Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 42919308 . T A CCDS6140.1:NM_002027.2:c.351ttT>ttA_NP_002018.1:p.117F>L Homo sapiens farnesyltransferase, CAAX box, alpha (FNTA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcq 1 P49354 100.0 0.0 X-RAY
 2001-11-02 PHE A:117 A:117 18.0 0.086 H -60.6 -44.8 18.0 0.086 0.0 HOH
 2.965
 O
 O
1ld7 1 P49354 100.0 0.0 X-RAY
 2002-06-19 PHE A:117 A:117 20.0 0.095 H -58.8 -47.9 20.0 0.095 0.0 HOH
 3.369
 CE2
 O
1ld8 1 P49354 100.0 0.0 X-RAY
 2002-06-19 PHE A:117 A:117 20.0 0.095 H -59.9 -45.6 20.0 0.095 0.0 HOH
 3.318
 CE2
 O
1mzc 1 P49354 100.0 0.0 X-RAY
 2003-07-08 PHE A:117 A:117 19.0 0.09 H -60.9 -47.7 19.0 0.09 0.0 HOH
 3.344
 CE2
 O
1s63 1 P49354 100.0 0.0 X-RAY
 2004-07-27 PHE A:117 A:117 19.0 0.09 H -61.1 -48.2 19.0 0.09 0.0 HOH
 3.308
 O
 O
1sa4 1 P49354 100.0 0.0 X-RAY
 2004-06-08 PHE A:117 A:117 18.0 0.086 H -59.4 -47.4 18.0 0.086 0.0 HOH
 3.348
 O
 O
1tn6 1 P49354 100.0 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 18.0 0.086 H -62.0 -45.7 18.0 0.086 0.0 HOH
 3.266
 O
 O
2h6f 1 P49354 100.0 0.0 X-RAY
 2006-08-29 PHE A:117 A:117 19.0 0.09 H -61.4 -46.9 19.0 0.09 0.0 HOH
 3.316
 O
 O
2h6g 1 P49354 100.0 0.0 X-RAY
 2006-08-29 PHE A:117 A:117 19.0 0.09 H -59.3 -46.1 19.0 0.09 0.0 HOH
 3.279
 O
 O
2h6h 1 P49354 100.0 0.0 X-RAY
 2006-08-29 PHE A:117 A:117 19.0 0.09 H -60.4 -47.2 19.0 0.09 0.0 HOH
 3.367
 O
 O
2h6i 1 P49354 100.0 0.0 X-RAY
 2006-08-29 PHE A:117 A:117 20.0 0.095 H -52.8 -44.1 20.0 0.095 0.0
2iej 1 P49354 100.0 0.0 X-RAY
 2007-01-23 PHE A:117 A:117 18.0 0.086 H -54.9 -47.6 18.0 0.086 0.0 HOH
 3.330
 CE2
 O
2f0y 1 P49354 100.0 0.0 X-RAY
 2006-11-14 PHE A:117 A:117 24.0 0.114 H -72.3 -35.7 24.0 0.114 0.0 HOH
 3.153
 CZ
 O
3e37 1 P49354 100.0 0.0 X-RAY
 2009-03-10 PHE A:117 A:117 19.0 0.09 H -58.4 -47.4 19.0 0.09 0.0 HOH
 3.281
 O
 O
1o5m 1 Q04631 93.1 0.0 X-RAY
 2003-10-21 PHE A:117 A:117 9.0 0.043 H -62.9 -45.6 9.0 0.043 0.0 HOH
 3.279
 CE2
 O
2zir 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 PHE A:117 A:117 10.0 0.048 H -61.3 -42.0 10.0 0.048 0.0 HOH
 3.104
 O
 O
2zis 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 PHE A:117 A:117 18.0 0.086 H -57.2 -48.1 18.0 0.086 0.0 HOH
 3.234
 O
 O
3ksl 1 Q5RKJ4 93.1 0.0 X-RAY
 2009-12-22 PHE A:117 A:117 10.0 0.048 H -61.5 -51.5 10.0 0.048 0.0 HOH
 3.419
 CE2
 O
3ksq 1 Q5RKJ4 93.1 0.0 X-RAY
 2010-01-26 PHE A:117 A:117 9.0 0.043 H -62.7 -48.5 9.0 0.043 0.0 HOH
 3.292
 CE2
 O
7rn5 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 PHE A:117 A:117 18.0 0.086 H -62.0 -46.1 18.0 0.086 0.0 HOH
 2.909
 HZ
 O
7rni 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 PHE A:117 A:117 18.0 0.086 H -60.2 -44.1 18.0 0.086 0.0 HOH
 2.818
 HZ
 O
1o1r 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 PHE A:120 A:117 10.0 0.048 H -59.7 -45.6 10.0 0.048 0.0 HOH
 3.194
 CE2
 O
1o1s 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 PHE A:120 A:117 10.0 0.048 H -57.9 -44.9 10.0 0.048 0.0 HOH
 3.256
 CE2
 O
1o1t 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 PHE A:120 A:117 10.0 0.048 H -61.0 -48.2 10.0 0.048 0.0 HOH
 3.175
 CE2
 O
1d8d 1 Q04631 92.84 0.0 X-RAY
 2000-02-09 PHE A:117 A:117 21.0 0.1 H -58.8 -50.5 21.0 0.1 0.0 HOH
 3.198
 CE2
 O
1d8e 1 Q04631 92.84 0.0 X-RAY
 2000-03-20 PHE A:117 A:117 19.0 0.09 H -54.6 -52.9 19.0 0.09 0.0 HOH
 3.291
 CE2
 O
1fpp 2 Q04631 92.84 0.0 X-RAY
 1999-06-08 PHE B:117 A:117 18.0 0.086 H -55.3 -42.9 18.0 0.086 0.0
1ft1 1 Q04631 92.84 0.0 X-RAY
 1998-03-18 PHE A:117 A:117 18.0 0.086 H -65.7 -46.9 18.0 0.086 0.0 HOH
 4.194
 CZ
 O
1jcr 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 PHE A:117 A:117 19.0 0.09 H -59.6 -50.3 19.0 0.09 0.0 HOH
 3.240
 CE2
 O
1jcs 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 PHE A:117 A:117 20.0 0.095 H -60.2 -50.5 20.0 0.095 0.0 HOH
 3.099
 CE2
 O
1kzo 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 PHE A:117 A:117 20.0 0.095 H -60.0 -48.2 20.0 0.095 0.0 HOH
 3.194
 CE2
 O
1kzp 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 PHE A:117 A:117 21.0 0.1 H -57.9 -51.7 21.0 0.1 0.0 HOH
 3.240
 CE2
 O
1n4p 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 PHE A:117 A:117 21.0 0.1 H -59.9 -43.5 21.0 0.1 0.0 HOH
 4.054
 CZ
 O
PHE C:117 C:117 20.0 0.095 H -59.2 -43.8 NA NA NA
PHE E:117 E:117 21.0 0.1 H -58.6 -44.5 NA NA NA
PHE G:117 G:117 20.0 0.095 H -58.9 -43.6 NA NA NA
PHE I:117 I:117 26.0 0.124 H -59.3 -44.6 NA NA NA
PHE K:117 K:117 23.0 0.11 H -58.5 -46.0 NA NA NA
1n4q 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 PHE A:117 A:117 21.0 0.1 H -59.1 -45.8 21.0 0.1 0.0 HOH
 3.263
 CE2
 O
PHE C:117 C:117 20.0 0.095 H -58.6 -46.5 NA NA NA
PHE E:117 E:117 21.0 0.1 H -57.7 -47.0 NA NA NA
PHE G:117 G:117 19.0 0.09 H -58.5 -45.5 NA NA NA
PHE I:117 I:117 24.0 0.114 H -58.9 -47.0 NA NA NA
PHE K:117 K:117 22.0 0.105 H -58.1 -47.3 NA NA NA
1n4r 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 PHE A:117 A:117 22.0 0.105 H -58.4 -43.8 22.0 0.105 0.0 HOH
 3.813
 CD2
 O
PHE C:117 C:117 19.0 0.09 H -57.3 -43.9 NA NA NA
PHE E:117 E:117 20.0 0.095 H -57.4 -45.4 NA NA NA
PHE G:117 G:117 21.0 0.1 H -57.3 -43.5 NA NA NA
PHE I:117 I:117 25.0 0.119 H -57.5 -44.6 NA NA NA
PHE K:117 K:117 20.0 0.095 H -56.1 -46.0 NA NA NA
1n4s 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 PHE A:117 A:117 21.0 0.1 H -61.3 -43.4 21.0 0.1 0.0 HOH
 3.965
 CZ
 O
PHE C:117 C:117 19.0 0.09 H -60.0 -44.1 NA NA NA
PHE E:117 E:117 19.0 0.09 H -60.0 -44.6 NA NA NA
PHE G:117 G:117 21.0 0.1 H -60.2 -42.7 NA NA NA
PHE I:117 I:117 24.0 0.114 H -59.6 -44.3 NA NA NA
PHE K:117 K:117 22.0 0.105 H -60.0 -45.1 NA NA NA
1s64 1 Q04631 92.84 0.0 X-RAY
 2004-07-27 PHE A:117 A:117 21.0 0.1 H -57.4 -44.4 21.0 0.1 0.0 HOH
 3.697
 CD2
 O
PHE C:117 C:117 21.0 0.1 H -57.7 -44.0 NA NA NA
PHE E:117 E:117 20.0 0.095 H -56.8 -45.8 NA NA NA
PHE G:117 G:117 22.0 0.105 H -57.8 -44.2 NA NA NA
PHE I:117 I:117 24.0 0.114 H -56.1 -44.9 NA NA NA
PHE K:117 K:117 22.0 0.105 H -57.7 -45.9 NA NA NA
1sa5 1 Q04631 92.84 0.0 X-RAY
 2004-06-08 PHE A:117 A:117 21.0 0.1 H -56.1 -50.9 21.0 0.1 0.0 HOH
 3.322
 CE2
 O
1tn7 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 21.0 0.1 H -56.0 -49.6 21.0 0.1 0.0 HOH
 3.242
 CE2
 O
1tn8 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 21.0 0.1 H -54.9 -51.2 21.0 0.1 0.0 HOH
 3.306
 CE2
 O
1tnb 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 22.0 0.105 H -54.7 -44.6 22.0 0.105 0.0 HOH
 3.116
 CE2
 O
PHE C:117 C:117 20.0 0.095 H -53.2 -43.4 NA NA NA
PHE E:117 E:117 19.0 0.09 H -53.1 -44.8 NA NA NA
PHE G:117 G:117 21.0 0.1 H -53.7 -43.3 NA NA NA
PHE I:117 I:117 26.0 0.124 H -52.6 -45.2 NA NA NA
PHE K:117 K:117 22.0 0.105 H -53.4 -44.9 NA NA NA
1tno 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 21.0 0.1 H -58.4 -43.4 21.0 0.1 0.0 HOH
 4.006
 CZ
 O
PHE C:117 C:117 21.0 0.1 H -58.9 -40.6 NA NA NA
PHE E:117 E:117 21.0 0.1 H -58.0 -42.7 NA NA NA
PHE G:117 G:117 24.0 0.114 H -59.5 -41.4 NA NA NA
PHE I:117 I:117 27.0 0.129 H -58.2 -42.6 NA NA NA
PHE K:117 K:117 24.0 0.114 H -57.8 -44.1 NA NA NA
1tnu 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 23.0 0.11 H -57.7 -42.7 23.0 0.11 0.0 HOH
 3.783
 CZ
 O
PHE C:117 C:117 21.0 0.1 H -56.1 -43.2 NA NA NA
PHE E:117 E:117 20.0 0.095 H -56.1 -43.7 NA NA NA
PHE G:117 G:117 19.0 0.09 H -56.5 -42.9 NA NA NA
PHE I:117 I:117 24.0 0.114 H -55.8 -45.1 NA NA NA
PHE K:117 K:117 22.0 0.105 H -55.6 -44.4 NA NA NA
1tny 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 20.0 0.095 H -57.0 -45.0 20.0 0.095 0.0 HOH
 3.889
 CZ
 O
PHE C:117 C:117 20.0 0.095 H -56.3 -43.4 NA NA NA
PHE E:117 E:117 21.0 0.1 H -55.2 -45.0 NA NA NA
PHE G:117 G:117 21.0 0.1 H -56.0 -44.1 NA NA NA
PHE I:117 I:117 26.0 0.124 H -54.0 -44.7 NA NA NA
PHE K:117 K:117 22.0 0.105 H -54.7 -45.2 NA NA NA
1tnz 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 PHE A:117 A:117 21.0 0.1 H -54.0 -43.2 21.0 0.1 0.0 HOH
 9.854
 O
 O
PHE C:117 C:117 22.0 0.105 H -53.3 -43.7 NA NA NA
PHE E:117 E:117 19.0 0.09 H -52.6 -44.1 NA NA NA
PHE G:117 G:117 21.0 0.1 H -52.6 -42.6 NA NA NA
PHE I:117 I:117 23.0 0.11 H -50.9 -45.8 NA NA NA
PHE K:117 K:117 20.0 0.095 H -51.6 -44.5 NA NA NA
3dpy 1 Q04631 92.84 0.0 X-RAY
 2008-09-30 PHE A:117 A:117 21.0 0.1 H -60.8 -44.2 21.0 0.1 0.0 HOH
 3.543
 CZ
 O
3e30 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 PHE A:117 A:117 20.0 0.095 H -55.1 -47.6 20.0 0.095 0.0 HOH
 3.183
 CE2
 O
3e32 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 PHE A:117 A:117 20.0 0.095 H -54.9 -50.9 20.0 0.095 0.0 HOH
 3.249
 CE2
 O
3e33 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 PHE A:117 A:117 15.0 0.071 H -61.4 -47.8 15.0 0.071 0.0 HOH
 3.695
 CZ
 O
3e34 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 PHE A:117 A:117 18.0 0.086 H -60.6 -48.4 18.0 0.086 0.0 HOH
 4.044
 CE2
 O
3eu5 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 PHE A:117 A:117 20.0 0.095 H -63.0 -44.5 20.0 0.095 0.0 HOH
 4.185
 CZ
 O
3euv 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 PHE A:117 A:117 22.0 0.105 H -67.2 -50.7 22.0 0.105 0.0 HOH
 6.261
 CE2
 O
4gtm 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 PHE A:117 A:117 12.0 0.057 H -60.3 -46.3 12.0 0.057 0.0 HOH
 3.187
 O
 O
4gto 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 PHE A:117 A:117 22.0 0.105 H -59.6 -48.2 22.0 0.105 0.0 HOH
 3.103
 O
 O
4gtp 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 PHE A:117 A:117 18.0 0.086 H -59.4 -47.8 18.0 0.086 0.0 HOH
 2.988
 O
 O
4gtq 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 PHE A:117 A:117 21.0 0.1 H -60.0 -46.6 21.0 0.1 0.0 HOH
 2.538
 O
 O
4gtr 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 PHE A:117 A:117 20.0 0.095 H -58.1 -49.2 20.0 0.095 0.0 HOH
 3.100
 O
 O
1qbq 1 Q04631 94.89 0.0 X-RAY
 1999-06-18 PHE A:73 A:117 19.0 0.09 H -59.2 -53.4 19.0 0.09 0.0 HOH
 3.230
 CE2
 O
3pz4 1 Q04631 92.84 0.0 X-RAY
 2011-05-11 PHE A:119 A:117 16.0 0.076 H -57.8 -46.4 16.0 0.076 0.0 HOH
 3.423
 CE2
 O
2r2l 1 Q5RKJ4 96.51 0.0 X-RAY
 2008-03-11 PHE A:64 A:117 9.0 0.043 H -59.2 -54.1 9.0 0.043 0.0 HOH
 3.199
 CE2
 O
1n95 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 PHE A:63 A:117 19.0 0.09 H -58.8 -53.5 19.0 0.09 0.0
1n9a 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 PHE A:63 A:117 19.0 0.09 H -59.2 -53.2 19.0 0.09 0.0
1ni1 1 Q04631 96.5 0.0 X-RAY
 2004-04-06 PHE A:63 A:117 22.0 0.105 H -54.0 -34.7 22.0 0.105 0.0
2bed 1 Q04631 96.49 0.0 X-RAY
 2006-08-08 PHE A:64 A:117 14.0 0.067 H -56.6 -53.8 14.0 0.067 0.0 HOH
 3.160
 CE2
 O
1ft2 1 Q04631 96.18 0.0 X-RAY
 1998-11-04 PHE A:63 A:117 16.0 0.076 H -58.4 -43.9 16.0 0.076 0.0
1n94 1 Q04631 96.18 0.0 X-RAY
 2003-01-07 PHE A:63 A:117 20.0 0.095 H -48.7 -67.2 20.0 0.095 0.0
1x81 1 Q04631 96.18 0.0 X-RAY
 2004-12-21 PHE A:63 A:117 14.0 0.067 H -43.9 -46.0 14.0 0.067 0.0
1nl4 1 Q04631 96.47 0.0 X-RAY
 2003-02-11 PHE A:63 A:117 17.0 0.081 H -44.7 -62.9 17.0 0.081 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p49354-f1 1 P49354 100.0 0.0 PHE A:117 A:117 19.0 0.09 H -63.1 -47.2