Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr8 86242031 . G A CCDS6237.1:NM_001128829.2:c.556Ctt>Ttt_NP_001122301.1:p.186L>F Homo sapiens carbonic anhydrase 1 (CA1), transcript variant 5, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5gmm 1 P00915 100.0 0.0 X-RAY
 2017-05-24 LEU A:186 A:185 24.0 0.141 S -77.7 151.6 24.0 0.141 0.0 HOH
 4.088
 CB
 O
LEU B:186 B:185 18.0 0.106 S -68.2 154.6 NA NA NA
6evr 1 P00915 100.0 0.0 X-RAY
 2018-06-06 LEU A:186 A:185 19.0 0.112 S -79.6 157.9 19.0 0.112 0.0 HOH
 2.824
 O
 O
LEU B:186 B:185 19.0 0.112 S -72.6 154.8 NA NA NA
6ex1 1 P00915 100.0 0.0 X-RAY
 2018-10-10 LEU A:186 A:185 21.0 0.124 S -77.4 151.9 21.0 0.124 0.0 HOH
 3.031
 O
 O
LEU B:186 B:185 17.0 0.1 S -77.7 151.0 NA NA NA
6f3b 1 P00915 100.0 0.0 X-RAY
 2018-10-10 LEU A:186 A:185 19.0 0.112 S -73.5 152.2 19.0 0.112 0.0 HOH
 2.719
 O
 O
LEU B:186 B:185 21.0 0.124 S -74.6 155.4 NA NA NA
6faf 1 P00915 100.0 0.0 X-RAY
 2018-10-10 LEU A:186 A:185 20.0 0.118 S -78.8 148.5 20.0 0.118 0.0 HOH
 4.503
 N
 O
LEU B:186 B:185 20.0 0.118 S -72.6 150.1 NA NA NA
6fag 1 P00915 100.0 0.0 X-RAY
 2018-10-10 LEU A:186 A:185 21.0 0.124 S -75.5 148.0 21.0 0.124 0.0 HOH
 4.612
 N
 O
LEU B:186 B:185 23.0 0.135 S -73.6 154.3 NA NA NA
6g3v 1 P00915 100.0 0.0 X-RAY
 2018-11-28 LEU A:186 A:185 22.0 0.129 S -74.9 151.6 22.0 0.129 0.0 HOH
 4.584
 N
 O
LEU B:186 B:185 20.0 0.118 S -62.1 150.0 NA NA NA
6hwz 1 P00915 100.0 0.0 X-RAY
 2018-12-26 LEU A:186 A:186 21.0 0.124 S -81.4 153.7 21.0 0.124 0.0 HOH
 4.480
 N
 O
LEU B:186 B:186 17.0 0.1 S -74.4 154.9 NA NA NA
6i0j 1 P00915 100.0 0.0 X-RAY
 2019-11-20 LEU A:186 A:185 21.0 0.124 S -79.3 153.3 21.0 0.124 0.0 HOH
 3.132
 O
 O
LEU B:186 B:185 12.0 0.071 S -74.1 155.1 NA NA NA
6i0l 1 P00915 100.0 0.0 X-RAY
 2019-11-20 LEU A:186 A:185 18.0 0.106 S -75.9 153.3 18.0 0.106 0.0 HOH
 2.968
 O
 O
LEU B:186 B:185 17.0 0.1 S -68.6 153.0 NA NA NA
6swm 1 P00915 100.0 0.0 X-RAY
 2020-10-07 LEU A:186 A:185 20.0 0.118 S -62.5 159.7 20.0 0.118 0.0 HOH
 5.574
 O
 O
LEU B:186 B:185 13.0 0.076 S -64.4 162.1 NA NA NA
6xze 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 17.0 0.1 S -76.0 154.0 17.0 0.1 0.0 HOH
 2.670
 O
 O
LEU B:186 B:185 15.0 0.088 S -76.8 155.8 NA NA NA
6xzo 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 18.0 0.106 S -77.7 155.7 18.0 0.106 0.0 HOH
 2.824
 O
 O
LEU B:186 B:185 15.0 0.088 S -76.1 158.0 NA NA NA
6xzs 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 16.0 0.094 S -75.2 153.4 16.0 0.094 0.0 HOH
 2.694
 O
 O
LEU B:186 B:185 15.0 0.088 S -76.2 155.8 NA NA NA
6xzx 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 17.0 0.1 S -76.8 155.2 17.0 0.1 0.0 HOH
 2.905
 O
 O
LEU B:186 B:185 11.0 0.065 S -79.6 157.7 NA NA NA
6xzy 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 19.0 0.112 S -79.2 153.5 19.0 0.112 0.0 HOH
 2.831
 O
 O
LEU B:186 B:185 15.0 0.088 S -78.9 157.1 NA NA NA
6y00 1 P00915 100.0 0.0 X-RAY
 2020-09-23 LEU A:186 A:185 17.0 0.1 S -76.6 154.0 17.0 0.1 0.0 HOH
 2.720
 O
 O
LEU B:186 B:185 15.0 0.088 S -75.1 155.6 NA NA NA
7q0d 1 P00915 100.0 0.0 X-RAY
 2022-01-12 LEU A:186 A:185 13.0 0.076 S -75.8 159.1 13.0 0.076 0.0 PEG
EDO
HOH
 3.607
9.555
2.734
 O
N
O
 O4
O2
O
LEU B:186 B:185 15.0 0.088 S -77.0 157.8 NA NA NA
1azm 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 20.0 0.118 S -81.1 153.1 20.0 0.118 0.0 HOH
 4.446
 N
 O
1bzm 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 19.0 0.112 S -80.3 154.2 19.0 0.112 0.0 HOH
 3.312
 O
 O
1czm 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 40.0 0.235 S -78.2 147.3 40.0 0.235 0.0 HG
HG
HG
HG
HG
HOH
 5.470
3.625
5.302
6.396
8.470
4.402
 CD2
O
CG
CG
CA
N
 HG
HG
HG
HG
HG
O
1hcb 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 21.0 0.124 S -80.0 160.8 21.0 0.124 0.0 HOH
 2.851
 O
 O
1hug 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 20.0 0.118 S -80.5 158.1 20.0 0.118 0.0 HOH
 4.294
 O
 O
1huh 1 P00915 100.0 0.0 X-RAY
 1994-04-30 LEU A:185 A:185 18.0 0.106 S -78.3 163.7 18.0 0.106 0.0 IOD
HOH
 5.772
2.202
 CD2
O
 I
O
2foy 1 P00915 100.0 0.0 X-RAY
 2006-04-04 LEU A:185 A:185 14.0 0.082 S -76.8 155.6 14.0 0.082 0.0 HOH
 2.779
 O
 O
LEU B:185 B:185 19.0 0.112 S -76.0 155.8 NA NA NA
2fw4 1 P00915 100.0 0.0 X-RAY
 2006-08-08 LEU A:185 A:185 20.0 0.118 S -80.0 149.1 20.0 0.118 0.0 HOH
 3.023
 O
 O
LEU B:185 B:185 18.0 0.106 S -72.7 155.8 NA NA NA
2nmx 1 P00915 100.0 0.0 X-RAY
 2007-04-24 LEU A:185 A:185 22.0 0.129 S -74.5 155.1 22.0 0.129 0.0 HOH
 2.725
 O
 O
LEU B:185 B:185 18.0 0.106 S -75.8 155.1 NA NA NA
2nn1 1 P00915 100.0 0.0 X-RAY
 2007-04-24 LEU A:185 A:185 14.0 0.082 S -75.2 153.4 14.0 0.082 0.0 HOH
 2.743
 O
 O
LEU B:185 B:185 17.0 0.1 S -74.6 156.8 NA NA NA
2nn7 1 P00915 100.0 0.0 X-RAY
 2007-05-08 LEU A:185 A:185 14.0 0.082 S -76.7 155.3 14.0 0.082 0.0 HOH
 2.784
 O
 O
LEU B:185 B:185 18.0 0.106 S -75.5 156.9 NA NA NA
3lxe 1 P00915 100.0 0.0 X-RAY
 2010-07-21 LEU A:185 A:185 22.0 0.129 S -78.8 152.4 22.0 0.129 0.0 HOH
 2.859
 O
 O
LEU B:185 B:185 19.0 0.112 S -71.0 152.4 NA NA NA
3w6h 1 P00915 100.0 0.0 X-RAY
 2013-03-13 LEU A:185 A:185 22.0 0.129 S -76.6 152.0 22.0 0.129 0.0
LEU B:185 B:185 23.0 0.135 S -79.5 152.4 NA NA NA
3w6i 1 P00915 100.0 0.0 X-RAY
 2013-03-13 LEU A:185 A:185 21.0 0.124 S -69.6 153.9 21.0 0.124 0.0 HOH
 2.741
 O
 O
LEU B:185 E:185 19.0 0.112 S -69.7 153.9 NA NA NA
4wr7 1 P00915 100.0 0.0 X-RAY
 2015-07-01 LEU A:185 A:185 15.0 0.088 S -72.5 160.0 15.0 0.088 0.0 HOH
 2.671
 O
 O
LEU B:185 B:185 14.0 0.082 S -78.1 162.0 NA NA NA
4wup 1 P00915 100.0 0.0 X-RAY
 2015-07-01 LEU A:185 A:185 15.0 0.088 S -73.3 152.8 15.0 0.088 0.0 HOH
 2.768
 O
 O
LEU B:185 B:185 16.0 0.094 S -72.1 155.7 NA NA NA
4wuq 1 P00915 100.0 0.0 X-RAY
 2015-07-01 LEU A:185 A:185 21.0 0.124 S -76.6 155.5 21.0 0.124 0.0 HOH
 2.878
 O
 O
LEU B:185 B:185 14.0 0.082 S -73.7 157.0 NA NA NA
5e2m 1 P00915 100.0 0.0 X-RAY
 2016-10-05 LEU A:185 A:185 15.0 0.088 S -72.5 156.2 15.0 0.088 0.0 HOH
 2.714
 O
 O
LEU B:185 B:185 12.0 0.071 S -76.6 158.5 NA NA NA
1j9w 1 P00915 99.62 0.0 X-RAY
 2001-06-13 LEU A:185 A:185 31.0 0.182 S -73.8 157.0 31.0 0.182 0.0 HOH
 3.265
 CD2
 O
LEU B:185 B:185 13.0 0.076 S -84.4 172.1 NA NA NA
1jv0 1 P00915 99.62 0.0 X-RAY
 2001-09-19 LEU A:185 A:185 33.0 0.194 S -74.3 158.8 33.0 0.194 0.0 HOH
 3.634
 CB
 O
LEU B:185 B:185 16.0 0.094 S -70.9 156.2 NA NA NA
1crm 1 P00915 99.23 0.0 X-RAY
 1995-02-07 LEU A:185 A:185 36.0 0.212 S -83.1 155.6 36.0 0.212 0.0 HG
HG
CL
H2S
HOH
 5.497
6.275
6.554
5.964
3.715
 CD1
CB
CD1
C
CB
 HG
HG
CL
S
O
2cab 1 P00915 99.23 0.0 X-RAY
 1984-02-02 LEU A:185 A:185 19.0 0.112 S -73.0 153.7 19.0 0.112 0.0
2it4 1 P00915 100.0 0.0 X-RAY
 2007-09-11 LEU A:181 A:185 22.0 0.129 S -79.6 150.0 22.0 0.129 0.0 HOH
 4.081
 O
 O
LEU B:181 B:185 15.0 0.088 S -83.3 152.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00915-f1 1 P00915 100.0 0.0 LEU A:186 A:186 10.0 0.059 S -78.5 153.2