Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr9 90344548 . A C CCDS6675.1:NM_001257971.1:c.682Atc>Ctc_NP_001244900.1:p.228I>L Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1cs8 1 P07711 99.37 0.0 X-RAY
 1999-08-23 ILE A:211 A:115 12.0 0.069 -103.6 135.3 12.0 0.069 0.0 HOH
 1.862
 O
 H1
6jd8 1 P07711 98.42 0.0 X-RAY
 2020-02-05 ILE A:255 A:211 2.0 0.011 -96.1 136.9 2.0 0.011 0.0 EOH
HOH
 8.872
5.219
 HG12
O
 HO
O
6jd0 1 P07711 97.47 0.0 X-RAY
 2020-02-05 ILE A:255 A:211 2.0 0.011 -93.9 138.6 2.0 0.011 0.0 GOL
GOL
CL
PO4
POL
POL
HOH
 6.661
7.541
5.266
6.812
8.470
9.956
2.718
 HG12
H
O
O
O
N
O
 H2
HO3
CL
O1
H11
HO
O
1cjl 1 P07711 98.4 0.0 X-RAY
 1997-08-12 ILE A:207 A:115 0.0 0.0 -97.9 140.0 0.0 0.0 0.0 HOH
 1.802
 O
 H2
3hwn 1 P07711 99.61 0.0 X-RAY
 2009-09-15 ILE A:153 A:115 19.0 0.109 -64.4 130.4 19.0 0.109 0.0 BD3
HOH
 7.081
4.349
 N
CG1
 N13
O
ILE B:153 B:115 15.0 0.086 E -87.5 132.9 NA NA NA
ILE C:153 C:115 14.0 0.08 E -77.6 125.0 NA NA NA
ILE D:153 D:115 21.0 0.12 -89.9 140.6 NA NA NA
3of8 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 ILE A:116 A:116 16.0 0.091 -85.6 141.8 16.0 0.091 0.0 HOH
 2.771
 O
 O
3of9 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 ILE A:116 A:116 21.0 0.12 -81.7 139.9 21.0 0.12 0.0
2xu3 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ILE A:115 A:115 17.0 0.097 -73.4 139.9 17.0 0.097 0.0 XU3
BTB
HOH
 9.231
9.241
2.721
 H
O
O
 H12
H31
O
2xu4 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ILE A:115 A:115 15.0 0.086 -85.2 141.2 15.0 0.086 0.0 DJT
HOH
 9.137
2.801
 H
O
 H17
O
2xu5 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ILE A:115 A:115 10.0 0.057 -76.8 136.3 10.0 0.057 0.0 HOH
 2.479
 O
 O
2yj2 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ILE A:115 A:115 12.0 0.069 -83.2 143.2 12.0 0.069 0.0 YJ2
HOH
 9.189
2.758
 H
HG12
 H11
O
2yj8 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ILE A:115 A:115 12.0 0.069 -81.1 144.3 12.0 0.069 0.0 YJ8
HOH
 9.203
2.746
 H
HG12
 H11
O
2yj9 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ILE A:115 A:115 10.0 0.057 -82.4 139.9 10.0 0.057 0.0 YJ9
HOH
 9.187
2.722
 H
O
 H17
O
2yjb 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ILE A:115 A:115 10.0 0.057 -77.1 138.2 10.0 0.057 0.0 YJ9
HOH
 9.230
2.719
 H
HG12
 H17
O
2yjc 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ILE A:115 A:115 12.0 0.069 -81.1 141.5 12.0 0.069 0.0 424
HOH
 9.967
2.752
 H
HG12
 CL2
O
3bc3 1 P07711 100.0 3e-166 X-RAY
 2008-03-18 ILE A:115 A:115 19.0 0.109 -77.1 141.3 19.0 0.109 0.0 OPT
HOH
 9.721
2.711
 N
O
 O51
O
ILE B:115 B:115 17.0 0.097 -76.6 142.2 NA NA NA
3h89 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ILE A:115 A:115 17.0 0.097 -75.0 144.9 17.0 0.097 0.0 NSX
HOH
 9.773
2.627
 O
O
 O51
O
ILE B:115 B:115 17.0 0.097 -74.6 145.0 NA NA NA
ILE C:115 C:115 16.0 0.091 -71.3 145.4 NA NA NA
ILE D:115 D:115 18.0 0.103 -69.7 145.5 NA NA NA
ILE E:115 E:115 19.0 0.109 -85.8 138.9 NA NA NA
ILE F:115 F:115 16.0 0.091 -91.3 137.2 NA NA NA
3h8b 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ILE A:115 A:115 18.0 0.103 -74.9 141.0 18.0 0.103 0.0 HOH
 2.774
 O
 O
ILE B:115 B:115 17.0 0.097 -75.6 140.6 NA NA NA
ILE C:115 C:115 16.0 0.091 -74.4 143.8 NA NA NA
ILE D:115 D:115 13.0 0.074 -74.0 144.1 NA NA NA
ILE E:115 E:115 16.0 0.091 -86.3 146.5 NA NA NA
ILE F:115 F:115 20.0 0.114 -79.8 144.5 NA NA NA
3h8c 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ILE A:115 A:115 11.0 0.063 -80.6 141.7 11.0 0.063 0.0 HOH
 3.113
 O
 O
ILE B:115 B:115 10.0 0.057 -82.1 140.0 NA NA NA
4axl 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 ILE A:115 A:115 17.0 0.097 -95.8 144.5 17.0 0.097 0.0 HOH
 2.898
 O
 O
4axm 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 ILE A:115 A:115 16.0 0.091 -77.5 144.4 16.0 0.091 0.0 HOH
 3.056
 O
 O
ILE B:115 B:115 16.0 0.091 -78.0 137.4 NA NA NA
ILE C:115 F:115 10.0 0.057 -67.8 141.1 NA NA NA
ILE D:115 I:115 15.0 0.086 -85.4 135.9 NA NA NA
ILE E:115 L:115 16.0 0.091 -75.7 134.6 NA NA NA
ILE F:115 O:115 18.0 0.103 -79.7 146.2 NA NA NA
5f02 1 P07711 100.0 3e-166 X-RAY
 2016-02-24 ILE A:115 A:115 12.0 0.069 -80.7 140.9 12.0 0.069 0.0 5T9
HOH
 9.253
2.746
 H
O
 H50
O
5mae 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 ILE A:115 A:115 11.0 0.063 -75.4 144.7 11.0 0.063 0.0 HOH
 2.800
 O
 O
5maj 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 ILE A:115 A:115 12.0 0.069 -81.2 142.2 12.0 0.069 0.0 HOH
 2.765
 O
 O
5mqy 1 P07711 100.0 3e-166 X-RAY
 2017-03-22 ILE A:115 A:115 12.0 0.069 -77.4 141.1 12.0 0.069 0.0 EDO
HOH
 7.170
2.789
 CG2
O
 O1
O
6ezp 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ILE A:115 A:115 14.0 0.08 -86.3 140.5 14.0 0.08 0.0 HOH
 2.774
 O
 O
6ezx 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ILE A:115 A:115 14.0 0.08 -60.5 137.2 14.0 0.08 0.0 HOH
 2.729
 O
 O
ILE B:115 B:115 17.0 0.097 E -92.7 125.6 17.0 0.097 0.0 HOH
 7.851
 O
 O
6f06 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ILE A:115 A:115 9.0 0.051 -91.8 142.7 9.0 0.051 0.0 ZN
HOH
 6.284
2.768
 N
O
 ZN
O
ILE B:115 B:115 7.0 0.04 -89.3 134.5 NA NA NA
2nqd 2 P07711 99.55 1e-165 X-RAY
 2007-07-24 ILE B:116 B:115 14.0 0.08 -82.3 139.1 14.0 0.08 0.0 HOH
 2.737
 O
 O
2xu1 1 P07711 99.55 2e-165 X-RAY
 2011-01-12 ILE A:115 A:115 18.0 0.103 -69.3 137.3 18.0 0.103 0.0 HOH
 2.678
 O
 O
ILE B:115 B:115 13.0 0.074 -77.7 138.1 NA NA NA
ILE C:115 C:115 16.0 0.091 -83.7 140.3 NA NA NA
ILE D:115 D:115 18.0 0.103 -99.3 141.2 NA NA NA
3hha 1 P07711 99.55 2e-165 X-RAY
 2009-06-23 ILE A:115 A:115 13.0 0.074 -86.3 140.5 13.0 0.074 0.0 HOH
 2.746
 O
 O
ILE B:115 B:115 21.0 0.12 -77.4 140.4 NA NA NA
ILE C:115 C:115 19.0 0.109 -98.5 141.9 NA NA NA
ILE D:115 D:115 17.0 0.097 -86.2 139.1 NA NA NA
3iv2 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 ILE A:115 A:115 21.0 0.12 -98.8 138.3 21.0 0.12 0.0 HOH
 2.726
 O
 O
ILE B:115 B:115 19.0 0.109 -98.2 146.6 19.0 0.109 0.0 HOH
 3.965
 N
 O
3k24 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 ILE A:115 A:115 16.0 0.091 -59.2 130.8 16.0 0.091 0.0 HOH
 9.915
 C
 O
ILE B:115 B:115 18.0 0.103 -89.0 142.0 NA NA NA
3kse 1 P07711 99.09 8e-165 X-RAY
 2010-12-01 ILE A:115 A:115 15.0 0.086 -79.6 140.5 15.0 0.086 0.0 HOH
 2.702
 O
 O
ILE B:115 B:115 13.0 0.074 -80.5 137.3 NA NA NA
ILE C:115 C:115 8.0 0.046 -80.9 138.0 NA NA NA
2vhs 1 P07711 91.82 1e-145 X-RAY
 2008-03-11 ILE A:115 A:115 16.0 0.091 -85.6 137.0 14.0 0.08 0.011 B:P07711:0.011
 HOH
 2.674
 O
 O
ILE B:115 B:115 15.0 0.086 -87.4 139.3 14.0 0.08 0.006 A:P07711:0.006
 HOH
 2.703
 O
 O
ILE C:115 C:115 14.0 0.08 -91.7 138.6 12.0 0.069 0.011 D:P07711:0.011
 HOH
 2.681
 O
 O
ILE D:115 D:115 14.0 0.08 -87.7 138.4 12.0 0.069 0.011 C:P07711:0.011
 HOH
 2.735
 O
 O
1icf 1 P07711 100.0 1e-129 X-RAY
 2000-01-12 ILE A:115 A:115 56.0 0.32 -82.4 139.4 16.0 0.091 0.229 B:P07711:0.229
 HOH
 2.630
 O
 O
ILE C:115 C:115 46.0 0.263 -88.6 143.2 NA NA NA
1mhw 1 P07711 100.0 1e-129 X-RAY
 2002-12-11 ILE A:115 A:115 49.0 0.28 -72.9 141.3 12.0 0.069 0.211 B:P07711:0.211
 HOH
 2.747
 O
 O
ILE C:115 B:115 43.0 0.246 -76.6 142.3 NA NA NA
5i4h 2 P07711 99.11 9e-78 X-RAY
 2016-04-13 ILE B:7 B:115 18.0 0.103 -98.3 138.3 18.0 0.103 0.0 HOH
 2.300
 HA
 H2

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07711-f1 1 P07711 100.0 0.0 ILE A:228 A:228 10.0 0.057 -92.4 134.6