Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 86249206 | . | G | A | CCDS6237.1:NM_001128829.2:c.322Cat>Tat_NP_001122301.1:p.108H>Y | Homo sapiens carbonic anhydrase 1 (CA1), transcript variant 5, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5gmm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2017-05-24 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -72.7 | 153.7 | 0.0 | 0.0 | 0.0 |
ZN 949 HOH |
7.765 7.196 4.696 |
CE1 CE1 N |
ZN O21 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -68.6 | 144.6 | NA | NA | NA | |||||||||||||
| 6evr | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-06-06 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -71.0 | 153.7 | 0.0 | 0.0 | 0.0 |
ZN BZW ACT HOH |
7.792 7.501 5.580 4.808 |
CE1 CE1 O N |
ZN O26 O O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -68.1 | 155.0 | NA | NA | NA | |||||||||||||
| 6ex1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -71.6 | 149.1 | 0.0 | 0.0 | 0.0 |
ZN N19 ACT HOH |
7.823 7.526 6.002 4.829 |
CE1 CE1 O N |
ZN O27 OXT O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -72.0 | 150.3 | NA | NA | NA | |||||||||||||
| 6f3b | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -68.0 | 148.9 | 0.0 | 0.0 | 0.0 |
ZN CJK ACT HOH |
7.878 7.363 5.633 4.906 |
CE1 CE1 O N |
ZN O22 CH3 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -68.7 | 151.9 | NA | NA | NA | |||||||||||||
| 6faf | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -75.1 | 150.9 | 0.0 | 0.0 | 0.0 |
ZN D3B HOH |
7.821 7.155 4.530 |
CE1 CE1 N |
ZN O3 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -69.1 | 153.0 | NA | NA | NA | |||||||||||||
| 6fag | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -71.3 | 150.1 | 0.0 | 0.0 | 0.0 |
ZN EON HOH |
7.804 7.122 4.671 |
CE1 CE1 N |
ZN O20 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -71.6 | 150.8 | NA | NA | NA | |||||||||||||
| 6g3v | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-11-28 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -69.9 | 149.2 | 0.0 | 0.0 | 0.0 |
ZN FO9 HOH |
7.822 7.469 4.869 |
CE1 CE1 N |
ZN O1 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -74.6 | 149.6 | NA | NA | NA | |||||||||||||
| 6hwz | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-12-26 | HIS | A:108 | A:108 | 0.0 | 0.0 | S | -72.8 | 150.3 | 0.0 | 0.0 | 0.0 |
ZN GXE HOH |
7.817 7.839 4.934 |
CE1 CE1 N |
ZN SE O |
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| HIS | B:108 | B:108 | 0.0 | 0.0 | S | -74.7 | 154.9 | NA | NA | NA | |||||||||||||
| 6i0j | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -69.5 | 153.8 | 0.0 | 0.0 | 0.0 |
ZN ACT GZE HOH |
8.018 5.922 6.742 4.844 |
CE1 O CE1 N |
ZN O O5 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -66.1 | 151.8 | NA | NA | NA | |||||||||||||
| 6i0l | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -72.4 | 152.4 | 0.0 | 0.0 | 0.0 |
ZN GZH ACT HOH |
7.894 7.290 5.724 4.837 |
CE1 CE1 O N |
ZN O14 CH3 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -71.1 | 150.7 | NA | NA | NA | |||||||||||||
| 6swm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-10-07 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -73.2 | 148.8 | 0.0 | 0.0 | 0.0 |
ZN LVW HOH |
8.011 7.375 8.482 |
CE1 CE1 CB |
ZN SE O |
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| HIS | B:108 | B:107 | 1.0 | 0.005 | S | -81.1 | 158.7 | NA | NA | NA | |||||||||||||
| 6xze | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -69.5 | 150.3 | 0.0 | 0.0 | 0.0 |
ZN O4Z HOH |
7.902 7.258 4.860 |
CE1 CE1 N |
ZN O03 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -69.5 | 151.9 | NA | NA | NA | |||||||||||||
| 6xzo | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -69.5 | 149.3 | 0.0 | 0.0 | 0.0 |
ZN O55 HOH |
7.870 7.171 4.889 |
CE1 CE1 N |
ZN O03 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -70.4 | 151.4 | NA | NA | NA | |||||||||||||
| 6xzs | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -70.2 | 150.1 | 0.0 | 0.0 | 0.0 |
ZN O5K HOH |
7.864 7.266 4.804 |
CE1 CE1 N |
ZN O03 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -68.1 | 150.8 | NA | NA | NA | |||||||||||||
| 6xzx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -72.0 | 152.2 | 0.0 | 0.0 | 0.0 |
ZN O5H HOH |
7.870 7.114 4.808 |
CE1 CE1 N |
ZN O04 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -71.5 | 151.6 | NA | NA | NA | |||||||||||||
| 6xzy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -71.1 | 151.8 | 0.0 | 0.0 | 0.0 |
ZN O5N HOH |
7.869 7.220 4.841 |
CE1 CE1 N |
ZN O04 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -71.6 | 151.3 | NA | NA | NA | |||||||||||||
| 6y00 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -68.0 | 149.2 | 0.0 | 0.0 | 0.0 |
ZN O5T HOH |
7.833 7.259 4.840 |
CE1 CE1 N |
ZN O04 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -68.6 | 152.0 | NA | NA | NA | |||||||||||||
| 7q0d | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2022-01-12 | HIS | A:108 | A:107 | 0.0 | 0.0 | S | -64.6 | 155.3 | 0.0 | 0.0 | 0.0 |
ZN 84Z EDO ACT ACT HOH |
7.843 7.372 6.648 9.069 8.212 4.844 |
CE1 CE1 C O O N |
ZN O9 O1 O CH3 O |
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| HIS | B:108 | B:107 | 0.0 | 0.0 | S | -69.6 | 153.1 | NA | NA | NA | |||||||||||||
| 1azm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -78.7 | 146.9 | 0.0 | 0.0 | 0.0 |
ZN AZM HOH |
7.888 7.099 4.726 |
CE1 CE1 N |
ZN O2 O |
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| 1bzm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -79.1 | 151.7 | 0.0 | 0.0 | 0.0 |
ZN MZM HOH |
7.901 7.259 4.658 |
CE1 CE1 N |
ZN O2 O |
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| 1czm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -74.5 | 151.7 | 0.0 | 0.0 | 0.0 |
ZN HG AAS HOH |
8.129 8.159 7.690 6.665 |
CE1 CB CE1 C |
ZN HG O2 O |
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| 1hcb | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -69.5 | 148.9 | 0.0 | 0.0 | 0.0 |
ZN BCT HOH |
7.940 7.290 5.062 |
CE1 CE1 N |
ZN O2 O |
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| 1hug | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -75.5 | 149.6 | 0.0 | 0.0 | 0.0 |
ZN AUC HOH |
8.106 8.671 4.788 |
CE1 CE1 N |
ZN N1 O |
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| 1huh | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -67.8 | 149.0 | 0.0 | 0.0 | 0.0 |
ZN IOD IOD HOH |
8.040 7.943 9.102 5.100 |
CE1 CE1 O N |
ZN I I O |
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| 2foy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-04-04 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -79.3 | 154.4 | 0.0 | 0.0 | 0.0 |
ZN B30 HOH |
7.822 7.345 4.891 |
CE1 CE1 N |
ZN O1 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -76.2 | 155.2 | NA | NA | NA | |||||||||||||
| 2fw4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-08-08 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -75.8 | 146.9 | 0.0 | 0.0 | 0.0 |
ZN HOH |
7.797 4.867 |
CE1 N |
ZN O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -74.7 | 148.4 | NA | NA | NA | |||||||||||||
| 2nmx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -79.9 | 153.6 | 0.0 | 0.0 | 0.0 |
ZN M25 HOH |
7.829 7.281 4.763 |
CE1 CE1 N |
ZN O2 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -80.1 | 152.7 | NA | NA | NA | |||||||||||||
| 2nn1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -78.3 | 155.9 | 0.0 | 0.0 | 0.0 |
ZN M28 HOH |
7.762 7.229 4.734 |
CE1 CE1 N |
ZN O2 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -77.8 | 154.4 | NA | NA | NA | |||||||||||||
| 2nn7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -77.3 | 156.9 | 0.0 | 0.0 | 0.0 |
ZN M29 HOH |
7.824 7.272 4.764 |
CE1 CE1 N |
ZN O2 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -76.1 | 156.9 | NA | NA | NA | |||||||||||||
| 3lxe | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -79.6 | 156.0 | 0.0 | 0.0 | 0.0 |
ZN TOR HOH |
7.760 7.640 4.650 |
CE1 CE1 N |
ZN OAS O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -77.8 | 156.2 | NA | NA | NA | |||||||||||||
| 3w6h | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | HIS | A:107 | A:107 | 1.0 | 0.005 | -80.9 | 141.5 | 1.0 | 0.005 | 0.0 |
ZN AZM |
7.838 7.726 |
CE1 CE1 |
ZN O1 |
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| HIS | B:107 | B:107 | 1.0 | 0.005 | -78.4 | 140.1 | NA | NA | NA | ||||||||||||||
| 3w6i | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -78.9 | 147.0 | 0.0 | 0.0 | 0.0 |
ZN HOH |
7.743 4.822 |
CE1 N |
ZN O |
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| HIS | B:107 | E:107 | 0.0 | 0.0 | S | -79.1 | 146.9 | NA | NA | NA | |||||||||||||
| 4wr7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -65.0 | 149.5 | 0.0 | 0.0 | 0.0 |
ZN 3TV HOH |
7.833 7.248 4.891 |
CE1 CE1 N |
ZN O4 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -67.7 | 152.3 | NA | NA | NA | |||||||||||||
| 4wup | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -70.6 | 150.2 | 0.0 | 0.0 | 0.0 |
ZN 3UF HOH |
7.769 7.214 4.929 |
CE1 CE1 N |
ZN O4 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -73.6 | 151.7 | NA | NA | NA | |||||||||||||
| 4wuq | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -71.3 | 154.1 | 0.0 | 0.0 | 0.0 |
ZN 3UG HOH |
7.849 7.198 4.885 |
CE1 CE1 N |
ZN O2 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -71.4 | 152.2 | NA | NA | NA | |||||||||||||
| 5e2m | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2016-10-05 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -70.8 | 151.9 | 0.0 | 0.0 | 0.0 |
ZN V14 HOH |
7.833 7.387 4.910 |
CE1 CE1 N |
ZN O8 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -70.7 | 153.3 | NA | NA | NA | |||||||||||||
| 1j9w | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-06-13 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -51.9 | 147.8 | 0.0 | 0.0 | 0.0 |
ZN EDO HOH |
7.810 7.542 4.901 |
CE1 CE1 N |
ZN C2 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -64.6 | 160.2 | NA | NA | NA | |||||||||||||
| 1jv0 | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-09-19 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -67.8 | 154.0 | 0.0 | 0.0 | 0.0 |
ZN EDO HOH |
7.828 7.603 4.790 |
CE1 CE1 N |
ZN C1 O |
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| HIS | B:107 | B:107 | 0.0 | 0.0 | S | -61.3 | 155.4 | NA | NA | NA | |||||||||||||
| 1crm | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1995-02-07 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -81.3 | 148.7 | 0.0 | 0.0 | 0.0 |
HG CL HOH |
7.863 8.064 4.648 |
CE1 CE1 N |
HG CL O |
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| 2cab | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1984-02-02 | HIS | A:107 | A:107 | 0.0 | 0.0 | S | -78.4 | 152.2 | 0.0 | 0.0 | 0.0 |
ZN |
7.865 |
CE1 |
ZN |
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| 2it4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-09-11 | HIS | A:103 | A:107 | 0.0 | 0.0 | S | -62.1 | 148.1 | 0.0 | 0.0 | 0.0 |
ZN PPF HOH |
7.944 7.619 4.641 |
CE1 CE1 N |
ZN O1 O |
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| HIS | B:103 | B:107 | 0.0 | 0.0 | S | -61.0 | 151.4 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00915-f1 | 1 | P00915 | 100.0 | 0.0 | HIS | A:108 | A:108 | 0.0 | 0.0 | S | -74.6 | 152.1 | |