Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 42939867 . G A CCDS6140.1:NM_002027.2:c.860cGt>cAt_NP_002018.1:p.287R>H Homo sapiens farnesyltransferase, CAAX box, alpha (FNTA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1jcq 1 P49354 100.0 0.0 X-RAY
 2001-11-02 ARG A:287 A:287 145.0 0.644 T -81.4 -30.1 145.0 0.644 0.0 GLC
FRU
HOH
 7.542
8.033
2.662
 N
N
N
 O6
O4
O
1ld7 1 P49354 100.0 0.0 X-RAY
 2002-06-19 ARG A:287 A:287 148.0 0.658 T -80.2 -31.1 148.0 0.658 0.0 GLC
FRU
HOH
 7.575
7.885
2.820
 N
N
N
 O6
O4
O
1ld8 1 P49354 100.0 0.0 X-RAY
 2002-06-19 ARG A:287 A:287 148.0 0.658 T -75.3 -31.0 148.0 0.658 0.0 GLC
FRU
HOH
 7.517
8.031
2.805
 N
N
N
 O6
O4
O
1mzc 1 P49354 100.0 0.0 X-RAY
 2003-07-08 ARG A:287 A:287 143.0 0.636 T -77.0 -27.4 143.0 0.636 0.0 GLC
FRU
HOH
 7.569
8.069
2.827
 N
N
N
 O6
O4
O
1s63 1 P49354 100.0 0.0 X-RAY
 2004-07-27 ARG A:287 A:287 146.0 0.649 T -78.1 -28.9 146.0 0.649 0.0 GLC
FRU
HOH
 7.474
7.957
2.716
 N
N
N
 O6
O4
O
1sa4 1 P49354 100.0 0.0 X-RAY
 2004-06-08 ARG A:287 A:287 143.0 0.636 T -77.3 -29.7 143.0 0.636 0.0 GLC
FRU
HOH
 7.512
7.997
2.797
 N
N
N
 O6
O4
O
1tn6 1 P49354 100.0 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 165.0 0.733 T -77.5 -29.7 165.0 0.733 0.0 GLC
FRU
HOH
 7.546
8.046
2.848
 N
N
O
 O6
O4
O
2h6f 1 P49354 100.0 0.0 X-RAY
 2006-08-29 ARG A:287 A:287 145.0 0.644 T -76.7 -29.2 145.0 0.644 0.0 GLC
FRU
HOH
 7.455
8.009
2.872
 N
N
N
 O6
O4
O
2h6g 1 P49354 100.0 0.0 X-RAY
 2006-08-29 ARG A:287 A:287 145.0 0.644 T -75.1 -31.9 145.0 0.644 0.0 GLC
FRU
HOH
 7.532
8.025
2.772
 N
N
N
 O6
O4
O
2h6h 1 P49354 100.0 0.0 X-RAY
 2006-08-29 ARG A:287 A:287 146.0 0.649 T -77.8 -29.1 146.0 0.649 0.0 GLC
FRU
HOH
 7.481
8.063
2.855
 N
N
N
 O6
O4
O
2h6i 1 P49354 100.0 0.0 X-RAY
 2006-08-29 ARG A:287 A:287 147.0 0.653 T -67.3 -32.5 147.0 0.653 0.0 GLC
FRU
HOH
 7.642
8.025
4.056
 N
N
CD
 O6
O4
O
2iej 1 P49354 100.0 0.0 X-RAY
 2007-01-23 ARG A:287 A:287 161.0 0.716 T -73.2 -29.3 161.0 0.716 0.0 GLC
FRU
HOH
 7.586
8.011
2.742
 N
N
O
 O6
O4
O
2f0y 1 P49354 100.0 0.0 X-RAY
 2006-11-14 ARG A:287 A:287 157.0 0.698 G -79.8 -13.6 157.0 0.698 0.0 HOH
 2.905
 CB
 O
3e37 1 P49354 100.0 0.0 X-RAY
 2009-03-10 ARG A:287 A:287 150.0 0.667 T -71.9 -29.5 150.0 0.667 0.0 GLC
FRU
HOH
 7.443
8.065
2.812
 N
N
O
 O6
O4
O
1o5m 1 Q04631 93.1 0.0 X-RAY
 2003-10-21 ARG A:287 A:287 147.0 0.653 T -72.5 -16.4 147.0 0.653 0.0 HOH
 2.766
 O
 O
2zir 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 ARG A:287 A:287 146.0 0.649 T -84.2 0.9 146.0 0.649 0.0 HOH
 4.114
 NE
 O
2zis 1 Q04631 93.1 0.0 X-RAY
 2009-02-24 ARG A:287 A:287 137.0 0.609 T -78.6 -3.2 137.0 0.609 0.0 HOH
 2.980
 CZ
 O
3ksl 1 Q5RKJ4 93.1 0.0 X-RAY
 2009-12-22 ARG A:287 A:287 146.0 0.649 T -78.5 -19.0 146.0 0.649 0.0 HOH
 3.808
 CG
 O
3ksq 1 Q5RKJ4 93.1 0.0 X-RAY
 2010-01-26 ARG A:287 A:287 151.0 0.671 T -77.1 -15.5 151.0 0.671 0.0 HOH
 3.965
 CB
 O
7rn5 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 ARG A:287 A:287 152.0 0.676 T -86.0 -12.7 152.0 0.676 0.0 HOH
 2.751
 HG3
 O
7rni 1 Q04631 93.1 0.0 X-RAY
 2021-09-08 ARG A:287 A:287 177.0 0.787 T -70.1 -28.5 177.0 0.787 0.0 HOH
 2.385
 HH21
 O
1o1r 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 ARG A:290 A:287 146.0 0.649 T -66.7 -18.5 146.0 0.649 0.0 HOH
 2.866
 O
 O
1o1s 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 ARG A:290 A:287 139.0 0.618 T -69.0 -10.6 139.0 0.618 0.0 HOH
 2.835
 CG
 O
1o1t 1 Q04631 93.1 0.0 X-RAY
 2003-05-06 ARG A:290 A:287 149.0 0.662 T -71.6 -12.2 149.0 0.662 0.0 HOH
 2.851
 O
 O
1d8d 1 Q04631 92.84 0.0 X-RAY
 2000-02-09 ARG A:287 A:287 149.0 0.662 T -75.2 -24.2 149.0 0.662 0.0 HOH
 2.951
 CG
 O
1d8e 1 Q04631 92.84 0.0 X-RAY
 2000-03-20 ARG A:287 A:287 146.0 0.649 T -73.0 -25.7 146.0 0.649 0.0 HOH
 3.205
 N
 O
1fpp 2 Q04631 92.84 0.0 X-RAY
 1999-06-08 ARG B:287 A:287 128.0 0.569 S -74.1 -3.1 128.0 0.569 0.0
1ft1 1 Q04631 92.84 0.0 X-RAY
 1998-03-18 ARG A:287 A:287 70.0 0.311 T -84.5 -9.9 70.0 0.311 0.0 HOH
 3.085
 NH1
 O
1jcr 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 ARG A:287 A:287 158.0 0.702 T -75.0 -18.2 158.0 0.702 0.0 HOH
 3.135
 CG
 O
1jcs 1 Q04631 92.84 0.0 X-RAY
 2001-11-02 ARG A:287 A:287 157.0 0.698 T -77.7 -27.2 157.0 0.698 0.0 HOH
 3.072
 CG
 O
1kzo 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 ARG A:287 A:287 158.0 0.702 T -70.9 -23.8 158.0 0.702 0.0 HOH
 2.950
 CG
 O
1kzp 1 Q04631 92.84 0.0 X-RAY
 2002-10-16 ARG A:287 A:287 148.0 0.658 T -75.0 -22.7 148.0 0.658 0.0 HOH
 3.051
 CG
 O
1n4p 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 ARG A:287 A:287 79.0 0.351 T -77.7 -29.0 79.0 0.351 0.0 HOH
 4.513
 NH1
 O
ARG C:287 C:287 74.0 0.329 T -80.1 -26.6 NA NA NA
ARG E:287 E:287 81.0 0.36 T -77.6 -26.8 NA NA NA
ARG G:287 G:287 77.0 0.342 T -78.4 -26.0 NA NA NA
ARG I:287 I:287 77.0 0.342 T -77.2 -27.0 NA NA NA
ARG K:287 K:287 79.0 0.351 T -80.1 -25.8 NA NA NA
1n4q 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 ARG A:287 A:287 81.0 0.36 T -78.2 -29.3 81.0 0.36 0.0 HOH
 4.555
 NH1
 O
ARG C:287 C:287 72.0 0.32 T -81.5 -27.0 NA NA NA
ARG E:287 E:287 80.0 0.356 T -77.8 -27.4 NA NA NA
ARG G:287 G:287 74.0 0.329 T -79.1 -26.9 NA NA NA
ARG I:287 I:287 76.0 0.338 T -77.9 -27.2 NA NA NA
ARG K:287 K:287 76.0 0.338 T -80.5 -26.2 NA NA NA
1n4r 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 ARG A:287 A:287 79.0 0.351 T -77.6 -31.5 79.0 0.351 0.0 HOH
 4.845
 NH1
 O
ARG C:287 C:287 77.0 0.342 T -79.5 -29.3 NA NA NA
ARG E:287 E:287 81.0 0.36 T -78.0 -29.6 NA NA NA
ARG G:287 G:287 82.0 0.364 T -79.1 -28.7 NA NA NA
ARG I:287 I:287 75.0 0.333 T -78.0 -29.6 NA NA NA
ARG K:287 K:287 79.0 0.351 T -79.4 -29.8 NA NA NA
1n4s 1 Q04631 92.84 0.0 X-RAY
 2003-11-18 ARG A:287 A:287 75.0 0.333 T -78.8 -27.5 75.0 0.333 0.0 HOH
 4.604
 NH1
 O
ARG C:287 C:287 73.0 0.324 T -81.1 -25.0 NA NA NA
ARG E:287 E:287 78.0 0.347 T -79.0 -26.4 NA NA NA
ARG G:287 G:287 77.0 0.342 T -79.5 -25.7 NA NA NA
ARG I:287 I:287 74.0 0.329 T -79.0 -25.6 NA NA NA
ARG K:287 K:287 78.0 0.347 T -80.8 -24.9 NA NA NA
1s64 1 Q04631 92.84 0.0 X-RAY
 2004-07-27 ARG A:287 A:287 82.0 0.364 T -78.2 -28.1 82.0 0.364 0.0 HOH
 4.348
 NH1
 O
ARG C:287 C:287 75.0 0.333 T -80.1 -26.2 NA NA NA
ARG E:287 E:287 85.0 0.378 T -77.7 -26.7 NA NA NA
ARG G:287 G:287 79.0 0.351 T -79.2 -26.3 NA NA NA
ARG I:287 I:287 75.0 0.333 T -78.4 -25.5 NA NA NA
ARG K:287 K:287 79.0 0.351 T -80.5 -26.1 NA NA NA
1sa5 1 Q04631 92.84 0.0 X-RAY
 2004-06-08 ARG A:287 A:287 151.0 0.671 T -74.3 -20.3 151.0 0.671 0.0 HOH
 2.929
 CG
 O
1tn7 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 155.0 0.689 T -80.7 -15.0 155.0 0.689 0.0 HOH
 3.092
 CG
 O
1tn8 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 141.0 0.627 T -80.0 -19.2 141.0 0.627 0.0 HOH
 2.967
 CG
 O
1tnb 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 77.0 0.342 T -80.6 -24.0 77.0 0.342 0.0 HOH
 4.755
 NH1
 O
ARG C:287 C:287 80.0 0.356 T -82.4 -21.6 NA NA NA
ARG E:287 E:287 82.0 0.364 T -83.9 -22.2 NA NA NA
ARG G:287 G:287 84.0 0.373 T -81.6 -22.7 NA NA NA
ARG I:287 I:287 80.0 0.356 T -80.6 -21.9 NA NA NA
ARG K:287 K:287 79.0 0.351 T -83.2 -23.8 NA NA NA
1tno 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 87.0 0.387 T -83.2 -21.3 87.0 0.387 0.0 HOH
 5.639
 C
 O
ARG C:287 C:287 84.0 0.373 T -84.8 -19.1 NA NA NA
ARG E:287 E:287 85.0 0.378 T -85.2 -18.8 NA NA NA
ARG G:287 G:287 87.0 0.387 T -84.6 -20.3 NA NA NA
ARG I:287 I:287 81.0 0.36 T -83.0 -21.7 NA NA NA
ARG K:287 K:287 88.0 0.391 T -85.0 -20.2 NA NA NA
1tnu 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 75.0 0.333 T -85.3 -13.4 75.0 0.333 0.0 HOH
 4.457
 NH1
 O
ARG C:287 C:287 80.0 0.356 T -86.4 -12.0 NA NA NA
ARG E:287 E:287 81.0 0.36 T -87.2 -12.9 NA NA NA
ARG G:287 G:287 76.0 0.338 T -85.2 -12.7 NA NA NA
ARG I:287 I:287 76.0 0.338 T -85.2 -12.8 NA NA NA
ARG K:287 K:287 75.0 0.333 T -86.8 -10.7 NA NA NA
1tny 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 80.0 0.356 T -80.2 -25.0 80.0 0.356 0.0 HOH
 4.499
 NH1
 O
ARG C:287 C:287 82.0 0.364 T -83.3 -22.3 NA NA NA
ARG E:287 E:287 86.0 0.382 T -83.0 -21.8 NA NA NA
ARG G:287 G:287 82.0 0.364 T -81.1 -23.5 NA NA NA
ARG I:287 I:287 83.0 0.369 T -81.3 -23.0 NA NA NA
ARG K:287 K:287 83.0 0.369 T -84.1 -20.2 NA NA NA
1tnz 1 Q04631 92.84 0.0 X-RAY
 2004-11-02 ARG A:287 A:287 78.0 0.347 T -82.2 -17.2 78.0 0.347 0.0
ARG C:287 C:287 81.0 0.36 T -84.0 -16.7 NA NA NA
ARG E:287 E:287 83.0 0.369 T -83.1 -17.0 NA NA NA
ARG G:287 G:287 80.0 0.356 T -82.5 -18.0 NA NA NA
ARG I:287 I:287 83.0 0.369 T -81.5 -17.0 NA NA NA
ARG K:287 K:287 81.0 0.36 T -83.0 -15.5 NA NA NA
3dpy 1 Q04631 92.84 0.0 X-RAY
 2008-09-30 ARG A:287 A:287 134.0 0.596 T -83.3 -9.5 134.0 0.596 0.0 HOH
 4.955
 O
 O
3e30 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 ARG A:287 A:287 165.0 0.733 T -68.3 -28.3 165.0 0.733 0.0 HOH
 3.524
 CG
 O
3e32 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 ARG A:287 A:287 169.0 0.751 T -69.8 -30.2 169.0 0.751 0.0 HOH
 3.437
 CG
 O
3e33 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 ARG A:287 A:287 150.0 0.667 T -75.9 -28.3 150.0 0.667 0.0 HOH
 3.228
 CG
 O
3e34 1 Q04631 92.84 0.0 X-RAY
 2009-03-10 ARG A:287 A:287 147.0 0.653 T -74.6 -23.0 147.0 0.653 0.0 HOH
 2.743
 NH1
 O
3eu5 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 ARG A:287 A:287 78.0 0.347 T -44.7 -38.4 78.0 0.347 0.0 HOH
 2.902
 CA
 O
3euv 1 Q04631 92.84 0.0 X-RAY
 2009-07-07 ARG A:287 A:287 156.0 0.693 T -81.9 -24.8 156.0 0.693 0.0 HOH
 3.108
 CG
 O
4gtm 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 ARG A:287 A:287 124.0 0.551 T -83.1 -32.4 124.0 0.551 0.0 HOH
 3.165
 CD
 O
4gto 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 ARG A:287 A:287 62.0 NA T -69.2 -30.1 62.0 NA NA HOH
 2.714
 N
 O
4gtp 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 ARG A:287 A:287 152.0 0.676 T -73.8 -29.5 152.0 0.676 0.0 HOH
 3.597
 N
 O
4gtq 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 ARG A:287 A:287 54.0 NA T -73.8 -13.7 54.0 NA NA HOH
 2.633
 CA
 O
4gtr 1 Q04631 92.84 0.0 X-RAY
 2012-10-24 ARG A:287 A:287 61.0 NA T -69.3 -35.0 61.0 NA NA HOH
 5.448
 N
 O
1qbq 1 Q04631 94.89 0.0 X-RAY
 1999-06-18 ARG A:243 A:287 107.0 0.476 T 168.8 -11.0 107.0 0.476 0.0 HOH
 6.022
 N
 O
3pz4 1 Q04631 92.84 0.0 X-RAY
 2011-05-11 ARG A:289 A:287 87.0 0.387 T -80.2 -38.0 87.0 0.387 0.0 HOH
 3.198
 NE
 O
2r2l 1 Q5RKJ4 96.51 0.0 X-RAY
 2008-03-11 ARG A:234 A:287 158.0 0.702 T -65.7 -26.8 158.0 0.702 0.0 HOH
 3.422
 CG
 O
1n95 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 ARG A:233 A:287 109.0 0.484 T 166.1 -13.4 109.0 0.484 0.0
1n9a 1 Q04631 96.5 0.0 X-RAY
 2003-01-07 ARG A:233 A:287 107.0 0.476 T 167.8 -13.0 107.0 0.476 0.0
1ni1 1 Q04631 96.5 0.0 X-RAY
 2004-04-06 ARG A:233 A:287 124.0 0.551 T 140.1 -36.2 124.0 0.551 0.0
2bed 1 Q04631 96.49 0.0 X-RAY
 2006-08-08 ARG A:234 A:287 129.0 0.573 T 150.9 -22.4 129.0 0.573 0.0 HOH
 2.538
 NH1
 O
1ft2 1 Q04631 96.18 0.0 X-RAY
 1998-11-04 ARG A:233 A:287 76.0 0.338 T -78.3 -16.9 76.0 0.338 0.0
1n94 1 Q04631 96.18 0.0 X-RAY
 2003-01-07 ARG A:233 A:287 96.0 0.427 S -62.4 -12.3 96.0 0.427 0.0
1x81 1 Q04631 96.18 0.0 X-RAY
 2004-12-21 ARG A:233 A:287 78.0 0.347 T -74.8 -17.8 78.0 0.347 0.0
1nl4 1 Q04631 96.47 0.0 X-RAY
 2003-02-11 ARG A:233 A:287 130.0 0.578 S 158.5 -7.1 130.0 0.578 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p49354-f1 1 P49354 100.0 0.0 ARG A:287 A:287 86.0 0.382 T -97.4 -17.1