Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 11695970 | . | A | C | CCDS5985.1:NM_004462.3:c.1106cAg>cCg_NP_004453.3:p.369Q>P | Homo sapiens farnesyl-diphosphate farnesyltransferase 1 (FDFT1), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3asx | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:339 | A:369 | 113.0 | 0.628 | T | -69.0 | 20.9 | 113.0 | 0.628 | 0.0 |
HOH |
2.634 |
NE2 |
O |
||
| 3lee | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2010-12-08 | GLN | A:339 | A:369 | 34.0 | NA | -94.9 | 151.6 | 34.0 | NA | NA |
HOH |
3.442 |
N |
O |
|||
| GLN | B:339 | B:369 | 81.0 | 0.45 | -44.6 | 161.8 | NA | NA | NA | ||||||||||||||
| GLN | C:339 | C:369 | 106.0 | 0.589 | -101.7 | -117.5 | NA | NA | NA | ||||||||||||||
| GLN | D:339 | D:369 | 140.0 | 0.778 | -153.7 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | E:339 | E:369 | 114.0 | 0.633 | 0.3 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | F:339 | F:369 | 62.0 | 0.344 | -92.2 | -115.2 | NA | NA | NA | ||||||||||||||
| 3q2z | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:339 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3q30 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2011-12-21 | GLN | A:339 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3v66 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-12-19 | GLN | A:339 | A:369 | 120.0 | 0.667 | H | -78.4 | -38.9 | 120.0 | 0.667 | 0.0 |
HOH |
2.619 |
OE1 |
O |
||
| 3vj8 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:342 | A:369 | 98.0 | 0.544 | -58.8 | 360.0 | 98.0 | 0.544 | 0.0 |
HOH |
2.849 |
OE1 |
O |
|||
| 3vj9 | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:342 | A:369 | 139.0 | 0.772 | -61.1 | 360.0 | 139.0 | 0.772 | 0.0 |
HOH |
2.932 |
OE1 |
O |
|||
| 3vja | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:342 | A:369 | 84.0 | 0.467 | -65.4 | 360.0 | 84.0 | 0.467 | 0.0 |
HOH |
2.545 |
O |
O |
|||
| GLN | B:342 | B:369 | 92.0 | 0.511 | -67.0 | 360.0 | NA | NA | NA | ||||||||||||||
| 3vjb | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:342 | A:369 | 181.0 | 1.0 | -118.2 | 360.0 | 90.0 | 0.5 | 0.5 |
C:P37268:0.506 |
HOH |
2.588 |
NE2 |
O |
||
| GLN | B:342 | B:369 | 136.0 | 0.756 | -59.3 | 360.0 | 123.0 | 0.683 | 0.073 |
A:P37268:0.072 |
HOH |
2.512 |
OE1 |
O |
|||||||||
| GLN | C:342 | C:369 | 196.0 | 1.0 | -101.4 | 360.0 | 182.0 | 1.0 | 0.0 |
B:P37268:0.078 |
HOH |
3.271 |
C |
O |
|||||||||
| GLN | D:342 | D:369 | 147.0 | 0.817 | -59.3 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | E:342 | E:369 | 189.0 | 1.0 | -74.0 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | F:342 | F:369 | 146.0 | 0.811 | 11.2 | 360.0 | NA | NA | NA | ||||||||||||||
| 3vjc | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2012-04-11 | GLN | A:342 | A:369 | 149.0 | 0.828 | -35.8 | 360.0 | 137.0 | 0.761 | 0.067 |
C:P37268:0.067 |
HOH |
3.815 |
CB |
O |
||
| GLN | B:342 | B:369 | 141.0 | 0.783 | -61.5 | 360.0 | 129.0 | 0.717 | 0.066 |
A:P37268:0.067 |
HOH |
2.732 |
NE2 |
O |
|||||||||
| GLN | C:342 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| GLN | D:342 | D:369 | 143.0 | 0.794 | -64.6 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | E:342 | E:369 | 82.0 | 0.456 | -92.7 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | F:342 | F:369 | 114.0 | 0.633 | -74.8 | 360.0 | NA | NA | NA | ||||||||||||||
| 3wef | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 143.0 | 0.794 | -17.5 | 360.0 | 98.0 | 0.544 | 0.25 |
C:P37268:0.25 |
HOH |
3.759 |
CG |
O |
||
| GLN | B:342 | B:369 | 145.0 | 0.806 | -62.2 | 360.0 | 128.0 | 0.711 | 0.095 |
A:P37268:0.094 |
HOH |
2.761 |
OE1 |
O |
|||||||||
| GLN | C:342 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| GLN | D:342 | D:369 | 141.0 | 0.783 | -56.8 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | E:342 | E:369 | 201.0 | 1.0 | -124.7 | 360.0 | NA | NA | NA | ||||||||||||||
| GLN | F:342 | F:369 | 149.0 | 0.828 | 54.8 | 360.0 | NA | NA | NA | ||||||||||||||
| 3weg | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 85.0 | 0.472 | -49.1 | 360.0 | 85.0 | 0.472 | 0.0 |
HOH |
2.395 |
NE2 |
O |
|||
| 3weh | 1 | P37268 | 100.0 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 115.0 | 0.639 | -61.5 | 360.0 | 115.0 | 0.639 | 0.0 |
HOH |
2.628 |
NE2 |
O |
|||
| 3wek | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 85.0 | 0.472 | -85.3 | 360.0 | 85.0 | 0.472 | 0.0 |
HOH |
2.516 |
O |
O |
|||
| 3wei | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 78.0 | 0.433 | -76.0 | 360.0 | 78.0 | 0.433 | 0.0 |
HOH |
2.192 |
OE1 |
O |
|||
| 3wej | 1 | P37268 | 99.71 | 0.0 |
X-RAY |
2014-02-12 | GLN | A:342 | A:369 | 90.0 | 0.5 | -49.1 | 360.0 | 90.0 | 0.5 | 0.0 |
HOH |
3.198 |
O |
O |
|||
| 1ezf | 1 | P37268 | 99.12 | 0.0 |
X-RAY |
2000-10-18 | GLN | A:339 | A:369 | 106.0 | 0.589 | -100.0 | -97.2 | 106.0 | 0.589 | 0.0 |
HOH |
3.409 |
CB |
O |
|||
| GLN | B:339 | B:369 | 66.0 | 0.367 | -59.4 | -103.8 | NA | NA | NA | ||||||||||||||
| GLN | C:339 | C:369 | 105.0 | 0.583 | -62.5 | -86.6 | NA | NA | NA | ||||||||||||||
| 3wc9 | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLN | B:359 | B:369 | 110.0 | 0.611 | -119.0 | 360.0 | 95.0 | 0.528 | 0.083 |
C:P37268:0.083 |
HOH |
3.134 |
O |
O |
|||||||||
| GLN | C:359 | C:369 | 142.0 | 0.789 | -107.1 | 360.0 | 125.0 | 0.694 | 0.095 |
A:P37268:0.094 |
HOH |
4.123 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 120.0 | 0.667 | -58.2 | 360.0 | 107.0 | 0.594 | 0.073 |
E:P37268:0.072 |
HOH |
3.171 |
O |
O |
|||||||||
| GLN | E:359 | E:369 | 152.0 | 0.844 | -82.1 | 360.0 | 139.0 | 0.772 | 0.072 |
F:P37268:0.072 |
HOH |
2.869 |
O |
O |
|||||||||
| GLN | F:359 | F:369 | 107.0 | 0.594 | -63.1 | 360.0 | 91.0 | 0.506 | 0.088 |
D:P37268:0.083 |
HOH |
2.549 |
O |
O |
|||||||||
| 3wcd | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 180.0 | 1.0 | -90.9 | 360.0 | 118.0 | 0.656 | 0.344 |
D:P37268:0.011 B:P37268:0.344 |
HOH |
2.864 |
C |
O |
||
| GLN | B:359 | B:369 | 128.0 | 0.711 | -90.0 | 360.0 | 113.0 | 0.628 | 0.083 |
C:P37268:0.083 |
HOH |
2.867 |
C |
O |
|||||||||
| GLN | C:359 | C:369 | 145.0 | 0.806 | -90.5 | 360.0 | 127.0 | 0.706 | 0.1 |
A:P37268:0.1 |
HOH |
2.868 |
OE1 |
O |
|||||||||
| GLN | D:359 | D:369 | 133.0 | 0.739 | -76.8 | 360.0 | 118.0 | 0.656 | 0.083 |
E:P37268:0.083 |
HOH |
2.797 |
NE2 |
O |
|||||||||
| GLN | E:359 | E:369 | 155.0 | 0.861 | -50.3 | 360.0 | 132.0 | 0.733 | 0.128 |
F:P37268:0.128 |
HOH |
2.869 |
OE1 |
O |
|||||||||
| GLN | F:359 | F:369 | 94.0 | 0.522 | -111.1 | 360.0 | 63.0 | 0.35 | 0.172 |
D:P37268:0.1 B:P37268:0.067 |
HOH |
3.208 |
O |
O |
|||||||||
| 3wcf | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 149.0 | 0.828 | -36.8 | 360.0 | 128.0 | 0.711 | 0.117 |
D:P37268:0.006 B:P37268:0.111 |
HOH |
2.488 |
OE1 |
O |
||
| GLN | B:359 | B:369 | 144.0 | 0.8 | -79.1 | 360.0 | 135.0 | 0.75 | 0.05 |
C:P37268:0.05 |
HOH |
2.469 |
O |
O |
|||||||||
| GLN | C:359 | C:369 | 146.0 | 0.811 | -75.6 | 360.0 | 132.0 | 0.733 | 0.078 |
A:P37268:0.078 |
HOH |
2.674 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 137.0 | 0.761 | -63.7 | 360.0 | 122.0 | 0.678 | 0.083 |
E:P37268:0.083 |
HOH |
2.499 |
O |
O |
|||||||||
| GLN | E:359 | E:369 | 143.0 | 0.794 | -54.4 | 360.0 | 127.0 | 0.706 | 0.088 |
F:P37268:0.089 |
HOH |
2.436 |
O |
O |
|||||||||
| GLN | F:359 | F:369 | 116.0 | 0.644 | -63.2 | 360.0 | 101.0 | 0.561 | 0.083 |
D:P37268:0.072 B:P37268:0.006 |
HOH |
2.645 |
OE1 |
O |
|||||||||
| 3wch | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 116.0 | 0.644 | -61.2 | 360.0 | 98.0 | 0.544 | 0.1 |
B:P37268:0.1 |
HOH |
2.466 |
OE1 |
O |
||
| GLN | B:359 | B:369 | 149.0 | 0.828 | -98.1 | 360.0 | 135.0 | 0.75 | 0.078 |
C:P37268:0.078 |
HOH |
4.331 |
O |
O |
|||||||||
| GLN | C:359 | C:369 | 145.0 | 0.806 | -70.9 | 360.0 | 131.0 | 0.728 | 0.078 |
A:P37268:0.078 |
HOH |
2.656 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 144.0 | 0.8 | -74.6 | 360.0 | 128.0 | 0.711 | 0.089 |
E:P37268:0.089 |
HOH |
4.023 |
O |
O |
|||||||||
| GLN | E:359 | E:369 | 147.0 | 0.817 | -71.9 | 360.0 | 128.0 | 0.711 | 0.106 |
F:P37268:0.106 |
HOH |
2.447 |
O |
O |
|||||||||
| GLN | F:359 | F:369 | 115.0 | 0.639 | -79.2 | 360.0 | 98.0 | 0.544 | 0.095 |
D:P37268:0.094 |
HOH |
3.965 |
O |
O |
|||||||||
| 3wci | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 179.0 | 0.994 | -107.2 | 360.0 | 117.0 | 0.65 | 0.344 |
B:P37268:0.344 |
HOH |
3.272 |
O |
O |
||
| GLN | B:359 | B:369 | 110.0 | 0.611 | -48.5 | 360.0 | 96.0 | 0.533 | 0.078 |
C:P37268:0.078 |
HOH |
2.663 |
O |
O |
|||||||||
| GLN | C:359 | C:369 | 142.0 | 0.789 | -73.6 | 360.0 | 109.0 | 0.606 | 0.183 |
A:P37268:0.183 |
HOH |
2.558 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 101.0 | 0.561 | -78.3 | 360.0 | 88.0 | 0.489 | 0.072 |
E:P37268:0.072 |
HOH |
2.376 |
OE1 |
O |
|||||||||
| GLN | E:359 | E:369 | 144.0 | 0.8 | -73.8 | 360.0 | 110.0 | 0.611 | 0.189 |
F:P37268:0.189 |
HOH |
2.626 |
O |
O |
|||||||||
| GLN | F:359 | F:369 | 192.0 | 1.0 | -85.0 | 360.0 | 146.0 | 0.811 | 0.189 |
D:P37268:0.256 |
HOH |
3.739 |
C |
O |
|||||||||
| 3wcj | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 177.0 | 0.983 | -120.7 | 360.0 | 100.0 | 0.556 | 0.427 |
B:P37268:0.428 |
HOH |
3.083 |
O |
O |
||
| GLN | B:359 | B:369 | 54.0 | 0.3 | -54.3 | 138.1 | 47.0 | 0.261 | 0.039 |
C:P37268:0.039 |
HOH |
2.979 |
CB |
O |
|||||||||
| GLN | C:359 | C:369 | 97.0 | 0.539 | -79.3 | 127.4 | 94.0 | 0.522 | 0.017 |
A:P37268:0.017 |
HOH |
3.021 |
OE1 |
O |
|||||||||
| GLN | D:359 | D:369 | 54.0 | 0.3 | -57.4 | 126.3 | 53.0 | 0.294 | 0.006 |
E:P37268:0.006 |
HOH |
2.859 |
NE2 |
O |
|||||||||
| GLN | E:359 | E:369 | 96.0 | 0.533 | -67.6 | 147.6 | 91.0 | 0.506 | 0.027 |
F:P37268:0.028 |
HOH |
3.344 |
O |
O |
|||||||||
| GLN | F:359 | F:369 | 96.0 | 0.533 | -129.9 | 360.0 | 71.0 | 0.394 | 0.139 |
D:P37268:0.1 B:P37268:0.039 |
HOH |
3.819 |
O |
O |
|||||||||
| 3wcl | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 124.0 | 0.689 | 57.6 | 360.0 | 105.0 | 0.583 | 0.106 |
B:P37268:0.106 |
HOH |
2.846 |
O |
O |
||
| GLN | B:359 | B:369 | 172.0 | 0.956 | 86.1 | 360.0 | 143.0 | 0.794 | 0.162 |
C:P37268:0.161 |
HOH |
2.738 |
OE1 |
O |
|||||||||
| GLN | C:359 | C:369 | 146.0 | 0.811 | -76.1 | 360.0 | 132.0 | 0.733 | 0.078 |
A:P37268:0.078 |
HOH |
2.623 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 186.0 | 1.0 | 88.4 | 360.0 | 158.0 | 0.878 | 0.122 |
E:P37268:0.156 |
HOH |
3.214 |
C |
O |
|||||||||
| GLN | E:359 | E:369 | 187.0 | 1.0 | 98.4 | 360.0 | 143.0 | 0.794 | 0.206 |
F:P37268:0.244 |
HOH |
3.409 |
OE1 |
O |
|||||||||
| GLN | F:359 | F:369 | 105.0 | 0.583 | -62.8 | 360.0 | 78.0 | 0.433 | 0.15 |
D:P37268:0.15 |
HOH |
2.939 |
CG |
O |
|||||||||
| 3wcm | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2014-06-18 | GLN | A:359 | A:369 | 201.0 | 1.0 | -126.7 | 360.0 | 134.0 | 0.744 | 0.256 |
D:P37268:0.083 B:P37268:0.317 |
HOH |
2.559 |
OE1 |
O |
||
| GLN | B:359 | B:369 | 194.0 | 1.0 | 51.1 | 360.0 | 170.0 | 0.944 | 0.056 |
C:P37268:0.133 |
HOH |
3.163 |
CA |
O |
|||||||||
| GLN | C:359 | C:369 | 96.0 | 0.533 | -61.2 | 132.7 | 88.0 | 0.489 | 0.044 |
A:P37268:0.044 |
HOH |
2.785 |
O |
O |
|||||||||
| GLN | D:359 | D:369 | 60.0 | 0.333 | -38.5 | -102.4 | 60.0 | 0.333 | 0.0 |
HOH |
2.655 |
NE2 |
O |
||||||||||
| GLN | E:359 | E:369 | 90.0 | 0.5 | -59.9 | 121.4 | 65.0 | 0.361 | 0.139 |
F:P37268:0.139 |
HOH |
2.813 |
OE1 |
O |
|||||||||
| GLN | F:359 | F:369 | 99.0 | 0.55 | -68.4 | 360.0 | 87.0 | 0.483 | 0.067 |
D:P37268:0.067 |
HOH |
2.867 |
O |
O |
|||||||||
| 3wsa | 1 | P37268 | 98.82 | 0.0 |
X-RAY |
2015-04-01 | GLN | A:359 | A:369 | 200.0 | 1.0 | -92.4 | 360.0 | 110.0 | 0.611 | 0.389 |
D:P37268:0.05 B:P37268:0.5 |
HOH |
3.512 |
O |
O |
||
| GLN | B:359 | B:369 | 187.0 | 1.0 | 58.3 | 360.0 | 154.0 | 0.856 | 0.144 |
C:P37268:0.183 |
HOH |
6.422 |
NE2 |
O |
|||||||||
| GLN | C:359 | C:369 | 96.0 | 0.533 | -52.0 | 107.2 | 93.0 | 0.517 | 0.016 |
A:P37268:0.017 |
HOH |
6.311 |
OE1 |
O |
|||||||||
| GLN | D:359 | D:369 | 70.0 | 0.389 | -19.7 | -82.4 | 70.0 | 0.389 | 0.0 |
HOH |
4.912 |
N |
O |
||||||||||
| GLN | E:359 | E:369 | 75.0 | 0.417 | -36.1 | 114.1 | 61.0 | 0.339 | 0.078 |
F:P37268:0.078 |
HOH |
8.261 |
C |
O |
|||||||||
| GLN | F:359 | F:369 | 102.0 | 0.567 | -35.4 | 360.0 | 87.0 | 0.483 | 0.084 |
D:P37268:0.083 |
HOH |
2.826 |
O |
O |
|||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p37268-f1 | 1 | P37268 | 100.0 | 0.0 | GLN | A:369 | A:369 | 137.0 | 0.761 | H | -86.6 | -37.3 | |