Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr8 | 86250521 | . | A | C | CCDS6237.1:NM_001128829.2:c.195caT>caG_NP_001122301.1:p.65H>Q | Homo sapiens carbonic anhydrase 1 (CA1), transcript variant 5, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 5gmm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2017-05-24 | HIS | A:65 | A:64 | 44.0 | 0.226 | S | -87.7 | -11.8 | 44.0 | 0.226 | 0.0 |
ZN 949 949 949 HOH |
7.797 3.383 5.884 8.581 3.054 |
CE1 NE2 NE2 NE2 O |
ZN F25 C18 C5 O |
||
| HIS | B:65 | B:64 | 44.0 | 0.226 | S | -89.6 | -9.4 | NA | NA | NA | |||||||||||||
| 6evr | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-06-06 | HIS | A:65 | A:64 | 40.0 | 0.205 | S | -100.3 | -9.9 | 40.0 | 0.205 | 0.0 |
ZN BZW GOL HOH |
7.812 6.192 5.678 2.612 |
CE1 CE1 NE2 O |
ZN C22 O3 O |
||
| HIS | B:65 | B:64 | 37.0 | 0.19 | S | -100.5 | -8.1 | NA | NA | NA | |||||||||||||
| 6ex1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:65 | A:64 | 44.0 | 0.226 | S | -97.3 | -7.3 | 44.0 | 0.226 | 0.0 |
ZN N19 HOH |
7.916 5.293 2.652 |
CE1 NE2 NE2 |
ZN C22 O |
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| HIS | B:65 | B:64 | 43.0 | 0.221 | S | -96.2 | -11.8 | NA | NA | NA | |||||||||||||
| 6f3b | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:65 | A:64 | 40.0 | 0.205 | S | -94.9 | -13.1 | 40.0 | 0.205 | 0.0 |
ZN CJK HOH |
7.736 6.637 2.610 |
CE1 CE1 NE2 |
ZN C17 O |
||
| HIS | B:65 | B:64 | 39.0 | 0.2 | S | -97.2 | -11.5 | NA | NA | NA | |||||||||||||
| 6faf | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:65 | A:64 | 42.0 | 0.215 | S | -87.4 | -17.4 | 42.0 | 0.215 | 0.0 |
ZN D3B GOL HOH |
7.821 5.146 7.359 3.091 |
CE1 NE2 NE2 ND1 |
ZN O23 O3 O |
||
| HIS | B:65 | B:64 | 40.0 | 0.205 | S | -84.1 | -17.9 | NA | NA | NA | |||||||||||||
| 6fag | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-10-10 | HIS | A:65 | A:64 | 39.0 | 0.2 | S | -90.8 | -14.5 | 39.0 | 0.2 | 0.0 |
ZN GOL EON HOH |
7.910 7.032 4.937 2.746 |
CE1 NE2 NE2 O |
ZN O3 O11 O |
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| HIS | B:65 | B:64 | 40.0 | 0.205 | S | -93.7 | -10.9 | NA | NA | NA | |||||||||||||
| 6g3v | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-11-28 | HIS | A:65 | A:64 | 37.0 | 0.19 | S | -97.7 | -10.5 | 37.0 | 0.19 | 0.0 |
ZN FO9 HOH |
7.951 6.353 3.104 |
CE1 CE1 ND1 |
ZN C1 O |
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| HIS | B:65 | B:64 | 35.0 | 0.179 | S | -100.0 | -8.5 | NA | NA | NA | |||||||||||||
| 6hwz | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2018-12-26 | HIS | A:65 | A:65 | 38.0 | 0.195 | S | -101.8 | -10.9 | 38.0 | 0.195 | 0.0 |
ZN GXE HOH |
7.607 6.946 2.848 |
CE1 CE1 ND1 |
ZN C5 O |
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| HIS | B:65 | B:65 | 35.0 | 0.179 | S | -102.9 | -8.2 | NA | NA | NA | |||||||||||||
| 6i0j | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | HIS | A:65 | A:64 | 44.0 | 0.226 | S | -94.0 | -13.1 | 44.0 | 0.226 | 0.0 |
ZN GZE HOH |
7.904 6.278 2.837 |
CE1 CE1 O |
ZN C18 O |
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| HIS | B:65 | B:64 | 40.0 | 0.205 | S | -97.5 | -11.2 | NA | NA | NA | |||||||||||||
| 6i0l | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2019-11-20 | HIS | A:65 | A:64 | 38.0 | 0.195 | S | -93.7 | -12.6 | 38.0 | 0.195 | 0.0 |
ZN GZH HOH |
7.741 6.980 2.800 |
CE1 CE1 O |
ZN C11 O |
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| HIS | B:65 | B:64 | 38.0 | 0.195 | S | -99.4 | -9.2 | NA | NA | NA | |||||||||||||
| 6swm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-10-07 | HIS | A:65 | A:64 | 35.0 | 0.179 | S | -105.4 | -21.2 | 35.0 | 0.179 | 0.0 |
ZN LVW HOH |
7.597 7.689 4.714 |
CE1 CE1 CB |
ZN C5 O |
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| HIS | B:65 | B:64 | 39.0 | 0.2 | S | -96.6 | -23.8 | NA | NA | NA | |||||||||||||
| 6xze | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 42.0 | 0.215 | S | -94.1 | -9.3 | 42.0 | 0.215 | 0.0 |
ZN O4Z HOH |
7.774 6.800 2.790 |
CE1 CE1 O |
ZN C07 O |
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| HIS | B:65 | B:64 | 42.0 | 0.215 | S | -92.3 | -11.7 | NA | NA | NA | |||||||||||||
| 6xzo | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 40.0 | 0.205 | S | -93.3 | -11.2 | 40.0 | 0.205 | 0.0 |
ZN O55 HOH |
7.753 6.989 2.753 |
CE1 CE1 O |
ZN C09 O |
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| HIS | B:65 | B:64 | 41.0 | 0.21 | S | -98.5 | -8.1 | NA | NA | NA | |||||||||||||
| 6xzs | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 41.0 | 0.21 | S | -94.6 | -9.4 | 41.0 | 0.21 | 0.0 |
ZN O5K HOH |
7.790 6.843 2.713 |
CE1 CE1 O |
ZN C09 O |
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| HIS | B:65 | B:64 | 40.0 | 0.205 | S | -93.6 | -9.4 | NA | NA | NA | |||||||||||||
| 6xzx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 43.0 | 0.221 | S | -89.3 | -10.6 | 43.0 | 0.221 | 0.0 |
ZN O5H HOH |
7.801 5.186 2.663 |
CE1 NE2 NE2 |
ZN N14 O |
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| HIS | B:65 | B:64 | 39.0 | 0.2 | S | -96.5 | -8.9 | NA | NA | NA | |||||||||||||
| 6xzy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 40.0 | 0.205 | S | -95.1 | -9.0 | 40.0 | 0.205 | 0.0 |
ZN O5N HOH |
7.778 5.272 2.740 |
CE1 NE2 O |
ZN N14 O |
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| HIS | B:65 | B:64 | 39.0 | 0.2 | S | -94.6 | -10.2 | NA | NA | NA | |||||||||||||
| 6y00 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2020-09-23 | HIS | A:65 | A:64 | 43.0 | 0.221 | S | -93.8 | -9.8 | 43.0 | 0.221 | 0.0 |
ZN O5T HOH |
7.790 5.112 2.681 |
CE1 NE2 O |
ZN C15 O |
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| HIS | B:65 | B:64 | 39.0 | 0.2 | S | -95.6 | -8.5 | NA | NA | NA | |||||||||||||
| 7q0d | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2022-01-12 | HIS | A:65 | A:64 | 36.0 | 0.185 | S | -99.0 | -10.6 | 36.0 | 0.185 | 0.0 |
ZN 84Z EDO EDO HOH |
7.797 4.958 6.828 9.121 2.823 |
CE1 NE2 O N NE2 |
ZN C15 C2 C1 O |
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| HIS | B:65 | B:64 | 37.0 | 0.19 | S | -100.8 | -11.3 | NA | NA | NA | |||||||||||||
| 1azm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 42.0 | 0.215 | S | -92.6 | -7.6 | 42.0 | 0.215 | 0.0 |
ZN AZM HOH |
8.051 6.806 2.841 |
NE2 NE2 CD2 |
ZN N2 O |
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| 1bzm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 49.0 | 0.251 | S | -89.3 | -15.6 | 49.0 | 0.251 | 0.0 |
ZN MZM HOH |
7.894 6.403 2.700 |
CE1 CE1 NE2 |
ZN C5 O |
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| 1czm | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 45.0 | 0.231 | S | -91.3 | -9.0 | 45.0 | 0.231 | 0.0 |
ZN AAS HOH |
7.777 6.719 2.958 |
CE1 CE1 NE2 |
ZN C5 O |
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| 1hcb | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 41.0 | 0.21 | S | -89.2 | -9.7 | 41.0 | 0.21 | 0.0 |
ZN BCT HOH |
8.058 7.913 2.857 |
CE1 CE1 ND1 |
ZN O1 O |
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| 1hug | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 45.0 | 0.231 | S | -91.4 | -9.6 | 45.0 | 0.231 | 0.0 |
ZN AUC AUC HOH |
7.892 9.164 9.351 2.847 |
CE1 CE1 CE1 NE2 |
ZN AU AU O |
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| 1huh | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
1994-04-30 | HIS | A:64 | A:64 | 43.0 | 0.221 | S | -86.0 | -20.0 | 43.0 | 0.221 | 0.0 |
ZN IOD HOH |
7.757 8.060 2.628 |
CE1 CE1 ND1 |
ZN I O |
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| 2foy | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-04-04 | HIS | A:64 | A:64 | 43.0 | 0.221 | S | -101.9 | -7.0 | 43.0 | 0.221 | 0.0 |
ZN B30 B30 HOH |
7.949 4.506 3.597 2.871 |
CE1 NE2 CA ND1 |
ZN CU O1 O |
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| HIS | B:64 | B:64 | 45.0 | 0.231 | S | -104.1 | -6.3 | NA | NA | NA | |||||||||||||
| 2fw4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2006-08-08 | HIS | A:64 | A:64 | 40.0 | 0.205 | S | -105.9 | -2.2 | 40.0 | 0.205 | 0.0 |
ZN HIS HOH |
7.897 6.332 2.857 |
CE1 CE1 O |
ZN N O |
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| HIS | B:64 | B:64 | 41.0 | 0.21 | S | -101.7 | -13.8 | NA | NA | NA | |||||||||||||
| 2nmx | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | HIS | A:64 | A:64 | 38.0 | 0.195 | S | -101.8 | -7.7 | 38.0 | 0.195 | 0.0 |
ZN M25 HOH |
7.838 6.694 2.773 |
CE1 CE1 O |
ZN C8 O |
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| HIS | B:64 | B:64 | 39.0 | 0.2 | S | -100.0 | -8.5 | NA | NA | NA | |||||||||||||
| 2nn1 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-04-24 | HIS | A:64 | A:64 | 41.0 | 0.21 | S | -99.7 | -9.1 | 41.0 | 0.21 | 0.0 |
ZN M28 HOH |
7.739 5.948 2.768 |
CE1 NE2 O |
ZN O5 O |
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| HIS | B:64 | B:64 | 39.0 | 0.2 | S | -97.0 | -9.6 | NA | NA | NA | |||||||||||||
| 2nn7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | HIS | A:64 | A:64 | 36.0 | 0.185 | S | -99.4 | -8.0 | 36.0 | 0.185 | 0.0 |
ZN M29 HOH |
7.708 6.876 2.625 |
CE1 CE1 O |
ZN C5 O |
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| HIS | B:64 | B:64 | 41.0 | 0.21 | S | -97.0 | -10.8 | NA | NA | NA | |||||||||||||
| 3lxe | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2010-07-21 | HIS | A:64 | A:64 | 39.0 | 0.2 | S | -94.6 | -17.4 | 39.0 | 0.2 | 0.0 |
ZN TOR HOH |
8.179 3.042 2.914 |
NE2 NE2 O |
ZN OAA O |
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| HIS | B:64 | B:64 | 39.0 | 0.2 | S | -94.2 | -12.5 | NA | NA | NA | |||||||||||||
| 3w6h | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | HIS | A:64 | A:64 | 40.0 | 0.205 | S | -109.6 | -15.9 | 40.0 | 0.205 | 0.0 |
FLB ZN AZM |
7.081 7.784 6.312 |
CE1 CE1 CE1 |
C1 ZN N4 |
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| HIS | B:64 | B:64 | 38.0 | 0.195 | S | -107.2 | -15.6 | NA | NA | NA | |||||||||||||
| 3w6i | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2013-03-13 | HIS | A:64 | A:64 | 40.0 | 0.205 | S | -93.0 | -15.3 | 40.0 | 0.205 | 0.0 |
FLB ZN HOH |
6.208 8.021 2.878 |
CE1 NE2 CD2 |
C1 ZN O |
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| HIS | B:64 | E:64 | 41.0 | 0.21 | S | -92.8 | -15.3 | NA | NA | NA | |||||||||||||
| 4wr7 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:64 | A:64 | 38.0 | 0.195 | S | -99.0 | -9.7 | 38.0 | 0.195 | 0.0 |
ZN 3TV ACT HOH |
7.744 6.751 7.466 2.719 |
CE1 CE1 NE2 O |
ZN F18 OXT O |
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| HIS | B:64 | B:64 | 38.0 | 0.195 | S | -102.6 | -7.0 | NA | NA | NA | |||||||||||||
| 4wup | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:64 | A:64 | 44.0 | 0.226 | S | -93.6 | -10.2 | 44.0 | 0.226 | 0.0 |
ZN 3UF HOH |
7.985 6.943 2.488 |
CE1 CE1 O |
ZN C7 O |
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| HIS | B:64 | B:64 | 39.0 | 0.2 | S | -96.9 | -9.2 | NA | NA | NA | |||||||||||||
| 4wuq | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2015-07-01 | HIS | A:64 | A:64 | 44.0 | 0.226 | S | -94.8 | -9.3 | 44.0 | 0.226 | 0.0 |
ZN 3UG HOH |
7.709 6.913 2.707 |
CE1 CE1 O |
ZN F12 O |
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| HIS | B:64 | B:64 | 41.0 | 0.21 | S | -103.4 | -8.1 | NA | NA | NA | |||||||||||||
| 5e2m | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2016-10-05 | HIS | A:64 | A:64 | 46.0 | 0.236 | S | -96.5 | -6.4 | 46.0 | 0.236 | 0.0 |
ZN V14 HOH |
7.988 3.047 2.735 |
CE1 CE1 O |
ZN O17 O |
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| HIS | B:64 | B:64 | 42.0 | 0.215 | S | -101.3 | -5.3 | NA | NA | NA | |||||||||||||
| 1j9w | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-06-13 | HIS | A:64 | A:64 | 44.0 | 0.226 | S | -99.1 | -6.3 | 44.0 | 0.226 | 0.0 |
ZN EDO HOH |
7.721 7.074 2.672 |
CE1 CE1 ND1 |
ZN O1 O |
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| HIS | B:64 | B:64 | 43.0 | 0.221 | S | -120.7 | -14.1 | NA | NA | NA | |||||||||||||
| 1jv0 | 1 | P00915 | 99.62 | 0.0 |
X-RAY |
2001-09-19 | HIS | A:64 | A:64 | 37.0 | 0.19 | S | -98.8 | -10.2 | 37.0 | 0.19 | 0.0 |
ZN ZN CL EDO HOH |
8.044 2.070 3.658 7.546 2.778 |
CE1 CE1 CE1 CE1 CD2 |
ZN ZN CL O2 O |
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| HIS | B:64 | B:64 | 37.0 | 0.19 | S | -94.8 | -15.8 | NA | NA | NA | |||||||||||||
| 1crm | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1995-02-07 | HIS | A:64 | A:64 | 40.0 | 0.205 | S | -100.4 | -10.7 | 40.0 | 0.205 | 0.0 |
HG CL HOH |
7.819 8.321 2.854 |
CE1 CE1 ND1 |
HG CL O |
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| 2cab | 1 | P00915 | 99.23 | 0.0 |
X-RAY |
1984-02-02 | HIS | A:64 | A:64 | 40.0 | 0.205 | S | -88.9 | -14.6 | 40.0 | 0.205 | 0.0 |
ZN |
7.814 |
CE1 |
ZN |
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| 2it4 | 1 | P00915 | 100.0 | 0.0 |
X-RAY |
2007-09-11 | HIS | A:60 | A:64 | 39.0 | 0.2 | S | -96.9 | -14.2 | 39.0 | 0.2 | 0.0 |
ZN PPF HOH |
7.690 6.929 2.615 |
CE1 CE1 NE2 |
ZN O2 O |
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| HIS | B:60 | B:64 | 40.0 | 0.205 | S | -101.2 | -11.8 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00915-f1 | 1 | P00915 | 100.0 | 0.0 | HIS | A:65 | A:65 | 37.0 | 0.19 | S | -125.8 | -13.1 | |