Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 86242008 | . | C | A | CCDS6237.1:NM_001128829.2:c.579tgG>tgT_NP_001122301.1:p.193W>C | Homo sapiens carbonic anhydrase 1 (CA1), transcript variant 5, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5gmm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2017-05-24 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -103.5 | 153.5 | 12.0 | 0.047 | 0.0 |
HOH |
2.980 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 17.0 | 0.067 | E | -102.5 | 149.4 | NA | NA | NA | |||||||||||||
| 6evr | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-06-06 | TRP | A:193 | A:192 | 13.0 | 0.051 | E | -100.4 | 152.3 | 13.0 | 0.051 | 0.0 |
HOH |
2.876 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 13.0 | 0.051 | E | -106.6 | 155.0 | NA | NA | NA | |||||||||||||
| 6ex1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | TRP | A:193 | A:192 | 15.0 | 0.059 | E | -100.6 | 150.3 | 15.0 | 0.059 | 0.0 |
HOH |
2.956 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -103.3 | 150.1 | NA | NA | NA | |||||||||||||
| 6f3b | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -104.8 | 153.6 | 12.0 | 0.047 | 0.0 |
HOH |
2.917 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 11.0 | 0.043 | E | -106.2 | 150.6 | NA | NA | NA | |||||||||||||
| 6faf | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -99.1 | 152.2 | 12.0 | 0.047 | 0.0 |
HOH |
3.130 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -105.1 | 149.7 | NA | NA | NA | |||||||||||||
| 6fag | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -96.6 | 146.6 | 12.0 | 0.047 | 0.0 |
HOH |
3.072 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 13.0 | 0.051 | E | -101.2 | 145.9 | NA | NA | NA | |||||||||||||
| 6g3v | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-11-28 | TRP | A:193 | A:192 | 11.0 | 0.043 | E | -101.0 | 147.3 | 11.0 | 0.043 | 0.0 |
HOH |
6.157 |
CZ3 |
O |
||
| TRP | B:193 | B:192 | 11.0 | 0.043 | E | -98.2 | 152.1 | NA | NA | NA | |||||||||||||
| 6hwz | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-12-26 | TRP | A:193 | A:193 | 12.0 | 0.047 | E | -93.3 | 148.2 | 12.0 | 0.047 | 0.0 |
HOH |
5.515 |
C |
O |
||
| TRP | B:193 | B:193 | 10.0 | 0.039 | E | -104.2 | 145.7 | NA | NA | NA | |||||||||||||
| 6i0j | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | TRP | A:193 | A:192 | 13.0 | 0.051 | E | -103.2 | 149.6 | 13.0 | 0.051 | 0.0 |
GOL HOH |
4.998 2.914 |
CZ2 NE1 |
O3 O |
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| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -105.0 | 150.9 | NA | NA | NA | |||||||||||||
| 6i0l | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | TRP | A:193 | A:192 | 14.0 | 0.055 | E | -102.1 | 153.0 | 14.0 | 0.055 | 0.0 |
HOH |
2.875 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -103.4 | 153.9 | NA | NA | NA | |||||||||||||
| 6swm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-10-07 | TRP | A:193 | A:192 | 10.0 | 0.039 | E | -89.8 | 150.7 | 10.0 | 0.039 | 0.0 |
HOH |
6.643 |
CZ3 |
O |
||
| TRP | B:193 | B:192 | 14.0 | 0.055 | E | -104.9 | 156.1 | NA | NA | NA | |||||||||||||
| 6xze | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 11.0 | 0.043 | E | -104.0 | 152.4 | 11.0 | 0.043 | 0.0 |
HOH |
2.879 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 11.0 | 0.043 | E | -103.3 | 152.4 | NA | NA | NA | |||||||||||||
| 6xzo | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 11.0 | 0.043 | E | -106.5 | 151.2 | 11.0 | 0.043 | 0.0 |
HOH |
2.903 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 11.0 | 0.043 | E | -106.3 | 152.4 | NA | NA | NA | |||||||||||||
| 6xzs | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -104.1 | 151.6 | 12.0 | 0.047 | 0.0 |
HOH |
2.902 |
NE1 |
O |
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| TRP | B:193 | B:192 | 13.0 | 0.051 | E | -105.9 | 151.8 | NA | NA | NA | |||||||||||||
| 6xzx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -102.1 | 151.6 | 12.0 | 0.047 | 0.0 |
HOH |
2.963 |
NE1 |
O |
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| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -103.6 | 152.5 | NA | NA | NA | |||||||||||||
| 6xzy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 11.0 | 0.043 | E | -102.3 | 153.0 | 11.0 | 0.043 | 0.0 |
HOH |
2.850 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 11.0 | 0.043 | E | -103.3 | 151.9 | NA | NA | NA | |||||||||||||
| 6y00 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | TRP | A:193 | A:192 | 12.0 | 0.047 | E | -105.4 | 152.1 | 12.0 | 0.047 | 0.0 |
HOH |
2.863 |
NE1 |
O |
||
| TRP | B:193 | B:192 | 12.0 | 0.047 | E | -103.3 | 152.8 | NA | NA | NA | |||||||||||||
| 7q0d | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2022-01-12 | TRP | A:193 | A:192 | 17.0 | 0.067 | E | -105.7 | 152.5 | 17.0 | 0.067 | 0.0 |
ACT EDO HOH |
5.235 2.906 3.424 |
CZ3 NE1 CH2 |
CH3 O1 O |
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| TRP | B:193 | B:192 | 13.0 | 0.051 | E | -104.8 | 151.4 | NA | NA | NA | |||||||||||||
| 1azm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 14.0 | 0.055 | E | -118.1 | 144.2 | 14.0 | 0.055 | 0.0 |
HOH |
2.599 |
NE1 |
O |
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| 1bzm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 14.0 | 0.055 | E | -113.0 | 150.5 | 14.0 | 0.055 | 0.0 |
HOH |
2.800 |
NE1 |
O |
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| 1czm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 16.0 | 0.063 | E | -115.3 | 151.9 | 16.0 | 0.063 | 0.0 |
HG HG HG HG HOH |
9.423 7.316 6.991 5.943 2.648 |
N N N CZ3 NE1 |
HG HG HG HG O |
||
| 1hcb | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -108.5 | 149.9 | 13.0 | 0.051 | 0.0 |
HOH |
2.966 |
NE1 |
O |
||
| 1hug | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -112.5 | 148.6 | 13.0 | 0.051 | 0.0 |
HOH |
2.874 |
NE1 |
O |
||
| 1huh | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | TRP | A:192 | A:192 | 11.0 | 0.043 | E | -99.9 | 149.0 | 11.0 | 0.043 | 0.0 |
IOD HOH |
6.649 3.316 |
N NE1 |
I O |
||
| 2foy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-04-04 | TRP | A:192 | A:192 | 12.0 | 0.047 | E | -118.2 | 150.6 | 12.0 | 0.047 | 0.0 |
HOH |
2.843 |
NE1 |
O |
||
| TRP | B:192 | B:192 | 13.0 | 0.051 | E | -117.7 | 150.6 | NA | NA | NA | |||||||||||||
| 2fw4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-08-08 | TRP | A:192 | A:192 | 15.0 | 0.059 | E | -99.6 | 143.8 | 15.0 | 0.059 | 0.0 |
HOH |
2.983 |
NE1 |
O |
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| TRP | B:192 | B:192 | 23.0 | 0.09 | E | -103.6 | 163.3 | NA | NA | NA | |||||||||||||
| 2nmx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | TRP | A:192 | A:192 | 12.0 | 0.047 | E | -120.7 | 148.8 | 12.0 | 0.047 | 0.0 |
HOH |
2.827 |
NE1 |
O |
||
| TRP | B:192 | B:192 | 9.0 | 0.035 | E | -119.3 | 151.5 | NA | NA | NA | |||||||||||||
| 2nn1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | TRP | A:192 | A:192 | 11.0 | 0.043 | E | -121.3 | 149.0 | 11.0 | 0.043 | 0.0 |
HOH |
2.841 |
NE1 |
O |
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| TRP | B:192 | B:192 | 11.0 | 0.043 | E | -119.7 | 153.1 | NA | NA | NA | |||||||||||||
| 2nn7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | TRP | A:192 | A:192 | 12.0 | 0.047 | E | -120.8 | 150.6 | 12.0 | 0.047 | 0.0 |
DMS HOH |
3.059 6.116 |
NE1 CZ3 |
O O |
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| TRP | B:192 | B:192 | 12.0 | 0.047 | E | -119.5 | 153.2 | NA | NA | NA | |||||||||||||
| 3lxe | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -115.3 | 148.1 | 13.0 | 0.051 | 0.0 |
HOH |
2.937 |
NE1 |
O |
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| TRP | B:192 | B:192 | 11.0 | 0.043 | E | -118.3 | 152.6 | NA | NA | NA | |||||||||||||
| 3w6h | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -109.3 | 160.4 | 13.0 | 0.051 | 0.0 | ||||||
| TRP | B:192 | B:192 | 12.0 | 0.047 | E | -112.0 | 160.0 | NA | NA | NA | |||||||||||||
| 3w6i | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | TRP | A:192 | A:192 | 11.0 | 0.043 | E | -102.5 | 148.3 | 11.0 | 0.043 | 0.0 |
HOH |
6.057 |
CZ3 |
O |
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| TRP | B:192 | E:192 | 10.0 | 0.039 | E | -102.4 | 148.8 | NA | NA | NA | |||||||||||||
| 4wr7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -108.9 | 154.6 | 13.0 | 0.051 | 0.0 |
HOH |
2.915 |
NE1 |
O |
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| TRP | B:192 | B:192 | 26.0 | 0.102 | E | -105.7 | 154.7 | NA | NA | NA | |||||||||||||
| 4wup | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | TRP | A:192 | A:192 | 14.0 | 0.055 | E | -106.9 | 150.1 | 14.0 | 0.055 | 0.0 |
HOH |
2.925 |
NE1 |
O |
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| TRP | B:192 | B:192 | 14.0 | 0.055 | E | -106.8 | 150.7 | NA | NA | NA | |||||||||||||
| 4wuq | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | TRP | A:192 | A:192 | 11.0 | 0.043 | E | -105.6 | 153.5 | 11.0 | 0.043 | 0.0 |
HOH |
2.859 |
NE1 |
O |
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| TRP | B:192 | B:192 | 23.0 | 0.09 | E | -103.8 | 144.9 | NA | NA | NA | |||||||||||||
| 5e2m | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2016-10-05 | TRP | A:192 | A:192 | 14.0 | 0.055 | E | -105.8 | 147.4 | 14.0 | 0.055 | 0.0 |
HOH |
2.885 |
NE1 |
O |
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| TRP | B:192 | B:192 | 22.0 | 0.086 | E | -98.8 | 153.3 | NA | NA | NA | |||||||||||||
| 1j9w | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-06-13 | TRP | A:192 | A:192 | 13.0 | 0.051 | E | -101.7 | 148.6 | 13.0 | 0.051 | 0.0 |
HOH |
6.000 |
CZ3 |
O |
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| TRP | B:192 | B:192 | 22.0 | 0.086 | E | -104.2 | 150.6 | NA | NA | NA | |||||||||||||
| 1jv0 | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-09-19 | TRP | A:192 | A:192 | 11.0 | 0.043 | E | -111.2 | 147.5 | 11.0 | 0.043 | 0.0 |
HOH |
2.882 |
NE1 |
O |
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| TRP | B:192 | B:192 | 27.0 | 0.106 | E | -96.5 | 147.3 | NA | NA | NA | |||||||||||||
| 1crm | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1995-02-07 | TRP | A:192 | A:192 | 18.0 | 0.071 | E | -115.6 | 148.3 | 18.0 | 0.071 | 0.0 |
HG HG CL H2S HOH |
7.229 7.019 7.098 7.930 2.778 |
N N N N NE1 |
HG HG CL S O |
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| 2cab | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1984-02-02 | TRP | A:192 | A:192 | 9.0 | 0.035 | E | -113.7 | 147.6 | 9.0 | 0.035 | 0.0 | ||||||
| 2it4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-09-11 | TRP | A:188 | A:192 | 13.0 | 0.051 | E | -107.3 | 157.3 | 13.0 | 0.051 | 0.0 |
HOH |
2.786 |
NE1 |
O |
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| TRP | B:188 | B:192 | 22.0 | 0.086 | E | -104.8 | 153.8 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00915-f1 | 1 | P00915 | 100.0 | 0.0 | TRP | A:193 | A:193 | 12.0 | 0.047 | E | -97.1 | 150.5 | |