Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 42919280 . A C CCDS6140.1:NM_002027.2:c.323cAg>cCg_NP_002018.1:p.108Q>P Homo sapiens farnesyltransferase, CAAX box, alpha (FNTA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcq 1 P49354 100.0 0.0 X-RAY
 2001-11-02 GLN A:108 A:108 143.0 0.794 H -59.9 -36.2 143.0 0.794 0.0 HOH
 6.521
 N
 O
1ld7 1 P49354 100.0 0.0 X-RAY
 2002-06-19 GLN A:108 A:108 153.0 0.85 H -60.3 -29.7 153.0 0.85 0.0 HOH
 3.556
 CB
 O
1ld8 1 P49354 100.0 0.0 X-RAY
 2002-06-19 GLN A:108 A:108 152.0 0.844 H -61.5 -30.1 152.0 0.844 0.0 HOH
 3.435
 CA
 O
1mzc 1 P49354 100.0 0.0 X-RAY
 2003-07-08 GLN A:108 A:108 152.0 0.844 H -61.7 -28.8 152.0 0.844 0.0 HOH
 3.963
 CB
 O
1s63 1 P49354 100.0 0.0 X-RAY
 2004-07-27 GLN A:108 A:108 144.0 0.8 H -61.9 -36.8 144.0 0.8 0.0 HOH
 2.952
 NE2
 O
1sa4 1 P49354 100.0 0.0 X-RAY
 2004-06-08 GLN A:108 A:108 144.0 0.8 H -64.3 -35.0 144.0 0.8 0.0 HOH
 3.178
 OE1
 O
1tn6 1 P49354 100.0 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 147.0 0.817 H -60.4 -36.1 147.0 0.817 0.0 HOH
 3.164
 OE1
 O
2h6f 1 P49354 100.0 0.0 X-RAY
 2006-08-29 GLN A:108 A:108 144.0 0.8 H -62.3 -35.5 144.0 0.8 0.0 HOH
 3.154
 NE2
 O
2h6g 1 P49354 100.0 0.0 X-RAY
 2006-08-29 GLN A:108 A:108 144.0 0.8 H -61.3 -35.8 144.0 0.8 0.0 HOH
 3.105
 NE2
 O
2h6h 1 P49354 100.0 0.0 X-RAY
 2006-08-29 GLN A:108 A:108 145.0 0.806 H -62.8 -34.2 145.0 0.806 0.0 HOH
 3.109
 NE2
 O
2h6i 1 P49354 100.0 0.0 X-RAY
 2006-08-29 GLN A:108 A:108 144.0 0.8 H -55.6 -37.8 144.0 0.8 0.0
2iej 1 P49354 100.0 0.0 X-RAY
 2007-01-23 GLN A:108 A:108 148.0 0.822 H -60.3 -37.6 148.0 0.822 0.0 HOH
 3.468
 NE2
 O
2f0y 1 P49354 100.0 0.0 X-RAY
 2006-11-14 GLN A:108 A:108 146.0 0.811 H -58.1 -15.4 146.0 0.811 0.0 HOH
 2.780
 OE1
 O
3e37 1 P49354 100.0 0.0 X-RAY
 2009-03-10 GLN A:108 A:108 147.0 0.817 H -63.9 -36.1 147.0 0.817 0.0 HOH
 3.592
 CA
 O
1o5m 1 Q04631 93.1 0.0 X-RAY
 2003-10-21 GLN A:108 A:108 133.0 0.739 H -59.0 -35.6 133.0 0.739 0.0 HOH
 2.712
 NE2
 O
2zir 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 GLN A:108 A:108 145.0 0.806 H -56.8 -54.7 145.0 0.806 0.0 GOL
HOH
 6.352
4.520
 CG
O
 O3
O
2zis 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 GLN A:108 A:108 139.0 0.772 H -59.7 -52.1 139.0 0.772 0.0 GOL
HOH
 6.032
3.171
 OE1
OE1
 O3
O
3ksl 1 Q5RKJ4 93.1 0.0 X-RAY
 2009-12-22 GLN A:108 A:108 141.0 0.783 H -57.2 -34.7 141.0 0.783 0.0 HOH
 3.301
 NE2
 O
3ksq 1 Q5RKJ4 93.1 0.0 X-RAY
 2010-01-26 GLN A:108 A:108 139.0 0.772 H -56.0 -38.8 139.0 0.772 0.0 HOH
 4.252
 O
 O
7rn5 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 GLN A:108 A:108 138.0 0.767 H -60.1 -36.1 138.0 0.767 0.0 ACE
HOH
 9.816
3.009
 HE21
HB2
 O
O
7rni 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 GLN A:108 A:108 144.0 0.8 H -63.2 -44.0 144.0 0.8 0.0 HOH
 3.193
 HB2
 O
1o1r 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 GLN A:111 A:108 133.0 0.739 H -58.7 -34.2 133.0 0.739 0.0 HOH
 2.623
 NE2
 O
1o1s 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 GLN A:111 A:108 134.0 0.744 H -59.2 -36.1 134.0 0.744 0.0 HOH
 2.633
 NE2
 O
1o1t 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 GLN A:111 A:108 134.0 0.744 H -61.0 -38.4 134.0 0.744 0.0 HOH
 2.673
 NE2
 O
1d8d 1 Q04631 92.84 0.0 X-RAY
 2000-02-09 GLN A:108 A:108 150.0 0.833 H -61.0 -41.5 150.0 0.833 0.0 HOH
 3.601
 NE2
 O
1d8e 1 Q04631 92.84 0.0 X-RAY
 2000-03-20 GLN A:108 A:108 149.0 0.828 H -55.1 -52.9 149.0 0.828 0.0 HOH
 6.928
 CA
 O
1fpp 2 Q04631 92.84 0.0 X-RAY
 1999-06-08 GLN B:108 A:108 140.0 0.778 H -63.2 -40.8 139.0 0.772 0.006 A:Q02293:0.006
1ft1 1 Q04631 92.84 0.0 X-RAY
 1998-03-18 GLN A:108 A:108 149.0 0.828 H -58.0 -41.2 149.0 0.828 0.0 HOH
 2.694
 OE1
 O
1jcr 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 GLN A:108 A:108 149.0 0.828 H -58.2 -41.5 149.0 0.828 0.0 HOH
 3.401
 NE2
 O
1jcs 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 GLN A:108 A:108 149.0 0.828 H -62.5 -39.3 149.0 0.828 0.0 HOH
 3.515
 NE2
 O
1kzo 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 GLN A:108 A:108 146.0 0.811 H -57.5 -40.2 146.0 0.811 0.0 HOH
 3.056
 NE2
 O
1kzp 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 GLN A:108 A:108 149.0 0.828 H -59.1 -38.4 149.0 0.828 0.0 HOH
 3.717
 CB
 O
1n4p 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 GLN A:108 A:108 145.0 0.806 H -53.1 -27.8 80.0 0.444 0.362 B:P53610:0.361
 HOH
 3.483
 N
 O
GLN C:108 C:108 141.0 0.783 H -52.9 -27.6 NA NA NA
GLN E:108 E:108 149.0 0.828 H -52.3 -28.1 NA NA NA
GLN G:108 G:108 146.0 0.811 H -51.7 -27.4 NA NA NA
GLN I:108 I:108 149.0 0.828 H -52.5 -27.0 NA NA NA
GLN K:108 K:108 146.0 0.811 H -54.8 -28.7 NA NA NA
1n4q 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 GLN A:108 A:108 145.0 0.806 H -57.2 -28.5 79.0 0.439 0.367 B:P53610:0.367
 HOH
 3.431
 N
 O
GLN C:108 C:108 140.0 0.778 H -56.7 -27.7 NA NA NA
GLN E:108 E:108 146.0 0.811 H -55.7 -28.6 NA NA NA
GLN G:108 G:108 145.0 0.806 H -56.3 -28.3 NA NA NA
GLN I:108 I:108 150.0 0.833 H -56.1 -27.2 NA NA NA
GLN K:108 K:108 146.0 0.811 H -57.8 -29.8 NA NA NA
1n4r 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 GLN A:108 A:108 145.0 0.806 H -51.4 -28.9 80.0 0.444 0.362 B:P53610:0.361
 HOH
 8.309
 NE2
 O
GLN C:108 C:108 141.0 0.783 H -50.8 -29.5 NA NA NA
GLN E:108 E:108 148.0 0.822 H -49.5 -29.1 NA NA NA
GLN G:108 G:108 147.0 0.817 H -49.8 -28.7 NA NA NA
GLN I:108 I:108 151.0 0.839 H -49.4 -28.4 NA NA NA
GLN K:108 K:108 147.0 0.817 H -52.2 -29.0 NA NA NA
1n4s 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 GLN A:108 A:108 147.0 0.817 H -52.4 -30.9 82.0 0.456 0.361 B:P53610:0.361
 HOH
 3.512
 N
 O
GLN C:108 C:108 140.0 0.778 H -52.8 -30.1 NA NA NA
GLN E:108 E:108 144.0 0.8 H -51.3 -31.1 NA NA NA
GLN G:108 G:108 149.0 0.828 H -50.9 -30.4 NA NA NA
GLN I:108 I:108 149.0 0.828 H -52.4 -29.4 NA NA NA
GLN K:108 K:108 147.0 0.817 H -54.8 -30.2 NA NA NA
1s64 1 Q04631 92.84 0.0 X-RAY
 2004-07-27 GLN A:108 A:108 147.0 0.817 H -52.8 -32.9 83.0 0.461 0.356 B:P53610:0.356
 HOH
 3.511
 N
 O
GLN C:108 C:108 139.0 0.772 H -51.7 -33.4 NA NA NA
GLN E:108 E:108 145.0 0.806 H -51.4 -33.6 NA NA NA
GLN G:108 G:108 146.0 0.811 H -50.8 -33.2 NA NA NA
GLN I:108 I:108 150.0 0.833 H -51.2 -32.4 NA NA NA
GLN K:108 K:108 146.0 0.811 H -52.2 -33.9 NA NA NA
1sa5 1 Q04631 92.84 0.0 X-RAY
 2004-06-08 GLN A:108 A:108 143.0 0.794 H -57.7 -46.9 143.0 0.794 0.0 HOH
 5.008
 NE2
 O
1tn7 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 151.0 0.839 H -59.9 -44.5 151.0 0.839 0.0 HOH
 5.072
 NE2
 O
1tn8 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 148.0 0.822 H -59.6 -39.9 148.0 0.822 0.0 HOH
 5.321
 NE2
 O
1tnb 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 146.0 0.811 H -57.7 -28.3 80.0 0.444 0.367 B:P53610:0.367
 HOH
 3.716
 N
 O
GLN C:108 C:108 136.0 0.756 H -59.1 -28.7 NA NA NA
GLN E:108 E:108 140.0 0.778 H -56.3 -28.4 NA NA NA
GLN G:108 G:108 140.0 0.778 H -56.6 -27.9 NA NA NA
GLN I:108 I:108 146.0 0.811 H -58.4 -28.3 NA NA NA
GLN K:108 K:108 141.0 0.783 H -59.8 -29.1 NA NA NA
1tno 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 141.0 0.783 H -59.6 -27.5 78.0 0.433 0.35 B:P53610:0.35
 HOH
 3.662
 CB
 O
GLN C:108 C:108 136.0 0.756 H -60.9 -27.8 NA NA NA
GLN E:108 E:108 139.0 0.772 H -58.4 -26.5 NA NA NA
GLN G:108 G:108 143.0 0.794 H -59.5 -28.0 NA NA NA
GLN I:108 I:108 148.0 0.822 H -59.8 -27.2 NA NA NA
GLN K:108 K:108 144.0 0.8 H -61.8 -27.3 NA NA NA
1tnu 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 147.0 0.817 H -50.4 -31.0 80.0 0.444 0.373 B:P53610:0.372
 HOH
 3.621
 N
 O
GLN C:108 C:108 141.0 0.783 H -51.1 -31.7 NA NA NA
GLN E:108 E:108 146.0 0.811 H -48.5 -31.7 NA NA NA
GLN G:108 G:108 146.0 0.811 H -49.6 -31.1 NA NA NA
GLN I:108 I:108 152.0 0.844 H -51.1 -30.4 NA NA NA
GLN K:108 K:108 151.0 0.839 H -52.3 -31.7 NA NA NA
1tny 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 142.0 0.789 H -59.4 -28.6 80.0 0.444 0.345 B:P53610:0.344
 HOH
 3.635
 N
 O
GLN C:108 C:108 135.0 0.75 H -59.5 -29.5 NA NA NA
GLN E:108 E:108 138.0 0.767 H -58.5 -28.8 NA NA NA
GLN G:108 G:108 140.0 0.778 H -57.9 -28.2 NA NA NA
GLN I:108 I:108 143.0 0.794 H -59.8 -28.2 NA NA NA
GLN K:108 K:108 141.0 0.783 H -60.7 -28.9 NA NA NA
1tnz 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 GLN A:108 A:108 150.0 0.833 H -47.4 -34.6 83.0 0.461 0.372 B:P53610:0.372
 HOH
 8.559
 NE2
 O
GLN C:108 C:108 139.0 0.772 H -47.6 -35.0 NA NA NA
GLN E:108 E:108 146.0 0.811 H -46.1 -34.1 NA NA NA
GLN G:108 G:108 140.0 0.778 H -46.1 -33.9 NA NA NA
GLN I:108 I:108 150.0 0.833 H -48.2 -33.9 NA NA NA
GLN K:108 K:108 149.0 0.828 H -49.6 -34.8 NA NA NA
3dpy 1 Q04631 92.84 0.0 X-RAY
 2008-09-30 GLN A:108 A:108 146.0 0.811 H -58.4 -45.5 146.0 0.811 0.0 HOH
 7.405
 C
 O
3e30 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 GLN A:108 A:108 146.0 0.811 H -59.6 -37.7 146.0 0.811 0.0 HOH
 3.277
 NE2
 O
3e32 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 GLN A:108 A:108 146.0 0.811 H -62.0 -39.7 146.0 0.811 0.0 HOH
 3.329
 NE2
 O
3e33 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 GLN A:108 A:108 146.0 0.811 H -59.0 -42.1 146.0 0.811 0.0 HOH
 5.107
 NE2
 O
3e34 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 GLN A:108 A:108 151.0 0.839 H -58.0 -41.9 151.0 0.839 0.0 HOH
 3.637
 N
 O
3eu5 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 GLN A:108 A:108 148.0 0.822 H -53.1 -42.5 148.0 0.822 0.0 HOH
 5.063
 OE1
 O
3euv 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 GLN A:108 A:108 142.0 0.789 H -66.9 -48.6 142.0 0.789 0.0 HOH
 7.487
 OE1
 O
4gtm 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 GLN A:108 A:108 139.0 0.772 H -63.2 -37.6 136.0 0.756 0.016 B:Q02293:0.017
 HOH
 2.202
 OE1
 O
4gto 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 GLN A:108 A:108 144.0 0.8 H -49.0 -50.0 144.0 0.8 0.0 HOH
 2.617
 OE1
 O
4gtp 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 GLN A:108 A:108 143.0 0.794 H -57.3 -57.8 143.0 0.794 0.0 HOH
 2.801
 CG
 O
4gtq 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 GLN A:108 A:108 145.0 0.806 H -59.6 -46.4 145.0 0.806 0.0 HOH
 2.495
 OE1
 O
4gtr 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 GLN A:108 A:108 139.0 0.772 H -67.6 -33.1 135.0 0.75 0.022 B:Q02293:0.022
 HOH
 2.359
 OE1
 O
1qbq 1 Q04631 94.89 0.0 X-RAY
 1999-06-18 GLN A:64 A:108 140.0 0.778 H -54.3 -34.3 140.0 0.778 0.0 ACT
HOH
 7.372
4.170
 N
CB
 CH3
O
3pz4 1 Q04631 92.84 0.0 X-RAY
 2011-05-11 GLN A:110 A:108 140.0 0.778 H -62.3 -35.5 131.0 0.728 0.05 B:Q02293:0.05
 HOH
 4.142
 CB
 O
2r2l 1 Q5RKJ4 96.51 0.0 X-RAY
 2008-03-11 GLN A:55 A:108 135.0 0.75 H -56.6 -40.9 135.0 0.75 0.0 HOH
 2.644
 NE2
 O
1n95 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 GLN A:54 A:108 142.0 0.789 H -54.2 -34.6 142.0 0.789 0.0
1n9a 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 GLN A:54 A:108 141.0 0.783 H -53.2 -35.6 141.0 0.783 0.0
1ni1 1 Q04631 96.5 0.0 X-RAY
 2004-04-06 GLN A:54 A:108 144.0 0.8 H -51.8 -47.0 144.0 0.8 0.0
2bed 1 Q04631 96.49 0.0 X-RAY
 2006-08-08 GLN A:55 A:108 129.0 0.717 H -52.9 -63.8 129.0 0.717 0.0 HOH
 3.524
 OE1
 O
1ft2 1 Q04631 96.18 0.0 X-RAY
 1998-11-04 GLN A:54 A:108 153.0 0.85 H -55.2 -51.8 153.0 0.85 0.0
1n94 1 Q04631 96.18 0.0 X-RAY
 2003-01-07 GLN A:54 A:108 141.0 0.783 H -59.7 -26.5 141.0 0.783 0.0
1x81 1 Q04631 96.18 0.0 X-RAY
 2004-12-21 GLN A:54 A:108 147.0 0.817 H -51.3 -28.9 147.0 0.817 0.0
1nl4 1 Q04631 96.47 0.0 X-RAY
 2003-02-11 GLN A:54 A:108 141.0 0.783 H -49.5 -45.1 141.0 0.783 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p49354-f1 1 P49354 100.0 0.0 GLN A:108 A:108 151.0 0.839 H -64.0 -32.4