 -37.8 18.0 0.1 0.044 F:P37268:0.044
 HOH
 4.804
 N
 O
GLN F:330 F:340 36.0 0.2 H -68.7 -33.8 21.0 0.117 0.083 D:P37268:0.083
 HOH
 3.341
 NE2
 O
3wcl 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 20.0 0.111 H -60.0 -44.9 9.0 0.05 0.061 B:P37268:0.061
 HOH
 3.125
 O
 O
GLN B:330 B:340 44.0 0.244 H -60.0 -43.4 28.0 0.156 0.088 C:P37268:0.089
 HOH
 3.302
 NE2
 O
GLN C:330 C:340 47.0 0.261 H -65.2 -47.5 14.0 0.078 0.183 A:P37268:0.183
 BH3
HOH
 9.069
3.083
 NE2
NE2
 OAB
O
GLN D:330 D:340 49.0 0.272 H -58.3 -36.0 26.0 0.144 0.128 E:P37268:0.128
 HOH
 2.737
 O
 O
GLN E:330 E:340 36.0 0.2 H -71.4 -35.1 21.0 0.117 0.083 F:P37268:0.083
 HOH
 3.973
 CB
 O
GLN F:330 F:340 58.0 0.322 H -64.8 -45.5 24.0 0.133 0.189 D:P37268:0.189
 HOH
 2.926
 NE2
 O
3wcm 1 P37268 98.82 0.0 X-RAY
 2014-06-18 GLN A:330 A:340 69.0 0.383 H -64.7 -41.6 54.0 0.3 0.083 B:P37268:0.083
 HOH
 2.877
 O
 O
GLN B:330 B:340 77.0 0.428 H -56.8 -45.4 35.0 0.194 0.234 C:P37268:0.233
 HOH
 2.674
 OE1
 O
GLN C:330 C:340 37.0 0.206 H -63.9 -44.4 21.0 0.117 0.089 A:P37268:0.089
 HOH
 3.899
 CA
 O
GLN D:330 D:340 62.0 0.344 H -59.5 -50.7 32.0 0.178 0.166 E:P37268:0.167
 HOH
 3.104
 OE1
 O
GLN E:330 E:340 48.0 0.267 H -62.7 -46.5 37.0 0.206 0.061 F:P37268:0.061
 HOH
 3.011
 O
 O
GLN F:330 F:340 63.0 0.35 H -66.2 -34.8 38.0 0.211 0.139 D:P37268:0.139
 HOH
 3.609
 NE2
 O
3wsa 1 P37268 98.82 0.0 X-RAY
 2015-04-01 GLN A:330 A:340 72.0 0.4 H -58.7 -44.4 58.0 0.322 0.078 B:P37268:0.078
 HOH
 4.012
 CB
 O
GLN B:330 B:340 63.0 0.35 H -69.1 -34.3 39.0 0.217 0.133 C:P37268:0.133
 HOH
 8.259
 O
 O
GLN C:330 C:340 49.0 0.272 H -52.4 -50.1 22.0 0.122 0.15 A:P37268:0.15
 HOH
 9.516
 CG
 O
GLN D:330 D:340 53.0 0.294 H -63.0 -39.7 35.0 0.194 0.1 E:P37268:0.1
GLN E:330 E:340 52.0 0.289 H -69.7 -53.0 34.0 0.189 0.1 F:P37268:0.1
 HOH
 9.514
 NE2
 O
GLN F:330 F:340 45.0 0.25 H -66.1 -32.6 27.0 0.15 0.1 D:P37268:0.1
 HOH
 3.363
 NE2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p37268-f1 1 P37268 100.0 0.0 GLN A:340 A:340 36.0 0.2 H -54.9 -52.0